AspirinKineticsMutagenesis, Site-DirectedBinding SitesMolecular Sequence DataAmino Acid SequenceEnzyme ActivationCatalysisEscherichia coliCatalytic DomainPlatelet Aggregation InhibitorsSubstrate SpecificityRecombinant ProteinsCysteineAnti-Inflammatory Agents, Non-SteroidalModels, MolecularBase SequenceMutationOxidation-ReductionHydrogen-Ion ConcentrationCloning, MolecularEnzyme StabilitySpectrophotometryProtein ConformationAmino Acid SubstitutionStructure-Activity RelationshipRabbitsProtein BindingMolecular WeightTiclopidineSequence Homology, Amino AcidThromboxane B2Electrophoresis, Polyacrylamide GelCyclooxygenase InhibitorsPlatelet AggregationSalicylatesPlatelet Function TestsDrug Therapy, CombinationBlood PlateletsSodium SalicylateFibrinolytic AgentsHemorrhageAsthma, Aspirin-InducedAnticoagulantsWarfarinTablets, Enteric-CoatedCyclooxygenase 1Bleeding TimeGastrointestinal HemorrhageProstaglandin-Endoperoxide SynthasesPlatelet ActivationThromboxanesIbuprofenThromboxane A2Dose-Response Relationship, DrugThrombosisCyclooxygenase 2 InhibitorsDouble-Blind MethodDipyridamoleLipoxinsAcetaminophenDrug ResistanceIndomethacinRisk FactorsMyocardial InfarctionSulfinpyrazoneGastric MucosaCyclooxygenase 2Reye SyndromeStrokeTreatment OutcomeStomach UlcerProspective StudiesProstaglandinsNaproxen