EnzymeEnzymesIndoleamineProteinsTET1HomogentisateMethylationBacterialReductaseBacteriaSuperfamilyHydroxylationTumorGeneGenesMicroenvironmentAccumulationAbnormalInhibitionProtein ExpressionCytochromeProcessesReactionsOxygenasesMesenchymalCompoundsDeficiencyRestrictionSymptomsStrainsFamilyToxicIronTissuesSoilPipelinePotentialAdditionVarietyCellsExhibitStructureAbilityProvide
Enzyme9
- A 'nitric oxide dioxygenase' is an enzyme that is capable of carrying out this reaction. (wikipedia.org)
- PAHs could be degraded by bacteria under aerobic conditions through the initial oxidation of the aromatic ring, which is catalyzed by the dioxygenase enzyme. (omicsonline.org)
- Specific activities of Catechol-2,3-dioxygenase and effects of temperature and pH and their stabilities on the enzyme relative activities were observed. (openmicrobiologyjournal.com)
- During our work in recent years on the genetic engineering of enzyme substrate specificities, we have obtained substantial expertise in biotransformations involving two different families of enzymes, aryl-hydroxylating dioxygenases and sucrose-utilizing glycosyltransferases. (helmholtz-hzi.de)
- IDO (indoleamine-2,3-dioxygenase) is an intracellular enzyme found in antigen presenting cells that mediates immune suppression in the tumor microenvironment . (shu.edu)
- AKU is caused by the lack of an enzyme called homogentisic acid dioxygenase. (nihr.ac.uk)
- When LGS1 was expressed with known SL biosynthetic enzyme genes including the cytochrome P450 SbMAX1a in Nicotiana benthamiana leaves, 5DS and its diastereomer 4-deoxyorobanchol (4DO) were produced in approximately equal amounts, while the production of 5DS was significantly larger than that of 4DO when Sb3500 was also co-expressed. (bvsalud.org)
- Decreased activity of the enzyme cysteine dioxygenase was demonstrated in one affected child. (medscape.com)
- A deficiency of the hepatic enzyme homogentisate 1,2-dioxygenase (HGO) forces the accumulation of homogentisic acid, which is rapidly cleared in the kidney and excreted. (medscape.com)
Enzymes6
- NODs belong to the larger family of well-established free radical and reactive oxygen detoxifying enzymes that includes superoxide dismutase, catalase, and peroxidase. (wikipedia.org)
- In particular, certain types of ALKBH enzymes are dioxygenases that directly reverse DNA methylation damage via transfer of a methyl group from the DNA adduct onto α-ketoglutarate and release of metabolic products including succinate and formaldehyde. (frontiersin.org)
- The DNMT family enzymes include DNMT1, DNMT3a and DNMT3b. (spandidos-publications.com)
- IDO1 (indoleamine-2, 3-dioxygenase-1) and TDO (tryptophan-2, 3-dioxygenase) are enzymes that mediate cancer-induced immune suppression. (centerwatch.com)
- α-Ketoglutarate (αKG)-dependent dioxygenases are a superfamily of enzymes that require oxygen, reduced iron, and αKG for their catalytic functions. (bvsalud.org)
- These sac-like compartments contain enzymes needed to break down many different substances, including fatty acids and certain toxic compounds. (medlineplus.gov)
Indoleamine2
- It acts by targeting indoleamine 2,3 dioxygenase (IDO) and programmed death-ligand 1 (PD-L1) antigens. (pharmaceutical-technology.com)
- The T-cell/histiocyte-rich large B-cell lymphoma signature is hallmarked by up-regulation of CCL8, interferon-γ, indoleamine 2,3 dioxygenase, VSIG4 and Toll-like receptors. (haematologica.org)
Proteins4
- The network shown was trimmed to include only Rieske proteins that contain the non-heme iron catalytic domain (IPR017941, IPR005805, and IPR domains listed in the figure). (nature.com)
- This cupin signature is found as a central component of many microbial proteins including certain types of phosphomannose isomerase, polyketide synthase, epimerase, and dioxygenase. (embl-heidelberg.de)
- As well as these single-domain cupins, this survey has identified other classes of two-domain bicupins including bacterial gentisate 1, 2-dioxygenases and 1-hydroxy-2-naphthoate dioxygenases, fungal oxalate decarboxylases, and legume sucrose-binding proteins. (embl-heidelberg.de)
- As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal ferredoxin at the end fused to an FAD/NADP(P) domain. (nih.gov)
TET12
- We also leverage on complementary genomic and epigenomic approaches to elucidate how genetic variants and nutritional stressors interact with TET1 and other dioxygenases in the etiologies of congenital malformations including neural tube defects. (bcm.edu)
- In contrast, the Ten-Eleven-Translocation (TET) dioxygenase family, including TET1, TET2 and TET3, mediates active DNA demethylation and hydroxylate-methylated DNA by converting 5-methylcyto-sine to 5-hydroxymethylcytosine to regulate DNA methylation status. (spandidos-publications.com)
Homogentisate1
- Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype-phenotype correlations in the largest cohort of patients with AKU. (cdc.gov)
Methylation2
- In particular, the Tet-Eleven-Translocation (TET) DNA dioxygenases erase DNA methylation by reiterative oxidation of 5-methylcytosine via 5-hydroxymethylcytosine. (bcm.edu)
- Moreover, in the ketamine group, the level of Ten‑Eleven‑Translocation methylcytosine dioxygenase for demethylation as determined by reverse transcription‑quantitative PCR assay was increased in comparison with the control group, but that was not the case for the level of DNA methyltransferases for methylation. (spandidos-publications.com)
Bacterial1
- The net reaction for the reaction catalyzed by nitric oxide dioxygenase is shown below: 2NO + 2O2 + NAD(P)H → 2NO3− + NAD(P)+ + H+ Nitric oxide is a ubiquitous small molecule that is integrated in a wide variety of physiological processes including smooth muscle vasodilation, platelet disaggregation, neurotransmission, and immune response to bacterial infection. (wikipedia.org)
Reductase3
- Electron donors may include ascorbate, cytochrome b5 or ferredoxin reductase. (wikipedia.org)
- Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. (nih.gov)
- In dioxygenase FAD/NAD(P) binding domain, the reductase transfers 2 electrons from NAD(P)H to the oxygenase which insert into an aromatic substrate, an initial step in microbial aerobic degradation of aromatic rings. (nih.gov)
Bacteria4
- The most well studied NO dioxygenase is flavohemoglobin (flavoHb), shown to the right: Studies have shown that flavohemoglobins are induced by NO, nitrite, nitrate, and NO-releasing agents in various bacteria and fungi. (wikipedia.org)
- Additionally, flavoHbs have been shown to protect bacteria, yeast, and Dictyostelium discoideum against growth inhibition and damage mediated via NO. Nitric oxide dioxygenase was discovered, and first reported in 1998, as an inducible O2-dependent enzymatic activity that protected bacteria against nitric oxide toxicity. (wikipedia.org)
- Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. (expasy.org)
- Bacteria have been studied extensively, and there is information regarding their ability to degrade xenobitics, including PAHs [ 6 ]. (omicsonline.org)
Superfamily1
- In addition to numerous flavohemoglobins, many distantly related members of the hemoglobin superfamily including the muscle myoglobin, the non-symbiotic plant hemoglobin and symbiotic plant leghemoglobin, the neuronal neuroglobin, and the mammalian cytoplasmic cytoglobin appear to function as nitric oxide dioxygenases (NODs), although the cellular electron donor(s) for many globins have yet to be defined. (wikipedia.org)
Hydroxylation2
- Furthermore, hydroxylation by dioxygenases generates potential substrates for the glycosyltransferases. (helmholtz-hzi.de)
- Mononuclear nonheme iron(II) and 2-oxoglutarate (Fe/2OG)-dependent oxygenases and halogenases are known to catalyze a diverse set of oxidative reactions, including hydroxylation, halogenation, epoxidation, and desaturation in primary metabolism and natural product maturation. (bvsalud.org)
Tumor1
- The tumor microenvironment (TME) includes a host of cells (mesenchymal, immune, vascular), cytokines, and other signaling molecules that serve to abrogate the innate and adaptive immune responses against the tumor. (shu.edu)
Gene2
- Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. (frontiersin.org)
- Moreover, a dioxygenase gene, nidA3B3, was detected in Mycobacterium vanbaalenii PYR-1 as an alternate degradation pathway which could catalyze both the initial dihydroxylation of pyrene [ 11 ] to be pyrene cis-4,5-dihydrodiol, and an alternate detoxification pyrene pathway to be pyrene cis-1,2-dihydrodiol [ 12 ]. (omicsonline.org)
Genes2
- nidA and nidB genes are encoding genes for large and small subunits of napthalene-inducible dioxygenase [ 7 , 8 ]. (omicsonline.org)
- We also identified other genes, including IDO1 and BAMBI, that may influence the RPE and therefore outer blood-retinal barrier integrity during ocular infection and inflammation, or are associated with degeneration, as seen for example in aging. (molvis.org)
Microenvironment1
- Fibrotic livers are characterized by an inflammatory microenvironment that is composed of various immunologically active cells, including liver-resident populations (e.g. (mdpi.com)
Accumulation1
- One proposed hypothesis is that abnormal peroxidation of lipofuscin to neuromelanin and deficient cysteine dioxygenase lead to abnormal iron accumulation in the brain. (medscape.com)
Abnormal1
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
Inhibition2
- Additionally NO, with its lone radical on the nitrogen atom, is implicated in a number of secondary mechanisms of toxicity, including catalase inhibition (resulting in hydrogen peroxide toxicity), Fe-S center iron liberation, and the formation of dinitosyl-iron complexes. (wikipedia.org)
- The herbicide functions by inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD). (bcpc.org)
Protein Expression1
- Andrew P. Robinson , D. M. Simpson , Kerrm Yau , Sarah Canada , and William G. Johnson "Aryloxyalkanoate Dioxygenase-12 Soybean Protein Expression," Weed Science 63(1), 229-234, (1 January 2015). (bioone.org)
Cytochrome1
- More recently, another protein has been identified as a NO dioxygenase - rhodobacter sphaeroides haem protein (SHP), a novel cytochrome with NO dioxygenase activity. (wikipedia.org)
Processes1
- Traditional methods of oil spill cleaning include processes such as controlled burns , skimmers, vacuum pumping, low-pressure flush, manual mechanical cleanup, gelling agent , and many more [3] , most of which merely remove the hydrocarbon from the affected water or environment and transfers them to another location. (kenyon.edu)
Reactions2
- The mechanism of action has still not been entirely deduced, however, the leading theory suggests that the conversion is carried out through a series of redox reactions involving iron centers as shown in the series of half reactions below: Another theory developed more recently (2009) suggests that a NO dioxygenase activity could also proceed through phenolic nitration via a putative heme-peroxynitrite intermediate. (wikipedia.org)
- This bacterium is highly abundant in freshwaters (up to 20 % of the total community) and has been shown to persisting UV radiation as well as reactive oxygen species (ROS) that are produced in freshwaters by photolytic reactions of organic matter including HS. (europa.eu)
Oxygenases1
- They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). (bvsalud.org)
Mesenchymal1
Compounds1
- In collaboration with the group of Prof. M. Seeger we have shown that our strains are able to hydroxylate various benzene derivatives, including compounds with unsaturated and cyclic substituents, e. g. biphenyls or diphenylmethanes, as well as compounds containing condensed rings and heteroatoms, like biphenylenes, benzofurans, indoles and bipyridyls, natural and synthetic isoflavones (57). (helmholtz-hzi.de)
Deficiency1
- In felines taurine is considered indispensable and dietary deficiency leads to several clinical problems, including retinal degeneration and developmental abnormalities [ 13 ]. (intechopen.com)
Restriction1
- ORFADIN contains nitisinone, which is a hydroxyphenyl- pyruvate dioxygenase inhibitor indicated as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 ( HT -1). (rxlist.com)
Symptoms2
- The symptoms and signs of ketamine-induced ulcerative cystitis (KIC) include increased voiding frequency, non-voiding contraction, hematuria and dysuria. (spandidos-publications.com)
- AKU affects all the major joints including the spine once the symptoms start to show, this is usually when patients reach their 20s. (nihr.ac.uk)
Strains1
- They include 8 plasmodial strains obtained from mating crosses with 22 different myxamoebal strains and two sclerotia. (go.jp)
Family2
- NO dioxygenase belongs to the family of oxidoreductases, more specifically those acting on paired donors, with O2 as oxidant and with incorporation of two atoms of oxygen into the other donor. (wikipedia.org)
- The Jumonji family of DNA and histone demethylases, as iron (II)- and alpha-ketoglutarate-dependent dioxygenases, are potentially epigenetic rheostats that integrate environmental inputs with the genome and epigenome to regulate pre-natal development. (bcm.edu)
Toxic1
- Toxic effects of oil and their products on the soil environment include enhancing hydrophobicity of soils, disturbance of water availability to vegetation, and direct toxicity to plants and microorganisms. (openmicrobiologyjournal.com)
Iron3
- The pcaH was significant in the β-ketoadipate pathway [9] where the pathway as it conserves biochemically, and is a major class of non-heme-iron containing dioxygenase [ 10 ]. (omicsonline.org)
- These include iron chelators as well as fosmetpantotenate. (medscape.com)
- Therefore, they have the potential to sense the availabilities of oxygen, iron, and specific metabolites, including αKG and its structurally related metabolites. (bvsalud.org)
Tissues1
- Mononuclear myeloid cells include terminally differentiated macrophages and dendritic cells (DC), as well as monocytes, which under inflammatory conditions differentiate in tissues to macrophages and DCs. (aacrjournals.org)
Soil2
- Its beneficial attributes include ability to fix nitrogen, improve soil and provide protein rich animal feed. (biomedcentral.com)
- The benefits of red clover to farming include nitrogen fixation, soil improvement and high nutritive value in terms of protein-rich feed for livestock. (biomedcentral.com)
Pipeline1
- Its pipeline includes various drug modalities such as prophylactic vaccines, therapeutic vaccines, intratumoral immuno-oncology, localized therapeutics, and liver intracellular. (pharmaceutical-technology.com)
Potential1
- These properties of MSCs provided a rationale to investigate their potential for treatment of a variety of diseases, including COPD. (bmj.com)
Addition2
- In addition, your package will include a detailed data report in both TSV and JSONL formats. (nih.gov)
- Since other unknown regulators, in addition to LGS1 encoding a sulfotransferase, appear to be necessary for the stereoselective biosynthesis of 5DS, we examined Sobic.005G213500 (Sb3500), encoding a 2-oxoglutarate-dependent dioxygenase, as a candidate regulator, which is co-expressed with LGS1 and located 5'-upstream of LGS1 in the sorghum genome. (bvsalud.org)
Variety2
- Registered users receive a variety of benefits including the ability to customize email alerts, create favorite journals list, and save searches. (bioone.org)
- Pre-oil spill samples are what someone would expect in other beaches of similar location without contamination, which include a variety of diverse organisms that exhibit high level of interactions [5] . (kenyon.edu)
Cells3
- 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
- 2 , 3 , 9 Indeed, the atypical B cells of NLPHL and THRLBCL share many characteristics, including expression of pan-B-cell markers, germinal center B-cell origin and common chromosomal imbalances. (haematologica.org)
- Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)
Exhibit1
- This is an $8,000 award to be used by the artist to support their creative practice, and also includes opportunities for fellowship recipients to exhibit their work at the Virginia Museum of Fine Arts and other museum sites. (smcm.edu)
Structure1
- Structure, O2 binding, and reduction of globins appear optimized for a NO dioxygenase function. (wikipedia.org)
Ability1
- New trait technology incorporating 2,4-D resistance in soybean is dependent upon the ability of the plant to metabolize 2,4-D by the aryloxyalkanoate dioxygenase-12 protein (AAD-12). (bioone.org)
Provide1
- Historically, nitric oxide dioxygenase (around 1.8 billion years ago) served to provide the modern day analogue of hemoglobin/myoglobin function for oxygen storage and transport. (wikipedia.org)