Nuclear chromatinGenesHistoneTumorTranscriptionGene expressionNucleiTranscriptionalSomatic mutationsMutationsGenomeEffectorRegulatesMitosisNucleoliLandscapesAssayMechanismCytoplasmPrevalenceDefectsPediatricReplicationDisordersAssemblyHistonesGeneticRapidlyCancerHighBirthsComplexHigherCellPatientsDiseaseFormStudyCases
Nuclear chromatin5
- The tumor cells were arranged in focal acinar or follicular pattern with a round-to-oval nucleus, moderate anisonucleosis, fine nuclear chromatin, and moderate-to-abundant fragile cytoplasm with the focal presence of fine granules. (cytojournal.com)
- Previous studies have demonstrated that fractal characteristics of nuclear chromatin are of prognostic importance in neoplasias. (biomedcentral.com)
- We have therefore investigated whether the fractal dimension of nuclear chromatin measured in routine histological preparations of malignant melanomas could be a prognostic factor for survival. (biomedcentral.com)
- In the multivariate Cox regression, stratified for the presence or absence of metastases at diagnosis, only the Clark level and fractal dimension of the nuclear chromatin were included as independent prognostic factors in the final regression model. (biomedcentral.com)
- So, there is strong evidence that the fractal dimension of the nuclear chromatin texture is a new and promising variable in prognostic models of malignant melanomas. (biomedcentral.com)
Genes7
- The next most prevalent aberrations include a cohort of chromatin-modifying genes with diverse roles including PBRM1 , SETD2 , BAP1 , and KMD5C . (springer.com)
- We identify key binding motifs, including ERE, AP-1, and TCF sites, and we determine enrichment of binding to cis-regulatory chromatin sites of genes involved in tumor development, cell migration, cell adhesion, apoptosis, and Wnt signaling pathways. (scilifelab.se)
- Their published paper is titled "Driver mutations in histone H3.3 and chromatin remodeling genes in pediatric glioblastoma. (genengnews.com)
- patients that suffer from both CHD and NDD show enrichment of variants in genes that encode chromatin modifiers. (caseygiffordlab.com)
- We already knew that the response to pathogenic bacteria in the gut involves remodeling of the DNA-protein package known as chromatin, enabling access for the expression of genes involved in inflammation," corresponding author Toshiaki Ohteki says. (medindia.net)
- This led us to investigate the role of IFNγ in a similar context, and we found that IFNγ loosened the chromatin structure around the promoters of two genes encoding inflammatory mediators, leading to an increase in their expression. (medindia.net)
- 2021). Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers. (who.int)
Histone7
- In mice, rapamycin treatment increases expression of histone proteins and Wdfy3 transcription, and alters chromatin organisation in the small intestine, suggesting the mTORC1-histone axis is at least partially conserved in mammals and may offer new targets for anti-ageing interventions. (sdbonline.org)
- We find that depletion of JMJD1B increases the protein levels of the histone chaperone tNASP leading to an accumulation of newly synthesized histones H3 and H4 at early steps of the histone maturation cascade, which perturbs chromatin assembly. (biomedcentral.com)
- Chromatin immunoprecipitation assay was performed to evaluate the histone modification of gene loci that are regulated by lunasin and cytokine. (weeksmd.com)
- Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent. (biomedcentral.com)
- These and other PTMs generate a combinatorial histone code that demarcates chromatin regions for transcription activation or repression [ 2 ]. (biomedcentral.com)
- Thus, drug-like molecules that target chromatin modifying enzymes to reprogram selected histone PTMs in tumour cells may have potential as cancer chemopreventive agents. (biomedcentral.com)
- On the basis of technology, the Epigenetics Market is segmented into DNA methylation, histone modifications, and other technologies (includes non-coding RNA and chromatin remodeling). (arberbiotech.com)
Tumor2
- Genome-wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity. (scilifelab.se)
- Cancer is a genetic disease with incidence driven by inherited (germline) variation in the person and evolution driven by somatic events in the tumor. (dana-farber.org)
Transcription3
- Meiotic sex chromosome inactivation only happens in male, which may partially be the reason why only Spo11 mutant spermatocytes but not oocytes fail to transition from prophase I to metaphase I. However the asynapsis does not happen only within sex chromosomes, and such transcription regulation was suspended until it was further expanded to all the chromosomes as meiotic silencing of unsynapsed chromatin, but the effector gene is not found yet. (wikipedia.org)
- All four of the samples also harbored mutations in ATRX, which encodes part of the transcription/chromatin remodeling complex involved in binding H3.3 to DNA. (genengnews.com)
- We have also shown that Af4 functions as part of a large multiprotein complex that stimulates RNA polymerase II elongation and mediates chromatin remodelling during transcription. (ox.ac.uk)
Gene expression3
- Importantly, Brwd1 renormalization rescued aberrant BAF localization, along with associated changes in chromatin accessibility and gene expression. (nih.gov)
- ERβ is a nuclear receptor that regulates gene expression through interactions with the chromatin. (scilifelab.se)
- In parallel, molecular measurements such as gene expression and chromatin activity across individuals are being collected at an unprecedented rate. (dana-farber.org)
Nuclei3
- By combining super-resolution microscopy and chromatin fiber analyses with proximity ligation assays on intact nuclei, old H3 was found to be preferentially incorporated by the leading strand, whereas newly synthesized H3 is enriched on the lagging strand. (sdbonline.org)
- Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
- 5-7 Morphologically, BL involves monomorphic medium-sized B cells with basophilic cytoplasm, numerous mitotic figures, rounded nuclei with finely clumped chromatin, myriad apoptosis, and tingible body macrophages, which result in a classic "starry sky" pattern. (cancernetwork.com)
Transcriptional3
- Elevated expression of H3/H4 in intestinal enterocytes in Drosophila alters chromatin organization, induces intestinal autophagy through transcriptional regulation, prevents age-related decline in the intestine. (sdbonline.org)
- The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function. (ox.ac.uk)
- I am a clinically trained pathologist that studies chromatin based-mechanism of transcriptional control in both cancers of lymphoid and epithelial origin. (nih.gov)
Somatic mutations2
- We also reported that haplo-insufficiency of ATAD5 in mice developed tumors and high incidences of somatic mutations of ATAD5 in human tumors. (nih.gov)
- An international consortium led by researchers at McGill University sequenced the exomes of 48 pediatric GBM samples and found somatic mutations in the H3.3-ATRX-DAXX chromatin remodeling pathway in 44% of tumors and recurrent H3F3A mutations in 31% of tumors. (genengnews.com)
Mutations1
- Molecular modeling experiments showed that the newly identified CBX1 mutations affected HP1β's ability to bind to chromatin. (medicalxpress.com)
Genome4
- Recent analyses of the whole genome sequencing data enable us to predict cancer incidence for healthy people at present. (intechopen.com)
- Maintaining a proper supply of soluble histones throughout the cell cycle is important to ensure chromatin and genome stability. (biomedcentral.com)
- Enzymes that modify chromatin and associated proteins by the addition or removal of acetyl or methyl groups play a key role in genome regulation [ 1 ]. (biomedcentral.com)
- Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure, its genome and epigenome. (basicmedicalkey.com)
Effector1
Regulates1
- Previously, we showed that ATAD5 protein, which is a mammalian homolog of yeast Elg1 protein, regulates the level of PCNA in chromatin during normal DNA replication as well as ubiquitylated PCNA in response to DNA damage. (nih.gov)
Mitosis2
- Inhibition of NEK6 can lead to the termination of mitosis, chromatin spindle defects, and abnormal chromosomal differentiation [ 5 - 7 ]. (hindawi.com)
- During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. (neobiotechnologies.com)
Nucleoli1
- However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
Landscapes2
- TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment. (stanford.edu)
- Characterization of Chromatin Landscapes to Identify Therapeutic Vulnerabilities in Diffuse Midline Gliomas. (alexslemonade.org)
Assay1
- Using a sequential nucleoside analog incorporation assay, a high incidence of unidirectional replication fork movement is detected in testes-derived chromatin and DNA fibers. (sdbonline.org)
Mechanism1
- Results point to chromatin remodeling mechanism as potential therapeutic target. (genengnews.com)
Cytoplasm1
- The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)
Prevalence4
- From Clinical Phenotype to Genotypic Modelling: Incidence and Prevalence of Recessive Dystrophic Epidermolysis Bullosa (RDEB). (stanford.edu)
- We aimed to investigate change over time in incidence, prevalence and age at diagnosis among Turner syndrome (TS), Klinefelter syndrome (KS), Triple X syndrome (Triple X) and Double Y syndrome (Double Y). (biomedcentral.com)
- In the present study we aimed to investigate change over time in incidence, prevalence, and age at diagnosis in a national cohorts of SCAs. (biomedcentral.com)
- The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)
Defects1
- Specifically, we find that if JMJD1B is not present, chromatin assembly defects and DNA damage are observed. (biomedcentral.com)
Pediatric1
- Reporting in Nature the McGill investigators suggest their findings "provide a rationale for targeting the chromatin remodeling machinery" in pediatric GBM. (genengnews.com)
Replication1
Disorders2
- Neurological disorders represent a large share of the disease burden worldwide, and the incidence of age-related forms will continue to rise with life expectancy. (ox.ac.uk)
- The incidence of neurodevelopmental delay disorders (NDD), such as autism, is higher in CHD patients compared to control cohorts. (caseygiffordlab.com)
Assembly1
- Hat1 is implicated in chromatin assembly and DNA repair but its role in cell functions is not clearly elucidated. (sdbonline.org)
Histones1
- Following their synthesis, histones undergo a series of maturation steps to prepare them for deposition onto chromatin. (biomedcentral.com)
Genetic2
- In general, a more aggressive behaviour is usually found in genetically unstable neoplasias with a higher number of genetic or epigenetic changes, which on the other hand, provoke a more complex chromatin rearrangement. (biomedcentral.com)
- By combining genetic diagnoses that could be related, the incidence together is not that low," said Dr. Izumi, who has an appointment in the Children's Medical Center Research Institute at UT Southwestern. (medicalxpress.com)
Rapidly1
- Therefore, the purpose of this book chapter is to understand the structure of mammalian sperm chromatin and its impact on the rapidly advancing postgenomic era. (basicmedicalkey.com)
Cancer4
- Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lac. (cn1699.cn)
- Recently we have refocused the efforts in my lab to define and reveal how alteration and/or disruption of gene regulation contributes to cancer incidence, evolution, and outcome. (nih.gov)
- The large share of this segment is attributed to the increasing incidence of cancer and the ability of this technique to study different types of cancer with quality outcomes. (arberbiotech.com)
- 2022). Chromatin Remodeler Smarca5 Is Required for Cancer-Related Processes of Primary Cell Fitness and Immortalization. (who.int)
High1
- Increase in epigenetics research activities, favorable government funding initiatives, high R&D expenditure, rising incidence of various diseases, and the presence of key players in the region are the key factors driving the growth of the Epigenetics Industry in North America. (arberbiotech.com)
Births2
- With an incidence of ~1 in 800 births, Down syndrome (DS) is the most common chromosomal condition linked to intellectual disability worldwide. (nih.gov)
- Incidence CF affects 1 in 2500 births in Caucasian popula- tions, 1 in 20 000 in black populations, and 1 in 1 million in Oriental populations. (forexinfolink.com)
Complex1
Higher2
- The higher incidence of ccRCC in male patients may partially be accounted by mono-allelic inactivation of the chromatin remodelling gene, KDM5C on the X chromosome [ 6 ]. (springer.com)
- The increased nuclear fractal dimension found in the more aggressive melanomas is the mathematical equivalent of a higher complexity of the chromatin architecture. (biomedcentral.com)
Cell1
- We use cell lines engineered to express ERβ, optimize and validate an ERβ antibody for chromatin-immunoprecipitation (ChIP), and perform ChIP-Seq. (scilifelab.se)
Patients1
Disease2
- Understanding this relationship may inform public health strategies to curb the incidence of cardiometabolic disease in Canada and elsewhere. (cdc.gov)
- Understanding the association between vitamin D and cardiometabolic risk in Canadians may provide a clearer understanding of how this micronutrient modulates cardiometabolic disease and may inform public health strategies to curb the incidence of cardiometabolic disease in Canada and elsewhere. (cdc.gov)
Form1
- Nuclear area, form factor and fractal dimension of chromatin texture were obtained from digitalized images of hematoxylin-eosin stained tissue micro array sections. (biomedcentral.com)
Study1
- 0.0001), KS ( P = 0.02), and Double Y ( P = 0.03) increased during the study period whereas the incidence of 45,X TS decreased ( P = 0.0006). (biomedcentral.com)
Cases1
- Incidence of medulloblastoma is 1.5-2 cases per 100,000 population, with 350 new cases in the United States each year. (medscape.com)