• The Glomerular Endothelium Restricts Albumin Filtration. (qxmd.com)
  • Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. (qxmd.com)
  • While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. (qxmd.com)
  • Dr. Katusic's team is interested in the development of optimal therapeutic interventions designed to exert a protective effect on vascular endothelium in the cerebral circulation. (mayo.edu)
  • Evidence continues to substantiate the importance of healthy cerebral blood vessels in the prevention of Alzheimer's disease. (mayo.edu)
  • Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. (hindawi.com)
  • Cerebral endothelium is probably one of the most specific types since it is the crucial element of the well-known blood-brain barrier. (hindawi.com)
  • Cerebral endothelium is a one cell layer on the inner wall of the vessels and as such is a difficult subject to image. (hindawi.com)
  • Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
  • Your endothelium is the thin layer of cells lining your blood vessels, heart and lymphatic system. (embracingnutrition.co.uk)
  • Kaposi sarcoma, is a malignant tumor of the lymphatic endothelium caused by the human herpesvirus 8 (HHV8), also referred to as Kaposi's sarcoma-associated herpesvirus (KSHV), and arises from a cancer of the lymphatic endothelial lining. (cdc.gov)
  • In the first phase of the extravasation process, selectins such as L-selectin on leukocytes and E- and P-selectin on endothelial cells lead to a loose connection that permits tethering and rolling of leukocytes on the endothelium under hydrodynamic shear [ 10 ]. (biomedcentral.com)
  • [1] When flow increases in a coronary vessel, the resulting increase in shear stress on the endothelium leads to the production of endothelium-derived relaxing factor(s). [2] Although metabolic control may be primarily responsible for the close matching of coronary blood flow to tissue needs, myogenic and endothelial regulatory mechanisms play synergistic roles via transduction of intravascular pressure and flow, respectively. (silverchair.com)
  • therefore, the association between certain periodontal pathogens and coronary artery disease or stroke is gaining more importance. (medscape.com)
  • The oxygen sensing and signal transduction machinery is located in the pulmonary arterial smooth muscle cells (PASMCs) of the pre-capillary vessels, albeit the physiological response may be modulated in vivo by the endothelium. (ersjournals.com)
  • Collagen from calfskin was purchased tion, hardening of the capillary endothelium from Sigma, St. Louis, Missouri, USA. (who.int)
  • There are two general pathways that explain EDH Diffusible factors are endothelium-derived substances that are able to pass through internal elastic layer (IEL), reach underlying vascular smooth muscle cells at a concentration sufficient to activate ion channels, and initiate smooth muscle hyperpolarization and relaxation. (wikipedia.org)
  • Since EDHF's contribution is greatest at level of small arteries, the changes in the EDHF action are of critical importance for the regulation of organ blood flow, peripheral vascular resistance, and blood pressure, and in particular when production of NO is compromised. (wikipedia.org)
  • In some arteries, eicosanoids and K+ ions may themselves initiate a conducted endothelial hyperpolarization, thus suggesting that electrotonic signalling may represent a general mechanism through which the endothelium participates in the regulation of vascular tone. (wikipedia.org)
  • In rat subepicardial arteries, flow-induced dilation is endothelium-dependent and mediated by both NO and a prostanoid. (silverchair.com)
  • In the thoracic aorta of OLETF rats, endothelium-dependent relaxation was markedly attenuated compared with that of control (LETO) rats in association with a significant increase in superoxide production (2,421.39 ± 407.01 nmol · min −1 · mg −1 ). (diabetesjournals.org)
  • Experiments show that when NO and Prostacyclin (Vasodilators) are inhibited there is still another factor causing the vessels to dilate Despite the ongoing debate of its intriguingly variable nature and mechanisms of action, the contribution of EDHF to the endothelium-dependent relaxation is currently appreciated as an important feature of "healthy" endothelium. (wikipedia.org)
  • Neganova A. I., Postnov D. E. Mathematical Modeling of Endothelium-Induced Smooth Muscle Cell Relaxation. (sgu.ru)
  • Our experiments have shown the importance of E-selectin in EPC adhesion to HUVECs and the potential utility of gene silencing of E-selectin in EPC recruitment. (scirp.org)
  • The importance of adhesion molecules in traumatic and septic diseases has been widely recognized. (biomedcentral.com)
  • While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
  • In the peripheral posterior stroma, there were dust-like, bright, granular deposits that tended to increase in number and density toward Descemet's membrane, masking the peripheral endothelium. (scielo.br)
  • Dr. Katusic's studies are focused on understanding mechanisms responsible for normal endothelial function and repair of injured endothelium. (mayo.edu)
  • Dr. Katusic's research is designed to define mechanisms linking dysfunctional endothelium with progression of cognitive decline. (mayo.edu)
  • Nillson H., Aalkjar C.Vasomotion : Mechanisms and Physiological Importance // Molecular Interventions. (sgu.ru)
  • The strategic location of endothelial cells is of critical functional importance. (mayo.edu)
  • As with TEC, our understanding of NES has been improved through the phenotypic identification of new subpopulations, such studies on thymic mesenchyme and endothelium have provided new and important insight into their complexity and functional importance. (frontiersin.org)
  • The normal function of the endothelium was thus restored, cell proliferation in the blood vessel walls decreased significantly and the narrowing of the blood vessels reversed. (medicalnewstoday.com)
  • Perhaps the most well-known function of the endothelium is to keep the inside of your blood vessels smooth so plaque deposits don't build up. (embracingnutrition.co.uk)
  • The proper amount of NO secretion is therefore of paramount importance, as imbalance of this contractility function will lead to hypertension, the silent killer. (detoxamin.com)
  • Improved understanding of vascular biology is crucial for all cardiologists, and particularly interventional cardiologists, as maintenance of a competently functioning endothelium is critical for long-term vascular health. (nature.com)
  • What do you know about Endothelium Health? (embracingnutrition.co.uk)
  • In this article, you'll learn about endothelium and blood vessel health, and how you can look after yours. (embracingnutrition.co.uk)
  • The vascu- ability in health and disease are poorly unders- lar endothelium is formed by a sheet of endothe- tood. (bvsalud.org)
  • The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
  • Infection begins with non-specific symptoms like fever, headache, and muscle pain, but unmitigated damage to the vascular endothelium quickly results in organ failure, necrosis, and ultimately death. (cdc.gov)
  • This study employed scanning electron microscopy and light microscopy to observe seed surface micromorphology and seed coat anatomy in the Scrophulariaceae s.l. to investigate seed characters of taxonomic importance. (intechopen.com)
  • Of importance is the normal appearance of the most superficial epidermal layer on the far left, which was overlying the dermal layer, which contained a cellular infiltrate, and a proliferation of vascular elements. (cdc.gov)
  • Endothelium-derived CNP has been proposed to act as an EDHF via specific C-subtype of natriuretic peptide receptor, however the evidence in favour of CNP's acting as EDHF has yet to be determined. (wikipedia.org)
  • The recognition of endothelium in brain blood vessels as a major therapeutic target significantly advanced efforts to develop pharmacological therapies, as well as gene- and cell-based therapies. (mayo.edu)
  • There have been four new epidemiologic studies since the 2006 monograph, which have been of limited importance and do not change the overall picture. (who.int)