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Thromboxane B2TetrahydrocortisolThromboxane A2gamma-Glutamyl Hydrolase11-beta-Hydroxysteroid DehydrogenasesHydroxysteroid DehydrogenasesReceptors, ThromboxaneThromboxanesButyrylcholinesteraseThromboxane-A SynthaseIodide PeroxidaseBiotransformationReceptors, Thromboxane A2, Prostaglandin H26-Ketoprostaglandin F1 alphaProstaglandin Endoperoxides, Synthetic15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidProstaglandinsEicosanoidsPlatelet AggregationBlood PlateletsEpoprostenolArachidonic AcidsProstaglandins HHydrazinesArachidonic AcidProstaglandin EndoperoxidesCyclooxygenase InhibitorsProstaglandin-Endoperoxide SynthasesIndomethacinDinoprostoneCyclooxygenase 1AspirinProstaglandin H2Prostaglandins EProstaglandins FLeukotriene B4IbuprofenEicosanoic AcidsPentanoic AcidsProstaglandins DReceptors, ProstaglandinBleeding TimeProstanoic AcidsDinoprostSRS-AMethacrylatesProstaglandin AntagonistsPlatelet Aggregation InhibitorsImidazolesCyclooxygenase 2beta-ThromboglobulinRadioimmunoassayChromatography, High Pressure Liquid12-Hydroxy-5,8,10,14-eicosatetraenoic AcidLeukotrienes4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineVasoconstrictionDose-Response Relationship, DrugProstaglandin D2Anti-Inflammatory Agents, Non-SteroidalLipoxygenase InhibitorsCyclooxygenase 2 InhibitorsRabbitsVasoconstrictor AgentsHydroxyeicosatetraenoic AcidsRats, Inbred StrainsPlatelet Activating FactorAdenosine DiphosphateProstaglandins, SyntheticFatty Acids, UnsaturatedBenzoxepinsIsoenzymesPlatelet CountDogsCalcimycinLipoxygenaseLungSulfonamidesGuinea PigsGas Chromatography-Mass SpectrometryPlatelet ActivationSulfinpyrazoneAnnonaceaeMeclofenamic AcidHaliclonaPhospholipases APyridinesMetabolomicsHydroxy AcidsThrombinIntramolecular OxidoreductasesMetabolomeMicrosomesRats, Sprague-DawleySerotoninPulmonary CirculationRats, WistarBlood PressureTime FactorsPhospholipases A2

TXB2DrugPlatelet aggregationReceptor antagonistPlateletsInhibitProstaglandinIngredientsFormationProduction

TXB21

• Thromboxane B2 (TXB2) is an inactive metabolite/product of thromboxane A2. (wikipedia.org)

Drug2

• Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). (wikipedia.org)
• The remainder of the drug was found in the stool as both metabolites and unabsorbed drug. (laodongdongnai.vn)

Platelet aggregation4

• An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro. (wikipedia.org)
• Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation. (wikimili.com)
• Thromboxane A 2 (TXA 2 ), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets as well as increasing platelet aggregation. (wikimili.com)
• Low-dose, long-term aspirin use irreversibly blocks the formation of thromboxane A 2 in platelets , producing an inhibitory effect on platelet aggregation . (wikimili.com)

Receptor antagonist3

• Ifetroban is a potent and selective thromboxane receptor antagonist. (wikimili.com)
• The inhibitors of the target effects of thromboxane are the thromboxane receptor antagonist , including terutroban . (wikimili.com)
• Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. (wikimili.com)

Platelets5

• Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). (wikipedia.org)
• Thromboxane-A synthase , an enzyme found in platelets , converts the arachidonic acid derivative prostaglandin H 2 to thromboxane. (wikimili.com)
• The mechanism of secretion of thromboxanes from platelets is still unclear. (wikimili.com)
• These "Sticky platelets" secrete several chemicals, including thromboxane A2 that stimulate vasoconstriction, reducing blood flow at the site. (wikimili.com)
• The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. (wikimili.com)

Inhibit2

• Thromboxane inhibitors are broadly classified as either those that inhibit the synthesis of thromboxane, or those that inhibit the target effect of it. (wikimili.com)
• Thromboxane synthase inhibitors inhibit the final enzyme ( thromboxane synthase ) in the synthesis of thromboxane. (wikimili.com)

Prostaglandin1

• Ex vivo, meloxicam (at doses of 7.5 mg and 15 mg) was found to be more active in inhibiting COX-2, having a greater inhibitory effect on lipopolysaccharide-stimulated prostaglandin E2 production (COX-2-controlled response) than on thromboxane production involved in blood clotting (COX-1-controlled response). (ru-pills.com)

Ingredients1

• The inactive ingredients in naproxen sodium tablets include: magnesium stearate, microcrystalline cellulose, povidone and talc. (medlibrary.org)

Formation1

• Thromboxane is named for its role in blood clot formation ( thrombosis ). (wikimili.com)

Production1

• People with asthma tend to have increased thromboxane production, and analogs of thromboxane act as bronchoconstrictors in patients with asthma. (wikimili.com)