Including adipose tissue and skeletal muscle. Medical search. Frequent questions

However, its main function is to be a reserve of lipids, which can be oxidised to meet the energy needs of the body and to protect it from excess glucose by storing triglycerides produced by the liver from sugars, although some evidence suggests that most lipid synthesis from carbohydrates occurs in the adipose tissue itself. (wikipedia.org)
FA composition was measured for brain, heart, liver, skeletal muscle, erythrocytes and plasma phospholipids, as well as adipose tissue and plasma triglycerides. (nih.gov)
Background: Glucocorticoids (GCs) modulate glucose homeostasis by acting on metabolic tissues including liver, adipose and skeletal muscle. (endocrine-abstracts.org)
Insulin resistance is defined as an inadequate response by insulin target tissues, such as skeletal muscle, liver, and adipose tissue, to the physiologic effects of circulating insulin. (jci.org)
The hallmarks of impaired insulin sensitivity in these three tissues are decreased insulin-stimulated glucose uptake into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue. (jci.org)
Its pathophysiology is likely to involve insulin resistance at the level of both skeletal muscle and visceral adipose tissue and altered fluxes of metabolic substrates between these tissues that in turn impair liver metabolism. (erudit.org)
The researchers found a variety of beneficial effects of NMN supplementation, including in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight and physical activity levels. (wustl.edu)
12 Other important effects of leptin include increase in glucose utilization, inhibition of lipogenesis, stimulation of fatty acid oxidation, and reduction of trigliceride accumulation in liver and skeletal muscles, accounting for leptin's insulin-sensitizing properties. (researchgate.net)
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. (wjgnet.com)
Target organs for insulin include the liver, skeletal muscle, and adipose tissue. (ziprx.ca)
Therefore, this study was conducted to determine the effect of CLA on production, meat quality, and its nutrigenomic effect on edible parts of rabbit carcass including skeletal muscle, liver, and adipose tissue. (cu.edu.eg)
There was tissue specific sensing of CLA, since subcutaneous adipose tissue gene expression of PPARA was downregulated, however, CPT1A tended to be upregulated in liver of CLAL group only (P = 0.09). (cu.edu.eg)
In addition to skeletal muscle [ 14 ], the protective effects of long-term exercise training in the regulation of inflammation and metabolic dysfunction via SIRT1 signaling pathway have been less investigated in peripheral tissues such as kidney and liver. (biomedcentral.com)
Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. (affbiotech.com)
Furthermore, the main function of chylomicrons is to transport absorbed triglycerides from the intestine to the skeletal muscles, adipose tissue, and liver while the main function of VLDL is to transport newly-synthesized triglycerides from the liver to the adipose tissue. (pediaa.com)
Usually, chylomicrons are responsible for the transport of these triglycerides into the peripheral tissues and liver for storage. (pediaa.com)
We have identified epigenetic modifications in pancreatic islets, skeletal muscle, adipose tissue, and the liver from individuals with type 2 diabetes compared with controls. (lu.se)
They have made several groundbreaking discoveries such as genome-wide epigenetic modifications in pancreatic islets, skeletal muscle, adipose tissue and the liver from patients with type 2 diabetes compared with non-diabetic control subjects. (lu.se)

The postmortem examination showed marked subcutaneous and visceral adipose tissue depletion, as well as moderate skeletal muscle loss, especially in the axial skeleton. (cdc.gov)

The two types of adipose tissue are white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which generates body heat. (wikipedia.org)
Adipose tissue - more specifically brown adipose tissue - was first identified by the Swiss naturalist Conrad Gessner in 1551. (wikipedia.org)
The two superficial depots are the paired inguinal depots, which are found anterior to the upper segment of the hind limbs (underneath the skin) and the subscapular depots, paired medial mixtures of brown adipose tissue adjacent to regions of white adipose tissue, which are found under the skin between the dorsal crests of the scapulae. (wikipedia.org)
Chronic central ghrelin infusion resulted in increases in the glucose utilization rate of white and brown adipose tissue without affecting skeletal muscle. (jci.org)
Newborns rely on nonshivering thermogenesis to metabolize brown adipose tissue (BAT) and release energy. (nih.gov)
18 F -fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), a recognized therapeutic target of obesity. (spiedigitallibrary.org)
Brown adipose tissue (BAT) is known to play a critical role in cold-induced nonshivering thermogenesis (CIT) to maintain body temperature. (spiedigitallibrary.org)

In humans, adipose tissue is located: beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow), intermuscular (Muscular system) and in the breast (breast tissue). (wikipedia.org)
In the integumentary system, which includes the skin, it accumulates in the deepest level, the subcutaneous layer, providing insulation from heat and cold. (wikipedia.org)
Visceral fat is different from subcutaneous fat underneath the skin, and intramuscular fat interspersed in skeletal muscles. (wikipedia.org)
C) Areas of subcutaneous adipose tissue (SAT) (blue) and skeletal muscle (SM) (orange) were segmented on the field-of-view extended sections. (studyfinds.org)
It is associated with increased volumes of visceral fat, which is also known as organ fat is located inside the peritoneal cavity ,packed in between internal organs as opposed to subcutaneous fat which is found underneath the skin and intramuscular fat which is found interspersed in skeletal muscle (Anderson, Anderson, 2006). (ukessays.com)

The team found that patients with 20% or more loss of skeletal muscle or adipose tissue at the time they were diagnosed had lower lung-cancer specific and overall survival rates. (auntminnie.com)
One of the hallmark features of sarcopenia is the loss of skeletal muscle without disturbance to the adipose tissues. (medscape.com)

Higher amounts of whey versus egg protein stimulate the greatest post-treatment anabolic skeletal muscle response, though test proteins with higher amounts of WPH more favorably affected post-treatment markers related to adipose tissue lipolysis. (biomedcentral.com)
an effect which may be explained by an increased expression of adipose tissue lipolysis-related gene expression patterns following chronic supplementation [ 12 ], an increase in protein-induced thermogenesis (reviewed in [ 15 ]), and/or a consistent reduction in food intake given its satiety-stimulatory effects as discussed above. (biomedcentral.com)
Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)
The mechanisms behind weight increase with ruxolitinib is incompletely understood, although decreased adipose tissue lipolysis and increased appetite due to blocking the effects of leptin in the hypothalam. (researchgate.net)

We then discuss how obesity leads to insulin resistance via a complex interplay among systemic fatty acid excess, microhypoxia in adipose tissue, ER stress, and inflammation. (jci.org)
These include eating diets high in certain inflammation-promoting foods (e.g., polyunsaturated fats, simple carbohydrates- especially refined sugars 1 , common allergens like casein and gluten 2 ), being in colder temperatures 3 , experiencing menopause (with hormone fluctuations) 4 , experiencing psychological stress 5 and exposure to environmental toxins. (totalhealthmagazine.com)
More recent studies suggest that inflammation in adipose tissue could be a key factor leading to these illnesses. (bu.edu)
Furthermore, monocytes (differentiating to macrophages) play an important role in obesity-induced, insulin resistance-associated inflammation of the adipose tissue and skeletal muscle. (unimedizin-mainz.de)
We use data from the population-based Gutenberg Health Study (GHS) at baseline, including targeted proteomics data of 92 inflammation related proteins, microarray-based transcriptomics data of monocytes, thrombin generation curves and activation of coagulation factors, as well as detailed clinical data. (unimedizin-mainz.de)
Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in obesity-related diseases such as type 2 diabetes. (biomedcentral.com)
Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in metabolic diseases, particularly obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease [ 1 ]. (biomedcentral.com)
SIRT1 regulates metabolism and inflammation in various tissues [ 4 ] which can be the key regulator of exercise-mediated protection against diabetes at tissue level. (biomedcentral.com)
A lot of the damage begins with the overproduction of reactive oxygen species and the generation of inflammation, but we don't have specific ways to intervene on that right now in microvascular tissue," Dr Barrett explained. (medscape.com)
supports the concept that metabolic reprogramming, inflammation, and genome instability (including epige- netic changes) underlie many of the other hal marks and foster multiple hallmark functions. (who.int)

In obesity, adipose tissue is also implicated in the chronic release of pro-inflammatory markers known as adipokines, which are responsible for the development of metabolic syndrome, a constellation of diseases, including type 2 diabetes, cardiovascular disease and atherosclerosis. (wikipedia.org)
Insulin resistance is a major metabolic feature of obesity and is a key factor in the etiology of a number of diseases, including type 2 diabetes. (jci.org)
Instances of abnormal body composition like obesity and loss of muscle mass are associated with chronic health conditions like heart disease. (studyfinds.org)
Introduction: Exercise training-induced muscle contraction manipulates white adipose tissue (WAT) and protects against several disorders, including obesity, obesity-induced complications. (ac.ir)
We have shown that genetic and non-genetic factors, such as single nucleotide polymorphisms (SNPs), exercise, diet, obesity, and age alter the epigenetic pattern in human tissues affecting type 2 diabetes. (lu.se)
Dr. Ling's research group has also shown that genetic and non-genetic factors such as SNPs, exercise, diet, obesity and age alter the genome-wide epigenetic pattern in human primary tissues for type 2 diabetes. (lu.se)

It is characterized by a cluster of risk factors of atherosclerosis including insulin resistance, hyperinsulinemia, impaired glucose tolerance or type 2 diabetes, hypertension, dyslipidemia, and coagulation abnormalities. (erudit.org)

Additionally, the expression of some fat storage enzymes was decreased in ghrelin-deficient mice, which led us to conclude that central ghrelin is of physiological relevance in the control of cell metabolism in adipose tissue. (jci.org)
Adipose tissue plays an important role in metabolism through its storage and release of triglycerides, peptide hormones (adipokines) and other proteins, and in the case of brown fat, for its role in thermogenesis ( 1 ). (diabetesjournals.org)
GC access to corticosteroid receptors in these tissues is regulated e.g. by pre-receptor metabolism. (endocrine-abstracts.org)
In skeletal muscle, the investigators - including the study's first author, Kathryn Mills, the research supervisor in Imai's lab - found that NMN administration helps energy metabolism by improving the function of mitochondria, which operate as cellular power plants. (wustl.edu)
Thus, regular physical activity leads to a reduction of adipose tissue mass and improves metabolism. (pfeiffertheface.com)
With an increasing duration of exercise, glucose uptake by muscle begins to decline, and there is an increased dependency on free fatty acids for energy metabolism. (pfeiffertheface.com)
Furthermore, our results are consistent with the fact that endurant individuals rely preferentially on lipid metabolism, because oxidative phosphorylation of fatty acids in muscle mitochondria produces a high yield of ATP, necessary for prolonged contraction of muscle fibers. (pfeiffertheface.com)
Abnormalities associated with cancer cachexia include anorexia, weight loss, muscle loss and atrophy, anemia and alterations in carbohydrate, lipid and protein metabolism ( 2 , 3 ). (spandidos-publications.com)
Insulin acts via specific membrane-bound receptors on target tissues to regulate the metabolism of carbohydrates, proteins, and fats. (ziprx.ca)
The 68-page scientific statement, which was published online November 8 in the Journal of Clinical Endocrinology & Metabolism , sets out the potential targets for novel therapies, which include not only reducing hyperglycemia but also activating protective factors found in normal tissue. (medscape.com)

All data suggest that exercise (contracting skeletal muscles)-induced myokines (IL-6, SPARC, Irisin, etc.) may manipulate and modulate adipose tissue cargo secretion (adipokines including Leptin, Adiponectin, Visfatin, IL-6, etc.) and vice versa. (ac.ir)
Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (affbiotech.com)

Extensive changes in diet SFA, MUFA and PUFA had minimal effect on membranes (average slopes 0.01, 0.07, 0.07 respectively), but considerable influence on adipose tissue and plasma triglycerides (average slopes 0.27, 0.53, 0.47 respectively). (nih.gov)
However, the main function of VLDL is to transport endogenous triglycerides into the storage tissues. (pediaa.com)
Furthermore, their main function is to transport triglycerides from the sources to the tissues that store them. (pediaa.com)

In addition to adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages. (wikipedia.org)
The Adipoq-Cre exhibited no observable recombination in any other tissues examined, whereas both aP2-Cre lines resulted in recombination in endothelial cells of the heart and nonendothelial, nonmyocyte cells in the skeletal muscle. (diabetesjournals.org)
Attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells. (prospecbio.com)

Insulin is an anabolic hormone that promotes glucose uptake, glycogenesis, lipogenesis, and protein synthesis of skeletal muscle and fat tissue through the tyrosine kinase receptor pathway. (medscape.com)

Soft tissue is defined as the supportive tissue of various organs and the nonepithelial, extraskeletal structures exclusive of lymphohematopoietic tissues. (medscape.com)
This protein is active in many different organs and tissues, including the heart, muscles used for movement (skeletal muscles), fatty (adipose) tissue, and the kidneys. (medlineplus.gov)
Normal metabolic balance is maintained by a complex homeostatic system involving multiple tissues and organs. (erudit.org)
However, the current evidence suggests that muscle-adipose crosstalk may count toward a potential mechanism that is targeted by exercise to exert its beneficial role, including alteration in organs profile in a preventive and therapeutic approach. (ac.ir)

Reduced kidney size and morphological alterations including decreased glomerular cross-sectional area and hepatic macrovesicles were observed in db/db + Ex mice compared with untrained db/db mice. (biomedcentral.com)

During exercise, triacylglycerols, an energy reservoir in adipose tissue, are hydrolyzed to free fatty acids (FAs) which are then released to the circulation, providing a fuel for working muscles. (pfeiffertheface.com)
According to Shawn Wells, CSO of NNB Nutrition, L-Baiba is also associated with the browning of white adipose tissues, in which the oxidation of fatty acids allows more fat to be converted to ketones as fuel for exercise. (nutritionaloutlook.com)
Dietary supplementation of CLA did not alter growth performance, however, the fat percentage of longissimus lumborum muscle was decreased, with an increase in protein and polyunsaturated fatty acids (PUFA) percentage. (cu.edu.eg)
Fatty acids are the preferred energy source for the heart and an important energy source for skeletal muscle during prolonged exertion. (msdmanuals.com)

Deplection of lean body mass is one of the main consequences of cachexia which involves not only skeletal muscle but also affects cardiac proteins, resulting in alterations in heart performance. (spandidos-publications.com)

5 Stress exposure initiates downstream release of endogenous glucocorticoids (GCs), which bind to GC receptors on target metabolic and immune system tissue (eg, adipose tissue, skeletal muscle, pancreas). (psychiatrictimes.com)

But one of the study's most important findings was that there is an association between circulating GDF15 (a gene that regulates inflammatory pathways, angiogenesis, cell repair and cell growth) and loss of body weight, skeletal muscle, and adipose tissue, which the investigators noted supports "the potential therapeutic relevance of targeting GDF15 in the management of CAC. (auntminnie.com)
Conclusion: There is a need to provide a comprehensive picture of underlying mechanisms in muscle contraction-induced skeletal muscle-adipose tissue crosstalk to offer a new perspective and insight into the mechanistic preventive and therapeutic role of exercise-induced skeletal muscle-adipose tissue pivotal talk. (ac.ir)

We examined the acute effects of different dietary protein sources (0.19 g, dissolved in 1 ml of water) on skeletal muscle, adipose tissue and hypothalamic satiety-related markers in fasted, male Wistar rats (~250 g). (biomedcentral.com)
Whey protein is the BEST protein for growing muscle mass, getting lean, and looking ripped and toned. (proteinfactory.com)
These make up one third of muscle protein. (proteinfactory.com)
reducing the breakdown of protein and protecting muscle tissue. (proteinfactory.com)
limit muscle protein synthesis, due to inefficient use of essential amino acids [8]. (proteinfactory.com)
as a key stimulus in the initiation of muscle protein synthesis [9]. (proteinfactory.com)
Whey protein is a rich source of bioavailable cysteine, with a concentration three or four times higher than other protein sources, including soya and casein [13]. (proteinfactory.com)
The BCAA's are to me the most important thing about whey protein because BCAA's are the building blocks of muscle. (proteinfactory.com)
Leptin, the protein product of the ob gene, is a hormone that is secreted principally by adipose tissue (adipocyte-derived hormone). (researchgate.net)
In addition to the increased muscle protein degradation found during cancer growth, the presence of the tumor also induces an increased rate of DNA fragmentation in skeletal muscle in both rats and mice ( 8 ). (spandidos-publications.com)
For analysis of this unique dataset, we use a bioinformatics approach including the detection of protein and transcript clusters with different expression patterns during diabetes development (Figure 1), pathway and network analysis of these clusters, identification of subgroups of individuals with different disease development paths, and characterization of these subgroups based on clinical data at baseline as well as disease development and clinical outcome during 5 years follow-up. (unimedizin-mainz.de)
Skeletal muscle effects of insulin include increased protein synthesis and increased glycogen synthesis. (ziprx.ca)
Alongside this, hypoglycemia causes the suppression of factors that are protective against microvascular complications, including insulinlike growth factor, antioxidant enzymes, platelet-derived and vascular endothelial growth factors, transforming growth factor beta, and activated protein C. (medscape.com)

In an obese person, excess adipose tissue hanging downward from the abdomen is referred to as a panniculus. (wikipedia.org)

White adipose tissue stimulates, produces, and secretes adipokines. (ac.ir)
Under pathophysiological conditions, mitochondrial dysfunction results in overproduction of mitochondrial reactive oxygen species (ROS) and further stimulates nuclear factor-kappa B (NF-κB) activity, thus leading to cellular damage and tissue dysfunction [ 2 , 3 ]. (biomedcentral.com)

This study aimed to assess the predictive ability of the pancreas-to-muscle signal intensity ratio on T1-weighted MRI (SIR on T1-w MRI) for POPF after distal pancreatectomy (DP). (bvsalud.org)

In humans, it's produced by skeletal muscle during exercise, playing a role in the benefits of regular exercise, including healthy glucose uptake, increased free fatty acid oxidation, reduced fat mass, and mitochondrial health. (nutritionaloutlook.com)

Amongst the pathogenic contributions, metabolic dysregulations comprise a cluster of conditions including dyslipidemia, altered proinsulin processing by pancreatic beta cells, hyperinsulinemia, insulin resistance, and impaired glucose homeostasis. (unimedizin-mainz.de)

Far from being hormonally inert, adipose tissue has, in recent years, been recognized as a major endocrine organ, as it produces hormones such as leptin, estrogen, resistin, and cytokines (especially TNFα). (wikipedia.org)
The primary endogenous pyrogens (cytokines) include interleukin-1 (IL-1) and interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). (nih.gov)
OBJECTIVE- Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. (diabetesjournals.org)

Humans begin to lose muscle mass starting in our 30s and 40s. (medscape.com)
MRLs include adjustments to reflect human variability and extrapolation of data from laboratory animals and humans. (cdc.gov)

Adipose tissue (also known as body fat, or simply fat) is a loose connective tissue composed mostly of adipocytes. (wikipedia.org)
Apart from adipocytes, which comprise the highest percentage of cells within adipose tissue, other cell types are present, collectively termed stromal vascular fraction (SVF) of cells. (wikipedia.org)
13 Leptin is synthesized and released predominantly by adipocytes, and its serum concentrations correlate positively with body mass index (BMI) and the amount of adipose tissue. (researchgate.net)

The peripheral portion of the tumor compresses surrounding, normal soft tissue because of centripetal expansile growth. (medscape.com)
This results in the formation of a relatively well-defined zone of compressed fibrous tissue that may contain scattered tumor cells. (medscape.com)
Currently, poor prognosis groups for melanoma include those with high tumor burdens, brain metastases, refractoriness to anti-PD1 therapy, and elevated LDH. (aad.org)
In colorectal cancer, the expression level of miR-720 in tumor tissues is higher than that in normal tissues ( 13 ) . (researchsquare.com)
Retrospective analyses have linked body composition to outcomes across multiple solid tumor types, including breast, prostate and colorectal cancers," the team wrote. (auntminnie.com)
The investigators also reported that those patients who developed cancer-associated cachexia at relapse of lung cancer and showed loss of fatty or muscle tissue or body-mass weight loss had particular tumor genomic and transcriptomic profiles compared with people who didn't develop these features -- specifically "inflammatory signaling" and "epithelial-mesenchymal transitional pathways," the team wrote. (auntminnie.com)
Previous studies carried out in our laboratory demonstrated that formoterol treatment in tumor-bearing animals resulted in an amelioration of muscle loss through different mechanisms that include muscle apoptosis and proteolysis ( 19 ). (spandidos-publications.com)

Circulating orexigenic and anorexigenic factors, including ghrelin and leptin, are produced in the. (researchgate.net)

In skeletal muscle, FASN and PPARG were upregulated in CLAH group only (P ≤0.01). (cu.edu.eg)
0.01) in adipose tissue of CLA groups. (cu.edu.eg)

Both the mesenteric and omental depots incorporate much lymphoid tissue as lymph nodes and milky spots, respectively. (wikipedia.org)

Past work by Imai and co-senior author Jun Yoshino, MD, PhD, an assistant professor of medicine, has shown that NAD levels decrease in multiple tissues as mice age. (wustl.edu)
Importantly, the researchers also found that NMN in the blood is quickly converted to NAD in multiple tissues. (wustl.edu)

These results unravel the existence of what we believe to be a new CNS-based neuroendocrine circuit regulating metabolic homeostasis of adipose tissue. (jci.org)

Three X-chromosome loci had plausible candidate genes, including AR (on Xq12), TSR2 and KLF8 (both on Xp11.21). (nature.com)
Initial studies of bariatric surgery patients by the Ruderman laboratory established (1) that they could be subdivided into insulin resistant (75%) and insulin sensitive (25%) subgroups and (2) that these subgroups were distinguished by differences in AMPK activity, oxidative stress and the expression of inflammatory, mitochondrial and other genes in their adipose tissue. (bu.edu)

Collectively, the data herein support a role for the MPCs in adipogenesis in a 3-D environment and that they may contribute to the ectopic accumulation of adipose tissue. (cheric.org)

We discuss how pathways that "sense" nutrients within skeletal muscle are readily able to regulate insulin action. (jci.org)

Administration of the β2-agonist formoterol (0.3 mg/kg for 7 days) in rats bearing Yoshida AH-130 ascites hepatoma tumors, a model which induces a strong loss of both body and muscle weight, resulted in a significant reversal of the muscle wasting process, as reflected by individual muscle weights. (spandidos-publications.com)
Exercise training as a well-established tool induces crosstalk between skeletal muscle and white adipose tissue through myokines and adipokines, respectively, to facilitate this communication in an endocrine manner. (ac.ir)

Adipose tissue contains many small blood vessels. (wikipedia.org)

The statement notes that the vascular complications of diabetes result from interactions between systemic metabolic abnormalities such as hyperglycemia, dyslipidemia, and genetic and epigenetic modulators and local tissue responses to toxic metabolites. (medscape.com)

Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)
Results: in vivo studies outcomes reinforce in vivo data and demonstrate organ-dependent crosstalk between skeletal muscle and adipose tissue via myokines and adipokines. (ac.ir)

Mice have eight major adipose depots, four of which are within the abdominal cavity. (wikipedia.org)
NMN can be given safely to mice and is found naturally in a number of foods, including broccoli, cabbage, cucumber, edamame and avocado. (wustl.edu)

Cancer-associated cachexia -- a condition that manifests as a loss of body weight, specifically of skeletal muscle and adipose tissue -- is a significant contributor to morbidity and mortality in patients with non-small cell lung cancer, wrote a team led by Dr. Othman Al-Sawaf of University College London Cancer Institute in the U.K. (auntminnie.com)
Instead, emerging evidence suggests that the quantity and quality of muscle is a major determinant of morbidity and mortality. (medscape.com)

The epigenome includes DNA methylation, histone modifications, and non-coding RNA. (lu.se)

It is our goal to establish an ARC focused on understanding the relationship between metabolic disorders and Adipose Tissue Biology by studying adipose tissues from insulin sensitive and insulin resistant patients obtained during and after Bariatric Surgery. (bu.edu)
Interestingly, monocytes have also been implicated as mediator linking insulin resistance to thrombotic complications, since insulin resistant monocytes have increased tissue factor expression, which is regarded as central trigger of coagulation and thrombus formation. (unimedizin-mainz.de)

Examples include but are not limited to everyday aches and pains, alterations in digestion and absorption 7 , behavioral changes 8 , minor disruption in microcirculation and blood flow over the course of the aging process 9 , and a minor negative impact on immune health. (totalhealthmagazine.com)

Current achievements in the field of soft-tissue tumors are the result of advances in molecular biology, oncogenetics, imaging techniques, immunochemistry, diagnosis by fine-needle aspiration (FNA), surgical reconstruction, radiation therapy, and tissue banking. (medscape.com)
Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. (diabetesjournals.org)
Thus, different "adipocyte-specific" Cre lines display different degrees of efficiency and specificity, illustrating important differences that must be taken into account in their use for studying adipose biology. (diabetesjournals.org)
With collective efforts of faculty representing different expertise and disciplines, we are posed to begin the development at BUMC of a unique center of knowledge in the field of adipose tissue biology pre- and -post bariatric surgery. (bu.edu)

Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
These measures capture the percentage of fat, bone, and muscle in the body. (studyfinds.org)

Moreover, formoterol relaxes bronchial smooth muscle and also provides important clinical benefits in symptomatic patients with chronic obstructive pulmonary disease ( 18 ). (spandidos-publications.com)

When we're looking at the CT images, the primary focus is on identifying nodules suspicious for lung cancer, but there is much more anatomical information coded in the space, including information on body composition," says study lead author Kaiwen Xu, a Ph.D. candidate in the Department of Computer Science at Vanderbilt University, in a media release . (studyfinds.org)

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. (research.com)

Many homeostatic processes, including appetite and food intake, are controlled by neuroendocrine circuits involving the CNS. (jci.org)

Perhaps one of the most relevant characteristics of cachexia is that of asthenia, which reflects the significant muscle wasting that occurs in the cachectic cancer patient ( 7 ). (spandidos-publications.com)

The research included 651 patients with early-stage non-small cell lung cancer who had been treated with surgery and systemic therapy, and it was part of the TRACERx Consortium (TRAcking non-small cell lung Cancer Evolution through therapy Rx) study. (auntminnie.com)
They found that by including these measurements, predicting lung cancer , heart disease, and all-cause mortality death risk was improved. (studyfinds.org)

Among 149 original articles, the relevant papers including in vivo and in vitro, were included. (ac.ir)

Anatomy61

Organisms17

Diseases25

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology2

Phenomena and Processes62

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science3

Health Care4

Liver18

Visceral adipose tissue1

Brown adipos7

Subcutaneous5

Loss of skeletal muscle2

Lipolysis4

Inflammation10

Obesity6

Type 2 diabet1

Metabolism10

Modulate2

Triglycerides3

Endothelial cells3

Lipogenesis1

Organs4

Hepatic1

Fatty acids4

Proteins1

Receptors1

Therapeutic2

Protein13

Obese1

Stimulates2

Pancreas1

Oxidation1

Pancreatic1

Cytokines3

Humans2

Adipocytes3

Tumor7

Leptin1

0.012

Lymph nodes1

Multiple tissues2

Homeostasis1

Genes2

Accumulation1

Regulate1

Induces2

Blood vessels1

Epigenetic1

Adipokines2

Mice2

Morbidity and morta2

Histone modifications1

Insulin resistant2

Immune1

Biology4

Bone4

Chronic1

Composition1

Citation1

Homeostatic1

Occurs1

Lung2

Vivo1