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  • testicular
  • Compared to germinomatous tumors, nongerminomatous tumors tend to grow faster, have an earlier mean age at time of diagnosis (~25 years versus ~35 years, in the case of testicular cancers ), and have a lower 5 year survival rate. (omicsgroup.org)
  • antitumor
  • The present application relates generally to cancer treatment and, in particular, to checkpoint regulator antagonists, including anti-T cell Ig and ITIM domain (TIGIT) inhibitors, PD-1 inhibitors, PD-L1 inhibitors capable of modulating pathways associated with antitumor immunity, including bispecific and trispecific checkpoint regulator antagonists thereof. (freepatentsonline.com)
  • pluripotent
  • This finding is of paramount interest since a priori cultured ES cells were not thought to be totipotent (able to contribute to all tissues of the embryo including extraembryonic tissue), but pluripotent (able to differentiate into the majority of somatic embryonic tissue excluding the germline and extraembryonic tissue). (upmc.edu)
  • Because the ectopic transplantation of normal peri-implantation embryos can give rise to pluripotent cell lines, the direct derivation of pluripotent cell lines in vitro was attempted without the teratocarcinoma step. (biologists.org)
  • symptoms
  • Due to the lack of effective screening and the fact that early-stage disease manifests few symptoms, most ovarian cancer cases are diagnosed at an advanced stage when the disease has metastasized to the peritoneal cavity ( 2 ). (jimmunol.org)
  • lung cancer
  • The instant invention provides a method of treating a cancer selected from the group consisting of non-small cell lung cancer and breast cancer with an mTOR inhibitor and an αvβ3 integrin antagonist, wherein the mTOR inhibitor is ridaforolimus, everolimus, temsirolimus or a combination thereof. (patentsencyclopedia.com)
  • It has been incriminated as a predisposing factor for cervical cancer, but there are cases of cervical cancer not related to HPV infection, exactly like there is lung cancer not related to smoking. (gynecologists.gr)
  • Indeed, smoking does not have such a strong association to lung cancer pathophysiology, as it seems to be the case with HPV and cervical cancer. (gynecologists.gr)
  • Growth
  • Estrogen effects are not limited only to regulate reproductive physiology and function but also to regulate many other important nonreproductive functions, including cell growth, proliferation, apoptosis, immune responses, and metabolism. (hindawi.com)
  • Some studies have reported promotional effects of synthetic estrogens ethinylestradiol in oral contraceptive [ 11 - 13 ] and diethylstilbestrol [ 14 ] on liver cancer growth. (hindawi.com)
  • The phosphatidylinositol-3-kinase (PI3K) signaling pathway is important for the growth and survival of cancer cells in many different types of human malignancy. (patentsencyclopedia.com)
  • The available analytes include cytokines, chemokines, growth factors, cancer markers and other common markers. (bosterbio.com)
  • resistance
  • In conclusion, our study identifies the CD44 + CD24 − phenotype, self-renewal, high tumorigenicity, differentiation potential, and drug resistance of ovarian CSC-LCs. (springer.com)
  • Mimeault M, Hauke R, Mehta PP, Batra SK (2007) Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. (springer.com)
  • colorectal cancer
  • Beacon Biomedical Inc., a medical diagnostic development company and CLIA laboratory based in Phoenix Arizona, today announced the launch of BeScreened™-CRC, a blood-based laboratory developed test (LDT) for colorectal cancer (CRC) screening that is 95% accurate at detecting CRC in adults ages 50-75 years of age with an overall 91% sensitivity and 86% specificity for CRC stages I-IV. (azbio.org)
  • Beacon's mission is to save more lives by helping improve patient CRC screening and detecting colorectal cancer earlier. (azbio.org)
  • The company's lead product, BeScreened™-CRC, is a blood-based test for the early detection of colorectal cancer. (azbio.org)
  • chemotherapy
  • Current treatment options for ovarian cancer involve surgical debulking followed by chemotherapy. (jimmunol.org)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of platinum-based chemotherapy and decreases the quality of life of cancer patients. (springer.com)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common side effects of platinum-based chemotherapeutic drugs and a frequent cause for discontinuation of therapeutic treatments, affecting both the efficacy of the cancer treatment and the quality of life of cancer patients (Boyette-Davis et al. (springer.com)
  • characteristics
  • This chapter reviews the world literature on the clinical characteristics and modern management of the aforementioned tumors, using the new histologic classification of ovarian tumors developed by the World Health Organization ( Table 2 ). (glowm.com)
  • incidence
  • pure or mixed gonadal dysgenesis and may exhibit varied karyotypes including 46XY or 45X, 46XY (1) Approximately 12% of individuals with Turner syndrome have Y chromosome material, but the incidence of gonadoblastoma in these individuals is about 7-10% (2). (upmc.edu)
  • clinical
  • Many Ab molecules directly or indirectly targeting angiogenesis have been identified, and one of them, ramucirumab, has been tested in 27 phase I-III clinical trials in a broad array of cancers. (mdpi.com)
  • Integrin inhibition has shown potent anti-cancer effects in preclinical studies, and could have potential for clinical development. (patentsencyclopedia.com)
  • recognition
  • Since the advent of phage display technology, dating back to 1985, antibody libraries displayed on filamentous phage surfaces have been used to identify specific binders for many different purposes, including the recognition of tumors. (mdpi.com)
  • adults
  • Ovarian malignancies in children may represent an array of unique problems for the clinician who is more accustomed to diagnosing and treating ovarian neoplasia in adults. (glowm.com)
  • therapy
  • The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. (freepatentsonline.com)
  • 9. A method of increasing the responsiveness of a subject to a cancer therapy, of increasing the sensitivity of a tumour in a subject to a cancer therapy, or of speeding the recovery of a subject undergoing cancer therapy, the method comprising administration of an effective amount of milk fat or a milk fat analogue to a subject in need thereof, separately, simultaneously or sequentially with administration of the therapy. (sumobrain.com)
  • See, Abraham R T and Gibbons, J J, "The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. (patentsencyclopedia.com)
  • 8. The method of claim 1, wherein said subject has been administered an anti-cancer therapy. (patentsencyclopedia.com)
  • mice
  • In contrast to humans, several other species including mice and sheep carry infectious endogenous retroviruses ( 1 - 3 ). (frontiersin.org)
  • liver cancer
  • Depending on the type of estrogens and animal models, the reported effects are controversial, although the majority of the literature supports estrogens' protective roles in liver cancer. (hindawi.com)
  • diagnostics
  • Beacon Biomedical Inc is a molecular proteomic diagnostics company focused on developing and commercializing both CLIA laboratory and point-of-care CLIA waived tests for earlier cancer detection. (azbio.org)
  • common
  • Our selection of available conjugates include a variety of common fluorophores, Alexa Fluors, biotin, and HRP. (bosterbio.com)
  • FALSE Warts in the mouth and pharynx are directly related to oral sex practice and it appears to be a common and serious problem as they may commonly develop into cancer. (gynecologists.gr)
  • It is as common and serious problem as cervical cancer and we have not yet developed a screening program, as is the case with Pap smears and cervical cancer. (gynecologists.gr)