Nitric oxideGlomerular endotheliumVasodilationAtherosclerosisCerebralLymphaticShearCoronaryInflammationInflammatoryCapillaryVascular SmoothArteriesRegulatesRelaxationDiameterAdhesionPeripheralMaintainsMechanismsFunctional importanceImportantHealthyFunctionOilsHealthLeadsOrganInvestigateNormalProductionBlood flowEvidenceCellsDamageFlowBrainCoverChange
Nitric oxide9
- However, endothelium that has regenerated after percutaneous coronary intervention is incompetent in terms of its integrity and function, with poorly formed cell junctions, reduced expression of antithrombotic molecules, and decreased nitric oxide production. (nature.com)
- L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. (hindawi.com)
- Although nitric oxide (NO) is recognized as the primary factor at level of arteries, increased evidence for the role of another endothelium-derived vasodilator known as endothelium-derived hyperpolarizing factor (EDHF) has accumulated in the last years. (wikipedia.org)
- The generation of animals that lack both endothelial nitric oxide synthase (eNOS) and COX-1 (Cyclooxygenase-1, a protein that acts as an enzyme to speed up the production of certain chemical messengers), has allowed a direct assessment of the involvement of EDHF to endothelium-dependent relaxation in small arteries. (wikipedia.org)
- The sudden decline in the production of nitric oxide by the endothelium plays an important role in the development of pulmonary hypertension. (medicalnewstoday.com)
- Your endothelium controls the diameter of your arteries with the help of a substance called nitric oxide. (embracingnutrition.co.uk)
- In turn, nitric oxide helps the endothelium to remain healthy by reducing inflammation. (embracingnutrition.co.uk)
- Influence of the endothelium is modeled as the increase of nitric oxide (NO) concentration and subsequent production of cyclic quanosine monophosphate (cGMP). (sgu.ru)
- This lining tissue generates the powerful arterial vessel dilator nitric oxide (N.O.). The endothelium also produces prostacyclin which slows the clotting of blood and also causes beneficial dilating of arteries. (detoxamin.com)
Glomerular endothelium3
- The Glomerular Endothelium Restricts Albumin Filtration. (qxmd.com)
- Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria in many systemic and localized vascular disorders. (qxmd.com)
- While the glomerular endothelium is a porous sieve that filters prodigious amounts of water and small solutes, it also bars the bulk of albumin and large plasma proteins from passing into the glomerular filtrate. (qxmd.com)
Vasodilation6
- These findings suggest that upregulated expression of p22phox mRNA and enhanced NADH oxidase activity contribute to the impaired endothelium-dependent vasodilation in OLETF rats. (diabetesjournals.org)
- Vascular complications are responsible for the excess mortality associated with diabetes ( 1 ), and impaired endothelium-dependent vasodilation has been described in humans and in animal models of the disease ( 2 - 6 ). (diabetesjournals.org)
- Each of your blood vessels has an inner lining known as the endothelium which regulates the widening (vasodilation) or narrowing (vasoconstriction) of the vessel to control blood flow. (juvenon.com)
- Volatile anesthetics attenuate agonist-induced endothelium-dependent vasodilation of coronary arteries. (silverchair.com)
- This study considered the hypothesis that the anesthetics may also attenuate flow-induced endothelium-dependent vasodilation. (silverchair.com)
- Volatile anesthetics attenuate agonist-mediated endothelium-dependent vasodilation (EDD) of both conductance [3,4] and resistance arteries [5,6] in vitro and of pulmonary vessels in vivo. (silverchair.com)
Atherosclerosis3
- Injury to vascular endothelium, such as that induced by aging, high cholesterol, diabetes or hypertension, is considered a key initiating event in the development of atherosclerosis, leading to impairment of brain blood flow. (mayo.edu)
- Damage to the endothelium is known as endothelial dysfunction and it's believed to be a forerunner of atherosclerosis. (embracingnutrition.co.uk)
- Soluble vascular cell adhesion molecule-1, a protein related to the endothelium and a marker of atherosclerosis, was also decreased after the meal containing the plant-based fat. (tissuerecovery.com)
Cerebral5
- Dr. Katusic's team is interested in the development of optimal therapeutic interventions designed to exert a protective effect on vascular endothelium in the cerebral circulation. (mayo.edu)
- Evidence continues to substantiate the importance of healthy cerebral blood vessels in the prevention of Alzheimer's disease. (mayo.edu)
- Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. (hindawi.com)
- Cerebral endothelium is probably one of the most specific types since it is the crucial element of the well-known blood-brain barrier. (hindawi.com)
- Cerebral endothelium is a one cell layer on the inner wall of the vessels and as such is a difficult subject to image. (hindawi.com)
Lymphatic3
- Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
- Your endothelium is the thin layer of cells lining your blood vessels, heart and lymphatic system. (embracingnutrition.co.uk)
- Kaposi sarcoma, is a malignant tumor of the lymphatic endothelium caused by the human herpesvirus 8 (HHV8), also referred to as Kaposi's sarcoma-associated herpesvirus (KSHV), and arises from a cancer of the lymphatic endothelial lining. (cdc.gov)
Shear2
- In the first phase of the extravasation process, selectins such as L-selectin on leukocytes and E- and P-selectin on endothelial cells lead to a loose connection that permits tethering and rolling of leukocytes on the endothelium under hydrodynamic shear [ 10 ]. (biomedcentral.com)
- [1] When flow increases in a coronary vessel, the resulting increase in shear stress on the endothelium leads to the production of endothelium-derived relaxing factor(s). [2] Although metabolic control may be primarily responsible for the close matching of coronary blood flow to tissue needs, myogenic and endothelial regulatory mechanisms play synergistic roles via transduction of intravascular pressure and flow, respectively. (silverchair.com)
Coronary1
- therefore, the association between certain periodontal pathogens and coronary artery disease or stroke is gaining more importance. (medscape.com)
Inflammation3
- iii) infection of vascular endothelium/ heart pericytes with subsequent local inflammation (vasculitis) and clot formation [ 9 ]. (springer.com)
- When LDL is damaged or oxidised by free radicals, it can cause changes in your immune system, sparking off inflammation which damages your endothelium. (embracingnutrition.co.uk)
- We also know the importance of having low inflammation since that's a risk factor for all chronic diseases and especially cardiovascular disease. (tissuerecovery.com)
Inflammatory1
- CD54 known also as intercellular adhesion molecule-1 (ICAM-1) is an adhesion molecule crucial in inflammatory process by controlling monocyte endothelium interactions. (iiarjournals.org)
Capillary2
- The oxygen sensing and signal transduction machinery is located in the pulmonary arterial smooth muscle cells (PASMCs) of the pre-capillary vessels, albeit the physiological response may be modulated in vivo by the endothelium. (ersjournals.com)
- Collagen from calfskin was purchased tion, hardening of the capillary endothelium from Sigma, St. Louis, Missouri, USA. (who.int)
Vascular Smooth1
- There are two general pathways that explain EDH Diffusible factors are endothelium-derived substances that are able to pass through internal elastic layer (IEL), reach underlying vascular smooth muscle cells at a concentration sufficient to activate ion channels, and initiate smooth muscle hyperpolarization and relaxation. (wikipedia.org)
Arteries3
- Since EDHF's contribution is greatest at level of small arteries, the changes in the EDHF action are of critical importance for the regulation of organ blood flow, peripheral vascular resistance, and blood pressure, and in particular when production of NO is compromised. (wikipedia.org)
- In some arteries, eicosanoids and K+ ions may themselves initiate a conducted endothelial hyperpolarization, thus suggesting that electrotonic signalling may represent a general mechanism through which the endothelium participates in the regulation of vascular tone. (wikipedia.org)
- In rat subepicardial arteries, flow-induced dilation is endothelium-dependent and mediated by both NO and a prostanoid. (silverchair.com)
Regulates1
- In addition, the endothelium regulates the diameter of the blood vessels and adapts the distribution of the blood to the body's functional requirements. (medicalnewstoday.com)
Relaxation3
- In the thoracic aorta of OLETF rats, endothelium-dependent relaxation was markedly attenuated compared with that of control (LETO) rats in association with a significant increase in superoxide production (2,421.39 ± 407.01 nmol · min −1 · mg −1 ). (diabetesjournals.org)
- Experiments show that when NO and Prostacyclin (Vasodilators) are inhibited there is still another factor causing the vessels to dilate Despite the ongoing debate of its intriguingly variable nature and mechanisms of action, the contribution of EDHF to the endothelium-dependent relaxation is currently appreciated as an important feature of "healthy" endothelium. (wikipedia.org)
- Neganova A. I., Postnov D. E. Mathematical Modeling of Endothelium-Induced Smooth Muscle Cell Relaxation. (sgu.ru)
Diameter1
- One other important function of your endothelium is to regulate the diameter of your blood vessels. (embracingnutrition.co.uk)
Adhesion2
- Our experiments have shown the importance of E-selectin in EPC adhesion to HUVECs and the potential utility of gene silencing of E-selectin in EPC recruitment. (scirp.org)
- The importance of adhesion molecules in traumatic and septic diseases has been widely recognized. (biomedcentral.com)
Peripheral2
- While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
- In the peripheral posterior stroma, there were dust-like, bright, granular deposits that tended to increase in number and density toward Descemet's membrane, masking the peripheral endothelium. (scielo.br)
Maintains1
- The endothelium maintains vascular homeostasis through the release of active vasodilators. (wikipedia.org)
Mechanisms3
- Dr. Katusic's studies are focused on understanding mechanisms responsible for normal endothelial function and repair of injured endothelium. (mayo.edu)
- Dr. Katusic's research is designed to define mechanisms linking dysfunctional endothelium with progression of cognitive decline. (mayo.edu)
- Nillson H., Aalkjar C.Vasomotion : Mechanisms and Physiological Importance // Molecular Interventions. (sgu.ru)
Functional importance2
- The strategic location of endothelial cells is of critical functional importance. (mayo.edu)
- As with TEC, our understanding of NES has been improved through the phenotypic identification of new subpopulations, such studies on thymic mesenchyme and endothelium have provided new and important insight into their complexity and functional importance. (frontiersin.org)
Important3
- Endothelium forms the inner cellular lining of blood vessels and plays an important role in many physiological functions including the control of vasomotor tone. (hindawi.com)
- We know that it is important to have a healthy endothelial function because the endothelium is the inner layer of the blood vessels. (tissuerecovery.com)
- Dr. Daniel LaPerriere describes the endothelium and why is it important for brain health. (drtalks.com)
Healthy3
- Figure 1: The structure and function of healthy endothelium. (nature.com)
- Preservation of healthy endothelium is of major importance in the prevention and treatment of stroke. (mayo.edu)
- The importance of healthy blood vessels is no secret. (embracingnutrition.co.uk)
Function3
- The normal function of the endothelium was thus restored, cell proliferation in the blood vessel walls decreased significantly and the narrowing of the blood vessels reversed. (medicalnewstoday.com)
- Perhaps the most well-known function of the endothelium is to keep the inside of your blood vessels smooth so plaque deposits don't build up. (embracingnutrition.co.uk)
- The proper amount of NO secretion is therefore of paramount importance, as imbalance of this contractility function will lead to hypertension, the silent killer. (detoxamin.com)
Oils1
- Omega 3 oils have been found in research to improve endothelium health. (embracingnutrition.co.uk)
Health4
- Improved understanding of vascular biology is crucial for all cardiologists, and particularly interventional cardiologists, as maintenance of a competently functioning endothelium is critical for long-term vascular health. (nature.com)
- What do you know about Endothelium Health? (embracingnutrition.co.uk)
- In this article, you'll learn about endothelium and blood vessel health, and how you can look after yours. (embracingnutrition.co.uk)
- The vascu- ability in health and disease are poorly unders- lar endothelium is formed by a sheet of endothe- tood. (bvsalud.org)
Leads1
- The incompetent endothelium leads to late stent thrombosis and the development of in-stent neoatherosclerosis. (nature.com)
Organ1
- Infection begins with non-specific symptoms like fever, headache, and muscle pain, but unmitigated damage to the vascular endothelium quickly results in organ failure, necrosis, and ultimately death. (cdc.gov)
Investigate1
- This study employed scanning electron microscopy and light microscopy to observe seed surface micromorphology and seed coat anatomy in the Scrophulariaceae s.l. to investigate seed characters of taxonomic importance. (intechopen.com)
Normal1
- Of importance is the normal appearance of the most superficial epidermal layer on the far left, which was overlying the dermal layer, which contained a cellular infiltrate, and a proliferation of vascular elements. (cdc.gov)
Production1
- When the endothelium is damaged, N.O. production is reduced. (detoxamin.com)
Blood flow1
- The endothelium is the interior layer of blood vessels, which has an optimal smooth surface and hence ensures low-friction blood flow. (medicalnewstoday.com)
Evidence1
- Endothelium-derived CNP has been proposed to act as an EDHF via specific C-subtype of natriuretic peptide receptor, however the evidence in favour of CNP's acting as EDHF has yet to be determined. (wikipedia.org)
Cells2
- Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
- He discusses the functions endothelial cells perform and their importance. (drtalks.com)
Damage1
- High levels of sugar in your blood can encourage oxidative stress and so damage your endothelium. (embracingnutrition.co.uk)
Flow1
- Immunohistochemistry and flow cytometry failed to show PSGL-1 expression on resting or inflamed endothelium or on platelets. (rupress.org)
Brain1
- The recognition of endothelium in brain blood vessels as a major therapeutic target significantly advanced efforts to develop pharmacological therapies, as well as gene- and cell-based therapies. (mayo.edu)
Cover1
- If laid out, your endothelium would cover the area of over four Olympic swimming pools, and weigh around 1kg. (embracingnutrition.co.uk)
Change1
- There have been four new epidemiologic studies since the 2006 monograph, which have been of limited importance and do not change the overall picture. (who.int)