Importin human nuclear protein. Medical search. Frequent questions

Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)
The nucleus of a eukaryotic cell is separated from the cytoplasm by the nuclear envelope, and large molecules such as proteins are transported in and out of the nucleus by transport receptors. (oist.jp)
Nucleocytoplasmic transport of large molecules, including proteins and RNAs, require transport receptors. (nii.ac.jp)
The transport receptors recognize cargo molecule and the receptor-cargo complexes are translocated through the nuclear pore complex. (nii.ac.jp)
Jafarinia, H , Van der Giessen, E & Onck, PR 2022, ' Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors ', Scientific Reports , vol. 12, nr. 1, 21324. (rug.nl)
RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors. (utsouthwestern.edu)
Chromosome area maintenance 1 proteins (CRM1 or known as XPO1) can be a member of the importin superfamily of nuclear move receptors (karyopherins). (cancerhugs.com)
Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2 (PubMed:15465011). (cansar.ai)
Exportin 7has two types of receptors, designated importins and exportins, both of which recognize proteinsthat contain nuclear localization signals (NLSs) and are targeted for transport either in or out of thenucleus via the NPC. (sdfca.org)
3. Biedroń R, Konopiński MK, Marcinkiewicz J, Józefowski S. Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages. (southernbiotech.com)
8. Gao H, Yallampalli U, Yallampalli C. Protein restriction to pregnant rats increases the plasma levels of angiotensin II and expression of angiotensin II receptors in uterine arteries. (southernbiotech.com)
Many nuclear transport procedures are mediated by soluble transportation receptors that understand particular sequences or structural characteristics of their cargoes and facilitate the passage of receptor-cargo complexes through the NPC. (irjs.info)
Transport receptors constantly shuttle between the nucleus and cytoplasm, thereby rapidly crossing the permeability barrier of nuclear pores (59). (irjs.info)
The largest class of nuclear transport receptors is the superfamily of importin -like factors (also named karyopherins) that PCI-32765 distributor can be classified as importins (import karyopherin) and exportins (export karyopherin) depending on the direction in which they transport the cargo (reviewed PCI-32765 distributor in references 25, 32, 43, 72, and 80). (irjs.info)

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. (wikipedia.org)
Furthermore, we were able to detect an interaction between HTNV N protein and importin α, a nuclear import molecule responsible for shuttling NF-κB to the nucleus. (mssm.edu)
importin α is a typical nuclear import receptor which transport hundreds of functional proteins into the nucleus. (oist.jp)
AR-containing proteins (ARPs) with a hydrophobic residue at the 13th position of two consecutive ARs bind RanGDP efficiently, and consequently enter the nucleus. (ox.ac.uk)
Rev is imported into the nucleus by the host protein importin β (Impβ), but how Rev associates with Impβ is poorly understood. (nih.gov)
Karyopherins are proteins that help eukaryotic cells transport molecules between their cytoplasm and nucleus. (prospecbio.com)
In most cases, karyopherin-mediated transport occurs through nuclear pores, which serve as a portal into and out of the nucleus. (prospecbio.com)
Karyopherins may act as imports (helping proteins enter the nucleus) or exports (helping proteins leave the nucleus) (i.e., helping proteins get out of the nucleus). (prospecbio.com)
Importin beta is a form of karyopherin that helps cargo proteins get into the nucleus. (prospecbio.com)
First, it binds importin alpha, a form of karyopherin that binds the cargo protein in the cytoplasm, before the cargo protein is imported into the nucleus through the nuclear pore driven by energy from the Ran gradient. (prospecbio.com)
Without the aid of the importin alpha adapter protein, Importin beta can transport proteins into the nucleus. (prospecbio.com)
Exportin 7 translocates proteins and large RNAsthrough the nuclear pore complex (NPC) and is localized to the cytoplasm and nucleus. (sdfca.org)
Export and import of mRNA and specific proteins from the nucleus is a key step in intracellular signaling and can lead to cell proliferation or apoptosis. (researchsquare.com)
By using fluorescent fusion proteins, we show that TAF10 does not have an intrinsic nuclear localization signal (NLS) and needs one of its three interaction partners to be transported into the nucleus. (hal.science)
Experiments using fluorescence recovery after photobleaching show that TAF10 does not associate with any cytoplasmic partner but that once transported into the nucleus it binds to nuclear structures. (hal.science)
Thus, here we describe a novel role of the three mammalian interacting partners in the nuclear localization of TAF10, and our data suggest that a complex network of regulated cytoplasmic associations may exist among these factors and that this network is important for the composition of different TFIID and TFTC-type complexes in the nucleus. (hal.science)
The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. (theinfolist.com)
Importins load cargoes in the absence of PCI-32765 distributor Ran in the cytoplasm and release their cargo upon RanGTP binding in the nucleus (27, 33, 58). (irjs.info)
Proteins bearing a classical nuclear localization signal (cNLS) are imported into the nucleus by the importin / heterodimer (26, 49, 55). (irjs.info)
https://doi.org/10.1083/jcb.201604025 ) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. (rupress.org)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (prosci-inc.com)
NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import.The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (prosci-inc.com)

Dive into the research topics of 'Hantaan virus nucleocapsid protein binds to importin α proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B'. Together they form a unique fingerprint. (mssm.edu)
We recently discovered that importin α directly binds DNA and revealed the unique binding property. (oist.jp)
Importin α binds multiple DNA sequences with different affinities, and efficiently slides along DNA. (oist.jp)
In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. (lookformedical.com)

To gain insight into how this can affect nucleocytoplasmic transport, we use coarse-grained molecular dynamics simulations to study the molecular interaction of poly-PR, the most toxic DPR, with several Kapβs (importins and exportins). (rug.nl)
Using the ONCOMINE and Gene Expression Omnibus (GEO) databases, we compared the gene expression of 24 importins and exportins in 20 cancer microarray datasets and then analyzed the survival of the candidate genes, CSE1L (Chromosome Segregation Like 1 protein/CAS) was finally selected. (researchsquare.com)
Cargo binding and release of importins and exportins is controlled by a steep RanGTP gradient, which is maintained across the nuclear envelope through the asymmetric distribution of factors that regulate the guanine nucleotide-bound state of Ran (25, 41, PCI-32765 distributor 43, 47, 76). (irjs.info)
Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)

To pass through the nuclear pore, most proteins need karyopherins. (prospecbio.com)

Regulation of nuclear import is fundamental to eukaryotic biology. (ox.ac.uk)
The website of exchange may be the nuclear pore complicated (NPC), among the largest macromolecular assemblies inside a eukaryotic cell, which may be traversed inside a unaggressive or a facilitated way. (irjs.info)
A subset of these proteins is conserved across eukaryotic kingdoms. (embl.de)
Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. (prosci-inc.com)

The transporter classification database belongs to the nuclear pore complex family (TCDB). (prospecbio.com)

Surprisingly, importin α interacts simultaneously with cargo proteins and DNA, suggesting that importin α plays a role not only in nuclear import but also in the functional regulation of cargo proteins on DNA. (oist.jp)
Rev interacts with Crm1 through a leucine-rich nuclear export signal located in its C-terminus, and with RRE through an Arginine rich motif (ARM) located in the N-terminal region. (nih.gov)
Proteomics revealed Orf6 interacts with nucleopore proteins (RAE1, XPO1, RANBP2 and nucleoporins). (biomedcentral.com)
For example, HIV-1 Vpr protein interacts with host proteins to modify host cell energy metabolism, oxidative status and proteasome function. (biomedcentral.com)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. (xenbase.org)
Structural basis for nuclear transport mechanism by the nuclear transport receptor and improvement of a synchrotron beamline. (nii.ac.jp)
Journal Article] Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. (nii.ac.jp)
Dependency on IPO13, an importin-β receptor that mediates nuclear import of the MAGOH/B-Y14 heterodimer 9 , is highly correlated with dependency on both MAGOH and MAGOHB. (nih.gov)
We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)

Predictive identification of exonic splicing enhancers in human genes. (xenbase.org)
Human cells have seven family members of importin α genes that have cargo specificities, and these family members are differentially expressed depending on the tissue type. (oist.jp)
Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:11371646, PubMed:11717357, PubMed:12860203, PubMed:19386761, PubMed:12787071, PubMed:12154011). (cansar.ai)
TFIID, comprising the TATA box binding protein (TBP) and 13 TBP-associated factors (TAFs), plays a role in nucleation in the assembly of the RNA polymerase II preinitiation complexes on protein-encoding genes. (hal.science)
naturally circulating viruses lacked the important contributors to viral pathogenesis: genes encoding proteins functioning in inhibition of cellular transcription and downregulation of the cellular antiviral response. (bio-biz-navi.com)
Alternative splicing is the primary mechanism by which a limited number of protein-coding genes can generate proteome diversity. (biologists.com)
As the genomes of different organisms are sequenced and annotated it is becoming apparent that the complexity of an organism does not depend on the total number of protein-coding genes. (biologists.com)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)

This code, experimentally tested in 17 ARPs, predicts the nuclear-cytoplasmic localization of over 150 annotated human ARPs with high accuracy and is acquired by the most common familial melanoma-associated CDKN2A mutation, leading to nuclear accumulation of mutant p16ink4a. (ox.ac.uk)
In human cells, exogenously expressed TAF10 remains rather cytoplasmic and leptomycin B does not affect this localization. (hal.science)
The cytoplasmic-nuclear transport of TAF10 is naturally observed during the differentiation of adult male germ cells. (hal.science)
Importin α-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion. (southernbiotech.com)

Importin 13 (IPO13), a member of the importin-β superfamily, was originally identified in the fetal rat lung and differentially expressed in cells of epithelial and mesenchymal origin. (molvis.org)

It was identified in a high-throughput chemical screen as inhibiting recognition of the nuclear localizing Human Immunodeficiency Virus 1 (HIV-1) integrase protein by the host heterodimeric importin (IMP) α/β1 complex, and has since been shown to bind directly to IMPα to induce conformational changes that prevent its normal function in mediating nuclear import of key viral and host proteins. (encyclopedia.pub)
Rev has been reported to interact with many host proteins including importin-ß, histone chaperons (Nap1 and B23), and tubulin through its ARM domain. (nih.gov)
We also used Mass-Spec Affinity purification to identify the host proteins interacting with SARS-CoV-2 Orf6 protein and tested a drug that could inhibit a specific Orf6 and host protein interaction. (biomedcentral.com)

However, immunofluorescence antibody staining demonstrated that cells expressing HTNV N protein and a green fluorescent protein-p65 fusion had limited p65 nuclear translocation. (mssm.edu)
In addition, silencing of the IPO13 gene blocked nuclear translocation of c-Jun. (molvis.org)
Moreover, KPNA2 mediated the nuclear translocation of CREB3L1, thus allowing it to activate downstream ECM signaling. (biomedcentral.com)

Importin subunit alpha-4 also known as karyopherin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene. (wikipedia.org)
A human BRCA1 gene knockout. (xenbase.org)
Alternative splicing (AS) is the mechanism by which exons of a single gene can be spliced in various combinations to encode a diverse set of proteins. (biologists.com)
The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. (thermofisher.com)
The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. (prosci-inc.com)

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. (utsouthwestern.edu)
Additionally, the nucleocytoplasmic RanGTP gradient regulates Exportin 7distribution, and enables Exportin 7 to bind and release proteins and large RNAs before and aftertheir transportation. (sdfca.org)

1 heterodimer responsible for IN nuclear import, Ivermectin has since been confirmed to inhibit IN nuclear import and HIV-1 replication. (governmentpropaganda.net)

The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system. (wikipedia.org)

AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (lookformedical.com)

The list of adapter-independent cargoes is constantly increasing and includes, for instance, the transcription factors CREB, Jun, Fos (23), Smad-3 (81), the retroviral proteins Rev and Tat in human immunodeficiency virus type 1 (HIV-1) (74), the. (irjs.info)

The animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. (tcdb.org)
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. (theinfolist.com)

Background Chromosome Area Maintenance 1 (CRM1) is a nuclear exporter and its inhibitor has anti-tumor activity in different cancers. (cancerhugs.com)
If the activity of CRM1-mediated move can be obstructed, proteins function can end up being changed. (cancerhugs.com)
As a result, CRM1 inhibitors could SCH 442416 IC50 become used as a book course of focusing on therapy against human being malignancy. (cancerhugs.com)
These little molecule inhibitors covalently hole to the cysteine remains (Cys528) in the NES-binding groove of CRM1 proteins [16]C[17]. (cancerhugs.com)
In the meantime, the amounts of CRM1 proteins are raised in lung tumor tissue when likened to regular lung tissue. (cancerhugs.com)

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import" (PDF). (wikipedia.org)
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. (ox.ac.uk)
The majority of nuclear import pathways are mediated by importin-cargo interactions. (ox.ac.uk)
Yet not all nuclear proteins interact with importins, necessitating the identification of a general importin-independent nuclear import pathway. (ox.ac.uk)
Here, we identify a code that determines importin-independent nuclear import of ankyrin repeats (ARs), a structural motif found in over 250 human proteins with diverse functions. (ox.ac.uk)
The RaDAR (RanGDP/AR) pathway represents a general importin-independent nuclear import pathway and is frequently used by AR-containing transcriptional regulators, especially those regulating NF-κB/p53. (ox.ac.uk)
Journal Article] Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β. (nii.ac.jp)
The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. (utsouthwestern.edu)
Competes with importin KPNB1 for binding to IGFBP3 which is likely to block IGFBP3 nuclear import (PubMed:26216267). (cansar.ai)
competes with importin KPNB1 for binding to IGFBP3, blocking IGFBP3 nuclear import (PubMed:14561895, PubMed:19623253, PubMed:26216267). (cansar.ai)
The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. (hal.science)

The regulation of expression of X-box-binding protein-1 (XBP1), a transcriptional factor, involves an unconventional mRNA splicing that removes the 26 nucleotides intron. (mdpi.com)

Inhibits amyloid-beta protein 40 fibril formation (PubMed:27349871). (cansar.ai)
Also inhibits amyloid-beta protein 42 fibril formation (PubMed:28282805). (cansar.ai)

Reports from in vitro studies suggest that ivermectin acts by inhibiting the host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host's antiviral response. (antiochherald.com)
2007). These proteins are important for the regulation of intracellular pH (pH i ) and play crucial roles in the epithelial absorption of HCO 3 - (e.g., in the renal proximal tubule) and secretion of HCO 3 - (e.g., in the pancreatic duct). (tcdb.org)

KPNA3, encodes a protein similar to certain nuclear transport proteins of Xenopus and human. (wikipedia.org)
The genome encodes only 4 nonstructural (ns) proteins nsP1 to -4 which are translated directly from the genomic RNA and interact with host factors to form replicative enzyme complexes (8 34 35 These complexes synthesize the negative-strand RNA intermediates fresh viral genomes and the subgenomic RNA. (bio-biz-navi.com)
The SARS-CoV-2 viral genome encodes 28 confirmed proteins. (biomedcentral.com)

Human TAF10, a subunit of both TFIID and TFTC, has three histone fold-containing interaction partners: TAF3, TAF8, and SPT7Like (SPT7L). (hal.science)

Although the C-terminal domain comprises a small percentage of the total protein, this domain in some cases (i) has PSD-95/Discs Large/ZO-1-binding motifs that may be important for protein-protein interactions (e.g. (tcdb.org)
She currently studies the underlying mechanisms of viral pathogenesis, viral protein-host protein interactions, and the potential use of humanized scFvs and nanobodies for treatment. (nih.gov)
Dr. Eren's research focuses on understanding the structural and mechanistic aspects of Rev-host protein interactions and finding target regions to inhibit Rev activity using antibodies, synthetic peptides, and aptamers. (nih.gov)
We set out to identify the SARS-CoV-2 pathogenic proteins that through host interactions cause the cellular damages underlying COVID-19 symptomatology. (biomedcentral.com)

Interestingly, the DNA binding domain of importin α is a chameleon sequence that changes its structure depending on the environments and it regulates each step of nuclear transport function of importin α by interacting with several molecules. (oist.jp)

Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
The unaggressive setting applies for EGF little substances but becomes inadequate for proteins having a molecular mass higher than 40 kDa. (irjs.info)

Importin 13 competes with NF-YA for binding towards the NF-YB/NF-YC dimer. (irjs.info)

The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implicates Importin-11 as a novel tumor suppressor. (rupress.org)
However, the finding by two independent research groups that mice expressing mutant PTEN proteins that selectively lack lipid phosphatase activity develop worse tumors than mice expressing no PTEN argues strongly against PTEN having dominant tumor suppressor functions that act fully independently of its PIP 3 phosphatase activity. (rupress.org)

Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). (wikipedia.org)
The predicted amino acid sequence shows similarity to Xenopus importin, yeast SRP1, and human RCH1 (KPNA2), respectively. (wikipedia.org)
Amino acid substitution during functionally constrained divergent evolution of protein sequences. (xenbase.org)

Overall, our results suggest that poly-PR might cause length-dependent defects in cargo loading, cargo release, Kapβ transport and Ran gradient across the nuclear envelope. (rug.nl)
It is enclosed by the nuclear envelope , also known as the nuclear membrane. (theinfolist.com)

To make these viruses incapable of transmission by mosquito vectors and to differentially regulate manifestation of viral structural proteins their replication was made dependent on the internal ribosome access sites derived from additional positive-polarity RNA (RNA+) viruses. (bio-biz-navi.com)
The rational design of the genomes was complemented by selection methods which adapted viruses to replication in cells culture and produced variants which (i) shown different levels of replication and production of the individual structural proteins (ii) efficiently induced the antiviral response in infected cells (iii) were incapable of replication in cells of mosquito source and (iv) efficiently replicated in Vero cells. (bio-biz-navi.com)
The high rates of alphavirus replication and viremia development are critically determined by efficient function of viral MAP2K2 genome replication machinery and rapid build up of virus-specific structural proteins in the infected cells. (bio-biz-navi.com)
The 26S subgenomic RNA serves as a template for translation of the structural proteins: capsid and glycoproteins E2 and E1 which ultimately form infectious viral particles (43). (bio-biz-navi.com)

The soluble, liquid portion of the nucleoplasm is called the karyolymph nucleosol, or nuclear hyaloplasm. (theinfolist.com)

Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy. (nih.gov)

These inhibitors are selectively inhibitors of nuclear move (SINE), and possess been demonstrated to end up being effective for dealing with specific types of malignancies, including pancreatic tumor, severe myeloid leukemia, mantle cell lymphoma, causing in significant development apoptosis and inhibition of tumour cells with no serious toxicity [20]C[22]. (cancerhugs.com)
The development of specific inhibitors of importins is challenging, and many attempts are still in their infancy. (researchsquare.com)

Therefore, a multifaceted perspective is necessary to understand the role of importin α in cellular activities. (oist.jp)
Instead they utilize the same structural and nonstructural proteins to function not only in computer virus replication but also in interference with the cellular antiviral response (24-26). (bio-biz-navi.com)
Treatment with Selinexor, an FDA-approved inhibitor for XPO1, attenuated Orf6-induced cellular toxicity in human 293 T cells. (biomedcentral.com)

Analysis of missense variation in human BRCA1 in the context of interspecific sequence variation. (xenbase.org)
We will also review the function and properties of the chameleon sequence of importin α and propose a new model of chromatin regulation focusing on the crosstalk between nuclear transport and DNA binding. (oist.jp)
A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
The ARM is a highly specific sequence which contains a nuclear localization signal. (nih.gov)

Characterized protein members of the AE family are found in animals, plants and yeast. (tcdb.org)
In humans, the AE family (also called the SLC4 family) is composed of 10 paralogous members, among which are the proteins that perform Na + -independent Cl-HCO 3 - exchange (e.g. (tcdb.org)
As noted above, the AE or solute carrier 4 (SLC4) family includes 10 members (SLC4A1-5, SLC4A7-11), which are expressed in multiple tissues in the human body. (tcdb.org)
The genus in the family contains several human being and animal pathogens. (bio-biz-navi.com)
We have investigated the role of the alternative-splicing factor Sfrs1, an arginine/serine-rich (SR)protein family member, during mouse retinal development. (biologists.com)
Proteins bearing ncNLSs directly bind to one of the approximately 20 members of the importin family present in higher eukaryotes (72). (irjs.info)
The double-stranded RNA duplex leads RNA-induced silencing complex (RISC), containing a member of the conserved Argonaute (Ago) protein family, to target sites of mRNAs, resulting in the destabilization of the mRNAs and/or inhibition of translation [ 4 , 5 ]. (biomedcentral.com)
During her postdoctoral studies at the University of Massachusetts Medical School (UMASS), she focused on the structure and function of outer membrane proteins, mainly Occ-family of porins from P. aeruginosa , and their role in bacterial pathogenesis and antibiotic resistance. (nih.gov)
The cAMP responsive element binding protein 3 (CREB3) family members locate in the endoplasmic reticulum (ER) membrane and act as transcription factors when cleaved by S1P and S2P proteases. (biomedcentral.com)
Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)

In addition, ivermectin docking may interfere with the attachment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to the human cell membrane. (antiochherald.com)
Discovered in 1975, ivermectin was marketed successfully from 1981 for parasitic infection indications in animals, and then approved for human use for activity against onchocerciasis (river blindness) in 1987. (encyclopedia.pub)
Ivermectin therefore warrants further investigation for possible benefits in humans. (governmentpropaganda.net)

Recombinant Human Wnt-3a (Catalog # 5036-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. (novusbio.com)
Full length human recombinant protein of human KIF2C produced in HEK293T cell. (thermofisher.com)

We report here that the nucleocapsid (N) protein of HTNV was able to inhibit TNF-α-induced activation of NF-κB, as measured by a reporter assay, and the activation of endogenous p65, an NF-κB subunit. (mssm.edu)

Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. (tcdb.org)

Recently, IPO13 was reported to play a role in human physiologic and pathologic function. (molvis.org)

HIV-1 Rev mediates the nuclear export of intron-containing viral RNA transcripts and is essential for viral replication. (nih.gov)

Journal Article] Crystallization and preliminary X-ray diffraction analysis of human importin β-Snail zinc finger domain complex. (nii.ac.jp)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)

Western blot analysis of HEK293 embryonic kidney cell line whole cell lysate probed with Mouse anti Human c-myc antibody ( MCA2200 ) followed by HRP conjugated Goat anti Mouse IgG secondary antibody visualized using chemiluminescence. (bio-rad-antibodies.com)
Alexa-FluorA647 conjugated Mouse anti Human c-myc antibody, clone 9E10 ( MCA2200A647 ) used for the evaluation of c-myc on dicidual NK cells demonstrating the correlation between c-myc and CD122 expression. (bio-rad-antibodies.com)
Donkey Anti-Goat IgG(H+L)-AP antibody with minimal reactivity to mouse and rat serum proteins for use in ELISA, immunohistochemistry, and western blot assays. (southernbiotech.com)
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NUP50. (prosci-inc.com)

Plays a role in up-regulation of anti-apoptotic protein BIRC6/APOLLON, leading to inhibition of neuronal cell death (PubMed:25138702). (cansar.ai)

These protein consist of growth government bodies and suppressors of cell apoptosis, nuclear localization of which can be needed for their correct function [4]. (cancerhugs.com)

We will review the nuclear transport function of importin α and present our recent findings on the function of DNA binding. (oist.jp)
Like many proteins, the function of PTEN is controlled in part by ubiquitination-the covalent ligation of units of the small regulatory protein ubiquitin. (rupress.org)

Poly-PR makes contact with the inner surface of most importins, which strongly interferes with Kapβ binding to cargo-NLS, IBB, and RanGTP in a poly-PR length-dependent manner. (rug.nl)

It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, directly bind to several importins. (rug.nl)

We examined each of the individual SARS-CoV-2 proteins for their cytotoxicity in HEK 293 T cells and their subcellular localization in COS-7 cells. (biomedcentral.com)

TAF10 binding to importin beta in vitro is dependent on the coexpression of either TAF8 or TAF3, but not SPT7L. (hal.science)

Anatomy7

Organisms1

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes18

Information Science3

Receptors14

Nucleus22

Binds4

Exportins4

Karyopherins1

Eukaryotic4

Pore complex1

Interacts5

Receptor6

Genes8

Cytoplasmic4

Superfamily1

Host proteins3

Translocation3

Gene5

RNAs2

Heterodimer1

Karyopherin1

Phosphorylation2

Adapter1

Residues2

CRM15

Import11

MRNA1

Inhibits2

Intracellular2

Encodes3

Histone1

Interactions4

Regulates1

Mechanism1

Molecular2

Competes1

Tumor suppressor3

Amino acid3

Envelope2

Structural proteins4

Soluble1

Characterization2

Inhibitors2

Cellular3

Sequence4

Family10

Ivermectin3

Recombinant2

Nucleocapsid1

Cytoskeletal1

IPO131

Mediates1

Complex2

Antibody4

Regulation1

Consist1

Function2

Cargo1

Directly bind1

Subcellular localization1

Vitro1