C57BLBALBSpontaneousVariable susceptibilityC57LLociMurineMammaryGenomes ProjectTumorsAnnotationSusceptibilityGlomerularSpeciesProteinsSequencesMeSHBiomedical researchLaboratory mouseCommonlyThymocytesGenetic backgroundSusceptibleTissueGenome DatabaseExperimental2018TransgenicLungQuantitativeDataEmbryonicVariantsNudeDemonstrateIgG1NeuronsOrganGeneticsIdenticalVirusCellDeletionSpecificAuthorsBrainModelsCancerStudies
C57BL11
- For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
- C57BL/6 lymph node cells were incubated simultaneously with FITC Mouse Anti-Mouse Vβ 5.1, 5.2 T-Cell Receptor (Cat. (bdbiosciences.com)
- HET3 mice used in this program are (F2) offspring of CByB6F1/J and C3D2F1/J (combining BALB/cBy, C57BL/6, C3H, and DBA/2) strains. (jax.org)
- J:235854 lists J:27148 as the reference for these mice but then describes them as "B6C3F1" when the mice in the given reference were C57BL/6J mice fostered on C3Hf/Nctr mice. (jax.org)
- Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Mice, Inbred C57BL" by people in this website by year, and whether "Mice, Inbred C57BL" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)
- Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
- Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
- Fresh thymocytes from BALB/cJ (GIX-), C57BL/6J (GIX-), and 129/J (GIX+) mouse strains were also reactive with Friend gp71 antiserum, and this activity, as well as that of an antiserum prepared against purified AKR gp71, were also group specific. (duke.edu)
- The fraction of positive cells (by visual immunofluorescence) varies between strains from about 25-45% in A.CA to 65-85% in C57BL/6, and high levels are dominant in F1 hybrids. (jax.org)
BALB2
- However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
- Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
Spontaneous5
- A mouse model with complete deletion of the Akt1 gene manifests growth retardation and increased spontaneous apoptosis in tissues such as testes and thymus. (wikipedia.org)
- The "Ak" in Akt refers to the AKR mouse strain that develops spontaneous thymic lymphomas. (wikipedia.org)
- The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. (jax.org)
- Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
- Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively. (aspetjournals.org)
Variable susceptibility2
- There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
- We aimed to expand our knowledge about the variable susceptibility of inbred strains to this model and test for genetic variants associated with this trait. (bvsalud.org)
C57L1
- Using two independent AKR/J-derived sets of recombinant inbred mouse strains, AKXL (AKR/J x C57L/J) and AKXD (AKR/J x DBA/2J), as well as the HP/EiTy strain (an Emv-13-carrying inbred strain partially related to AKR/J mice) (Taylor et al. (jax.org)
Loci6
- All AKR/J mice carry at least three endogenous ecotropic viral loci which have been designated Emv-11 (Akv-1), Emv-13 (Akv-3), and Emv-14 (Akv-4) (Jenkins et al. (jax.org)
- Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
- Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
- To that end, we sought to measure differential susceptibility to cigarette smoke-induced emphysema in the mouse, identify genetic loci associated with this quantitative trait, and find homologous human genes associated with COPD. (bvsalud.org)
- These gene loci are deleted in mice having the a (e.g. (bdbiosciences.com)
- The pre-publication data that we release is embargoed for publication except for analyses of single chromosomes in single strains or single gene loci across multiple strains. (mousegenomes.org)
Murine1
Mammary1
- L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
Genomes Project1
Tumors3
- Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (lookformedical.com)
- Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. (uchicago.edu)
- Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
Annotation2
- Annotation of mouse strain AKR/J genome assembly provided by GENCODE consortium. (jax.org)
- High quality reference genomes and annotation are available for seventeen inbred mouse strains. (mousegenomes.org)
Susceptibility5
- We performed a systematic review of the literature describing strain and organ specific response to injury in order to determine whether genetic susceptibility plays a role in fibrogenesis. (biomedcentral.com)
- There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
- The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
- Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
- Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
Glomerular1
Species2
- Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
- In parallel, multiple technologies and manual finishing were used to produce an 85-Mb reference genome assembly from the more readily available mouse parasite species T. muris (Online Methods and Supplementary Note ). (nature.com)
Proteins2
- Cell cultures derived from recombinant inbred strains that carry only Emv-13 failed to express detectable infectious virus, viral proteins, or cytoplasmic ecotropic virus-specific RNA even after treatment with 5-iodo-2-deoxyuridine or 5-azacytidine, an inhibitor of DNA methylation. (jax.org)
- Quantitative targeted absolute proteomic analysis of 31 membrane proteins showed that P-glycoprotein (P-gp/mdr1a) protein expression levels were significantly increased in brain capillaries of PTZ (129%), EL (143%), and PHT mice (192%) compared with controls. (aspetjournals.org)
Sequences2
- We report here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory model Trichuris muris . (nature.com)
- Here we present high-quality genome sequences for T. trichiura and T. muris , the first duo of a major human STH and its mouse counterpart. (nature.com)
MeSH1
- Mice, Inbred DBA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Biomedical research2
Laboratory mouse1
- T. muris is an established laboratory mouse model for human trichuriasis and shares with T. trichiura many aspects of its biology, including the specialized niche within the host. (nature.com)
Commonly2
- Chronic cigarette smoke exposure in the mouse is a commonly used animal model of COPD. (bvsalud.org)
- This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
Thymocytes2
Genetic background1
- This work demonstrates that the genetic background contributes significantly to the magnitude and longevity of vaccine-induced IgG1, IgG2b, and IgG3 titers in mice. (bvsalud.org)
Susceptible2
- Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
- Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. (jefferson.edu)
Tissue1
- Gene expression of ANT2 is reduced in lung tissue from COPD patients and in a mouse smoking model, and overexpression of ANT1 and ANT2 resulted in enhanced oxidative respiration and ATP flux. (bvsalud.org)
Genome Database1
- To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
Experimental2
- Pathobiology of aging mice and GEM: background strains and experimental design. (jax.org)
- Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. (jax.org)
20181
- In 2018, we produced the first draft reference genomes for sixteen inbred strains (described in this paper ). (mousegenomes.org)
Transgenic1
- C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. (jax.org)
Lung2
- A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)
- Gut microbiota modulates bleomycin-induced acute lung injury response in mice. (uchicago.edu)
Quantitative1
- A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)
Data4
- Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)
- Using RNA sequencing data from whipworm-infected mice, we describe the regulated T helper 1 (T H 1)-like immune response of the chronically infected cecum in unprecedented detail. (nature.com)
- Gene expression data from mice with low-dose whipworm infection provide a detailed description of a regulated T H 1-like immune response to the infected cecum that is not limited to the immediate site of infection. (nature.com)
- For individual strain files see the "Inbred Strain Exome Data" subdirectory. (jax.org)
Embryonic1
- The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
Variants1
- Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
Nude1
- In the periphery, the antigen is found on a few percent of lymph node and not on splenic T cells, and it is absent in nude mice. (jax.org)
Demonstrate1
- We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
IgG13
- IgG1, IgG2b, and IgG3 titers against diphtheria toxoid (DT), pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (Prn) were measured in mice from 28 different inbred and wild-derived strains vaccinated with an aluminum hydroxide-adjuvanted DTaP vaccine. (bvsalud.org)
- The ratio of IgG1 and IgG3 titers identified Th1 and Th2-prone mouse strains. (bvsalud.org)
- TLR4-deficient C3H/HeJ mice had an enhanced IgG1 response compared with C3H/HeOuJ mice with intact TLR4. (bvsalud.org)
Neurons1
- Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. (ouhsc.edu)
Organ1
- Few studies have assessed the effect of the same injury stimulus in different organ systems using the same strains of mouse. (biomedcentral.com)
Genetics2
- Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
- Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)
Identical1
- Restriction endonuclease digestion and hybridization with an ecotropic virus-specific hybridization probe of DNAs from strains which transmit only Emv-13 yielded enzyme cleavage patterns identical to those observed with DNAs from strains transmitting Emv-11 or Emv-14 or both. (jax.org)
Virus1
- Strains which transmit Emv-11 or Emv-14 or both were found to produce virus spontaneously, whereas strains that transmit Emv-13 alone were negative for virus expression. (jax.org)
Cell3
- The MR9-4 monoclonal antibody specifically recognizes the Vβ 5.1 and Vβ 5.2 T-cell Receptors of strains having the b haplotype (e.g. (bdbiosciences.com)
- Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. (ouhsc.edu)
- Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)
Deletion1
- Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. (uchicago.edu)
Specific2
- In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. (wikipedia.org)
- The titers and duration of vaccine-specific IgG subclass responses were different among mouse strains, indicating that genetic factors contribute to this variation. (bvsalud.org)
Authors1
- The authors state, "Stock A Strain k AKR mouse originally inbred in the laboratory of Dr. C. P. Rhoads by K. B. Rhoads at the Rockefeller Institute. (wikipedia.org)
Brain1
- In all mice, reconstructed K p brain values agreed well with the observed values within a 1.21-fold range. (aspetjournals.org)
Models1
- Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)
Cancer1
- L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
Studies1
- Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)