Loading...
  • vitro
  • In this study, we report several lines of evidence that the inhibitors of GSK3β (LiCl and SB216763) enhance peripheral myelin gene expression in vitro and in vivo via the binding of β-catenin to TCF/LEF transcription factors present in PMP22 and MPZ promoters. (pnas.org)
  • Verapamil reduces myocardial oxygen consumption in vitro directly by intervening in the energy consuming metabolic process of the myocardial cell, and indirectly by diminishing the peripheral resistance (afterload). (intekom.com)
  • overcome
  • To best understand how cholinergic neurons exert their functions in distinct pathways and how to overcome the difficulty of mAChR subtype selectivity and peripheral side effects, Lee's group has profiled and characterized genes that are uniquely or selectively expressed in cholinergic neuron subtypes and which uniquely regulate electrophysiology of mAChR subtypes. (salk.edu)
  • normal
  • Most persons show no signs of abnormality at this level while some may already show signs of euphoria with a loss of the normal balance between inhibitions and impulses. (arrivealive.mobi)
  • rapid
  • Some patients with paroxysmal and/or chronic atrial fibrillation or atrial flutter and coexisting accessory AV pathway have developed an increased anterograde conduction across the accessory pathway bypassing the AV node, producing a very rapid ventricular response or ventricular fibrillation after receiving intravenous verapamil (or digitalis). (intekom.com)
  • effect
  • The effect of verapamil on AV conduction and the SA node may lead to asymptomatic first-degree AV block and transient bradycardia, sometimes accompanied by nodal escape rhythms. (intekom.com)