DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
ClemastineSneezingKetotifenPyrrolidinesHistamine H1 AntagonistsAnti-Allergic AgentsMaximal Expiratory Flow RateHistamine Antagonists
AntihistamineSedativeDrugsAntihistaminesSubstancePrescriptionSymptomsDosageAcuteCommonAntibioticsAvoidMedicationsActiveGenericRandomized contrPeoplePatientsDatabaseEffects of clemastinePlaceboDrowsinessHydrogen fumarateDimethyl fumarateAntihistamine medicationsEfficacyMyelinRemyelinationSedationAnticholinergicTabletRhinorrheaTablets2023ParticipantsSymptoms of allergiesDoseAlcoholSodium2020ClinicalIndicationsColdsPreparationsAllergiesReactionsRelieveFrequentInteractionsOpticTwice dailyReBUILDYearsSideTreatmentGastrointestinalStudyRelapsesDiseaseGroupMonthsWorkEffective
Antihistamine4
  • Clemastine is an antihistamine with anticholinergic (drying) and sedative side effects. (ncats.io)
  • Tavist, which contains the active ingredient clemastine, is an antihistamine that's used for alleviating symptoms associated with allergies. (canpharm.com)
  • Clemastine is an antihistamine used to relieve the symptoms caused by allergic reactions like hay fever or urticaria. (practo.com)
  • A common antihistamine used to treat symptoms of allergies and the common cold, called clemastine fumarate, partially reversed damage to the visual system in people with multiple sclerosis (MS) in a preliminary study released today that will be presented today at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016. (healthrising.org)
Sedative1
Drugs2
  • This document includes a partial list of the drugs (formulary) for our plan which is current as of 11/01/2014. (gotomydoctor.com)
  • This document is a partial formulary and includes only some of the drugs covered by GlobalHealth Medicare. (gotomydoctor.com)
Antihistamines1
Substance1
  • Nevertheless, some chemical substance classes are generally associated with particular inhibition, including pyridine, pyrimidine and azole derivatives13. (morainetownshipdems.org)
Prescription3
  • Implementation of judicious prescribing strategies, including selection of the most effective antibiotic, prescription of an appropriate dose, and treating for the shortest possible duration. (medscape.com)
  • In general, non-prescription medications that were reported in the prescription drug section of the household adult questionnaire were moved to the non-prescription medications section (the expanded non-prescription pain relief medications section to be described later), but those medications reported on the household youth questionnaire were deleted since a non-prescription medications section was not included on the youth questionnaire. (cdc.gov)
  • Our licensed pharmacists and pharmacy technicians are your trusted source for safe, affordable and accurate prescription medications for horses, livestock and pets, including Prascend , Adequan Equine , Equioxx , LongRange for cattle , Apoquel for dogs , Atopica for cats and many more. (valleyvet.com)
Symptoms2
  • Clemastine fumarate tablets are indicated for the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus, and lacrimation. (ncats.io)
  • Clemastine fumarate syrup is indicated for relief of symptoms associated with allergic rhinitis. (pharmacy-tech-test.com)
Dosage1
  • Development and Validation of a Simultaneous HPLC Method for Assay and Dissolution of Bisoprolol fumarate and Amlodipine besylate in Pharmaceutical Dosage. (rjpdft.com)
Acute1
  • In November 2013, The American Academy of Pediatrics released a set of three basic principles for the effective use of antibiotics to treat pediatric URIs, including acute otitis media, acute bacterial sinusitis, and streptococcal pharyngitis. (medscape.com)
Common1
  • Common choices include ceftriaxone or other third-generation cephalosporins, cefuroxime, and cefamandole. (medscape.com)
Antibiotics1
  • We can supply your veterinary practice and pet pharmacy with all types of pet prescriptions, including sedatives, tranquilizers, antibiotics, anti-fungal medications, and heart medications. (myrxvaletforpets.com)
Avoid1
Medications2
  • The typical path to approval in the 21st century may include basic research leading to understanding of mechanisms of disease progression and prevention such as chemical pathways, or candidate medications that aid or interfere with such pathways, which may be tested in vitro or in an animal model. (wikipedia.org)
  • Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, and death. (pdr.net)
Active5
  • Active principal monomethyl fumarate itself, (Bafiertam), approved in April 2020. (wikipedia.org)
  • Active SPMS (aSPMS, formerly progressive-relapsing): In the US, the approval of cladribine includes active SPMS (aSPMS, SPMS with relapses) in its approval. (wikipedia.org)
  • Clemastine Fumarate is the active ingredient in Tavist. (canpharm.com)
  • Clemastine, the active ingredient in Tavist, is typically available over the counter. (canpharm.com)
  • Clemastine fumarate (CF), discovered by us and various other 4933436N17Rik researchers to become active against lifestyle cycle stages have got different quantities and compositions of sterol classes. (morainetownshipdems.org)
Generic1
Randomized contr1
  • METHODS: A rigorous literature search identified 6 studies, including 1 randomized controlled trial and 5 self-controlled trials, totaling 154 patients who underwent deep brain stimulation, providing 308 pairs of data for analysis. (bvsalud.org)
People1
  • TIP: Since most people scan Web pages, include your best thoughts in your first paragraph. (pharmacy-tech-test.com)
Patients2
  • This medicine is not recommended for use in patients with a known allergy to clemastine or any other components present along with it. (practo.com)
  • Here, in mice carrying pathogenic C5024T in mt-tRNAAla and in patients with mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS) syndrome carrying A3243G in mt-tRNALeu, we found memory T and B cells to have lower pathogenic mtDNA mutation burdens than their antigen-inexperienced naive counterparts, including after vaccination. (bvsalud.org)
Database1
  • Current status of Chinese herbal preparations included in LiverTox database]. (nih.gov)
Effects of clemastine5
Placebo11
  • At baseline (day 1), the mean symptom-severity scores +/- SEM for the clemastine fumarate and placebo groups were not significantly different. (nih.gov)
  • The first group received oral clemastine fumarate twice daily for 3 months and then placebo for 2 months, while the second group received the placebo for 3 months and the active treatment for 2 months. (medscape.com)
  • Although there were more reports of fatigue when the participants were taking clemastine fumarate than placebo, no one reported any treatment-related serious adverse events. (medscape.com)
  • mean age, 40.2 years) received clemastine fumarate 5.36 mg twice daily for 90 days and then 60 days of matching placebo. (medscape.com)
  • The efficacy of clemastine relative to placebo at increasing the myelin water fraction (MWF) (measured in %) from magnetic resonance imaging of the corpus callosum. (ucsfhealth.org)
  • In this phase II study, 50 people with relapsing MS took either clemastine for three months followed by placebo for two months or placebo for three months followed by clemastine for two months. (mstrust.org.uk)
  • Half of the participants will take clemastine and half will take placebo for three months. (mstrust.org.uk)
  • Participants will take either clemastine plus metformin or placebo for 24 weeks. (mstrust.org.uk)
  • For the first three months of the study, people were given either the antihistamine clemastine fumarate or a placebo. (activemsers.org)
  • This trial will recruit 50 participants with relapsing MS. Half will take a placebo (dummy drug) and the other half will take both metformin and clemastine. (mssociety.org.uk)
  • The researchers found that the immune cells in 10 healthy volunteers injected with 2mg clemastine were less active than in volunteers given a placebo. (mssociety.org.uk)
Drowsiness2
  • Transient drowsiness, the most common adverse reaction associated with clemastine fumarate, occurs relatively frequently and may require discontinuation of therapy in some instances. (nih.gov)
  • Clemastine enters the brain and causes drowsiness, so it is known as a sedating antihistamine. (mssociety.org.uk)
Hydrogen fumarate1
  • The chemical name is (+)-2-[-2- [(p-chloro-α-methyl-α-phenylbenzyl) oxy] ethyl]-1-methylpyrrolidine hydrogen fumarate. (nih.gov)
Dimethyl fumarate1
  • Place in MS Therapy: Disease Modifying Agents Oral dimethyl fumarate (Tecfidera) or teriflunomide (Aubagio) offer convenience. (techdiy.info)
Antihistamine medications1
  • tell your doctor and pharmacist if you are allergic to clemastine, other antihistamine medications, any other medications, or any of the ingredients in clemastine tablets or liquid. (medlineplus.gov)
Efficacy1
  • Safety and efficacy of clemastine fumarate have not been established in children under the age of 12 years. (nih.gov)
Myelin7
  • Full results from a randomized controlled trial (RCT) suggest that the over-the-counter (OTC) antihistamine clemastine fumarate is safe and effective for treating chronic demyelinating injury in multiple sclerosis (MS)֫ - even in patients who have had symptoms of myelin degeneration for years. (medscape.com)
  • Myelin in the central nervous system "is a specialised extension of the oligodendrocyte plasma membrane and clemastine fumarate can stimulate differentiation of oligodendrocyte precursor cells [OPCs] in vitro, in animal models, and in human cells," they write. (medscape.com)
  • Clemastine is being tested for its ability to boost myelin repair. (mstrust.org.uk)
  • Previous research in mice with an MS-like condition and a small clinical trial have shown that clemastine may promote myelin repair. (mssociety.org.uk)
  • Researchers want to know if the combination of metformin and clemastine could repair myelin damage in relapsing MS. (mssociety.org.uk)
  • Although both metformin and clemastine have been trialled in people with MS before, the effects of metformin on myelin repair in people has not been tested. (mssociety.org.uk)
  • And evidence from animal studies has shown that metformin enhances the effect of clemastine on myelin repair, but the two drugs have never been tested in combination. (mssociety.org.uk)
Remyelination2
  • Researchers at the University of Cambridge are conducting a phase II study to establish whether the combination of clemastine and metformin can promote remyelination. (mstrust.org.uk)
  • Researchers found that clemastine improved the speed at which messages travelled from the eye to the brain - an early indication that clemastine can boost remyelination. (mssociety.org.uk)
Sedation1
  • clemastine and olopatadine intranasal both increase sedation. (medscape.com)
Anticholinergic1
  • Clemastine fumarate is an antihistamine with anticholinergic (drying) and sedative side effects. (nih.gov)
Tablet3
Rhinorrhea3
  • Clemastine fumarate tablets are indicated for the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus, and lacrimation. (nih.gov)
  • The purpose of this study was to test the effectiveness of clemastine fumarate, a first-generation antihistamine, for treatment of sneezing and rhinorrhea associated with naturally occurring common colds. (nih.gov)
  • 24 hours) of cold symptoms that included rhinorrhea or sneezing were studied. (nih.gov)
Tablets1
  • Clemastine fumarate tablets are also indicated for the relief of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. (nih.gov)
20231
  • Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Sep 2023) and others. (drugs.com)
Participants2
  • No statistically significant treatment-related changes were observed in exploratory pharmacodynamic outcome measures included for the 21 participants of the extension cohort. (multiple-sclerosis-research.org)
  • To be included in the study, participants had to have a delay in transmission time beyond 118 milliseconds in at least one eye and had to have evidence that they had an adequate number of nerve fibers to reinsulate. (activemsers.org)
Symptoms of allergies2
  • A common antihistamine used to treat symptoms of allergies and the common cold, called clemastine fumarate, partially reversed damage to the visual system in people with multiple sclerosis (MS) in a preliminary study released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016. (activemsers.org)
  • Clemastine helps control symptoms of allergies and colds but does not treat the cause of these symptoms or speed recovery. (medlineplus.gov)
Dose4
  • The dose of clemastine was higher than normally used for treating allergies. (mstrust.org.uk)
  • Implementation of judicious prescribing strategies, including selection of the most effective antibiotic, prescription of an appropriate dose, and treating for the shortest possible duration. (medscape.com)
  • If your doctor has told you to take clemastine regularly, take the missed dose as soon as you remember it. (medlineplus.gov)
  • Do not use more than the recommended dose of clemastine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. (drugs.com)
Alcohol4
  • Clemastine has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc. (nih.gov)
  • talk to your doctor about the safe use of alcohol while you are taking clemastine. (medlineplus.gov)
  • There is 1 alcohol/food/lifestyle interaction with clemastine. (drugs.com)
  • You should avoid or limit the use of alcohol while being treated with clemastine. (drugs.com)
Sodium2
20202
  • Active principal monomethyl fumarate itself, (Bafiertam), approved in April 2020. (wikipedia.org)
  • In September 2020 we announced our new clinical trial, which will be testing clemastine in a Phase 2a clinical trial in combination with metformin, a drug which is already used to treat type 2 diabetes. (mssociety.org.uk)
Clinical1
  • Assessments included MRI, MR spectroscopy, plasma PK, and changes in clinical status, laboratory values and adverse events for three months. (multiple-sclerosis-research.org)
Indications1
  • It should be noted that clemastine is indicated for the dermatologic indications at the 2.68 mg dosage level only. (nih.gov)
Colds1
  • Randomized controlled trial of clemastine fumarate for treatment of experimental rhinovirus colds. (nih.gov)
Preparations1
  • Current status of Chinese herbal preparations included in LiverTox database]. (nih.gov)
Allergies1
  • Clemastine is currently used as an antihistamine for treating allergies, such as hay fever. (mstrust.org.uk)
Reactions1
  • Side effects of interferons may include flu-like symptoms and injection-site reactions. (techdiy.info)
Relieve1
Frequent1
  • Other recorded benefits included the need for less frequent use of epidural anesthesia and a significantly lower incidence of retained fetal membranes (chi 2 = 11. (teachingyoungwomentruth.org)
Interactions1
Optic2
  • The phase 2 ReBUILD crossover study included 50 patients with relapsing MS, a mean disease duration of 5 years, and chronic demyelinating optic neuropathy. (medscape.com)
  • The aim of this study is to assess clemastine in people with optic neuritis. (mstrust.org.uk)
Twice daily1
  • Researchers tested if 4 mg clemastine twice daily taken alongside a licensed disease modifying therapy (DMT) was better than taking the DMT alone. (mssociety.org.uk)
ReBUILD1
  • Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial. (mstrust.org.uk)
Years2
  • talk to your doctor about the risks and benefits of taking clemastine if you are 65 years of age or older. (medlineplus.gov)
  • Clemastine is already licensed for other conditions but will need to undergo larger phase 2 and phase 3 trials to definitively test its effectiveness in MS. This process will take several years. (mssociety.org.uk)
Side2
  • Clemastine may cause side effects. (medlineplus.gov)
  • Clemastine has not been widely tested in people with MS so its side effects specifically for people with MS are not yet known. (mssociety.org.uk)
Treatment2
  • Treatment with clemastine resulted in a small improvement in the speed of the nerve impulse. (mstrust.org.uk)
  • Current treatment recommendations include local or systemic administration of inhibitors of neuronal excitability (especially local anesthetics) and barriers to reduce scratching. (techdiy.info)
Gastrointestinal2
  • Pharmacokinetic studies in man utilizing 3 H and 14 C labeled compound demonstrates that: clemastine is rapidly and nearly completely absorbed from the gastrointestinal tract, peak plasma concentrations are attained in 2 to 4 hours, and urinary excretion is the major mode of elimination. (nih.gov)
  • Famotidine is prescribed to treat multiple digestive disorders of the gastrointestinal (GI) tract, including ulcers. (1family1health.com)
Study1
  • There's also some evidence from research with mice and from a very small study with healthy volunteers that clemastine may reduce immune activity. (mssociety.org.uk)
Relapses1
  • Active SPMS (aSPMS, formerly progressive-relapsing): In the US, the approval of cladribine includes active SPMS (aSPMS, SPMS with relapses) in its approval. (wikipedia.org)
Disease2
  • Clemastine fumarate should be used with caution in patients with: history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, and hypertension. (nih.gov)
  • Our team includes renowned experts in neurology, neuro-ophthalmology, neuropsychology, infectious disease and rehabilitative medicine. (ucsfhealth.org)
Group1
  • Clemastine fumarate belongs to the benzhydryl ether group of antihistaminic compounds. (nih.gov)
Months1
Work1
Effective1
  • In November 2013, The American Academy of Pediatrics released a set of three basic principles for the effective use of antibiotics to treat pediatric URIs, including acute otitis media, acute bacterial sinusitis, and streptococcal pharyngitis. (medscape.com)