Incidence and management of hypersensitivity reactions. Medical search. Frequent questions

They rarely present with severe reactions, including anaphylaxis, to blood transfusions or intravenous immunoglobulin due to the presence of IgA in these blood products. (wikipedia.org)
The incidence, characteristics, management and outcomes of anaphylaxis in pregnancy: a population-based descriptive study. (ox.ac.uk)
OBJECTIVE: The aim of this study was to estimate the incidence of anaphylaxis in pregnancy and describe the management and outcomes in the UK. (ox.ac.uk)
Anaphylaxis was defined as a severe, life-threatening generalised or systemic hypersensitivity reaction. (ox.ac.uk)
RESULTS: There were 37 confirmed cases of anaphylaxis in pregnancy, giving an estimated incidence of 1.6 (95% CI: 1.1-2.2) per 100 000 maternities. (ox.ac.uk)
CONCLUSIONS: Anaphylaxis is a rare severe complication of pregnancy and frequently the result of a reaction to antibiotic administration. (ox.ac.uk)
Second symposium on the definition and management of anaphylaxis: Summary report - Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. (ijccm.org)
Cetirizine-induced anaphylaxis: A rare adverse drug reaction. (ijccm.org)
Anaphylaxis is a serious, life-threatening hypersensitivity reaction. (biomedcentral.com)
The incidence of anaphylaxis is 4-5 per 100,000 persons per year and is reported to be increasing in recent years. (biomedcentral.com)
We analysed management of suspected anaphylaxis in children at a DGH and a regional referral center in UK. (biomedcentral.com)
We endeavor to improve our management by establishment of specialist allergy services at the tertiary hospital and anaphylaxis education among all doctors. (biomedcentral.com)
ALPROLIX is contraindicated in patients who have a known history of hypersensitivity reactions, including anaphylaxis, to the product or its excipients. (alprolixpro.com)
Allergic-type hypersensitivity reactions, including anaphylaxis, are possible with factor replacement therapies. (alprolixpro.com)
Oxygen supplementation, intravenous administration of physiological fluids and intramuscular injection of 0.5 ml adrenalin (1:1000) should be considered in the first line management of acute anaphylaxis. (indianradiology.com)
Hypersensitivity reactions, including anaphylaxis, have been reported with or without known hypersensitivity to other 5-HT 3 receptor antagonists. (tevausa.com)
Anaphylaxis is a severe allergic reaction that can be life threatening. (medicalnewstoday.com)

Hypersensitivity reactions (i.e. rash, urticaria and dyspnea) have been reported with Emgality in clinical studies. (pharmacytimes.com)
Zynrelef is contraindicated for use in patients undergoing obstetrical paracervical block anesthesia or coronary artery bypass graft (CABG) surgery, as well as among patients with a history of asthma, urticaria, other allergic-type reactions after taking aspirin or other NSAIDs or in those with hypersensitivity to any local anesthetic agent of the amide-type. (empr.com)
Generalized reactions may develop following injection and may take the form of allergic reactions including urticaria and, less commonly, angioneurotic edema. (rxmed.com)
Papular urticaria is a common and often annoying disorder manifested by chronic or recurrent papules caused by a hypersensitivity reaction to the bites of mosquitoes, fleas, bedbugs, and other insects. (medscape.com)
In addition, despite no known racial or sex predisposition, certain ethnic groups (specifically Asians) may be more predisposed to more intense reactions, and a small Nigerian study reported a slight female predominance for skin diseases such as papular urticaria and atopic dermatitis. (medscape.com)
Morphologic and immunohistochemical evidence suggest that a type I hypersensitivity reaction plays a central role in the pathogenesis of papular urticaria. (medscape.com)

Serious or fatal reaction to CM could be due to direct effect on basophils and mast cells or IgE mediated (type 1 hypersensitivity reaction). (indianradiology.com)

METHODS: We included patients diagnosed with a clinical hypersensitivity reaction during a procedure under general anesthesia over a 30-month period (February 2008 to August 2010). (anesthesiaexperts.com)
Experts with clinical practices in diverse regions of the world and extensive experience in managing complications related to HA fillers convened to propose and evaluate approaches to prevent delayed-onset adverse reactions after HA filler administration and manage late-onset nodules. (beso.academy)
The expert panel agreed to define delayed-onset adverse reactions as those presenting more than 4 weeks post treatment, with swelling, induration, and nodulation being the most common clinical signs. (beso.academy)
In October 2018, the sponsor invited 22 experts, selected based on the high volume of HA filler procedures performed, extensive experience in managing complications related to HA fillers, and clinical practice locations in diverse regions of the world, to participate in the Global HA Filler Complications Management Advisory Board. (beso.academy)
In clinical trials, the most common adverse reactions in chemotherapy-induced nausea and vomiting in adults (incidence ≥ 5%) were headache and constipation. (tevausa.com)
Their use should be considered an integral part of the management of patients undergoing abortion with carboprost tromethamine injection.Of those patients experiencing temperature elevation, approximately one-sixteenth had clinical diagnosis of endometritis. (drugcentral.org)
Finally, progress has been made in the characterization of skin sensitization in humans and in the clinical management of ACD. (cdc.gov)

Not recommended for management of systemic course juvenile rheumatoid arthritis because of the high frequency of adverse effects reported in children. (drugs.com)
Systemic adverse reactions including dryness of the mouth, tachycardia, headache, allergic reactions, nausea, vomiting, pallor, central nervous system disturbances and muscle rigidity have been reported with the use of tropicamide. (itbusinessnet.com)
Mild local reactions consisting of pain, erythema, tenderness and induration at the injection site are common and may be associated with systemic reactions including mild to moderate transient fever, chills, malaise and irritability. (rxmed.com)
Booster doses given more frequently than recommended above may lead to adverse local and systemic reactions. (rxmed.com)

[ 20 ] In some patients, the reaction may be to a dye rather than the active ingredient. (medscape.com)
Four of 10 patients who had only a rash experienced IgE-mediated reactions. (anesthesiaexperts.com)
Mild hypersensitivity perioperative reactions-involving only skin-should be considered in evaluating patients because a substantial number of these reactions are IgE mediated. (anesthesiaexperts.com)
Patients with Selective IgA deficiency rarely have severe reactions to blood transfusions. (wikipedia.org)
Allopurinol is well tolerated by most patients, but hypersensitivity reactions may develop, which can be severe or fatal. (medscape.com)
Because a skin rash may progress to a severe hypersensitivity reaction, patients who develop a skin rash should discontinue allopurinol. (medscape.com)
COVID-19 Vaccination Safety and Tolerability in Patients Allegedly at High Risk for Immediate Hypersensitivity Reactions. (cdc.gov)
Complement activation is unlikely to be a primary factor in initiating a serious reaction to CM. Avoiding CM administration in patients at high risk of serious reaction is advisable, but if the administration is deemed essential all precautions should be implemented and measures to treat serious reactions should be readily available. (indianradiology.com)
Aim and objectives The aim of this study was to assess the incidence of etoposide hypersensitivity and to evaluate potential risk factors for hypersensitivity in paediatric patients in a third level hospital. (bmj.com)
Conclusion and relevance The incidence of hypersensitivity reactions was moderate, affecting approximately 10% of patients. (bmj.com)
Caution in pediatric patients where rare incidences of central nervous system disturbances have been reported. (itbusinessnet.com)
In patients where nausea and vomiting must be avoided during the postoperative period, palonosetron hydrochloride injection is recommended even where the incidence of postoperative nausea and/or vomiting is low. (tevausa.com)
Palonosetron hydrochloride injection is contraindicated in patients known to have hypersensitivity to the drug or any of its components. (tevausa.com)
Synavive, a combination of prednisolone and dipyramidamole, was being studied as a safer alternative to steroids for symptom management in patients with moderate to severe RA. (the-rheumatologist.org)
Thrombosis, including deep venous thrombosis (DVT) and pulmonary embolism (PE), has been observed at an increased incidence in patients treated with Olumiant compared to placebo. (nationaleczema.org)
Tramadol hydrochloride tablets, USP should not be administered to patients who have previously demonstrated hypersensitivity to tramadol, any other component of this product or opioids. (prescriptiondrugs.com)
The most frequent adverse reactions observed are related to its contractile effect on smooth muscle.In patients studied, approximately two-thirds experienced vomiting and diarrhea, approximately one-third had nausea, one-eighth had temperature increase greater than F, and one-fourteenth experienced flushing.The pretreatment or concurrent administration of antiemetic and antidiarrheal drugs decreases considerably the very high incidence of gastrointestinal effects common with all prostaglandins used for abortion. (drugcentral.org)

48%) were mild, involving only skin, and 23 of 44 (52%) were anaphylactic reactions. (anesthesiaexperts.com)
Background: Epidemiological data on drug-induced anaphylactic reactions are limited in India and are largely depending on studies from developed countries. (ijccm.org)
Materials and Methods: The electronic databases were searched for Indian publications from 1998 to 2013 describing anaphylactic reactions. (ijccm.org)
Histamine (2-[3H-imidazol-4-yl]ethanamine) is an important chemical mediator that causes vasodilation and increased vascular permeability and may even contribute to anaphylactic reactions [ 1 ]. (hindawi.com)

There are conflicting data in the literature regarding the incidence of etoposide hypersensitivity reactions in adults and children. (bmj.com)
Management of rheumatoid arthritis in adults whose symptoms progress despite an adequate regimen of NSAIAs. (drugs.com)
Note: Diphtheria and Tetanus Toxoids Adsorbed, containing 25 Lf of diphtheria toxoid and 5 Lf of tetanus toxoid per 0.5 mL dose, should not be administered as a tetanus booster to children over 7 years of age or adults due to the risk of reaction to the high diphtheria toxoid component in this vaccine. (rxmed.com)
Tramadol hydrochloride tablets, USP are indicated for the management of moderate to moderately severe pain in adults. (prescriptiondrugs.com)

A Case Report of Hereditary Angioedema: Challenges in Diagnosis and Management. (cdc.gov)
Challenges in the Management of Hereditary Angioedema in Urban and Rural Settings: Results of a US Survey. (cdc.gov)
Global perceptions of the current and future impacts of COVID-19 on hereditary angioedema management. (cdc.gov)
COVID-19 and hereditary angioedema: Incidence, outcomes, and mechanistic implications. (cdc.gov)

BACKGROUND: The incidence of perioperative hypersensitivity reactions, which can be life-threatening, ranges from 1 in 20,000 to 1 in 1361. (anesthesiaexperts.com)
CONCLUSIONS: Perioperative reactions are more common than previously reported. (anesthesiaexperts.com)

Anyone with an amoxicillin rash needs prompt medical advice, as some reactions can become life threatening. (medicalnewstoday.com)
The type of rash that develops depends on whether the person is experiencing an allergic reaction to amoxicillin or not. (medicalnewstoday.com)

Discontinue use of ALPROLIX if hypersensitivity symptoms occur, and initiate appropriate treatment. (alprolixpro.com)
Management of the signs and symptoms of polyarticular course juvenile rheumatoid arthritis in children who have not responded adequately to NSAIAs. (drugs.com)
If a person has an allergic reaction to amoxicillin, symptoms could worsen quickly. (medicalnewstoday.com)
Overall, a grade three or higher reaction, which means those with symptoms that were severe enough to prevent daily activity, were reported by 2. (cdc.gov)

The overall incidence rates of adverse experiences in these trials were similar for tramadol hydrochloride and the active control groups, TYLENOL® with Codeine #3 (acetaminophen 300 mg with codeine phosphate 30 mg), and aspirin 325 mg with codeine phosphate 30 mg, however, the rates of withdrawals due to adverse events appeared to be higher in the tramadol hydrochloride groups. (prescriptiondrugs.com)

Insights from global experts on approaches to prevent and manage delayed-onset adverse reactions following HA filler administration, including late-onset nodules, support clinicians worldwide in optimizing patient outcomes and safety. (beso.academy)

Review article: Acute serious and fatal reactions to contrast media: our current understanding. (indianradiology.com)
Epinephrine HCl solution 1:1 000 should be available for immediate use in case an anaphylactic or acute hypersensitivity reaction occurs. (rxmed.com)

This can cause severe irritation and allergic reactions in some people. (medlineplus.gov)
Amoxicillin comes from penicillin , which is known to cause allergic reactions in some people. (medicalnewstoday.com)

Adjunct for management of mild to moderate ulcerative colitis. (drugs.com)

immediately discontinue infusion if a serious reaction occurs and initiate appropriate treatment. (drugs.com)

Frequent booster doses of tetanus toxoid in the presence of adequate or excessive serum levels of tetanus antitoxin have been associated with increased incidence and severity of reactions and should be avoided. (rxmed.com)
Table 2 reports the cumulative incidence rate of adverse reactions by 7, 30 and 90 days for the most frequent reactions (5% or more by 7 days). (prescriptiondrugs.com)

Five surgeries (11%) were suspended because of the severity of the reactions. (anesthesiaexperts.com)
Reactions were analyzed for severity, causality, and preventability. (ijccm.org)

4 In a double-blind, randomized, multi-center trial, the only adverse reaction that occurred at an incidence of greater than or equal to 5% and at a higher incidence with doxylamine-pyridoxine as compared to placebo was somnolence. (rhochistj.org)

People with selective IgA deficiency do not require special blood products unless they have a history of a severe allergic reaction to a blood transfusion. (wikipedia.org)

To report SUSPECTED ADVERSE REACTIONS, contact Lundbeck at 1-800-455-1141 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)
To report SUSPECTED ADVERSE REACTIONS, contact Cumberland Pharmaceuticals Inc. at 1-877-484-2700 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (drugs.com)

All hypersensitivity reactions were successfully managed with medication (corticoids and antihistamines). (bmj.com)
Hypersensitivity to any component of this medication. (tevapharm.com)
VIVJOA is the first and only FDA-approved medication for RVVC indicated to reduce the incidence of RVVC in females with a history of RVVC who are NOT of reproductive potential. (pharmiweb.com)
Although the reactions listed in the table are felt to be probably related to tramadol hydrochloride administration, the reported rates also include some events that may have been due to underlying disease or concomitant medication. (prescriptiondrugs.com)

Most common ocular adverse reactions include transient blurred vision, reduced visual acuity, photophobia, superficial punctate keratitis, and mild eye discomfort. (itbusinessnet.com)

The aim of this study was to determine the incidence of allergic reactions during general anesthesia in our hospital, to establish the incidence of the allergic reactions for each drug used, to assess the frequency of IgE-mediated reactions in even mild reactions, and to compare the degree of agreement between anesthesiologist suspicion and allergy diagnosis. (anesthesiaexperts.com)
Many consensus recommendations and practice guidelines have been published to advise clinicians about the diagnosis, prevention, and treatment of complications associated with HA fillers.However, few guidelines account for regional practice differencesor focus exclusively on delayed-onset reactions. (beso.academy)
The objective was to generate streamlined guidance on the diagnosis, prevention, and management of delayed-onset adverse reactions associated with HA fillers. (beso.academy)
An initial diagnosis of an allergic reaction or infective gastroenteritis was made. (pediatriconcall.com)
Early recognition and diagnosis of FPIES will therefore ensure appropriate management of this condition, will reduce the risk of repeated reactions and reduce the length of admissions for these infants. (pediatriconcall.com)

The most commonly reported adverse reactions (incidence ≥ 2% and at least 2% greater than placebo) were injection site reactions. (pharmacytimes.com)

Serious or fatal reactions to a contrast medium (CM) are unpredictable but fortunately rare. (indianradiology.com)
These 2 cases might imply the involvement of immunosuppression in the pathogenesis of syringomas, in contrast to the previous speculation of inflammatory reactions (4, 5). (medicaljournals.se)

The most common adverse reactions reported with Zynrelef (incidence 10% or greater) included constipation, vomiting, and headache. (empr.com)
The most common adverse reactions in postoperative nausea and vomiting (incidence ≥ 2%) were QT prolongation, bradycardia, headache, and constipation. (tevausa.com)

1) The actual incidence and prevalence of FPIES especially to solid food is not truly known due to the variability in presentation and non-specific diagnostic investigations. (pediatriconcall.com)

In practice, this requires that the chemical and contact hypersensitivity, toxicological evaluation has the physico-chemical properties necessary for in the context of hazard identification and risk assess- passage across the stratum corneum. (cdc.gov)

These reactions include cyclic or persistent edema and erythema and late-onset inflammation and/or nodules.Late-onset nodules had an incidence of 1.0% per patient in a recent retrospective study and may arise from a number of factors, including hypersensitivity, foreign body reaction, injection placement, infection, sterile abscess, or biofilm development. (beso.academy)

It has been shown that the incidence of reactions to tetanus toxoid rises according to the number of previously administered doses and occurs mainly in the over-immunized. (rxmed.com)

Adverse reactions to medications are common and often manifest as a cutaneous eruption. (medscape.com)
Although Selective IgA deficiency is common, severe reactions to blood transfusions are very rare. (wikipedia.org)
Additionally, irAEs usually require specific management, the most common of which are steroids and immunomodulatory therapies. (biomedcentral.com)

The reaction is thought to be caused by a hematogenously disseminated antigen deposited by an arthropod bite in a patient who is sensitive. (medscape.com)

Although the pathogenesis of eruptive syringoma remains unknown, some studies have suggested an association between syringomas and inflammatory reactions, such as contact dermatitis and drug hypersensitivity (4, 5). (medicaljournals.se)
Therefore, the identification of inflammatory cardiomyopathy is elusive and the true incidence of the condition remains unknown. (intechopen.com)
an initial phase during which sensitization is acquired, followed later (after subsequent exposure to the same chemical allergen) by elicitation of a cutaneous inflammatory reaction. (cdc.gov)

Very importantly, adjust the dose in persons with chronic renal insufficiency because a higher incidence of adverse effects is observed if the dose is not adjusted. (medscape.com)

A violent exothermic reaction, possibly an explosion, occurs when mercury comes in contact with chlorine dioxide, lithium, or rubidium. (cdc.gov)

The incidence of notified cases of clinically significant pulmonary disease rose from 2.2 (1999) to 3.2 (2005) per 100,000 population. (cdc.gov)
This in turn initiates the cutaneous inflam- matory reaction that is defined clinically as ACD. (cdc.gov)

ACETADOTE infusion may be carefully restarted after treatment of hypersensitivity has been initiated ( 5.1 ). (drugs.com)

The 2022 IDSOG Annual Meeting will gather healthcare professionals from Aug. 4-6, 2022, at the Reserve Hotel in Boston, Massachusetts, to discuss research and innovation in the epidemiology, pathophysiology, prevention, management and impact of infectious diseases in women. (pharmiweb.com)

History of serious reaction to CM, bronchial asthma or multiple allergies increases the incidence of serious reactions by a factor of 5. (indianradiology.com)

Background and importance Etoposide is widely used in paediatric chemotherapy treatment, although hypersensitivity can be severe and treatment limiting. (bmj.com)
All hypersensitivity reactions were mild and were resolved by standard treatment. (bmj.com)
a Critical Images slideshow, to help identify various skin reactions, recognize potential comorbidities, and select treatment options. (medscape.com)
5 It is indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. (rhochistj.org)

their functions being to recognize type hypersensitivity. (cdc.gov)

these reactions normally resolve with hyperpigmentation and may recur at the same site with reexposure to the drug. (medscape.com)
Data from the hospital electronic prescribing system were collected to determine the ratio of reactions for each drug. (anesthesiaexperts.com)
A method for estimating the probability of adverse drug reactions. (ijccm.org)
Comment: Hospital admissions resulting from preventable adverse drug reactions. (ijccm.org)

The induction of sensitization and internalize antigen encountered in the skin and to and the elicitation of allergic contact reactions are transport it, via afferent lymphatics, to regional lymph dependent upon, and are orchestrated by, T lympho- nodes. (cdc.gov)

Delayed-onset adverse reactions to hyaluronic acid (HA) fillers are uncommon but have received increased attention, particularly with regard to late-onset nodules. (beso.academy)
The panel recommended 5 general key approaches for the prevention of delayed-onset reactions (patient selection, anatomic location of injection/product selection, aseptic technique, injection procedure/filler, and posttreatment care). (beso.academy)
Reactions may range from mild to serious and occur soon after injection or with a delayed onset. (beso.academy)
Delayed-onset adverse reactions, though uncommon, are being recognized more frequently as an important area of concern with HA fillers. (beso.academy)
This article will present a global perspective on approaches to the prevention of delayed-onset adverse reactions after HA filler injections in general and the management of late-onset nodules in particular. (beso.academy)

High-molecular-weight iron dextran has produced a higher incidence of hypersensitivity reactions when compared with other formulations. (medscape.com)

A study that showed a greater incidence of adnexal skin tumours in organ transplant recipients than in immunocompetent individuals (7) corroborates the role of immunosuppression in syringoma development. (medicaljournals.se)
The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)

The overall safety profile of HA fillers is favorable, and adverse immune reactions are rare. (beso.academy)

Now, a child's healthcare provider will determine if at-home administration is appropriate, and if so, will provide instruction to a patient's caregiver on how to properly administer and monitor for any allergic reactions. (gsk.com)

Anatomy26

Organisms17

Diseases51

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology3

Phenomena and Processes24

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science10

Named Groups1

Health Care23

Geographicals1

Anaphylaxis17

Urticaria6

Type 1 hypersensitivi1

Clinical7

Systemic4

Patients17

Anaphylactic reactions4

Adults4

Angioedema4

Perioperative2

Rash2

Symptoms4

Overall incidence1

Outcomes1

Acute2

Allergic reactions in some people2

Moderate1

Discontinue1

Frequent2

Severity2

Compared to placebo1

Severe allergic reaction1

SUSPECTED ADVERSE REACTIONS2

Medication4

Transient1

Diagnosis5

Placebo1

Contrast2

Constipation2

Prevalence1

Assess1

Sterile1

Doses1

Common3

Disseminated antigen1

Inflammatory3

Chronic1

Occurs1

Clinically2

Infusion1

20221

History1

Treatment4

Recognize1

Drug4

Induction1

Onset5

Higher1

Skin2

Rare1

Administer1