We hypothesized that a high fat diet in non-human primates would induce changes in hepatic chromatin structure resulting in altered expression of fetal genes critical to the development of childhood and adult obesity. (nih.gov)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
Differentiation2
We carried out mosaic analysis to elucidate the functions of dMyc in the germline and somatic cells of the ovary during oogenesis, a process that involves cell proliferation, differentiation and growth. (biologists.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Proteins4
Movement of large molecules such as proteins and RNA through the pores is required for both gene expression and the maintenance of chromosomes. (wikipedia.org)
This size selectively allows the passage of small water-soluble molecules while preventing larger molecules, such as nucleic acids and larger proteins, from inappropriately entering or exiting the nucleus. (wikipedia.org)
Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Mitotic2
Cancer A clonal growth (cells all descended from one ancestral cell) that undergo continuing mitotic divisions and are not inhibited in their growth when they come in contact with neighboring cells (contact inhibition). (agemed.org)
In contrast to its dramatic effects on growth and endoreplication,dMyc is dispensable for the mitotic division cycles of both germline and somatic components of the ovary. (biologists.com)
Regulating gene expression1
The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expression. (wikipedia.org)
Pathology1
However, demonstration of whether and how these genes cause pathology is largely lacking. (sdbonline.org)
Interactions1
This presents a starting point for studies into the underlying mechanisms of AD including interactions with other AD-associated genes, like Rho1, Ankyrin, Tau and APP with the potential to identify new targets for treatment. (sdbonline.org)
Mammalian2
Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. (wikipedia.org)
It is an essential structural component of mammalian cell membranes. (absoluteastronomy.com)
649 Together, these membranes serve to separate the cell's genetic material from the rest of the cell contents, and allow the nucleus to maintain an environment distinct from the rest of the cell. (wikipedia.org)
Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell's external membrane. (agemed.org)
Molecular4
Concurrent alteration of p16 and PTEN tumor suppressor genes could be considered as potential molecular marker for specific subgroups of NSCLC patients. (ac.rs)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
To better understand the molecular changes associated with AD, genome-wide association studies (GWAS) have identified hundreds of candidate genes linked to the disease, like the receptor tyrosine kinase EphA1. (sdbonline.org)
Maintains1
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Expression5
Of interest, we have observed in a rodent transgenerational model of intrauterine growth restriction (IUGR) that a diet supplemented with essential nutrients, yet unaltered in its caloric content, prevents adult metabolic disease and is associated with abrogation of reprogrammed gene expression. (nih.gov)
The novel innovation and significance resides within its potential to provide (1) an expanded understanding of the mechanism through which a maternal high fat diet reprograms primate gene expression and (2) a simple intervention (essential nutrient supplementation with neither diet nor behavioral modification) with tremendous potential impact given the current obesity epidemic and the lack of efficacious therapeutics. (nih.gov)
The related concept of Longevity Determination , however, is the result of a species-specific genomic expression during early development that positions the somatic tissues of an organism to survive long after its reproductive period has been completed. (agemed.org)
Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. (ac.rs)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
Development1
This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
Membrane-bound1
PL: nuclei) is a membrane-bound organelle found in eukaryotic cells. (wikipedia.org)
Mechanisms1
Although the Myc oncogene has long been known to play a role in many human cancers, the mechanisms that mediate its effects in both normal cells and cancer cells are not fully understood. (biologists.com)
Humans1
Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. (absoluteastronomy.com)
Function2
The genes within these chromosomes are structured in such a way to promote cell function. (wikipedia.org)
Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
Occur1
The menstrual cycle is the scientific term for the physiological changes that can occur in fertile women for the purpose of sexual reproduction. (absoluteastronomy.com)
Cancer cells2
Cancer cells often spread (or metastasize ) throughout the body by way of the bloodstream or lymphatic vessels to form tumors in new locations beyond the primary site of origin. (agemed.org)
The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2: the unique way of multi-drug resistance modulation. (ac.rs)
Growth1
However, in cases in which the entire germline cyst or the whole follicular epithelium was mutant for dm , the growth of the entire follicle, including the wild-type cells, was delayed. (biologists.com)
Potential1
In this review we analyse the most relevant features of Ocular adnexa MALT lymphomas, underlining specific biological characteristics mainly related to the potential role of Chlamydia psittaci in lymphomagenesis. (biomedcentral.com)
Normal1
METHODS: DNA extraction and bisulfite modification as well as Infinium 450K methylation microarray detection were performed in 46 samples of sporadic colorectal cancer tissue, nine samples of colorectal adenoma, and 20 normal samples, and bioinformatic analysis was conducted involving genes enrichments of GO and KEGG. (bvsalud.org)
Specific2
MALT-lymphomas represent a wide range of extranodal lymphomas that often recognize environmental factors driving to specific genes deregulation. (biomedcentral.com)
Among environmental factors, some bacterial infections have been found associated to MALT lymphomas of specific anatomic districts, such as H. pylori in gastric MALT lymphoma, C. Jejuni in intestinal MALT lymphoma and Borrelia Burgdoferi in cutaneous B cell lymphoma [ 6 - 10 ]. (biomedcentral.com)
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
Single1
High density arrays of extraordinarily sensitive integrated microring resonators will allow many gene and protein signatures to be simultaneously quantitated from a single patient sample. (nih.gov)
Small1
small glial cells only have about a few hundred, with large Purkinje cells having around 20,000. (wikipedia.org)
Blood2
It is used to produce hormones and cell membranes and is transported in the blood plasma of all mammals. (absoluteastronomy.com)
Activity of peripheral blood polymorphonuclear cells. (ac.rs)