Currently, anetoderma is classified as either primary anetoderma, which is an idiopathic occurrence of atrophic lesions in areas of skin that appear normal prior to the onset of atrophy, or secondary anetoderma, which is preceded by an inflammatory, autoimmune, infectious, or neoplastic process. (medscape.com)
Anetoderma is a rare, benign disorder characterized microscopically by the pan-dermal loss of elastic fibers in the dermis and presenting clinically as circumscribed, skin-colored or grey-white atrophic macules and/or patches on the trunk and/or extremities. (jcadonline.com)
Idiopathic2
Furthermore, a 2016 study involving nine patients with idiopathic anetoderma found that the dermal expression of fibulin-4 (which binds tropoelastin and is involved in various aspects of elastic fiber development) was significantly decreased in anetoderma when compared with healthy controls. (medscape.com)
Historically, idiopathic lesions of anetoderma were classified clinically as either inflammatory (Jadassohn-Pellizzari type) or non-inflammatory (Schweninger-Buzzi type), although both types of lesions may be found in the same patient. (jcadonline.com)
Familial3
A familial form that manifests as primary anetoderma has also been described. (medscape.com)
Familial anetoderma is uncommon, with only 13 families reported in the literature. (medscape.com)
Possible explanations for the loss of elastic tissue include defective elastin synthesis, uncontrolled production of elastolytic enzymes, loss of elastolytic enzyme inhibitors, elastophagocytosis, or degeneration of elastic fibers secondary to local ischemia induced by microthromboses in dermal vessels. (medscape.com)
The exact incidence of anetoderma is unknown, but secondary anetoderma is probably more common than the primary form. (medscape.com)
This article will review a case of generalized anetoderma in a patient with secondary syphilis after being treated with intravenous penicillin, along with a concise literature review. (jcadonline.com)
Thus, the clinical findings in conjunction with microscopic analysis and negative blood examination confirmed a diagnosis of anetoderma in the setting of HIV and secondary syphilis. (jcadonline.com)
Interestingly, there is no concordance between the clinical and pathological findings in these two groups, as peri-vascular infiltration of inflammatory cells is present in all anetoderma lesions no matter the clinical appearance. (jcadonline.com)
Acne1
This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. (edu.au)
Tissue inhibitors2
Known elastolytic enzyme inhibitors include serine proteinase inhibitors (serpins) and tissue inhibitors of metalloproteinase (TIMPs). (medscape.com)
Anetoderma: an altered balance between metalloproteinases and tissue inhibitors of metalloproteinases. (medscape.com)
Elastolytic enzymes1
Elastolytic enzymes such as matrix metalloproteinases (MMPs) may be directly responsible for elastin degradation in anetoderma. (medscape.com)
Disorder1
Anetoderma, first described by Jadassohn in 1892, is a rare cutaneous disorder characterized by localized areas of elastolysis. (jcadonline.com)
Psoriasis1
Includes a greatly expanded discussion of atopic dermatitis and psoriasis and new therapeutic approaches for treating genetic disorders and systemic diseases such as ichthyoses and rheumatologic disorders. (medicscenter.com)
Both common and medical names have been included to help your search, as well as the names of medications and treatments. (edu.au)
Symptoms1
Symptoms of Lyme disease may include ongoing fatigue, pain, increased sensitivity to light and sound, difficulty remembering things or concentrating, fevers or sweats that come and go, sensitivity to chemicals (of all sorts), and depression or anxiety. (nizhonimedicine.com)
Skin3
Anetoderma ( anetos, Greek for slack) is a benign condition with focal loss of dermal elastic tissue, resulting in localized areas of flaccid or herniated saclike skin. (medscape.com)
Incisional biopsies can include the whole lesion (excisional), part of a lesion, or part of the affected skin plus part of the normal skin (to show the interface between normal and abnormal skin). (wikipedia.org)
Potential severe side effects include scarring and changes in skin color. (yourbestselves.com)
Names1
The condition has been reported under various names, including macular atrophy, anetoderma maculosa, and atrophia maculosa cutis. (medscape.com)
Review1
ARKACCHAISRI T. Serum sickness and hepatitis B vaccine including review of the literature . (revahb.fr)
Responsible1
This gene provides instructions for making a protein that is responsible for modifying other proteins, including Wnt proteins. (medscape.com)
Indented Type1
A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? (medscape.com)
Features1
Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. (bvsalud.org)