• Neuronal intranuclear hyaline inclusion disease (NIID) is a slowly progressive neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the central and peripheral nervous system, and also in the visceral organs. (radiopaedia.org)
  • Neuronal intranuclear hyaline inclusion disease is characterized by accumulation of eosinophilic intranuclear inclusions which can be found widely within both the central and peripheral nervous system including sympathetic and myenteric ganglion neurons, dorsal root ganglion neurons, and spinal motor neurons 1-3 . (radiopaedia.org)
  • Histologically, pseudorabies lesions are characterized by non-suppurative inflammation with intranuclear herpesvirus-type viral inclusion bodies (Figure 1). (tamu.edu)
  • Diagnosis may be difficult as it relies on finding intranuclear viral inclusion bodies on biopsy samples. (everycat.org)
  • CMV infection characteristically is associated with "owl's-eye" cells, which are large cells with basophilic intranuclear inclusions and a surrounding clear zone. (medscape.com)
  • Originally considered as primarily a pediatric disease, neuronal intranuclear hyaline inclusion disease has been increasingly recognized to be a heterogeneous disease with highly variable clinical manifestations, and ante-mortem diagnosis has been difficult. (radiopaedia.org)
  • Conventional brain MRI findings of patients with neuronal intranuclear hyaline inclusion disease strongly resemble those seen in fragile X-associated tremor/ataxia syndrome (FXTAS) , including symmetric white matter involvement in combination with hyperintense changes of the middle cerebellar peduncles 4 . (radiopaedia.org)
  • Neuronal intranuclear hyaline inclusion disease showing motor-sensory and autonomic neuropathy. (radiopaedia.org)
  • Pale bodies - Pale hyaline inclusion bodies found in the substantia nigra of the brain in patients with Parkinson's disease. (pathologicalbodies.com)
  • Cytoplasmic inclusions usually are present in cells infected with RNA viruses. (medscape.com)
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • Cytoplasmic inclusion bodies containing phosphorylated and truncated forms of TDP-43 are hallmarks of amyotrophic lateral sclerosis (ALS) and a subset of frontotemporal lobar degeneration (FTLD). (biomedcentral.com)
  • Papp-Lantos bodies - Cytoplasmic inclusion bodies found in glial cells of the brain in multiple-system atrophy (MSA), a degenerative neurological disorder. (pathologicalbodies.com)
  • Parabasal bodies - Cytoplasmic bodies closely associated with the nuclei, kinetoplasts and basal bodies in certain parasitic flagellate protozoa. (pathologicalbodies.com)
  • After the primary infection, the virus spreads from the infected epithelial cells to nearby sensory nerve endings and is transported along the nerve axon to the cell body located in the trigeminal ganglion. (medscape.com)
  • In several epithelial type cells of swine the virus causes marked cell enlargement and formation of large intranuclear inclusion bodies. (iastate.edu)
  • Epithelial scrapings with Giemsa stain may show multinucleated giant cells, resulting from coalescence of infected corneal epithelial cells and intranuclear viral inclusions. (medscape.com)
  • Materials and Method: We describe in detail two cases of epithelial ovarian carcinoma associated with proliferation of Russell bodies and Mott cells in desmoplastic tumor stroma. (ogu.edu.tr)
  • Oval fat bodies - These are degenerating renal tubular epithelial cells or macrophages containing abundant lipid. (pathologicalbodies.com)
  • Histopathological examination showed lobules and fascicles of uniform partly spindle-shaped tumor cells with oval nuclei and intranuclear clear inclusions (Fig. 1 ). (biomedcentral.com)
  • Owl's eye bodies - These are usually associated with the owl's eye inclusion bodies found in tissues infected with the cytomegalovirus infection, a disease which can cause multiple organ dysfunction. (pathologicalbodies.com)
  • Results: In the first case, monoclonal proliferation was diagnosed with intranuclear inclusions (Dutcher bodies) in plasma cells. (ogu.edu.tr)
  • Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and thus, the regulation of gene expression. (biomedcentral.com)
  • Spherical intranuclear membraneless bodies nucleated by PROMYELOCYTIC LEUKEMIA PROTEIN and various other proteins containing small ubiquitin-related modifier (SUMO) interaction motif (SIM) and/or sumoylated proteins (e.g. (bvsalud.org)
  • [ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)
  • Therefore, absence of inclusions does not always exclude infection or active disease. (medscape.com)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (nih.gov)
  • The presence of viral inclusions is diagnostic, although this method has low sensitivity. (medscape.com)
  • Pacchionian bodies - Enlarged fleshy processes or villi on the outer surface of the dura mater of the brain, also called arachnoid villi or arachnoid granulations. (pathologicalbodies.com)
  • Biochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with neuronal intranuclear inclusion disease. (nih.gov)
  • Neuronal intranuclear inclusions (NIIs) are thought to be formed due to an excessive accumulation of proteins within the nucleus [ 7 ]. (biomedcentral.com)
  • Cytoplasmic inclusions usually are present in cells infected with RNA viruses. (medscape.com)
  • Even cytoplasmic inclusions can be formed by accumulation of misfolded proteins, such as ⍺-synuclein in Parkinson disease (PD) or tau protein in Alzheimer disease (AD), which are thought to contain LCRs in their sequences. (biomedcentral.com)
  • Optineurin in Huntington's disease intranuclear inclusions. (nih.gov)
  • Protein aggregation and the formation of intracellular protein inclusion bodies are associated with many degenerative disorders, including Parkinson's and Huntington's diseases, and with cirrhosis of the liver( Carrell, 2005 ). (biologists.com)
  • The presence of viral inclusions is diagnostic, although this method has low sensitivity. (medscape.com)
  • Thus, the inclusions of these diseases are supposed to be composed of the proteins with low complexity regions (LCRs). (biomedcentral.com)
  • Frequency of intranuclear inclusions (Prowazek-Halberstaedter bodies) in trachoma and other conjunctival diseases. (nih.gov)
  • Some consider it a peculiar type of papillary thyroid carcinoma (PTC) because of its nuclear features and presence of psammoma bodies. (cytojournal.com)
  • After the primary infection, the virus spreads from the infected epithelial cells to nearby sensory nerve endings and is transported along the nerve axon to the cell body located in the trigeminal ganglion. (medscape.com)
  • CMV infection characteristically is associated with "owl's-eye" cells, which are large cells with basophilic intranuclear inclusions and a surrounding clear zone. (medscape.com)
  • Therefore, absence of inclusions does not always exclude infection or active disease. (medscape.com)
  • The diagnosis is made clinically and can be confirmed with culture data (targeting possible primary infection Primary infection Herpes Simplex Virus 1 and 2 sites) and biopsy Biopsy Removal and pathologic examination of specimens from the living body. (lecturio.com)
  • It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (doctorinternet.com)
  • The two types of spaces between which water and other body fluids are distributed: extracellular and intracellular. (lookformedical.com)
  • Fluids composed mainly of water found within the body. (lookformedical.com)
  • Human immunodeficiency virus (HIV) is a virus spread through certain body fluids that attacks the body's immune system, specifically the CD4 cells, often called T cells. (journalmc.org)
  • In order to establish a method to directly identify the components of NIIs, we first analyzed the huntingtin inclusion-rich fraction obtained from the brains of Huntington disease model mice. (biomedcentral.com)
  • Parkinsons is a neurodegenerative disease that leads to shaking, stiffness, and difficulty with walking , and causes a person to lose control over some body functions. (parkinsonsinfoclub.com)
  • LBD is characterized by the presence of Lewy bodies in the nerve cells of the brain, meaning that LBD patients have Lewy bodies in the brain.2 However, Lewy bodies are also common with other conditions, such as Alzheimer's and Parkinsons disease. (parkinsonsinfoclub.com)
  • The Inclusion Body Hepatitis disease (IBH) is one of the prevalent illnesses in our country these days and reported from different regions of Iran. (org.ir)
  • Ghorani M, Ghalyanchi Langeroudi A, Khordadmehr M, Hojabr Rajeoni A. Molecular and Histopathological Characterization of Inclusion Body Hepatitis (IBH) in Broiler Chickens in Isfahan Province. (org.ir)
  • Definition: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization. (doctorinternet.com)
  • Additional slender electron-dense secretory bodies ( micronemes ) surrounded by one or two polar rings may also be present. (eol.org)
  • Basal bodies are present. (eol.org)
  • As predicted by the name of this parkinsonism, multiple system atrophy affects multiple systems of the body. (parkinsonsinfoclub.com)
  • It affects both the motor skills movement system and the involuntary system of the body. (parkinsonsinfoclub.com)
  • This damage to the immune system makes it harder and harder for the body to fight off infections. (journalmc.org)