Implications human skeletal muscle skeletal muscle contractions. Medical search. Frequent questions

In skeletal muscle tissue, 10-100 endomysium-sheathed muscle fibers are organized into perimysium-wrapped bundles known as fascicles. (wikipedia.org)
One advantage of pennate muscles is that more muscle fibers can be packed in parallel, thus allowing the muscle to produce more force, although the fiber angle to the direction of action means that the maximum force in that direction is somewhat less than the maximum force in the fiber direction. (wikipedia.org)
The muscle cross sectional area (blue line in figure 1, also known as anatomical cross section area, or ACSA) does not accurately represent the number of muscle fibers in the muscle. (wikipedia.org)
A better estimate is provided by the total area of the cross sections perpendicular to the muscle fibers (green lines in figure 1). (wikipedia.org)
If the specific tension of the muscle fibers is known (force exerted by the fibers per unit of PCSA), it can be computed as follows: Total force = PCSA ⋅ Specific tension {\displaystyle {\text{Total force}}={\text{PCSA}}\cdot {\text{Specific tension}}} However, only a component of that force can be used to pull the tendon in the desired direction. (wikipedia.org)
For instance, when muscle mass increases due to physical development during childhood, this may be only due to an increase in length of the muscle fibers, with no change in fiber thickness (PCSA) or fiber type. (wikipedia.org)
In a pennate muscle, as a consequence of their arrangement, fibers are shorter than they would be if they ran from one end of the muscle to the other. (wikipedia.org)
One is, how, and to what extent, does the nervous system control protein expression in skeletal muscle fibers? (ucla.edu)
Whole muscle, single motor units and single muscle fibers are studied physiologically and biochemically. (ucla.edu)
Skeletal muscles contain a mix of different fibers, and the exact ratio depends on the specific muscle in question as well as the individual person. (oxygenmag.com)
EDG-5506 is an investigational orally administered small molecule myosin modulator designed to protect injury-susceptible fast skeletal muscle fibers in dystrophinopathies such as Duchenne muscular dystrophy (DMD) and BMD. (businesswire.com)
Skeletal muscle fibers regularly generate reactive oxygen species (ROS) at a sluggish price that will increase throughout muscle contraction. (ncbcs.org)
Further compounding the loss in function with age is preferential loss of cross-sectional area of stronger and faster contracting type II muscle fibers [ 9 ]. (hindawi.com)
The heart is constituted by three types of muscle: atrial, ventricular, and specialized excitatory and conducting fibers. (bvsalud.org)
There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fibers to their own rhythm. (bvsalud.org)

Thin filament length (TFL) is an important determinant of the force-sarcomere length (SL) relation of cardiac muscle. (bio5.org)
Reductions of cardiac muscle function and grip strength were noted by as much as 25 and 18 percent respectively. (nyhealthinsurer.com)
During his Fellowship he extended the study of thick filament-based regulation to cardiac muscle and he contributed to develop a novel paradigm of regulation of contractility in striated muscle. (kcl.ac.uk)
Current areas of interest include thin and thick filament-based regulation of contraction in human cardiac and skeletal muscle, the molecular basis of length-dependent activation in cardiac muscle, and alteration of these mechanisms in ageing and diseases. (kcl.ac.uk)
Cardiac muscle is controlled by the heart's sinoatrial node and produces rhythmic contractions that cause your heart to pump. (oxygenmag.com)
Dulhunty was amongst the first researchers to study single RyR ion channels from skeletal and cardiac muscle using lipid bilayer electrophysiology. (edu.au)
She has continued to study RyR channels, combining electrophysiology, biochemistry, protein chemistry, structural biology and molecular biology to explore normal RyR function and pathological changes that reduce skeletal muscle function and which can compromise cardiac muscle to the extent of causing heart attack. (edu.au)
The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. (bvsalud.org)

Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. (frontiersin.org)
I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. (bio5.org)
The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. (bio5.org)
Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. (bio5.org)
To examine gender-dimorphic regulation of skeletal muscle proteins between healthy control and STZ-induced diabetic rats of both genders, we performed differential proteome analysis using two-dimensional electrophoresis combined with mass spectrometry. (karger.com)
Proteomic analysis of skeletal muscle identified a total of 21 proteins showing gender-dimorphic differential expression patterns between healthy controls and diabetic rats. (karger.com)
Most interestingly, gender-specific proteome comparison showed that male and female rats displayed differential regulation of proteins involved in muscle contraction, carbohydrate, and lipid metabolism, as well as oxidative phosphorylation and cellular stress. (karger.com)
These mRNA molecules are translated into proteins at the site of injury to act as building blocks for muscle repair," explains William Roman. (scitechdaily.com)
The team found that the chemical interferes with the signals between proteins which enable muscles to function. (nyhealthinsurer.com)
These analyses consist of enzyme activities of single muscle or neural cells, cell morphology, the kinds of proteins synthesized, the modulations of the mRNA's of specific myonuclei as well as the physiological properties of the nerve and muscle cells. (ucla.edu)
The interests in the Muscle Research Group include the molecular structure and function of the proteins that regulate Ca 2+ signalling and contraction in skeletal muscle and the heart. (edu.au)
The two proteins are essential for muscle function, movement and heart beat. (edu.au)
Current information recommend that muscle-derived ROS primarily act on myofibrillar proteins to inhibit calcium sensitivity and depress power. (ncbcs.org)
Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)

Titin is a giant scaffold protein with multiple functions in striated muscle physiology. (frontiersin.org)
Gender differences in physiology and metabolism have important potential implications with regards to the development of new approaches for the intervention of metabolic diseases such as diabetes and obesity [ 1 ]. (karger.com)
This protective mechanism opens the road to a broader understanding of muscle repair in physiology and disease. (scitechdaily.com)
On the importance of these discoveries, Pura Muñoz-Cánoves says: "This finding constitutes an important advance in the understanding of muscle biology, in physiology and muscle dysfunction. (scitechdaily.com)
Luca Fusi obtained a PhD in Physiology from the University of Florence (Italy), during which he investigated the structure-function relation of the molecular motor of skeletal muscle in situ, combining sarcomere mechanics and small-angle X-ray diffraction in single muscle fibres. (kcl.ac.uk)
In 2023 he was appointed as Lecturer in Muscle Physiology at the Centre for Human and Applied Physiological Sciences in the School of Basic and Medical Biosciences. (kcl.ac.uk)
Her program features a translational approach that combines work in animal and cell-based models with human studies, using genetic engineering, molecular biology and mass spectrometry-based metabolomics and proteomics as tools to understand the interplay between mitochondrial physiology and cardiometabolic health. (dukecancerinstitute.org)
We propose to take a human systems physiology approach that couples whole body functional, whole tissue anatomic, and sub-cellular molecular and metabolic measures to address the molecular basis of sarcopenia, the molecular basis of exercise induced muscle growth, and optimal strategies with which to use exercise to counteract sarcopenia. (ukri.org)
In their excellent 2011 review entitled, Aging and Vascular Endothelial Function in Humans , Seals and colleagues at the University of Colorado's Department of Integrative Physiology, describe a number of nutritional interventions that may play a role in improving endothelial function. (holisticprimarycare.net)

Each muscle is composed of a number of fascicles grouped together by a sleeve of connective tissue, known as an epimysium. (wikipedia.org)
The current proteomic study revealed that impaired protein regulation was more prominent in the muscle tissue of female diabetic rats, which were more susceptible to STZ-induced diabetes. (karger.com)
Skeletal muscle tissue, the organ responsible for locomotion, is formed by cells that have more than one nucleus, an almost unique feature in our body. (scitechdaily.com)
The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
The brain integrates metabolic signals from peripheral tissues such as the liver, pancreas, adipose tissue, gut and muscle. (nature.com)
The extracellular matrix (ECM), and especially the connective tissue with its collagen, links tissues of the body together and plays an important role in the force transmission and tissue structure maintenance especially in tendons, ligaments, bone, and muscle. (fasciaguide.com)
Full understanding of these physiological processes will provide the physiological basis for understanding of tissue overloading and injury seen in both tendons and muscle with repetitive work and leisure time physical activity. (fasciaguide.com)
In our experiments we also study cell and tissue properties (nerve and muscle) that are important in generating the behavioral characteristics observed. (ucla.edu)
Smooth muscle tissue is found in your skin, blood vessels and organs and along the tracts of the urinary, respiratory and reproductive systems. (oxygenmag.com)
To determine the basis of these changes, we will sample tissue at the muscle mid-belly (loss of sarcomeres in parallel) and close to the distal aponeurosis (loss of sarcomeres in series). (ukri.org)
The newly discovered hormone, dubbed "MOTS-c," primarily targets muscle tissue, where it restores insulin sensitivity, counteracting diet-induced and age-dependent insulin resistance. (jaycampbell.com)

Spain) and published on October 15, 2021, in the scientific journal Science describes a new mechanism for muscle regeneration after physiological damage relying on the rearrangement of nuclei. (scitechdaily.com)

The mechanism of exercise-induced myopathy could be the cell membrane damage by lipid peroxidation and DNA fragmentation in the working muscle cells by free radicals generation. (scielo.org.ar)

Dulhunty's research has focussed on the translation of electrical signals in the surface membrane of muscle fibres into the release of the calcium ions from their internal in the sarcoplasmic reticulum (SR), to enable muscle contraction in the process of excitation contraction coupling (ECC). (edu.au)

2008) Human muscle blood flow and metabolic assessment applied to aging. (utah.edu)
For tendons, metabolic activity, circulatory responses, and collagen turnover are demonstrated to be more pronounced in humans than hitherto thought. (fasciaguide.com)
Overtraining and extra cardio can improve irritation, elevate cortisol, result in muscle breakdown, and influence metabolic well being. (dealssoreal.com)

Using a new tracer (D2O) approach we will measuring turnover of muscle sub-fractions (e.g. myofibrils, myoplasm, mitochondria, nuclei [satellite cells]) and correlate these with standard measures of anabolic signalling (e.g. detection of phosphorylation events in these pathways). (ukri.org)
Mitochondria represent about 5% of vascular smooth muscle cell volume, and 2-4% of endothelial cell volume. (holisticprimarycare.net)

Degradation of high-energy phosphates [ 36 ] and decreased mitochondrial respiratory control [ 21 ] were demonstrated in exercised muscle, indicating the energetic impairment. (scielo.org.ar)

Its central position in the sarcomere and the tight association to myosin are the basis for titin's role in maintaining the structural integrity of the sarcomere during the relaxation-contraction cycle. (frontiersin.org)

When a muscle contracts and shortens, the pennation angle increases. (wikipedia.org)
PCSA increases with pennation angle, and with muscle length. (wikipedia.org)
The twitch-interpolation technique evaluates central fatigue by assessing the level of central drive to the muscle (also called voluntary activation, VA). It involves a first percutaneous electric stimulation (PNS) of a nerve (or muscle motor point) during a maximal voluntary contraction (MVC), which normally increases the ongoing force-torque developed by the muscle (interpolated twitch). (nature.com)
2013). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. (greatist.com)
Intriguingly, when exposing individuals to either exclusive lengthening or shortening exercise training we have found that lengthening exercise increases muscle length and shortening exercise increases muscle width. (ukri.org)

4 ] used the relative skeletal muscle mass index which is calculated by normalizing appendicular skeletal muscle mass, measured by dual-energy X-ray absorptiometry, to height squared in meters to diagnose sarcopenia. (hindawi.com)

Reproducibility of knee extensor and flexor contraction velocity in healthy men and women assessed using tensiomyography: A registered report. (plos.org)
Langen G, Lohr C, Ueberschär O, Behringer M (2022) Reproducibility of knee extensor and flexor contraction velocity in healthy men and women assessed using tensiomyography: A study protocol. (plos.org)
The influence of loading intensity on muscle-tendon unit behavior during maximal knee extensor stretch shortening cycle exercise. (upsi.edu.my)

Enhancement of skeletal muscle in aged rats following high-intensity stretch-shortening contraction training. (cdc.gov)
slow- and fast-twitch muscles of rats. (edu.pk)

Rhythmic repetitive movements are also fundamental in activities of daily living and require low levels of muscle force (gait, typewriting, etc). (nature.com)

As such, a twitch provides information on muscle contractile properties and the functioning of the excitation-contraction coupling process. (plos.org)
She was awarded a DSc degree by the University of NSW in 1988 for her extensive research into muscle excitation-contraction coupling (ECC). (edu.au)
Excitation-contraction (EC) coupling is broadly defined as the signal transduction process that links a surface membrane action potential to contraction. (edu.au)

After one month, the extensor digitorum longus muscle was dissected out and force ofcontraction during fatigue in the skeletal muscle fibres was analysed on a computerised data acquisitionsystem. (edu.pk)

In 2014 he was awarded a King's Prize Fellowship to study a novel form of regulation of contractility in skeletal muscle based on the myosin filament. (kcl.ac.uk)

2010) Oxidative-nitrosative stress and its impact on vascular O2 transport to skeletal muslce, American College of Sports Medicine, Baltimore, MA. (utah.edu)

Behavior of fascicles and the myotendinous junction of human medial gastrocnemius following eccentric strength training. (upsi.edu.my)

In various experimental blocks, we validated a 3D-printed hand-fixation system permitting the execution of finger-tapping and maximal voluntary contractions (MVC). (nature.com)
Several formulas currently exist to calculate the rate of displacement during the contraction phase of the maximal twitch response. (plos.org)

The poultry sector is noted to make a considerable contribution to global nutrition and food security, which helps in the provision of cheap protein, essential micronutrients, and energy to humans ( 1 ). (frontiersin.org)

Dm provides information on skeletal muscle stiffness, morphological and structural changes [ 2 - 4 ]. (plos.org)

However, we currently understand little about the processes that regulate sarcopenia in humans. (ukri.org)

However, there was a clear contraction and time dependent transcriptional wave, with overrepresentation of genes associated with inflammation and cellular damage/apoptosis, and down-regulation of pathways concerning cellular metabolism. (gla.ac.uk)

Muscle fatigue induced by sustained contractions may develop at the muscle but also at neural levels (i.e., central fatigue) 1 . (nature.com)
For these reasons, we suggest that force and central drive to the muscle might not be key elements of neural adaptations of fatiguing repetitive movements. (nature.com)
The results show also that the neural influence that is associated with muscle fiber types is probably not mediated via the amount or pattern of activity of the motor units. (ucla.edu)
A second, and general question is how the neural networks in the lumbar spinal cord of mammals, including humans, control stepping and how this stepping pattern becomes modified by chronically imposing specific motor tasks on the limbs after complete spinal cord injury. (ucla.edu)

Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle. (upsi.edu.my)
Dr Bakker's research focuses on the mechanisms of muscle damage from sport and chronic diseases, including strenuous exercise, eccentric exercise and Duchenne muscular dystrophy. (edu.au)

The long-term goal of research in my lab is to understand the molecular mechanisms of muscle contraction. (bio5.org)

A new publication from King's researchers describes a new mechanism required for muscle contraction, which could have important implications for understanding. (kcl.ac.uk)

In further bad news (it's 2020 - there's enough for everybody), insulin resistance can also increase your risk for cancers of the colon and rectum. (greatist.com)
Conventional resistance exercise is composed of both lengthening and shortening muscle contractions (touch your shoulder and imagine lowering down a dumbbell (lengthening) and then lifting it again (shortening). (ukri.org)
Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)

Skeletal muscle is voluntary, meaning you can contract and extend it at will to run, jump, sit upright or type. (oxygenmag.com)
Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. (scireproject.com)

This activity-dependent improve in ROS manufacturing contributes to fatigue of skeletal muscle throughout strenuous train. (ncbcs.org)

Conversely, inactivity markedly decreases collagen turnover in both tendon and muscle. (fasciaguide.com)

William Roman, main author of the study and researcher at iMM and UPF Barcelona, explains: "Even in physiological conditions, regeneration is vital for muscle to endure the mechanical stress of contraction, which often leads to cellular damage. (scitechdaily.com)

The central drive to the muscle reduces when muscle force wanes during sustained MVC, and this is generally considered the neurophysiological footprint of central fatigue. (nature.com)
The question is if force loss and the failure of central drive to the muscle are responsible mechanisms of fatigue induced by un-resisted repetitive movements. (nature.com)
Our data suggest that force and central drive to the muscle are not determinants of fatigue induced by short-lasting un-resisted repetitive finger movements, even in the presence of increased inhibition of the motor cortex. (nature.com)
The question to be answered is if the failure of central drive to the muscle is a responsible mechanism of fatigue induced by different activities than those involving isometric contractions. (nature.com)
In addition to central fatigue, fatigue at peripheral level also reduces muscle performance. (nature.com)
Muscular fatigue causes a slowing of muscle contraction velocity, reversing as the muscle recovers from fatigue [ 21 - 24 ]. (plos.org)
Free radicals and muscle fatigue: Of ROS, canaries, and the IOC. (ncbcs.org)
Research in people, quadrupeds, and remoted muscle preparations point out that antioxidant pretreatment can delay muscle fatigue. (ncbcs.org)
NAC has been proven to inhibit fatigue in wholesome adults throughout electrical muscle activation, inspiratory resistive loading, handgrip train, and intense biking. (ncbcs.org)
These findings determine ROS as endogenous mediators of muscle fatigue and spotlight the significance of future analysis to (a) outline the mobile mechanism of ROS motion and (b) develop antioxidants as novel therapeutic interventions for treating fatigue. (ncbcs.org)
The role of ascorbic acid supplementation on force ofcontraction during fatigue of cold exposed skeletal muscles was evaluated in this study. (edu.pk)
in muscle fatigue. (edu.pk)

Further investigation of the myometrial and maternal peripheral response to uterine contractions in-vitro and in-vivo was also made with particular reference to the role of inflammation and myocyte damage. (gla.ac.uk)

Both cardiac and smooth muscles are involuntary, meaning you do not have conscious control over their actions. (oxygenmag.com)

Next, the team dissected the molecular mechanism of this observation: "Our experiments with muscle cells in the laboratory showed that the movement of nuclei to injury sites resulted in local delivery of mRNA molecules. (scitechdaily.com)
Researchers studied how triclosan affects human cardiac and skeletal muscles in the laboratory. (nyhealthinsurer.com)
His laboratory uses a combination of mechanical and structural methods, such as small-angle X-ray diffraction and fluorescence polarisation microscopy, to study the molecular mechanisms that control force generation in striated muscle at cellular and subcellular level. (kcl.ac.uk)
Studies are conducted with humans with spinal cord injury as well as with laboratory animals. (ucla.edu)
She returned to Australia in 1975 and established a Muscle Research Laboratory in the Department of Anatomy at The University of Sydney. (edu.au)
The Centre moved to the Australian National University in Canberra in 1984, where Dulhunty re-established the Muscle Research Laboratory. (edu.au)
Treatment with EDG-5506 led to a significant decrease in key biomarkers of muscle damage when assessed by laboratory assays. (businesswire.com)

The purpose of this mini-review is to discuss the implications sarcopenia has for the development of obesity and comorbidities that occur with aging. (hindawi.com)

Therefore, a shorter Tc is commonly associated with a higher contraction velocity [ 8 - 11 ]. (plos.org)
Fascicle length, pennation angle, lengthening and shortening velocity of their vastus lateralis muscle were analysed using ultrasonography method. (upsi.edu.my)
Comparison of force-velocity relationships of vastus lateralis muscle in isokinetic and in stretch‐shortening cycle exercises. (upsi.edu.my)

Results: The cold exposed group showed a significant delay in the force of contraction duringfatigue of skeletal muscle fibres compared to control group. (edu.pk)

Group III showed easy fatigability and abetter force of contraction than the cold exposed group. (edu.pk)

It is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in patients weighing at least 30 kg. (who.int)

Methods include single molecule atomic force microscopy (AFM), mechanical force measurements in permeabilized muscle cells, in vitro motility assays, biochemical enzyme and binding assays, immunofluorescent imaging, knockout/transgenic animal models and the development of a natural large animal model of HCM. (bio5.org)

Awai L, Bolliger M, Ferguson AR, Courtine G, Curt A. Influence of spinal cord integrity on gait control in human spinal cord injury. (scireproject.com)
Muscle atrophy is prevented in patients with acute spinal cord injury using functional electrical stimulation. (scireproject.com)
Assessment of functional improvement without compensation reduces variability of outcome measures after human spinal cord injury. (scireproject.com)

Concentric force enhancement during human movement. (upsi.edu.my)

MOTS-c has been shown to target the skeletal muscle and enhance glucose metabolism. (jaycampbell.com)

calcium handling in muscle. (edu.pk)

To induce experimental T1DM in animals, streptozotocin (STZ) has been widely used due to its cytotoxic activity against pancreatic β-cells [ 7,8 ], and chronic STZ-induced diabetic rodents mimic diabetic complications observed in diabetic humans [ 9 ]. (karger.com)
Insulin signaling is preserved in skeletal muscle during early diabetic ketoacidosis. (medscape.com)

The chemical also affects muscle function in fish and mice. (nyhealthinsurer.com)

Blocking this communication causes malfunction in both types of muscle cells. (nyhealthinsurer.com)
2. Delineate between the 3 types of muscle (skeletal, cardiac, and smooth)? (fsu.edu)

This myometrial transcriptional data therefore suggests that the inflammatory response of labour is associated with contraction, chemical or infection induced myometrial cellular damage, but would not be considered necessary for a contractile response. (gla.ac.uk)

We have shown that sarcopenia (viewed by DXA/ MRI) is due to specific architectural changes on an individual muscle level, viz: loss of sarcomeres in series and sarcomeres in parallel (by ultrasound). (ukri.org)

Sarcopenic muscles display wasting due to reductions both in muscle 'length ' at the muscle end, and muscle 'width' along the mid-section. (ukri.org)

2009) Effects of obstructive pulmonary disease and heart failure on skeletal muscle. (utah.edu)
Your heart is the hardest working muscle in your body, pumping approximately 5 quarts of blood per minute - that comes to about 2,000 gallons a day! (oxygenmag.com)
More narrowly the term encapsulates the processes that intervene between the action potential depolarization and Ca 2+ release from the SR. EC coupling in the heart depends on RyR activation by Ca 2+ ions that enter the muscle cell through the DHPR ion channel. (edu.au)
Skeletal muscle wasting occurs not only with older age but also with a large number of common illnesses: trauma, burn injury, diabetes, cancer, heart failure, renal failure, Alzheimer's disease, and arthritis (to name but a few). (ukri.org)
This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention. (news-medical.net)
Researchers from the University of Helsinki and the Folkhälsan Research Center, together with their international partners, have identified the genetic background of dilated cardiomyopathy, a disease that enlarges the heart muscle, in dogs and humans. (news-medical.net)
Based on a dataset encompassing more than 500 Dobermanns, the disease was associated with two nearby genomic loci, where changes were identified in genes that affect the functioning, energy metabolism and structure of the heart muscle. (news-medical.net)
The study revealed that these same risk genes cause heart muscle disease in human patients. (news-medical.net)
The identical genetic background suggests that, to a degree, similar problems with the functioning of the heart muscle lead to dilated cardiomyopathy in both humans and dogs. (news-medical.net)

Researchers used different in vitro models of injury and models of exercise in mice and humans to observe that upon injury, nuclei are attracted to the damage site, accelerating the repair of the contractile units. (scitechdaily.com)
The rate of muscle displacement is increasingly reported to assess contractile properties. (plos.org)
A muscle twitch is the contractile response to a single electrochemical signal of the nervous system or artificial electrical stimulation of the muscle. (plos.org)
In developing skeletal muscle, an important interplay between muscle cells and the ECM is present, and some evidence from adult human muscle suggests common signaling pathways to stimulate contractile and ECM components. (fasciaguide.com)

Unaccostumed overloading responses suggest an important role of ECM in the adaptation of myofibrillar structures in adult muscle. (fasciaguide.com)
This work is important to nanoparticle analysis as a result of it illustrates how nanoparticles can doubtlessly interrupt the autophagic pathway and has necessary implications for biomedical purposes of nanoparticles. (ncbcs.org)
To achieve this we will provide young and older volunteers with daily drinks of 'labelled water' from which we will be able to track longitudinal changes in important aspects in the building processes of muscle (by taking intermittent muscle samples from the muscle middle and end) over this entire period. (ukri.org)
To achieve this we will provide young and older volunteers with daily drinks of 'labelled water' during either lengthening or shortening contraction training after which we will be able to track longitudinal changes in important aspects in the building processes of muscle (by taking intermittent muscle samples from the muscle middle and end) over this entire period in youth and ageing. (ukri.org)
Aging is related to changes in muscle quantity and quality [ 1 ], both of which have important implications for functional performance [ 2 ]. (hindawi.com)

This review summarizes our current knowledge on titin as a central node for exercise-induced mechanosignaling and remodeling and further highlights the pathophysiological implications. (frontiersin.org)
Differential splicing of the titin gene results in numerous species- and muscle-specific titin isoforms. (frontiersin.org)
In the I-band part skeletal muscle titin is composed of a series of proximal Ig-domains, the N2A-domain (including the N2-A unique sequence), the PEVK domain [high abundance of proline (P), glutamic acid (E), valine (V), and lysine (K)] and the distal Ig-domains. (frontiersin.org)

2009) Exercise limitation in COPD: The role of skeletal muscle. (utah.edu)
2009) Richardson, R.S. (2009) Exercise limitation in COPD: The role of skeletal muscle. (utah.edu)
Lower-body muscle structure and its role in jump performance during squat, countermovement, and depth drop jumps. (upsi.edu.my)
He is also interested in the role of inflammatory mediators, such as cytokines and proteases, in muscle function. (edu.au)

Richardson, R.S. (2016) Vascular Aging and Mobility: Implications from Head to Toe. (utah.edu)

This project will have significant, perhaps groundbreaking, implications for our understanding of the control of skeletal muscle size in humans, particularly in relation to the problem of sarcopenia. (ukri.org)
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)

Your germicidal soap might contain triclosan , an effective antimicrobial agent that may also cause muscle impairment in humans. (nyhealthinsurer.com)

2008) Richardson, R.S. (2008) Skeletal muscle in COPD and CHF as targets for exercise training Exercise in Medicine, NTNU, Trondheim, Norwary. (utah.edu)
MOTS-c targets the skeletal muscle and acts on the folate cycle (one carbon pool) and inhibits the directly tethered de novo purine biosynthesis pathway. (jaycampbell.com)

Of course, it's always a large and fraught step from mice to humans, but if this discovery is transferable to humans, it could be used to allow organ function to be preserved when oxygen supply is limited, such as after a traumatic injury, the researchers say. (futurismic.com)
Warren Zapol, MD, the chief of Anesthesia and Critical Care at Massachusetts General Hospital and senior author of the study, sums it up: "This is as close to instant suspended animation as you can get, and the preservation of cardiac contraction, blood pressure and organ perfusion is remarkable. (futurismic.com)

If the central tendon branches within a pennate muscle, the muscle is called multipennate (Fig. 1C), as seen in the deltoid muscle in the shoulder. (wikipedia.org)

Muscle & Nerve, 39(6), 819-827. (upsi.edu.my)
In 1982 Dulhunty, with Professors Peter Gage and Peter Parry, was awarded and a Centre of Excellence for Nerve Muscle Research at the University of NSW. (edu.au)

Anatomy53

Organisms16

Diseases16

Chemicals and Drugs82

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes61

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena8

Information Science3

Health Care2

Fibers15

Cardiac muscle8

Proteins14

Physiology9

Tissue11

20211

Lipid1

Sarcoplasmic reticulum1

Metabolic3

Mitochondria2

Mitochondrial1

Sarcomere1

Increases5

Appendicular1

Knee extensor3

Rats2

Rhythmic1

Excitation3

Extensor1

Myosin1

Oxidative1

Gastrocnemius1

Maximal2

Protein1

Morphological1

Regulate1

Regulation1

Neural4

Eccentric2

Mechanisms of muscle1

Describes a new mechanism1

Resistance3

Voluntary2

Strenuous1

Decreases1

Physiological1

Fatigue12

Peripheral1

Smooth muscles1

Laboratory7

Obesity1

Velocity3

Fibres1

Fatigability1

Immunodeficiency virus1

Enzyme1

Spinal cord i3

Enhancement1

Glucose1

Calcium1

Diabetic2

Affects1

Types of muscle2

Cellular damage1

Sarcomeres1

Sarcopenic1

Heart9

Contractile4

Important5

Titin3

Role4

Vascular1

Control2

Impairment1

Targets2

Organ2

Shoulder1

Nerve2