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Doxazosin mesylate is a quinazoline compound that is a selective inhibitor of the alpha 1 subtype of alpha adrenergic receptors. (nih.gov)
The chemical name of doxazosin mesylate is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. (nih.gov)
Doxazosin mesylate is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8% at 25°C), and very slightly soluble in acetone and methylene chloride. (nih.gov)
Each doxazosin mesylate tablet, for oral administration, contains 1 mg, 2 mg, 4 mg, or 8 mg of doxazosin as the free base. (nih.gov)
In the human prostate, doxazosin mesylate antagonizes phenylephrine (alpha 1 agonist)-induced contractions, in vitro , and binds with high affinity to the alpha 1c adrenoceptor. (nih.gov)
Doxazosin mesylate acts within 1 to 2 weeks to decrease the severity of BPH symptoms and improve urinary flow rate. (nih.gov)
Since alpha 1 adrenoceptors are of low density in the urinary bladder (apart from the bladder neck), doxazosin mesylate should maintain bladder contractility. (nih.gov)
The efficacy of doxazosin mesylate was evaluated extensively in over 900 patients with BPH in double-blind, placebo-controlled trials. (nih.gov)
Doxazosin mesylate treatment was superior to placebo in improving patient symptoms and urinary flow rate. (nih.gov)
Uroflowmetric evaluations were performed at times of peak (2 to 6 hours post-dose) and/or trough (24 hours post-dose) plasma concentrations of doxazosin mesylate. (nih.gov)
In all three studies, doxazosin mesylate resulted in statistically significant relief of obstructive and irritative symptoms compared to placebo. (nih.gov)
Statistically significant improvements of 2.3 to 3.3 mL/sec in maximum flow rate were seen with doxazosin mesylate in STUDIES 1 and 2 , compared to 0.1 to 0.7 mL/sec with placebo. (nih.gov)
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tell your doctor and pharmacist if you are allergic to doxazosin, prazosin (Minipress), terazosin, any other medications, or any ingredients in doxazosin tablets or extended-release tablets. (medlineplus.gov)

you are allergic to any ingredient of Doxazosin or to similar medicines (eg, prazosin). (canadianbopharmacy.com)

If you stop taking doxazosin for a few days or longer, call your doctor. (medlineplus.gov)
If you miss taking doxazosin for a few days, you may need to restart treatment at the low dose and gradually increase your dose again. (elispot.biz)

Do not stop taking doxazosin without talking to your doctor. (medlineplus.gov)
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These highlights do not include all the information needed to use DOXAZOSIN TABLETS safely and effectively. (nih.gov)
See full prescribing information for DOXAZOSIN TABLETS. (nih.gov)
Hypersensitivity to doxazosin, other quinazolines, or any other ingredient in doxazosin tablets. (nih.gov)
Concomitant administration of doxazosin tablets with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension. (nih.gov)
Doxazosin tablets are indicated for the treatment of the signs and symptoms of BPH. (nih.gov)
Doxazosin tablets are indicated for the treatment of hypertension, to lower blood pressure. (nih.gov)
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Your doctor will start you on a low dose of doxazosin and gradually increase your dose, not more than once every 1 to 2 weeks. (medlineplus.gov)
Your doctor will have to start you again on the lowest dose of doxazosin and gradually increase your dose. (medlineplus.gov)
Doxazosin may cause a sudden drop in blood pressure after the first dose. (canadianbopharmacy.com)
If you miss a dose of Doxazosin, take it as soon as possible. (canadianbopharmacy.com)
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We found that doxazosin dose-dependently induced galectin-3 protein expression, with a statistically significant increase in expression with a dose as low as 0.01 μM. (emory.edu)
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It is important to continue taking this medication even if you feel wellMost people with high blood pressure do not feel sick. (myfon.com.my)
This medication works by relaxing blood vessels so blood can flow more easily.Doxazosin is also used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). (elispot.biz)
Examples of medication interactions include taking Cialis with erythromycin, ketoconazole, nitrates, rifampin and doxazosin. (toothache-pain-relief.org)
It is important to take this medication exactly as prescribed by your doctor. (medbroadcast.com)

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The selective alpha1 -adrenoceptor antagonist doxazosin has apparently beneficial effects on insulin sensitivity and on plasma lipid concentrations. (ox.ac.uk)

There are over 200 potential drug interactions with Cialis, meaning it is important to talk with your physician about all vitamins, supplements and herbal medications you may be taking. (toothache-pain-relief.org)

Doxazosin is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia or BPH), which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency. (medlineplus.gov)
Doxazosin, a drug commonly prescribed for hypertension and prostate disease, increases heart failure risk. (emory.edu)

Doxazosin controls high blood pressure and the symptoms of BPH but does not cure them. (medlineplus.gov)
Doxazosin is used for treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH). (canadianbopharmacy.com)
This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently (including during the middle of the night).Doxazosin belongs to a class of drugs known as alpha blockers. (elispot.biz)
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We believe it is important to know the extent of these side effects, as the clinician and patient will need to decide the cost of improved voiding symptoms. (medscape.com)

Strong cytochrome P450 (CYP) 3A inhibitors may increase exposure to doxazosin and increased risk of hypotension. (nih.gov)
The man was taking cilazapril and doxazosin - two drugs that are known to cause hypotension. (hdc.org.nz)

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Some medicines may interact with Doxazosin. (canadianbopharmacy.com)
Ask your health care provider if Doxazosin may interact with other medicines that you take. (canadianbopharmacy.com)
When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. (mayoclinic.org)

Although we previously reported that activation of protein kinase C (PKC) stimulates galectin-3 expression, blocking the PKC pathway with the PKC inhibitor chelerythrine did not prevent doxazosin-induced galectin-3 and collagen expression. (emory.edu)

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Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjects. (ox.ac.uk)
In order to understand these effects better, we investigated the acute effects of doxazosin on adipose tissue and forearm blood flow and on postprandial lipid metabolism in healthy subjects. (ox.ac.uk)

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Doxazosin is used alone or with other drugs to treat high blood pressure (hypertension). (elispot.biz)
Doxazosin may cause a sudden drop in your blood pressure, which could lead to dizziness or fainting, usually within 2 to 6 hours after you take it. (elispot.biz)

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Doxazosin is in a class of medications called alpha-blockers. (medlineplus.gov)

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It is important to educate patients about the nature of their disease and the risks associated with untreated hypertension. (medscape.com)

Use Doxazosin as directed by your doctor. (canadianbopharmacy.com)

Consistently, doxazosin treatment did not alter total and phosphorylated PKC. (emory.edu)

These antigens play an important role in the adhesion complexes that promote epithelial-stromal adhesion. (wikipedia.org)

In the present study, we investigated whether doxazosin could stimulate galectin-3 expression and collagen synthesis in cultured HL-1 cardiomyocytes. (emory.edu)
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This is why it's important to continue taking it for a long time (even if you think the medicine isn't working). (treated.com)

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To determine if the a1-adrenergic pathway is involved, we pretreated the cells with the irreversible a-adrenergic receptor blocker phenoxybenzamine and found that doxazosin-stimulated galectin-3 and collagen expression was similar to controls, suggesting that doxazosin acts independently of a1-adrenergic receptor blockade. (emory.edu)

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