Inbred strain mice inbred balb c. Medical search. Frequent questions

Common inbred strains include BALB/c, C3H, C57BL/6 and DBA. (uwm.edu)
Recombinant inbred strain, progenitor cross: (BALB/cBy female X C57BL/6By male). (jax.org)
Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). (prosci-inc.com)
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
C57BL/6 (B6), C57BL/10 (B10), and SJL mice showed markedly suppressed secondary anti-DNP responses when infected. (uky.edu)
In the present study a nest-building protocol was established using four different inbred mouse strains (CD1, BALB/c, C57Bl/6J, C3H) before assessing AD and FTD tau transgenic mice of Line 1 (L1) and Line 66 (L66) in this paradigm. (bvsalud.org)
C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. (ncard.org.au)
Congenic BALB/c CL4 strain expressing C57Bl/6 Thy 1.1 allele. (ncard.org.au)
JAX stock No# 002216 or C57BL/6J isogenic Rag1 knock-out strain is also available as Stock No. 034159 . (ncard.org.au)
Reproductive performance consisting of mean litter size, number of pups that wean (wean: born ratio) and mean reproductive index of three inbred mice strains, which are BALB/cMlac, C57BL/6Mlac and DBA/2Mlac, were investigated to provide some basic information on the breeding and maintaining of a foundation colony. (mahidol.ac.th)
CB6F1 hybrid mice, a cross between C57BL/6 and Balb/c mice, were tested for learning and memory using a radial water tread maze. (antpublisher.com)
We offer pharmacokinetic (PK) studies in widely used murine inbred (C57BL/6, BALB/c), or custom strains. (flywithabird.com)
While langerin+ cells are observed in comparable numbers and with comparable phenotypes in the epidermis, two distinct DC subsets bear langerin in peripheral, skin-draining lymph nodes of BALB/c mice (CD11c(high) CD8alpha(high) and CD11c(low) CD8alpha(low)), whereas only the latter subset is present in C57BL/6 mice. (cnrs.fr)
The CD11c(high) subset is detected in mesenteric lymph nodes and spleen of BALB/c mice, but is virtually absent from C57BL/6 mice. (cnrs.fr)
Furthermore, the absolute amounts of Compact disc4+Compact disc25+ and Compact disc4+Compact disc25+FoxP3+ cells in spleens of infected BALB/c mice were greater than those from infected C57BL/6 mice (Figure 1E & F). the pathogenesis of experimental disease, their exact part remains questionable. (rawveronica.com)
We wanted to determine whether Tregs donate to specific phenotypic results in BALB/c and C57BL/6 mice and if just how they function regarding control of parasitemia and creation of disease-exacerbating proinflammatory cytokines. (rawveronica.com)
Strategy/Results BALB/c and C57BL/6 mice had been contaminated intraperitoneally (i.p) with 103 clone TC13 and both kinetics of Tregs development and intracellular cytokine information in the spleens and livers were monitored directly by movement cytometry. (rawveronica.com)
CFD1 As opposed to a transient and non significant upsurge in the percentages and total numbers of Compact disc4+Compact disc25+Foxp3+ T cells (Tregs) in C57BL/6 mouse spleens and livers, a substantial upsurge in the percentage and total amounts of Tregs was seen in spleens of contaminated BALB/c mice. (rawveronica.com)
Ablation or raising the amount of Compact disc25+ cells in the fairly resistant C57BL/6 mice by anti-CD25 mAb treatment or by adoptive transfer of Compact disc25+ T cells, respectively, ameliorates or exacerbates parasitemia and creation of proinflammatory cytokines. (rawveronica.com)
Summary Collectively, our outcomes display that regulatory T cells donate to susceptibility in experimental murine trypanosomiasis in both highly vulnerable BALB/c and fairly resistant C57BL/6 mice. (rawveronica.com)
Writer Overview BALB/c mice are susceptible even though C57BL/6 is relatively resistant to experimental disease highly. (rawveronica.com)
For instance, BALB/c mice are extremely susceptible as the C57BL/6 mice are fairly resistant to disease with as assessed by the capability to control parasitemia and success period [3], [4]. (rawveronica.com)
FVC, FEV0.1, Crs, C and A in BALB/cJ and FVC, FEV0.1, and A in C57BL/6 J). Repetitive lung function measurements were obtained in C57BL/6 J mice. (biomedcentral.com)
The effects of psychogenic stressors, rat exposure and fox urine odor, on central monoamine functioning was assessed in two inbred strains of mice, BALB/cByJ and C57BL/6ByJ, thought to be differentially reactive to stressors. (aku.edu)
However, central amygdala 5-HIAA elevations as well as DOPAC increases in the prefrontal cortex elicited by fox odor were greater in C57BL/6ByJ than in BALB/cByJ mice. (aku.edu)
Although BALB/cByJ mice are more behaviorally reactive than C57BL/6ByJ mice, and also show greater corticosterone elevations in response to neurogenic and systemic stressors, it was previously shown that differential corticosterone changes were not elicited by a predator exposure. (aku.edu)
We have applied our method to a sample set of 3 inbred strains: BALB/c, C57BL/6 and C3H and observed differences in subclass-specific and strainspecific N-glycosylation of IgG, suggesting a significant genetic component in the regulation of Fclinked IgG N-glycosylation. (irb.hr)
Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgrounds were hybridized with probes homologous to the long terminal repeat (LTR) and envelope (env) regions of MMTV. (elsevierpure.com)
However, genomic blots of one gain mutant, B6.C-KH-84, exhibited restriction fragments which were not exhibited by either of the parental strains, C57BL/6 or BALB/c. (elsevierpure.com)
HET3 mice used in this program are (F2) offspring of CByB6F1/J and C3D2F1/J (combining BALB/cBy, C57BL/6, C3H, and DBA/2) strains. (jax.org)
J:235854 lists J:27148 as the reference for these mice but then describes them as "B6C3F1" when the mice in the given reference were C57BL/6J mice fostered on C3Hf/Nctr mice. (jax.org)
C3H/HeJ or C3H/HePas (susceptible), BALB/c (intermediate) and C57BL/6 (resistant) mice were infected with the CL or Colombian strain of Trypanosoma cruzi, and TNF activity was measured in the sera during the acute phase of the infection. (pasteur.fr)
Age- and sex-related differences in alcohol and nicotine effects in C57BL/6J mice. (musc.edu)
Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice. (musc.edu)
Chronic social isolation and chronic variable stress during early development induce later elevated ethanol intake in adult C57BL/6J mice. (musc.edu)
Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice. (musc.edu)
Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL/6 mice. (musc.edu)
Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice. (musc.edu)
Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal. (musc.edu)
Chronic intermittent ethanol exposure and withdrawal alters (3a,5a)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice. (musc.edu)
Forced swim stress increases ethanol consumption in C57BL/6J mice with a history of chronic intermittent ethanol exposure. (musc.edu)
Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. (musc.edu)
Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL/6J mice. (musc.edu)

Thus, the identification of innate and extrinsic factors that influence the ability to develop tolerance is a significant issue among inbred strains of mice, the BALB/cByJ (CBy) strain exhibits greater pulmonary tolerance to PMN and protein levels in lavage fluid than DBA/2J (D2) following 5 successive exposures (5X) to 10 mg/m3 ZnO. (cdc.gov)
The suppressive effect of Toxoplasma infection on initiation of memory cells to dinitrophenylated keyhole limpet hemocyanin (DNP-KLH) was drastically different among inbred strains of mice. (uky.edu)

The objective of this study was to determine if there is variation in susceptibility of different strains of mice to MLA and to identify factors responsible for the variation that could be used as a model for cattle. (usda.gov)
Both the protein expression differences and the potential identification of genetic markers discovered in mice will provide the basis for future experiments to identify genetic factors that correlate with susceptibility to larkspur toxicity in cattle. (usda.gov)
The toxicokinetic profiles of MLA in the susceptible A/J and resistant 129 strains were compared in order to determine if their differences in susceptibility are simply due to differences in their ability to eliminate MLA. (usda.gov)
Interestingly, the toll-like receptor 4 gene (Tlr4) has been shown to be a strong candidate susceptibility gene for ozone -induced increases in the BAL protein phenotype in inbred mice. (cdc.gov)
Likewise, different strains of inbred mice display varying amount of susceptibility to experimental disease. (rawveronica.com)
Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice? (pasteur.fr)
Thus, sera collected from mice of strains differing in their susceptibility or resistance to Trypanosoma cruzi infection were checked for the presence and level of TNF alpha, a cytokine able to exert acute toxic effects. (pasteur.fr)
Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)

In a retrospective study of 142 tumors observed over a period of 3 years, myoepitheliomas occurred spontaneously in A/HeJ, A/J, BALB/cJ, BALB/cByJ, LLC.A/Ckc, and NOD/Lt inbred strains of mice. (jax.org)

The tumor phenotype in mice takes eight weeks to develop from the H-Ras and shp53 model. (genengnews.com)
The tumor phenotype is revealed when mice appear lethargic and have an enlarged head. (genengnews.com)
A genome-wide screen using 298 F2 mice (CByD2FlxCByD2FI) that were phenotyped for the development of pulmonary tolerance following 5X ZnO exposure identified a significant quantitative trait locus (QTL) for the BAL protein phenotype on chromosome 1. (cdc.gov)
BALB/c nude mice: A spontaneous mutation in Foxn1 nu induces abnormal hair growth (nude phenotype). (ncard.org.au)
Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdcscid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironmentsevere combined immune deficient phenotype on Non obese diabetic genetic background. (ncard.org.au)

A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain. (jax.org)
Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors. (biomedcentral.com)
Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors. (biomedcentral.com)
The genesis from the C26 digestive tract carcinoma model In 1975, during an attempt to determine an animal digestive tract tumor model for natural and chemotherapy research, digestive tract tumors had been induced and transplanted in various inbred mouse strains. (bio-cavagnou.info)

The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. (wikipedia.org)
No LPS-reactive cells but normal frequencies of lipoprotein-reactive cells were found in C3H/HeJ mice, genetically nonreactive to LPS. (silverchair.com)
Central monoamine activity in genetically distinct strains of mice fol" by Shawn Hayley, Thomas Borowski et al. (aku.edu)
The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. (jax.org)
Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. (jax.org)
Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort. (musc.edu)

The protein expression of various nAChR subunits was also compared between the resistant 129 and susceptible A/J strains. (usda.gov)
Balb/C, C3H, DBA/2) are also highly susceptible to infection ( 1 , 6 , 7 ). (cdc.gov)
The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5. (prosci-inc.com)

Twenty-one mutants were identical in restriction patterns to the respective background strains with all tested restriction enzymes and both probes. (elsevierpure.com)
Pathobiology of aging mice and GEM: background strains and experimental design. (jax.org)

In addition to differences in the protein expression of nAChR subunits, other potential differences between these two strains will be evaluated in the future using genomic technologies. (usda.gov)

Histamine-induced microvascular leakage in pial venules: differences between the SJL/J and BALB/c inbred strains of mice. (tamu.edu)
Differences evident between the L1 and L66 tau transgenic mouse models are likely due to the different human tau species expressed in these mice. (bvsalud.org)
Here, we describe striking differences in langerin-expressing cells between inbred mouse strains. (cnrs.fr)
Similar differences are observed in other mouse strains. (cnrs.fr)
Based on the data obtained, strain differences and age-related changes in the spontaneous behavior of female mice of the CBRB and BALB/cJ strains were revealed. (labanimalsjournal.ru)

Laboratory mice are usually of the species Mus musculus. (wikipedia.org)
Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (Peromyscus leucopus) and the North American deer mouse (Peromyscus maniculatus). (wikipedia.org)
In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
More laboratory mice are used in research every year than any other animal species. (uwm.edu)
Three mammalian species are reservoir competent: the white-footed mouse ( Peromyscus leucopus ), raccoon ( Procyon lotor ), and gray squirrel ( Sciurus carolinensis ), although serologic and molecular evidence has suggested that numerous other small, medium, and large mammals may also be reservoirs ( 1 , 3 ). (cdc.gov)
FXGs were previously identified in mouse, rat, and human brains in a conserved subset of neuronal circuits but with species-dependent developmental profiles. (biorxiv.org)

The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)

This causes the genes to become homozygous (same strain) at nearly all the loci on the chromosomes. (uwm.edu)
Rs1h mRNA expression was detected in the retina of postnatal day (P)11 and adult CD1 mice, but not homozygous rd/rd mice by Northern blot analysis. (nih.gov)
homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity. (ncard.org.au)
Mice homozygous for the Rag1 tm1Mom mutation produce no mature T cells or B cells. (ncard.org.au)
For microarray analysis, muscle from three age-matched, wild-type +/+ Balb/By, inbred strain mice (WT) and 3 female and 3 male homozygous sfx/sfx mice were used. (biomedcentral.com)

The acute toxicity of methyllycaconitine (MLA) in ten different inbred strains of mice was compared. (usda.gov)
Acute death seen in contaminated BALB/c mice is definitely from the extreme production of pro-inflammatory cytokines usually. (rawveronica.com)
In this Methods entry, we describe protocols for the induction of L-arginine induced acute pancreatitis in rats and mice. (pancreapedia.org)
In a mouse model of LPS-induced acute inflammation, DSO2-ONJ demonstrated anti-inflammatory activity by inhibiting the production of the pro-inflammatory interleukin-6. (cnrs.fr)

Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi − the tumor growths briefly and then begins a rejection process in 100% of the animals. (biomedcentral.com)
In CBi/L FS mice the tumor behavior is more complex as it begins with an exponential growth pattern in all challenged mice and, after a variable length period, the tumor is completely eliminated in some individuals while in others continues growing exponentially or enters in a state of equilibrium where no additional growth is detectable. (biomedcentral.com)
The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. (elsevierpure.com)
Colombo, MP, Melvold, RW & Wettstein, PJ 1987, ' Inheritance of a mutant histocompatibility gene and a new mammary tumor virus genome in the B6.KH-84 mouse strain ', Immunogenetics , vol. 26, no. 1-2, pp. 99-104. (elsevierpure.com)
Wettstein, Peter J. / Inheritance of a mutant histocompatibility gene and a new mammary tumor virus genome in the B6.KH-84 mouse strain . (elsevierpure.com)
Outcomes We discovered that the C26 tumor, ectopically implanted in mice, can be an undifferentiated carcinoma, that ought to be known as 31008-19-2 manufacture such rather than as adenocarcinoma, a common misunderstanding. (bio-cavagnou.info)
In 1981, the digestive tract tumor 26 was further characterized em in vivo /em by inoculation of serial cell dosages into syngeneic BALB/c mice. (bio-cavagnou.info)

CD4 TCR transgenic mouse whose CD4 T cells predominantly recognise the MHC class II (I‑A d )‑restricted TCR specific for the PR8 influenza HA peptide 126-138 (HNTngvtaacshe) ( PMID: 7889402 ). (ncard.org.au)

In the early part of the 20th century, Harvard undergraduate Clarence Cook Little was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)
Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)

In contrast, AP-Variant 1 does not infect the white-footed mouse, DBA/2, and severely immunocompromised (SCID) mice ( 8 ). (cdc.gov)
These animals carry the severe combined immune deficiency mutation ( scid ) on the BALB/c background. (ncard.org.au)

Mice belong to the Euarchontoglires clade, which includes humans. (wikipedia.org)
This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. (wikipedia.org)
Similar to spirometry in cooperative humans, equipment for lung function testing such as the Buxco or the Flexivent system has been developed for mice. (biomedcentral.com)
While in humans such high-throughput studies of IgG N-glycans became usual, only one has been carried out in mice. (irb.hr)

CD8 TCR transgenic mouse whose CD8 T cells predominantly recognise the MHC class I (H-2K d ) restricted CL4 epitope of PR8 influenza HA protein. (ncard.org.au)

The laboratory mouse genome has been sequenced and many mouse genes have human homologues. (wikipedia.org)
Two strains may be bred together to produce a mixture of the genes of each strain. (uwm.edu)
1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
Both H-2-linked and -nonlinked genes appeared to be responsible for the regulation of the immunosuppression, since the suppressive effect of infection in B10.D2 mice, which have the B10 background and the same H-2 haplotype as BALB/c, was weaker than that of B10 mice, but stronger than in BALB/c mice. (uky.edu)
In order to identify the genes that regulate muscle development through Vitamin C (VC) pathway, we analyzed the gene expression profile in mouse muscle from femur. (biomedcentral.com)
2) Some of dystrophin relevant genes are also affected in the sfx mice. (biomedcentral.com)
Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. (musc.edu)

The expression of creatine kinase muscle type (Ckb) and Cdc42 binding protein kinase beta (Cdc42bpb), on the other hand, although at a low level are increased in both sfx and wild type mice. (biomedcentral.com)

Together they generated the DBA (Dilute, Brown and non-Agouti) inbred mouse strain and initiated the systematic generation of inbred strains. (wikipedia.org)

Cell populations derived from these transgenic mice can be distinguished from syngeneic host and other mice with the alternate allele via flow cytometry. (ncard.org.au)

Common laboratory inbred mouse strains such as BALB/c and C57Bl6/J form the backbone of much of our pre-clinical work. (ncard.org.au)
C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. (jax.org)

The 129 strain of mice had twice the amount of alpha 7 nAChR subunit expression as the A/J strain, which was in direct proportion to the approximate two fold difference in LD50. (usda.gov)
Rs1h mRNA expression was measured from the eyes of wild-type and rd/rd mice by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). (nih.gov)
However, Rs1h expression was detected in rd/rd mice by RT-PCR. (nih.gov)
BALB/c based mouse model in which the administration of diphtheria toxin (DT) leads to specific depletion of regulatory T cells (Treg) due to expression of DT receptor-enhanced GFP under the control of the Foxp3 promoter. (ncard.org.au)
Asbestos induced mesothelioma mouse model in which expression of the Simian Virus 40 large T antigen (SV40 TAg) is controlled by mesothelin tissue‑specific promoter. (ncard.org.au)
Because muscle forces are a strong determinant of bone structure, particularly during the process of growth and development, we examined the gene expression of muscle in sfx mice. (biomedcentral.com)
Our results indicated that 1) The expression of Myogenic factor 6 (Myf6) gene in sfx mice is increased in both female and male mice, while the increase in male mice is much higher than that in female mice. (biomedcentral.com)
In these mice, N-cad was efficiently expressed in the E-cad expression domains. (biomedcentral.com)
Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. (musc.edu)

The Ferric Chloride - induced thrombosis technique allows assessment of thrombosis progression in coisogenic strains, and in isogenic mice dosed with study compounds. (flywithabird.com)

The investment in training should be outweighed by the benefits observed with more reliable behavioral and physiological responses in the mice. (uwm.edu)
Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
In a previous study, we characterized behavioral phenotypes of a mouse model generated by a sequential process of early-life social stress imitating child abuse or maltreatment composed of maternal separation (MS), social defeat (SD), and social isolation (SI). (encephalitisjournal.org)
Solovieva A.S. , Aronov D.A. , Shubernetskaya O.S. , Kalinin M.A. , Moiseeva Е.V. Express-modification of cylinder test for assessing the behavioral parameters of young and old cbrb and BALB/CJ mice. (labanimalsjournal.ru)
Kalinin M.A. - participation in the performance of behavioral tests, in the maintenance of the collection, and experimental mice. (labanimalsjournal.ru)
Taken together with earlier findings, it appears that despite greater behavioral reactivity/anxiety, the strain-specific neurochemical changes elicited may be situation-specific such that the profile apparent in response to neurogenic and systemic stressors may not be evident in response to predator-related threats. (aku.edu)

The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. (wikipedia.org)
The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. (wikipedia.org)
The white-footed mouse serves as a natural reservoir for AP-ha, and laboratory studies have shown that numerous inbred strains of mice (e.g. (cdc.gov)
Myoepitheliomas in inbred laboratory mice. (jax.org)
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)

One naturally occurring genetic defect in mice results in an animal with no hair that is called a nude. (uwm.edu)

J:259852 Mouse Genome Informatics and the WTSI Mouse Genomes Project, MGI Strain Genome Feature and Gene Model Load. (jax.org)

The monoclonal antibody recognizes rat CD8 antigen (MW 34 kDa and 39 kDa) and is reactive with all common inbred strains. (hycultbiotech.com)

Antibodies directed against the specific mouse keratins K5, K6, and K14, and a broadly cross-reactive cytokeratin antibody stained acinar and ductal myoepithelial cells in normal mammary, salivary, and Harderian glands, and neoplastic cells in all cases. (jax.org)
Frequencies of mitogen-reactive B cells in the mouse. (silverchair.com)
and CBA and A/J. Very similar frequencies are found for lipoprotein-reactive B cells in BALB/c, BALB/c ν/ν, C3H/Tif, and C3H/HeJ mice. (silverchair.com)
SJL mice had significantly lower frequencies of LPS- and of lipoprotein-reactive B cells (1 in approximately 30 B cells). (silverchair.com)
The number of LPS- and of lipoprotein-reactive B cells in spleen was dependent upon the age of the mouse. (silverchair.com)
LPS-reactive B cells yielding IgM- and IgG-PFC responses could be found in mesenteric lymph nodes, bone marrow, thymus, thoracic duct, and peripheral blood of 6- to 8-wk old mice. (silverchair.com)

Forty myoepitheliomas were tested by the avidin-biotin complex technique with a panel of antisera specific for mouse keratins, intermediate filaments, and other cytoskeletal proteins to determine the cell type from which this neoplasm originated. (jax.org)

Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. (musc.edu)

Old CB6F1 male mice (30 months of age) had severe cognitive impairment, while it was virtually absent in young (6 months old) male mice. (antpublisher.com)

Immunodeficient mouse strains are invaluable when assessing the role of immune cell subsets in anti‑tumour immunity. (ncard.org.au)

Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. (musc.edu)

The Ferric Chloride- induced thrombosis model is a widely used technique to produce thrombus formation in the left carotid artery of the mouse. (flywithabird.com)

15-11C5 is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from Balb/c mice immunized with WAG/Rij spleen cells. (hycultbiotech.com)

Selective inbreeding of this mutant led us to the establishment of a colony of inbred hydronephrosis mice. (mahidol.ac.th)
Alcohol consumption and preference, as well as food and water consumption, total caloric intake, and weight were assessed in adult female and male Clock Δ19/Δ19 mutant mice or wild-type (WT) litter-mates, housed under a 12-hour:12-hour light:dark (L:D) cycle or a shortened 10-hour:10-hour L:D cycle. (mdpi.com)

The mutagenicity of 4-phenyl-1, 3-dithia-2-thioxo-cycLopent-4-ene (DT827B) was examined in reverse mutation tests using Salmonella tryphimurium and Escherichia coli, in the chromosomal aberration test with Chinese hamster ovary (CHO) cells, and in the micronucleus test using mice bone-marrow. (go.jp)
Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response. (cdc.gov)

In contrast, the suppression did not occur in BALB/c mice. (uky.edu)
Early wasting and subsequent mortality may occur in mice of some inbred strains following infection with Trypanosoma cruzi. (pasteur.fr)

The most commonly used methods for catching and picking up mice are grasping the animal near the tip of the tail, between thumb and forefinger, or by grasping the tail near the base or the neck between the ends of a smooth tipped forceps. (uwm.edu)
BALB/cJ : a commonly used inbred mouse stain. (ncard.org.au)

The spontaneous bone fracture (sfx) mouse is a mouse model which is deficient in the synthesis of VC because of the deletion in Gulo gene. (biomedcentral.com)
The purpose of the study was to analyze spontaneous behavior of young and old females of the original CBRB inbred strain with signs of parkinsonism after 80 weeks of age and females of the standard BALB/cJ strain of the same ages using express-test. (labanimalsjournal.ru)
The express modification of the cylinder test enabled to confirm not only the previously discovered motor traits of female CBRB mice, but also certain non-motor changes in spontaneous behavior that are similar to characteristics of patients with Parkinson's disease. (labanimalsjournal.ru)

There is a significant difference in myopathy and gene regulations in muscle of sfx mice between female and male mice. (biomedcentral.com)
In this study, we disrupted circadian rhythms in female and male mice using both environmental (i.e., shifting diurnal cycles) and genetic (i.e. (mdpi.com)

In a few experiments, mice had been injected with anti-CD25 mAb prior or post disease or adoptively (by intravenous path) given extremely enriched na?ve Compact disc25+ T lymphocytes ahead of infection as well as the inflammatory cytokine/chemokine amounts and success were monitored. (rawveronica.com)

Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
We recently addressed the question of interchangeability of the two cadherins by generating a mouse model in which N-cad cDNA was introduced into the E-cad locus. (biomedcentral.com)

L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
After inbreeding for 20 generations, a surprisingly high incidence of hydronephrosis was encountered and we finally obtained a strain of mice with a very high incidence of severe hydronephrosis affected on both sides of kidney and in both sexes as the process of inbreeding has been increased. (mahidol.ac.th)

The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
The first paper will examine correlates among attending, impulsive behavior, and short-term remembering in a mouse model of Alzheimer's disease. (abainternational.org)
The aim of this study was to evaluate cognitive impairment in a mouse model of AD-associated amyloidosis. (abainternational.org)
Potential factors contributing to lack of impairment in DMTP/3CSRT performance in the APPswe/PS1dE9 double mouse model of AD-associated amyloidosis will be discussed. (abainternational.org)
The aging CB6F1 mouse would be a potential model to study the relationship between changes in brain morphometry and cognitive impairment and the identification of possible therapeutic targets. (antpublisher.com)
The mouse model was sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order (MS/SD/SI model). (encephalitisjournal.org)
The model is simple and well-described ( ref). and typical study requires 8-10 mice/ group to be completed. (flywithabird.com)
We also reported an L-arginine induced pancreatitis model in mice using a two injection protocol (6). (pancreapedia.org)
This confirms the use of CBRB mice as an adequate model of parkinsonism. (labanimalsjournal.ru)

Inbred strains are the result of at least 20 generations of brother-sister mating. (uwm.edu)
From then on, a regular system of inbreeding involving full-sib (FS) mating was applied and maintained for more than 30 generations giving rise to CBi/L FS, CBi − FS and CBi FS lines. (biomedcentral.com)

Mice have been used in biomedical research since the 17th century (from May 30, 1678) when William Harvey used them for his studies on reproduction and blood circulation and Robert Hooke used them to investigate the biological consequences of an increase in air pressure. (wikipedia.org)
Recent studies that compared the prevalence of AP-ha to AP-Variant 1 in tick populations showed the variant to be the predominant strain at 2 of 3 sites and suggest that AP-Variant 1 is common in nature ( 4 , 5 ). (cdc.gov)
This subset of lung function parameters in orotracheally intubated mice is reliable, thereby allowing relevant longitudinal studies. (biomedcentral.com)
However, monitoring lung function in mice, as above described, requires a tracheostomy, a procedure that has hampered longitudinal studies in animal models of chronic respiratory diseases. (biomedcentral.com)
However, numerous studies have proposed methods to intubate mice, starting from Ho et al. (biomedcentral.com)

These mice have deficiencies in their immune systems and thereby prove valuable in the study of immune diseases and cancer. (uwm.edu)
7], the authors associated a poor response to IFN-β treatment with Th17-type immune responses in EAE mice. (nartsignaling.com)
Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)
Dive into the research topics of 'Macrophage-mediated suppression of immune responses in Toxoplasma-infected mice. (uky.edu)

Female mice aged 5 - 6 months were assessed in the home cage over a period of 7 days with nest-building behaviour scored by three independent experimenters at intervals of 1-, 2- and 7-days post nestlet introduction. (bvsalud.org)
BALB/c mice were more proficient than CD1 and C3H mice, while all strains displayed similar nest-building behaviour by day 7. (bvsalud.org)

Certainly, IL-10, which includes effective anti-inflammatory properties, is crucial for success of mice contaminated with VAT TC13 in 100 l BIRT-377 Tris-saline-glucose supplemented with 10% heat-inactivated fetal bovine serum BIRT-377 (FBS, Invitrogen, Burlington, ON). (rawveronica.com)
Only serum collected from infected C3H/He mice contained TNF activity. (pasteur.fr)
However, TNF activity could be measured in serum of all strains, following LPS infection, indicating that the infection was able to prime macrophages of infected mice to secrete TNF alpha. (pasteur.fr)
Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. (musc.edu)

In the three strains tested, the penicillin G and D-penicillamine injections resulted in approximately dose-dependent responses. (go.jp)
The infected DBA/2 and C3H/He mice produced moderately suppressed responses. (uky.edu)
However, in BALB/c mice, the responses were not affected even by inoculation with 1 × 10 4 organisms. (uky.edu)
The difference in the suppressive effect of infection between B6 and BALB/c mice was also observed in the primary anti-DNP antibody responses to DNP-KLH. (uky.edu)

The results of this study confirm previous reports that there is a fairly large animal to animal variability to larkspur toxicity, and that this variation is found across numerous strains of mice. (usda.gov)
Results suggest that white-tailed deer harbor a variant strain not associated with human infection, but contrary to published reports, white-tailed deer are not a reservoir for strains that cause human disease. (cdc.gov)
These results led to the current study, which was conducted to investigate the relative potential for white-tailed deer to be a reservoir for AP-ha, AP-Variant 1, or both strains. (cdc.gov)

APPswe/PS1dE9 double transgenic (Tg) male and female mice and non-transgenic (non-Tg) littermates were trained on a delayed-matching-to-position (DMTP) or 3-choice serial reaction time (3CSRT) task. (abainternational.org)
Previously, a low incidence of mild hydronephrosis was observed mostly in male mice and found only on the right kidney. (mahidol.ac.th)
Pathological analysis suggests that the diameters of male and female of sfx mice are smaller than that of Wt mice. (biomedcentral.com)

Abnormal brain oscillations were observed in the MS/SD/SI mice. (encephalitisjournal.org)

As a general rule, inbred mice tend to have longer gestation periods and smaller litters than outbred and hybrid mice. (wikipedia.org)

Here, we investigated the capacity of N-cad in supporting epithelial integrity in the mammary gland of adult mice. (biomedcentral.com)

Little and Castle collaborated closely with Abbie Lathrop who was a breeder of fancy mice and rats which she marketed to rodent hobbyists and keepers of exotic pets, and later began selling in large numbers to scientific researchers. (wikipedia.org)

In the tau mouse models, L66 presented with impaired nesting compared to wild-type on days 1 and 2 (not day 7), whereas L1 performed like wild-type on all days. (bvsalud.org)
Inbred and hybrid mouse strains can be useful models to investigate cognitive impairment and morphological changes at older ages. (antpublisher.com)
Animal models and, in particular, mice models, are important tools to investigate the pathogenesis of respiratory diseases and to test potential new therapeutic drugs. (biomedcentral.com)
Although other animals such as dogs, guinea pigs or rats have also been used as models of chronic respiratory disease [ 2 , 3 , 4 ], mice models offer unique opportunities related to deep knowledge of mouse biology, and possibility of genetic manipulation [ 5 ]. (biomedcentral.com)

Anatomy6

Organisms23

Diseases4

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology2

Phenomena and Processes34

Disciplines and Occupations2

Information Science4

Health Care1

C57BL43

Among inbred strains of mice2

Susceptibility8

CByJ1

Phenotype5

Tumors6

Genetically6

Susceptible3

Background strains2

Genomic1

Differences5

Species6

Murine1

Homozygous5

Acute4

Tumor8

PMID1

Clarence Cook L2

SCID2

Humans5

Transgenic mouse1

Genes7

Protein1

Dilute1

Syngeneic1

C57Bl62

Expression9

Isogenic1

Behavioral6

Laboratory5

Nude1

Genome Informatics1

Antigen1

Reactive6

Neoplasm1

Dendritic1

Virtually absent1

Subsets1

Resistant1

Widely1

Spleen1

Mutant2

Bone-marrow2

Occur2

Commonly2

Spontaneous3

Female and male mice2

Experiments1

Locus2

High incidence2

Model9

Generations2

Studies5

Immune4

Behaviour2

Serum4

Responses4

Results3

Male3

Abnormal1

Hybrid mice1

Adult1

Abbie Lathrop1

Models4