Inbred laboratory rat strain that spontaneously. Medical search. Frequent questions

Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. (wikipedia.org)
NOD mice Type 1 Diabetes Autoimmunity Mordes JP, Poussier P, Blankenhorn EP, Greiner DL: Rat models of type 1 diabetes: Genetics, environment and autoimmunity. (wikipedia.org)
one estimate of mice and rats used in the US alone in 2001 was 80 million. (wmflabs.org)
Quantitative Trait Loci and Candidate Genes for Neutrophil Recruitment in Sterile Inflammation Mapped in AXB-BXA Recombinant Inbred Mice. (genenetwork.org)
Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. (genenetwork.org)
Selective inbreeding of this mutant led us to the establishment of a colony of inbred hydronephrosis mice. (mahidol.ac.th)
After inbreeding for 20 generations, a surprisingly high incidence of hydronephrosis was encountered and we finally obtained a strain of mice with a very high incidence of severe hydronephrosis affected on both sides of kidney and in both sexes as the process of inbreeding has been increased. (mahidol.ac.th)
Reproductive performance consisting of mean litter size, number of pups that wean (wean: born ratio) and mean reproductive index of three inbred mice strains, which are BALB/cMlac, C57BL/6Mlac and DBA/2Mlac, were investigated to provide some basic information on the breeding and maintaining of a foundation colony. (mahidol.ac.th)
A number of studies have indicated that CR can increase the lifespan (50-300%) and reduce the onset of age-related diseases in a variety of organisms (e.g. rats, mice, flies, worms, and yeast). (longevitywiki.org)
[5] This means that while some mice strains obtain lifespan benefits, others may attain no benefit or even experience harmful consequences. (longevitywiki.org)
However, there was an anticancer effect in the CR group, as seen in other experiments with laboratory bred mice. (longevitywiki.org)
Authors argued that strong differences in longevity were not noted possibly because wild animals have a higher genetic variation than inbred mice, which could affect CR strength. (longevitywiki.org)
Inbred mice have shown to benefit significantly less from CR interventions than non-inbred mice, with some inbred mice strains not benefiting at all from CR. (longevitywiki.org)
The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi − and CBi/L inbred mice lines. (biomedcentral.com)
CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)
There is something of splitting of - mouse - hairs when it comes to making a point between historically wild house mice that have developed black coats and those black mice that are laboratory creations. (ecobear.co)
Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
Although other animals such as dogs, guinea pigs or rats have also been used as models of chronic respiratory disease [ 2 , 3 , 4 ], mice models offer unique opportunities related to deep knowledge of mouse biology, and possibility of genetic manipulation [ 5 ]. (biomedcentral.com)

An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. (mcw.edu)
The mode of blood pressure inheritance and some genetic markers of spontaneous hypertension were evaluated in a new set of recombinant inbred (RI) strains obtained by crossing of normotensive (BN.lx) and hypertensive (SHR) progenitor strains. (mcw.edu)
Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC 2016 MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. (genenetwork.org)
Xue Y, Li J, Yan L, Lu L, Liao FF 2015 Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains. (genenetwork.org)

P, Cervenka L, Falck JR, Imig JD, Kompanowska-Jezierska E. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats. (uams.edu)
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. (uams.edu)
Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method. (kyoto-u.ac.jp)
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
To prove the existence of an epistatic interaction we have analyzed congenic strains for chromosome 1 and 10 carrying high blood pressure QTL alleles from the spontaneously hypertensive rat on a normotensive background of the Wistar-Kyoto (WKY) rat. (mcw.edu)

This suggestion was confirmed by the detection of significant difference in blood pressure between SHR and SHR.1N congenic strains. (mcw.edu)
We have used inbred and congenic rat strains in F(2) segregation studies to discover epistasis in a polygenic model of hypertension. (mcw.edu)
Additionally, a double congenic strain was developed with both chromosome 1 and 10 high blood pressure QTL alleles on the WKY background. (mcw.edu)

In the present work we used spectral karyotyping (SKY) to identify cancer-related aberrations in a well-characterized experimental model for spontaneous endometrial carcinoma in the BDII rat tumor model. (biomedcentral.com)
Spontaneous cholangiofibrosis adjacent to a dilated common bile duct with intestinal metaplasia in a Royal College of Surgeons rat. (kyoto-u.ac.jp)
This strain is a spontaneous type 2 diabetes model animal. (or.jp)
A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT). (lookformedical.com)
Previously, we reported on progressive retinal degeneration in a spontaneous obese rat (WNIN/Ob) model. (molvis.org)
In this study we examined the entire mitochondrial genome in a series of chemically induced brain tumors in the C57BL/6J strain and spontaneous brain tumors in the VM mouse strain. (biomedcentral.com)

Blood pressure values of RI strains were continuously distributed between both progenitor strains, although normotensive strains slightly prevailed. (mcw.edu)

Two T1D susceptibility genes have been identified in the BB rat. (wikipedia.org)
As the majority of the genes are conserved among mammals, the use of inbred animal model systems may serve as a tool for identification of underlying genes and pathways involved in tumorigenesis in humans. (biomedcentral.com)
Positional cloning of rat mutant genes reveals new functions of these genes. (kyoto-u.ac.jp)
Male TSOD mouse spontaneously indicates obesity and diabetes with high probability, and plural genes participate in obesity and blood-sugar level. (or.jp)
Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)

To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens as well as the effects of repeated ethanol pretreatment on the basal release of these transmitters were examined in alcohol-preferring (P), alcohol-nonpreferring (NP), and genetically heterogeneous Wistar rats. (aspetjournals.org)

A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. (uams.edu)
Mutant strain of Rattus norvegicus which is used as a disease model of kernicterus. (lookformedical.com)

The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of T1D pathogenesis. (wikipedia.org)
The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells. (wikipedia.org)
Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. (wikipedia.org)
EC development in BDII rats has similarities in pathogenesis, histopathological and molecular properties to human EC, and thus the inbred BDII strain represents a unique model for analysis of EC tumorigenesis [ 14 ]. (biomedcentral.com)
This strain is used for pathogenesis research, drug development and evaluation of diabetes and complications. (or.jp)

The morphological structure of rats' liver was estimated by microscopy of prepared cuts of hepatic tissue. (bvsalud.org)

The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)
The tumor mtDNA was compared to that of mtDNA in brain mitochondrial populations from the corresponding syngeneic mouse host strain. (biomedcentral.com)

The most recurrent numerical alterations were gains in rat chromosome 4 (RNO4) and losses in RNO15. (biomedcentral.com)
The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3. (kyoto-u.ac.jp)
Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. (mcw.edu)
The N2 rats that are determined by genotyping to be heterozygous along the target chromosome are then backcrossed for ∼4 to 8 generations [e.g., marker assister selection for rats with most SS (blue) alleles]. (comprehensivephysiology.com)
This yields offspring with an isogenic SS background for all but the target chromosome as shown in (B). Selected male and female rats are then mated resulting in approximately 25% of the offspring being homozygous for the chromosome of interest. (comprehensivephysiology.com)
These rats are then inbred to produce a stable inbred consomic strain with the substitution of one entire chromosome from the BN strain into the background of the SS strain. (comprehensivephysiology.com)
Example of reduced blood pressure salt sensitivity resulting from substitution of chromosome 13 from the BN into the SS/Mcwi strain (SS‐13 BN consomic rat). (comprehensivephysiology.com)
Conversely, substitution of chromosome 18 from SS to the BN strain (BN‐18 SS ) resulted in a relatively small increase in MAP in response to the high‐salt diet. (comprehensivephysiology.com)
Generation of chromosome Y (chrY) consomic rats. (comprehensivephysiology.com)

They were originally derived from a Canadian colony of outbred Wistar rats that spontaneously develop hyperglycemia and ketoacidosis, characteristic of clinical onset of T1D. (wikipedia.org)
It is maintained in a closed colony of the circulation mating method, which is designed to delay inbreeding as much as possible. (or.jp)
This study established a low incidence hydronephrosis Wistar rat (Mlac:WR) colony at the National Laboratory Animal Center, Mahidol University, Thailand. (mahidol.ac.th)
Twenty Mlac:WR breeding pairs were randomized to determine the percentage of hydronephrosis in the original National Laboratory Animal Center colony. (mahidol.ac.th)

Nature Communications 7:10464 [Best reference on the BXD family of strains and the wide range of phenotypes that have been generated over the past 40 years. (genenetwork.org)

The strain of mouse technically is known as C57BL. (ecobear.co)

Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
Consomic rat panel in which each of the 20 autosomes and the X and Y chromosomes from the BN strain were transferred onto the SS genetic background. (comprehensivephysiology.com)

The origin of Wistar-Imamichi rat is Wistar Institute Standard Strain Lot No. 1359. (or.jp)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)

The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. (biomedcentral.com)
The strain of mouse which today is a distinct type was bred in the lab at the Bussey Institution at Harvard University. (ecobear.co)
Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)

Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat. (wikipedia.org)

A male individual from the donor strain is first crossed to a female from the host strain. (comprehensivephysiology.com)
Resulting F1 males are then backcrossed to a female from the host strain to generate the N2 generation. (comprehensivephysiology.com)
Males from the latter are backcrossed again to females from the host strain, the procedure being repeated ( n ) times. (comprehensivephysiology.com)
The genome of the final consomic strain is the same as that of the host strain, with the exception of the MSY from the donor strain. (comprehensivephysiology.com)

The following laboratory animals are available at IAR. (or.jp)
AALAS Position Statement on the Humane Care and Use of Laboratory Animals. (bvsalud.org)
The American Association for Laboratory Animal Science endorses the United States Government "Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training" and requires that all papers published in Comparative Medicine report research conducted in conformance with these principles. (bvsalud.org)
Aspartate aminotransferase and alkaline phosphatase activity in blood plasma of the experimental animals of the main group MG-1 reduced by 20.7 and 35.2% compared with indicators of the rats of the main group MG-2. (bvsalud.org)

Of these, four develop EC spontaneously, of which females from the BDII/Han strain (hereafter BDII) is prone to develop tumors with the highest incidence (more than 90% among the virgin females) [ 12 , 13 ]. (biomedcentral.com)
A) Reduced susceptibility to DMBA‐induced mammary tumors in SS.BN2 consomic rats ( n = 14) compared with SS ( n = 40), as reported by Adamovic et al. (comprehensivephysiology.com)

Progressive loss of photoreceptor cells was observed in WNIN/GR-Ob rats with an onset as early as 3 months. (molvis.org)

In this study, we investigated the additional effect of impaired glucose tolerance (IGT), an essential component of MetS, on retinal degeneration using the WNIN/GR-Ob rat model. (molvis.org)
WNIN/GR-Ob rats with added glucose intolerance developed retinal degeneration similar to the parent line WNIN/Ob. (molvis.org)

In the EPM, female rats showed lower anxiety-like behavior than males, whereas CHF rats were more anxious than CLF rats. (bvsalud.org)

Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. (inchem.org)

From then on, a regular system of inbreeding involving full-sib (FS) mating was applied and maintained for more than 30 generations giving rise to CBi/L FS, CBi − FS and CBi FS lines. (biomedcentral.com)

Rat models of type 1 diabetes: genetics, environment, and autoimmunity. (wikipedia.org)

Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)

This strain is used for experiments on the etiology of metabolic syndrome, non-alcoholic steatohepatitis, and evaluate foods and medicines. (or.jp)

The retinal morphology and ultrastructure of WNIN/GR-Ob and age-matched littermate lean rats were studied by microscopy and immunohistochemistry. (molvis.org)

BB rats are the most extensively studied rat model of T1D. (wikipedia.org)
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
Hepatoprotective and antioxidant activities of betulin as part of mayonnaise samples has been investigated in vivo on the model of toxic hepatitis initiated by carbon tetrachloride in male Wistar rats weighing 210-265 g. (bvsalud.org)
rats of the main groups were orally administered mayonnaise once a day at a dosage of 1 ml for 21 days after the formation of the model pathology: OG-1 with the added betulin (1 mg per 1 kg of body weight), OG-2 without betulin. (bvsalud.org)
The severity of retinal degeneration was greater in WNIN/GR-Ob rats compared to WNIN/Ob, suggesting a possible role for IGT in this model. (molvis.org)
Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model. (ufl.edu)

Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats. (kyoto-u.ac.jp)
The present study further ana- lyzed behavioral correlates of two novel breeding lines of rats, Carioca high-and low-conditioned freez- ing (CHF and CLF), based on defensive freezing responses to contextual cues previously associated with electric footshock. (bvsalud.org)
With collaborators, we are exploring the behavioral and anatomic consequences of induced malformations by testing rats in various auditory discrimination paradigms and subsequent examination of their brains. (dyslexialab.net)

Biobreeding rat, also known as the BB or BBDP rat, is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. (wikipedia.org)

Male and female rats from the 10th generation were used to assess anxiety-like reactions in the elevated plus maze (EPM), depressive-like behavior in the forced swim test (FST), and aversive memory in the contextual fear conditioning paradigm. (bvsalud.org)
Circuit and cell-specific contributions to decision making involving risk of explicit punishment in male and female rats. (ufl.edu)
Touchscreen-Based Cognitive Training Alters Functional Connectivity Patterns in Aged But Not Young Male Rats. (ufl.edu)
Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats. (ufl.edu)
Traumatic brain injury was induced on anesthetized male Sprague-Dawley rats by a standardized weight drop. (asahq.org)

First, to date, evidence on monoaminergic differences between high and low P rats is based largely on ex vivo, whole-tissue measures of DA and 5-HT rather than extracellular measures of transmitter release. (aspetjournals.org)

P and NP rats also show distinct differences with regard to brain DA transmission. (aspetjournals.org)

0.05, significantly different from the same strain on an LS diet 62. (comprehensivephysiology.com)

Diabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA). (wikipedia.org)
Sadelain MW, Qin HY, Sumoski W, Parfrey N, Singh B, Rabinovitch A. Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. (wikipedia.org)

Specifically, her laboratory employs an integrative approach that combines cognitive assessments with molecular, pharmacological and optogenetic methodologies. (ufl.edu)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)

Females 8 or more weeks of age show 4-day-estrous-cycle under certain conditions (see "other information" of "a basic manual as for breeding rats) Since the signs of estrus are clear and the ovulation time is concentrated in the midnight, it is quite useful for experiments on reproduction. (or.jp)

In ethanol-naive rats, significant line differences were observed with high basal 5-HT release in P rats, low 5-HT release in NP rats, and intermediate 5-HT levels in Wistar rats. (aspetjournals.org)
Shown is the mean arterial pressure (MAP) in conscious SS ( n = 18), SS‐13 BN ( n = 15), and BN ( n = 16) rats exposed to a high‐salt (4.0% NaCl) diet for 4 weeks. (comprehensivephysiology.com)

Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. (kyoto-u.ac.jp)
C) The transgenically labeled human 231 Luc+ breast cancer cells were orthotopically implanted in the MFP (see dashed lines) of SS IL2R γ and SS.BN3 IL2R γ rats. (comprehensivephysiology.com)

Breeder selection for breeding was carried out by using the progeny selection method, which selects offspring based on their characteristics, in combination with the breeding principle of maximum avoidance of inbreeding and the rotational mating system. (mahidol.ac.th)

Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. (inchem.org)
The authors performed histologic studies of neuronal survival in the rat hippocampus after traumatic brain injury and treatment with blood glutamate scavengers. (asahq.org)

During selection, the lines were inbred by limiting the population size [ 9 ] until an average theoretical inbreeding coefficient of approximately 0.985 was reached. (biomedcentral.com)

This has markedly diluted the original strain. (lookformedical.com)

The association between blood pressure and gene(s) within RT1 complex or gene(s) closely linked to it was found by RI strain analysis. (mcw.edu)
birch bark in fat-containing products (for example mayonnaise) on the blood biochemical parameters and liver morphological structure of rats with initiated acute toxic hepatitis. (bvsalud.org)
Based on biochemical parameters of rat blood plasma, it has been established that the administration of mayonnaise with betulin prevents the development of cytolic syndrome and suppresses the process of peroxidation by directly neutralizing free radicals. (bvsalud.org)

Immunohistochemical analysis showed decreased levels of rhodopsin and postsynaptic density protein-95 (PSD-95) proteins and increased levels of glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF), and calretinin in WNIN/GR-Ob rats compared with the age-matched lean controls, further supporting cellular stress/damage and retinal degeneration. (molvis.org)

I am interested in the changes in the brain that accompany minor neocortical malformations that are either induced or occur spontaneously. (dyslexialab.net)

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