• Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. (medscape.org)
  • Other clinical studies from the United States, Europe, and Asia have also influenced the treatment strategies for operable rectal cancer, as various approaches using preoperative or postoperative radiotherapy, with or without chemotherapy, have been examined. (biomedcentral.com)
  • A detrimental effect of RP on overall survival was observed in only few previous studies.s18-20sMaterials/MethodssPatient characteristicssAll consecutive patients with locally advanced NSCLC who underwent conventionally fractionated radiotherapy and concomitant chemotherapy (no immunotherapy) at our institution between 2009 and beginning of 2018 were included in this analysis. (sagepub.com)
  • iPlan simulates alternative cancer treatment approaches such as radiotherapy, surgery or local drug delivery (chemotherapy) and helps to identify, implement and monitor the best approach for each individual patient. (lungevity.org)
  • Analysis was done for surgery, radiotherapy (RT), chemotherapy and hormonal. (sagepub.com)
  • Low-grade intramedullary and surface osteosarcoma and periosteal sarcomas with pathological findings of high-grade disease - The NCCN recommends postoperative chemotherapy. (medscape.com)
  • Chemotherapy and/or radiotherapy are frequently given before or after surgery. (stanford.edu)
  • The other study, PORTEC (Post-Operative Radiation Therapy in Endometrial Carcinoma), compared the standard of care with adjuvant chemotherapy during and after radiotherapy for patients with high-risk endometrial cancer. (medpagetoday.com)
  • It had substantial changes com- diotherapy [12], and chemotherapy-combined radiotherapy pared to the previous edition of classification published in 2007. (bvsalud.org)
  • External radiotherapy (RT) techniques include 'conventional' or 2-dimensional (2D) RT, 3-dimensional (3D) conformal RT, and intensity-modulated radiation therapy (IMRT). (bcbsnd.com)
  • IMRT has been compared with 3-dimensional conformal radiotherapy (3D-CRT) for the treatment of stomach, hepatobiliary, and pancreatic cancers. (bcbsnd.com)
  • Studies using 3-dimensional conformal radiation therapy (3DCRT) show that elective nodal (EN) areas receive substantial incidental irradiation in non-small cell lung cancer (NSCLC) treated with involved-field radiation therapy (IFRT). (appliedradiationoncology.com)
  • 1,2 Major improvements in radiation technology have led to significant changes in radiation delivery for NSCLC, including 3D-conformal radiation treatment (3DCRT) and intensity-modulated radiation therapy (IMRT).These technologies have enabled the delivery of more conformal radiation to spare normal surrounding tissue. (appliedradiationoncology.com)
  • IMRT is being increasingly used for NSCLC with the potential for more conformal radiation, with one study demonstrating an increase in IMRT from 2% in 2002 to 25% in 2009. (appliedradiationoncology.com)
  • However, with the increasing use of IMRT, concerns have emerged that more conformal IFRT techniques may deliver less incidental irradiation to ENs and result in increased nodal failures, potentially compromising tumor control or patient survival. (appliedradiationoncology.com)
  • Intensity Modulated Radiotherapy (IMRT)for Whole Pelvic Radiation Therapy (WPRT) is considered superior to 3D conformal radiotherapy in dose distribution to targets and to spare normal tissue as (BM) supported by many dosimetric studies [ 7 ]. (oncologyradiotherapy.com)
  • For adjuvant radiation for cervical cancer, newer techniques such as intensity- modulated radiation therapy (IMRT) are being evaluated as less toxic options compared with three-dimensional conformal radiation therapy (3D-CRT). (nursingcenter.com)
  • The present study aimed to estimate the risk of second cancer risk after Three-dimensional conformal radiotherapy (3DCRT) and intensity modulated radiotherapy (IMRT) for early stage prostate cancer patient. (ac.ir)
  • Three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) plans were designed. (ac.ir)
  • Dosimetric evaluation of intensity modulated radiotherapy and 4-field 3-D conformal radiotherapy in prostate cancer treatment," Balkan Med. (ac.ir)
  • Maric, S. Lukic, M. Mijailovic, L. T. Latinovic, M. Zigic, and P. Banovic, "Dosimetric Comparison: Intensity Modulated Radiation Therapy Vs. 3D Conformal Radiotherapy In Prostate Cancer Radical Treatment," Serbian J. Exp. (ac.ir)
  • Incidence of Late Rectal and Urinary Toxicities after Three- Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Localized Prostate Cancer Acute symptoms," vol. 70, no. 4, pp. 1124-1129, 2008. (ac.ir)
  • Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomized trial. (springermedizin.at)
  • Depending on the type and stage of cancer, initial treatment, preoperative radiation therapy, postoperative radiation therapy, and symptomatic treatment are provided. (emergency.co.jp)
  • Is there any impact of PET/CT on radiotherapy planning in rectal cancer patients undergoing preoperative IMRT? (tubitak.gov.tr)
  • Thirty-nine patients who received either palliative repeat irradiation or IMRT as a boost were excluded from this analysis, leaving 126 patients for this analysis. (nih.gov)
  • Partial-breast irradiation (PBI), including Brachytherapy, Intraoperative RT, and external beam radiotherapy (EBRT), is an option for selected patients with unique pros and cons. (isrsy.org)
  • The EBRT accelerated partial breast irradiation (APBI) intensity-modulated radiotherapy (IMRT) Florence trial has shown positive results and long-term follow-up. (isrsy.org)
  • Due to increasing use of intensity-modulated radiation therapy (IMRT), we performed a dosimetric analysis of 3DCRT vs. IMRT comparing EN incidental irradiation. (appliedradiationoncology.com)
  • IFRT using IMRT delivers similar incidental irradiation doses as 3DCRT to EN stations and may be safely delivered without theoretical concern for increased EN failures. (appliedradiationoncology.com)
  • 7-10 A major contributor to low nodal failure rates may be the clinically meaningful incidental irradiation to EN stations delivered with IFRT. (appliedradiationoncology.com)
  • Due to the paucity of data to address this theoretical concern, we performed a dosimetric analysis of 3DCRT vs. IMRT treatment plans to compare incidental irradiation to thoracic nodal stations in locally advanced NSCLC. (appliedradiationoncology.com)
  • In patients with cancer located on the left side, breast radiotherapy is associated with the irradiation of part of the heart. (ctimeetingtech.com)
  • 3) The technique of irradiation of patients during deep inspiratory is a simple, non-invasive method of treatment of patients reducing the risk of radiation complications from the heart and the lungs in comparison with dynamic, IMRT, and Rapid Arc techniques. (ctimeetingtech.com)
  • Triweekly XELOX or capecitabine concurrent with neoadjuvant radiotherapy leads to similar long-term survival outcomes, acute toxicities and surgical complications in LARC patients. (biomedcentral.com)
  • Our findings demonstrate that a non-operative approach with high-dose radiotherapy and concurrent chemoradiotherapy can result in favorable outcomes. (mskcc.org)
  • Aim: The main objective of this study was evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy receiving concurrent chemo radiotherapy for evaluation of the response of treatment,toxicity profile and quality of life of both radiotherapy treatment modalities. (oncologyradiotherapy.com)
  • Concurrent chemo-radiotherapy is the usual treatment for locally advanced cervical cancer. (oncologyradiotherapy.com)
  • Evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy cases receiving concurrent chemo radiotherapy. (oncologyradiotherapy.com)
  • Tumor edge definition is an essential component for radiotherapy. (biomedcentral.com)
  • For radiotherapy, Novalis® is a comprehensive treatment system that shapes beams of focused high-energy radiation from different angles to deliver non-invasive, precise radiosurgery treatments that are designed to shrink or control the growth of tumor cells of the brain, head and neck, spine, liver, lung and prostate. (lungevity.org)
  • Data is easily and quickly gathered with BrainSUITE and can then be used in planning subsequent Novalis radiotherapy treatments, which may be required to eradicate any residual tumor traces. (lungevity.org)
  • After surgical resection, adjuvant radiotherapy with standard dose and volume recommended by guidelines [ 9 ] serves as a critical supplementary treatment for subclinical foci elimination. (biomedcentral.com)
  • The patient received adjuvant radiotherapy. (e-roj.org)
  • We report a morphological analysis of neck muscle atrophy and soft-tissue fibrosis in an oral cancer autopsy case after modified radical neck dissection (MRND) type I and adjuvant radiotherapy to gain more insight into the clinical picture of neck muscle atrophy and soft-tissue fibrosis. (e-roj.org)
  • The patient received adjuvant radiotherapy 5 weeks after the operation. (e-roj.org)
  • Twenty-three stage IIIA NSCLC patients treated with curative intent IMRT (median dose 72 Gy) were studied. (appliedradiationoncology.com)
  • At a median follow up of 21 months, 6 patients (26%) had isolated locoregional recurrences, with only 1 patient (4%) having an isolated EN failure (station 5, supraclavicular) without intrathoracic progression. (appliedradiationoncology.com)
  • PTV V95 coverage was similar between 3DCRT and IMRT plans (p = 0.20). (appliedradiationoncology.com)
  • IMRT also delivered less dose to ipsilateral station 5 compared to 3DCRT (mean 66 Gy vs. 71 Gy, p = 0.04). (appliedradiationoncology.com)
  • 8,9,11,12 However, studies on EN failure patterns to date have primarily utilized 3DCRT, and it is unclear whether these data are applicable to more advanced modalities like IMRT. (appliedradiationoncology.com)
  • Stage IIIB patients with contralateral N3 disease were excluded since nearly all portions of the mediastinum would be comprehensively treated with either 3DCRT or IMRT given contralateral nodal disease. (appliedradiationoncology.com)
  • The target dose coverage parameters were significantly improved in IMRT compared to 3DCRT. (ac.ir)
  • However, the colon D Mean significantly increased with in IMRT compared with 3DCRT. (ac.ir)
  • IMRT technique demonstrated a clear advantage in dose coverage, conformity, and homogeneity over 3DCRT and was superior in terms of OAR-sparing. (ac.ir)
  • The Second cancer risk for in field organs (rectum and bladder) was decreased with IMRT compared 3DCRT plan. (ac.ir)
  • In the head and neck region, where malignant growth often lies near critical normal tissues, intensity-modulated radiotherapy has the potential to ensure sufficient target coverage while significantly reducing toxicity. (snmjournals.org)
  • Toxicity associated with radiation therapy is decreased by placing the patient in the prone position on a belly board, however for patients who cannot tolerate prone positioning, IMRT decreases the volume of normal tissue irradiated. (biomedcentral.com)
  • Neoadjuvant treatment results in less late toxicity paralleled by improved functional outcome but comes along with increased wound complications compared to postoperative radiation. (springermedizin.at)
  • However, most studies found that individuals receiving IMRT experienced significantly less GI toxicity compared with individuals receiving 3D-CRT. (bcbsnd.com)
  • The available comparative evidence, together with dosimetry studies of organs at risk, would suggest that IMRT decreases toxicity compared with 3D-CRT in individuals who had GI cancers. (bcbsnd.com)
  • However, results are generally consistent that IMRT reduces GI and genitourinary toxicity. (bcbsnd.com)
  • Based on evidence with other cancers of the pelvis and abdomen that are proximate to organs at risk, it is expected that OS with IMRT would be at least as good as 3D-CRT, with a decrease in toxicity. (bcbsnd.com)
  • In pelvic malignancy treated with CHTRT, bone marrow sparing radiotherapy is an option to minimize toxicity [ 6 ]. (oncologyradiotherapy.com)
  • In a randomized trial among 300 patients with cervical cancer undergoing postoperative radiation, disease-free survival was similar with image-guided IMRT versus 3D-CRT (77 versus 81 percent), but three-year cumulative incidence of late toxicity was reduced (28 versus 49 percent) [3]. (nursingcenter.com)
  • 3,4 More recently, treatment has evolved to involved-field radiation therapy (IFRT), in which EN regions are omitted to deliver higher doses of radiation to gross disease while decreasing subclinical treatment volumes to reduce toxicities to the esophagus, lung and heart. (appliedradiationoncology.com)
  • This includes inverse treatment planning and dose optimisation software used for intensity-modulated radiation therapy (IMRT). (sagepub.com)
  • By combining ADT with a higher dose of EBRT delivered with 3D-CRT or IMRT radiation therapy the outcomes of stage III patients have been improved. (texasoncology.com)
  • The lower neck was treated with a conventional AP low-neck port abutted to the inferior IMRT dose distribution border. (nih.gov)
  • Objective To develop the method based on deep learning to predict the dose distribution of breast-conserving postoperative intensity-modulated radiotherapy(IMRT) for breast cancer,and to evaluate accuracy of the prediction model. (cjrmp.net)
  • Conclusions The deep learning-based method can accurately predict the dose distribution of breast-conserving postoperative IMRT for breast cancer,and it has been proven through experiments that by incorporating the features of distance between voxel and PTV can effectively improve the prediction accuracy,which helps physicists to improve the quality and consistency of treatment planning. (cjrmp.net)
  • To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 2. (stanford.edu)
  • To determine the maximum-tolerated dose (MTD) when capecitabine - oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 3. (stanford.edu)
  • IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk. (medscape.org)
  • When adjuvant radiation is indicated for cervical cancer, we suggest image-guided IMRT, but 3D-CRT is an acceptable alternative. (nursingcenter.com)
  • Postoperative adhesions that fix small-bowel loops within the pelvis make these loops susceptible to radiation injury. (medscape.com)
  • There is limited comparative evidence on survival outcomes following IMRT or 3D-CRT. (bcbsnd.com)
  • This series will provide valuable insights into the most recent evidence in breast radiotherapy, showcasing the TomoTherapy®, Radixact® and CyberKnife® Systems, which have been designed to improve patient treatment delivery and clinical outcomes. (accurayexchange.com)
  • Characterization of clinical outcomes after shorter course hypofractionated and standard-course radiotherapy for stage I-III curatively-treated Merkel cell carcinoma. (dana-farber.org)
  • There is no evidence to support claims that proton beam therapy provides improved cancer-free or quality-of-life outcomes when compared with less expensive alternatives like IMRT and surgery. (pkidd.com)
  • To analyze the patterns of locoregional failure in patients with head-and-neck cancer treated with inverse planning intensity-modulated radiotherapy (IMRT). (nih.gov)
  • Intensity-modulated radiotherapy as a means of reducing dose to bone marrow in gynecologic patients receiving whole pelvic radiotherapy. (medscape.org)
  • Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. (medscape.org)
  • Since its introduction in the previous decade, intensity-modulated radiotherapy has been widely applied in head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
  • As intensity-modulated radiotherapy permits lowering the dose to the organs at risk outside the target volume, the maximum dose becomes restricted by the presence of dose-limiting structures within the target volume, such as cartilage, connective tissue, nerves, and bone. (snmjournals.org)
  • We have shown that the target definition and coverage for patients treated with IMRT for parotid sparing is adequate. (nih.gov)
  • We studied 30 stage IIIA-IIIB NSCLC patients treated with curative intent IMRT at the University of Pennsylvania between 2009-2011 after approval from the institutional review board. (appliedradiationoncology.com)
  • The subject of analysis was a group of 50 patients treated in the National Institute of Oncology, Department of Radiotherapy, Gliwice from June 2018 to December 2019. (ctimeetingtech.com)
  • Surgery remains the mainstay of treatment for young-onset HNSCC, emphasizing performing en-bloc resection with a clear pathological margin greater than 5 mm, and achieving a good aesthetic and functional outcome and quality of life [ 7 , 8 ]. (biomedcentral.com)
  • One [v] notable study showed TomoDirect™ can be used to deliver hypofractionated whole breast radiotherapy with a simultaneous boost to the resection cavity. (geriatriccareers.com)
  • Results: There was statistically significant difference in favor of IMRT bone marrow sparing plans regarding a lower dose to organs at risk, total pelvic bone and bowel. (oncologyradiotherapy.com)
  • A single-institution phase I feasibility study of dose-escalated IMRT for non-operative locally advanced esophageal carcinoma. (wustl.edu)
  • We aimed to quantify the association between postoperative radiotherapy (PORT) and the risk of SPM development for index HNSCC among adolescent and young patients, who are particularly vulnerable to radiation-associated impacts due to their increased tissue susceptibilities and longer life expectancies. (biomedcentral.com)
  • Only a few studies have explored the association between radiotherapy and SPM incidence in HNSCC. (biomedcentral.com)
  • The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
  • These results confirm the added value of 18 F-FDG PET and 18 F-fluoromisonidazole PET for radiotherapy planning of HNSCC and suggest the potential of diffusion-weighted and dynamic enhanced MRI for dose painting and early response assessment. (snmjournals.org)
  • Treatment planning and delivery are more complex, time-consuming, and labor-intensive for IMRT than for 3D-CRT. (bcbsnd.com)
  • 6,13-17 Furthermore, recent cooperative group trials, including RTOG 0617 18 and RTOG 1308, 19 have allowed IMRT for treatment. (appliedradiationoncology.com)
  • Split-course radiotherapy (RT) was administered to a total dose of 40 Gy, with a 2-week treatment break. (cancernetwork.com)
  • Three [iv] treatment planning simulation studies incorporating the multileaf collimator of the new CyberKnife M6™ System found consistent reductions in treatment time for both radiosurgery and IMRT plans, with equivalent or improved plan quality relative to the prior circular collimator plans or IMRT plans generated for other radiotherapy systems. (geriatriccareers.com)
  • Background: This phase 2 prospective randomized double-arm study carried out at Clinical Oncology Department Tanta University, Radiotherapy Department, NCI, Cairo University and Gharbia cancer society through the period from May 2018 to December 2019 and enrolled 60 patients with cervical carcinoma. (oncologyradiotherapy.com)
  • Grade 3 neutropenia reported during radiotherapy was significantly difference (p=0.004) as 25% of patients in group A against 0% in group B. (oncologyradiotherapy.com)
  • More expensive (US$64k) than IMRT (US$39k) , but produces significantly more adverse gastrointestinal effects. (pkidd.com)
  • The rectum and bladder mean dose D Mean , V50Gy% and V40Gy % were significantly decreased with IMRT. (ac.ir)
  • The maximum dose (D Max ), D Mean , V30Gy % and V20Gy % for head of femurs significantly decreased with IMRT plans. (ac.ir)
  • However, the second cancer risk for colon was significantly increased in average by 91.2% with IMRT plans. (ac.ir)
  • Evidence has been inconsistent with the outcome of survival, with some studies reporting increased survival among individuals receiving IMRT compared with individuals receiving 3D-CRT, and other studies reporting no difference between groups. (bcbsnd.com)
  • The long-term survival rate of lung cancer patients receiving radiotherapy was not low, but the cumulative incidence of CPI gradually increased to 6.8% at 7 years after radiotherapy. (e-crt.org)
  • The IMRT plans were decreased SCR for the rectum by 10%, 26.6% and 19.5% for linear, plateau and linear-exponential dose- response models respectively. (ac.ir)
  • Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study. (springermedizin.at)
  • In 1917, the first case was reported of the development of radiation enteritis following the use of radiotherapy to treat malignancy. (medscape.com)
  • During the webinar, Dr. Chitapanarux will cover the latest evidence for hypofractionated breast radiotherapy and the use of TomoDirect™ and TomoHelical™ delivery. (accurayexchange.com)
  • This study aimed to investigate cumulative incidence and risk factors associated with chronic pulmonary infection (CPI) development after radiotherapy for lung cancer. (e-crt.org)
  • Between February 1997 and December 2000, 165 patients with histologically confirmed head-and-neck cancer were treated using a parotid-sparing inverse planning IMRT protocol. (nih.gov)
  • IMRT was used only in the upper neck for salivary sparing. (nih.gov)
  • Of the 17 failures, 5 (28%) were found outside of the IMRT field and in the lower neck. (nih.gov)
  • We present an autopsy case of neck muscle atrophy and soft-tissue fibrosis (sternocleidomastoid, omohyoid, digastric, sternohyoid, sternothyroid, and platysma muscles) within the radiation field after modified radical neck dissection type I and postoperative radiotherapy for floor of mouth cancer. (e-roj.org)
  • Image quality comparisons of coil setups in 3T MRI for brain and head and neck radiotherapy simulations. (dana-farber.org)
  • For individuals who have gastrointestinal (GI) tract cancers who receive IMRT, the evidence includes nonrandomized comparative studies, retrospective series, and a systematic review. (bcbsnd.com)
  • For individuals who have gynecologic cancers who receive IMRT, the evidence includes a systematic review, five (5) RCTs, and nonrandomized comparative studies. (bcbsnd.com)
  • J. Hall and C.-S. Wuu, "Radiation-induced second cancers: the impact of 3D-CRT and IMRT," Int. J. Radiat. (ac.ir)
  • Fifty-two patients (41%) received definitive IMRT. (nih.gov)
  • The mean dose for definitive IMRT patients was 72.64 +/- 4.83 Gy to CTV1 and 64.34 +/- 5.15 Gy to CTV2. (nih.gov)
  • Accuracy of hydro-multidetector row CT in the local T staging of oesophageal cancer compared to postoperative histopathological results. (helsedirektoratet.no)