• The objective of this study was to investigate the effect of high pressure processing (HPP) (100, 300 or 500 MPa for 2 or 5 min) on microbial inactivation, quality parameters and nutritional quality indices of mackerel fillets. (teagasc.ie)
  • In: de Souza Sant'Ana, A. (Ed). Quantitative Microbiology in Food Processing: Modeling the Microbial Ecology, First Edition. (usda.gov)
  • In this chapter, the efficacy of High Pressure Processing leading to microbial inactivation has been evaluated. (usda.gov)
  • PhD dissertation Title: Microbial inactivation in a liquid and a viscoelastic model system-Predictive modelling of heat adaptation phenomena after exposure to chaperones, metabolites and acids (ISBN 978-94-6018-467-3). (imperial.ac.uk)
  • Study and validation of microbial and enzymatic inactivation kinetics with High Hydrostatic Pressure technology. (imperial.ac.uk)
  • Cleaning removes organic matter, salts, and visible soils, all of which interfere with microbial inactivation. (daytondailynews.com)
  • Combination effect of papaya extract and high pressure processing on Salmonella inactivation on raw chicken breast meat and meat quality assessment. (usda.gov)
  • Experiments were conducted to determine the ability of an alcohol-quaternary ammonium sanitizer or water to reduce Salmonella inoculated onto stainless steel and shell egg processing equipment. (scialert.net)
  • Radiofrequency pasteurization process for inactivation of Salmonella spp. (bvsalud.org)
  • Since it is not chemically selective, no matter what the surface chemistry of the viral particle is, viral removal processes using nanofiltration techniques will still be effective. (wikipedia.org)
  • Viral inactivation is different from viral removal because, in the former process, the surface chemistry of the virus is altered and in many cases the (now non-infective) viral particles remain in the final product. (wikipedia.org)
  • He emphasized the point that study design needs to demonstrate the most economical route for carrying out efficient and robust viral removal and inactivation. (genengnews.com)
  • Biocatalysts kinetic parameters are usually considered constant during reactor operation, which may not be the case if significant enzyme inactivation occurs and reactivation strategies are used to prolong biocatalyst lifespan. (pucv.cl)
  • Usually X-inactivation occurs randomly, so that each X chromosome is active in about half the body's cells. (medlineplus.gov)
  • The effect of the partial inactivation and reactivation of penicillin G acylase from Escherichia coli immobilized in glyoxyl-agarose on the biocatalyst kinetic parameters was investigated. (pucv.cl)
  • The significant variation of biocatalyst kinetic parameters due to its inactivation and reactivation should be considered when the enzyme reactor performance is modeled, aspect which has not been given sufficient attention up to now. (pucv.cl)
  • Inactivation of Listeria monocytogenes/Flavobacterium sp. (scialert.net)
  • Careful donor selection, vigilant screening, lookback programs, inactivation of pathogens, and continuous efforts to develop new techniques for screening and inactivation will be required to make blood products, and thus blood transfusions, continually safe. (medscape.com)
  • Chapter One of this book provides inactivation kinetic models for PEF treatment. (novapublishers.com)
  • Some of the more widely used processes are as follows: Solvent/detergent inactivation Pasteurization (heating) Acidic pH inactivation In some cases viral inactivation is not a viable removal alternative because even the denatured or otherwise inactivated viral particles can have deleterious effects on the process stream or the product itself. (wikipedia.org)
  • Epigenetic modifications made to our DNA underpin many important processes in our bodies, and can be corrupted in disease. (edu.au)
  • Our researchers are using X-inactivation as a model of epigenetic changes, to discover new ways that genes are switched on and off. (edu.au)
  • It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
  • The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. (mdpi.com)
  • The Nsp5 main protease processes pp1b at eleven sites to release itself and Nsp4 to Nsp16 ( Chen et al , 2021 ). (elifesciences.org)
  • This process does not denature proteins, because the detergents only affect lipids and lipid derivatives. (wikipedia.org)
  • In addition, the molecular function of some of the described proteins suggests a central role for SVEVs in the cytotoxicity of the snake venom and sheds new light in the envenomation process. (nature.com)
  • Methylation of XIST is the switch that starts the process, recruiting DC1, and subsequently the proteins that inactivate the X chromosome. (drugdiscoverynews.com)
  • For efficient repair of DNA double strand breaks (DSBs) cells rely on a process that involves the Mre11/Rad50/Nbs1 complex, which may help to protect non-repaired DNA ends from separating until they can be rejoined by DNA repair proteins. (nih.gov)
  • This work demonstrates that neither inactivation of the major repair proteins XRCC3 and the DNA-dependent protein kinase (DNA-PK) nor inhibition of DNA-PK by vanillin influences the aggregation of DSB-containing chromosome domains. (nih.gov)
  • The study, published March 18, 2020, in Nature , confirms a long-standing hypothesis about ion channels, and represents a key advance in the understanding of the basic biological processes at work in most cells . (medicalxpress.com)
  • In mammals this involves upregulation of dosage sensitive X-linked genes, and inactivation of one X chromosome in every female somatic cell. (erasmusmc.nl)
  • The effectiveness of this process can vary greatly between viruses and its efficiency can change based on the buffer used. (wikipedia.org)
  • Effectiveness and robustness are not only defined by the level of the reduction factor, but also by the method of process-step analysis, e.g., sampling mode and application of high-sensitivity assays. (genengnews.com)
  • In order to achieve inactivation of the viruses in the sample, it is necessary to perform "special" purification processes that will chemically alter the virus in some way. (wikipedia.org)
  • The D-Min™ process ensures the viral inactivation and osteoinductivity of demineralized bone matrix. (medtronic.com)
  • X-inactivation ensures that females, like males, have only one active copy of the X chromosome in each body cell. (medlineplus.gov)
  • High-intensity ultrasound is used to alter, either physically or chemically, the properties of foods, for example to generate emulsions, disrupt cells, promote chemical reactions, inactivation microorganisms, tenderize meat and modify crystallization processes. (magiran.com)
  • The egg-based production process begins with CDC or another laboratory partner in the WHO Global Influenza Surveillance and Response System providing private sector manufacturers with candidate vaccine viruses (CVVs) grown in chicken eggs per current FDA regulatory requirements. (cdc.gov)
  • Katholieke Universiteit Leuven, Faculty of Engineering, Department of Chemical Engineering, Chemical and Biochemical Process Technology and Control Laboratory: PhD candidate. (imperial.ac.uk)
  • Oral rinse specimens were processed, stored and shipped to the Ohio State University Gillison Laboratory, Columbus, Ohio. (cdc.gov)
  • Detailed specimen collection and processing instructions are discussed in the NHANES Laboratory/Medical Technologists Procedures Manual (LPM). (cdc.gov)
  • Read the General Documentation on Laboratory Data file for detailed data processing and editing protocols. (cdc.gov)
  • This overarching process, which has come to be known simply as virus removal, is one in which all of the viruses in a given sample are removed by traditional extraction or [full energy] methods. (wikipedia.org)
  • 4) remodeling stage, characterized by the substitution process of replacement of primary by secondary bone tissue (21 days after tooth extraction, in alveolus of rats) 1 . (bvsalud.org)
  • The manufacturing processes include cold ethanol fractionation of Ig and viral inactivation and removal steps. (medscape.com)
  • The information presented in this chapter will expand the knowledge base regarding the important processing variables of this technology that would give the optimum efficacy for bacterial inactivation in food while maintaining the quality attributes especially for heat sensitive foods. (usda.gov)
  • Chapter Two discusses PEF in the winemaking process. (novapublishers.com)
  • This process, developed by the New York Blood Center, is the most widely used viral inactivation method to date. (wikipedia.org)
  • Viral inactivation is to stop the viruses in a given sample from contaminating the desired product either by removing viruses completely or rendering them non-infectious. (wikipedia.org)
  • Virus removal processes using nanofiltration techniques remove viruses specifically by size exclusion. (wikipedia.org)
  • This type of process is typically used for parvoviruses and other viruses containing a protein coat. (wikipedia.org)
  • Chromatographic methods of removing viruses are great for purifying the protein and are also effective against all types of viruses, but the level of virus removal is dependent on the column composition and the reagents that are used in the process. (wikipedia.org)
  • Viral inactivation renders viruses unable to infect. (wikipedia.org)
  • This process is only effective for viruses enveloped in a lipid coat, however. (wikipedia.org)
  • Cell culture-based flu vaccine production does not require chicken eggs because the vaccine viruses used to make vaccine are grown in mammalian cell cultures (no animals are harmed by this process). (cdc.gov)
  • by Gail Sofer, BioReliance Viruses present dangers (and therefore challenges) to biopharmaceutical manufacturing processes. (biopharminternational.com)
  • The proprietary demineralization process inactivates viruses while preserving the osteoinductive activity necessary for new bone formation. (medtronic.com)
  • This process has many of the advantages of the "traditional" removal techniques. (wikipedia.org)
  • and third, the removal or inactivation of potential harmful agents," he explained. (genengnews.com)
  • Title : Guidance on the inactivation or removal of select agents and toxins for future use (7 CFR Part 331, 9 CFR Part 121.3, 42 CFR Part 73.3) Corporate Authors(s) : Centers for Disease Control and Prevention (U.S). Office of Public Health Preparedness and Response. (cdc.gov)
  • Rather than simply rendering the virus inactive, some viral inactivation processes actually denature the virus completely. (wikipedia.org)
  • Originally, this production process also began with chicken egg-grown CVVs per FDA regulations. (cdc.gov)
  • Viral inactivation is used widely in the blood plasma industry. (wikipedia.org)
  • Many coagulants are widely used in conventional water treatment processes for tap water production. (degruyter.com)
  • The reduction in the processing time with the subsequent saving of energy compared to conventional thermal methods makes HPP a relatively energy efficient and suitable preservation treatment for the fish industry. (teagasc.ie)
  • Thermal processing is the most common intervention technology practiced in the food industry. (usda.gov)
  • High Pressure Processing is among the most preferred non-thermal processing intervention technologies developed for this purpose. (usda.gov)
  • Ultrasonic waves at high intensity alone can destroy the cell walls of microbes but when it is combined with a rapid thermal process for sterilizing foods to improve. (magiran.com)
  • Experimental design and mathematical modeling of Time Temperature integrators (TTI) for the chill chain management as well as for control of thermal industrial processes. (imperial.ac.uk)
  • Our aseptically processed fibers have some of the highest osteoinductive scores † on the market and this interconnected mesh of fibers enhances the osteoconductive potential of the product by providing a path for cellular infiltration. (medtronic.com)
  • The process of bone repair is an event finely regulated and characterized by different phases with predominance of specific cellular types, aiming at the formation of tissue in the affected area. (bvsalud.org)
  • Among the different study models of bone repair, the model of bone repair in tooth socket has been very adequate because it enables a chronological evaluation of the repair process, detailing the main cellular events at each stage 31 . (bvsalud.org)
  • Then the methods and processes of the production of these cylinders are reviewed. (magiran.com)
  • This survey article, organized by sample type, lists viral inactivation methods published during the past decade. (biopharminternational.com)
  • Surprisingly, not only did we find that spindle-generating TRN circuits engage in attentional processing, but we also discover that this engagement involves alpha oscillations, a waking rhythm with computational properties similar to spindles. (frontiersin.org)
  • The process of creating cell culture-based flu vaccines involves several steps. (cdc.gov)
  • As a process involving heat treatment, extrusion cooking can have both beneficial and detrimental effects on the nutritional quality of the product. (researchgate.net)
  • Effects of extrusion processing on the nutritional values of feeds for livestock have been well documented. (researchgate.net)
  • Cultivar mixtures of processing tomato in an organic agroecosystem. (ucdavis.edu)
  • Medtronic's processing facility, located in Eatontown, New Jersey, is accredited by the American Association of Tissue Banks (AATB), and is committed to providing quality and innovation in its various demineralized bone matrix tissue forms. (medtronic.com)
  • Controls in the D-Min™ process eliminate many of the variables that can affect the osteoinductivity of demineralized bone matrix. (medtronic.com)
  • The aim of this study was to evaluate comparatively the effect of fluoride (F) on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) involved in process of alveolar bone repair. (bvsalud.org)
  • Microscopically the process of bone repair was similar in all groups, being noted only a delay of the blood clot resorption and bone formation in the group of 50 ppm F. The expression for MMP-9 showed differences betweengroups only during the initial repair (7 days). (bvsalud.org)
  • Ours results suggest an effect of fluoride on the activity of MMPs 2 and 9 at the initial period of alveolar repair which could be associated to the process of blood clot remission and delay in bone repair. (bvsalud.org)
  • Considering from the initial stage of blood clot formation to the last stage of newly-formed bone tissue remodeling, several cells and signaling molecules are involved which regulate (and are also regulated) during the development of this process. (bvsalud.org)
  • Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are predictive of their functional organization in sleep and suggestive of their participation in sensory processing across states. (frontiersin.org)
  • Because X-inactivation leads to some cells that produce functional norrin protein and some cells that do not, females can have some features of Norrie disease. (medlineplus.gov)
  • Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)
  • Heart relaxation also stands out as an active process, dependent on the energetic output and on specific ion and enzymatic actions, with the role of sodium channel being outstanding in the functional process. (bvsalud.org)
  • Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. (lu.se)
  • Cell culture-based technology also has the potential for a faster start-up of the flu vaccine manufacturing process. (cdc.gov)
  • Ultrasonic processing is still in its infancy and requires a great deal of future research in order to develop the technology on an industrial scale, and to more fully elucidate the effect of ultrasound on the properties of foods. (magiran.com)
  • Our aseptic processing technology preserves the function of naturally occurring growth factors - yielding Grafton™ DBM's consistently high osteoinductivity scores. (medtronic.com)
  • Calmodulin (CaM)-mediated Ca2+-induced inactivation is an ion channel regulatory mechanism that protects cells against the toxic effects of Ca2+ overload. (columbia.edu)
  • Human cells infected with SARS-CoV-2 exhibit a decrease in TRMT1 protein levels and TRMT1-catalyzed tRNA modifications, consistent with TRMT1 cleavage and inactivation by Nsp5. (elifesciences.org)
  • Our work involving studies of tetraploid, triploid and diploid mouse ES cells revealed that initiation of XCI is a stochastic process, and indicated the presence of X-linked activators of XCI. (erasmusmc.nl)
  • Written by international experts from industry, research centers, and academia, Mathematical Modeling of Food Processing discusses the physical and mathematical analysis of transport phenomena associated with food processing. (taylorfrancis.com)
  • Further studies are needed to establish the relationship between the initial process of resorption of the blood clot, and the involvement of MMPs 2 and 9 and its regulators/tissue inhibitors. (bvsalud.org)
  • Industrial relevanceThe potential of HPP to inhibit spoilage and increase the shelf-life of mackerel fillets, while maintaining its quality and healthy attributes, could help the fish processing industry to ensure better quality raw material for further processing, thereby enabling the development of new, value-added products with extended shelf- life. (teagasc.ie)
  • The manufacturing process continues with quality testing, packaging and distribution. (cdc.gov)
  • We propose a mechanism of CaM-mediated Ca2+-induced inactivation that can be explored for therapeutic design. (columbia.edu)
  • Calcium (Ca2+) plays a major role in numerous physiological processes. (columbia.edu)
  • The coagulation process was evaluated by concentration (M), dosage (mL/L), and pH in terms of turbidity, total dissolved solids, and transmittance of light. (degruyter.com)
  • It has been observed that as a secondary effect, this process can lead to unintended clustering of multiple, initially separate, DSB-containing chromosome domains. (nih.gov)
  • There also is a cell culture-based production process for flu vaccines that was approved by FDA in 2012. (cdc.gov)
  • Through a prospective randomized study of production allograft, we were able to validate that the D-Min™ process yields a consistently osteoinductive product. (medtronic.com)
  • These findings show that chromothripsis is a major process that drives genome evolution in human cancer. (lu.se)
  • Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing across sleep and attention, and their disruption may lead to correlated dysfunction. (frontiersin.org)
  • Survey of shell egg processing plant sanitation programs: Effects on egg contact surfaces. (scialert.net)
  • Survey of shell egg processing plant sanitation programs: Effects on non-egg contact surfaces. (scialert.net)