Implicated in lipid metabolism basal metabolism. Medical search. Frequent questions

Dietary polyphenols have gained public interest in recent times due to their roles in the prevention of various diseases that implicate free radicals/reactive oxygen species. (frontiersin.org)

While the physiological role of adipose tissue in cholesterol and oxLDL metabolism remains to be established, the induction of OLR1 is a potential means by which PPARγ ligands regulate lipid metabolism and insulin sensitivity in adipocytes. (jci.org)
When activated, PPAR-γ up-regulates the transcription of genes mainly involved in fatty acid metabolism and triglyceride storage, promoting adipogenesis and lipids uptake to the adipose tissue [ 17 , 18 ] improving whole body insulin sensitivity. (biomedcentral.com)

Chronic high glucose dramatically influences β-cell lipid metabolism via substrate availability, changes in the activity and expression of enzymes of glucose and lipid metabolism, and modifications in the expression level of key transcription factors. (diabetesjournals.org)
The adipocyte is the major site of fatty acid storage in the body and plays a critical role in maintaining normal glucose and lipid homeostasis. (jci.org)

In the cell, RNF213 was shown to be involved in fatty acid metabolism ( 11 ), and to associate with intracellular lipid droplets in a manner dependent on its E3 ligase and ATPase activities ( 12 ). (biorxiv.org)

Oxidative and nitrosative stress caused by drug metabolism may be a trigger for keratinocyte apoptosis in the epidermis seen in toxic epidermal necrolysis (TEN) and Stevens Johnson syndrome (SJS). (e-ijd.org)

The cause of these lipid abnormalities in PE is unknown but disordered adipocyte function including exaggerated lipolysis and aberrant release of adipokines (such as IL-6 and TNF alpha) is a major candidate pathway. (gla.ac.uk)
The aims of this thesis were to acquire a better understanding of lipid metabolism and function in normal pregnancy, to determine if adipocyte function was altered in PE and, if so, to establish mechanisms. (gla.ac.uk)
Basal and lipopolysaccharide (LPS) stimulated adipocyte TNFα, IL-6, CCL-2, and CRP release was measured. (silverchair.com)
In addition, adipocyte basal lipolysis (55 %) and in vivo lipolysis index (30 %) were significantly decreased in apoCIII mice. (biomedcentral.com)
Thus, apoCIII overexpression resulted in increased NEFA availability to adipose uptake and decreased adipocyte lipolysis, favoring lipid enlargement of adipose depots. (biomedcentral.com)
Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)
If the capacity of the adipocyte to store lipids is exceeded, it can no longer regulate the release of FFAs into the circulation, which ultimately leads to the abnormal accumulation of lipid in nonadipose depots. (jci.org)
Obesity can be viewed as a state of long-term lipid disequilibrium that is marked by massive adipocyte hypertrophy and is a major risk factor for developing insulin resistance and type 2 diabetes. (jci.org)

Although the precise pathogenic mechanism of GDM has not been fully elucidated, it may occur as a result of abnormal glucose regulation and increased IR, inducing the disorders of glucose metabolism. (hindawi.com)
Microglia, the resident immune cells of the brain, are increasingly implicated in the regulation of brain health and disease. (biomedcentral.com)
As the field of microbiome research progresses, it is becoming increasingly clear that the microbes residing in and on the body play vital roles in the regulation of host physiology and metabolism. (layerorigin.com)
Accumulating evidence implicates IRE1α in the regulation of lipid metabolis. (researchgate.net)
This barrier also imparts distinctive function in immunology and microbiology of the skin by regulating inflammatory markers and modulation of the skin microbiome and indeed sebocytes recognition as immunomodulatory and immunocompetent cells is burgeoning through their contribution to production or regulation of cytokines, chemokines, adipokines such as leptin and lipid mediators. (hippocratesusa.com)
This novel and scientific network pharmacology-based study holistically deciphers that the pharmacological mechanisms of QXHC in the treatment of menstrual disorders may be associated with its involvement into hemopoiesis, analgesia, nutrients absorption and metabolism, mood regulation, as well as immune modulation. (biomedcentral.com)

The production of foie gras involves different metabolic pathways in the liver of overfed ducks such as lipid synthesis and carbohydrates catabolism, but the establishment of these pathways has not yet been described with precision during embryogenesis. (biomedcentral.com)
Dong and colleagues examined over 5,000 breast cancer patient samples and found that levels of the metabolic enzyme UGT8 were dramatically elevated in patients with basal-like breast cancer. (news-medical.net)
This natural inter-dependency between core microglial properties and metabolism offers a unique opportunity to modulate microglial activities via nutritional or metabolic interventions. (biomedcentral.com)
Systemic metabolism encompasses the metabolic inputs and outputs into all the cells and tissues of the body. (layerorigin.com)
Energy expenditure is facilitated by both stimulation of energy-consuming growth pathways (anabolism) as well as the burning of energy to support activity levels and basal metabolic needs (catabolism). (layerorigin.com)
With scientific evidence suggesting their role in inflammation, insulin sensitivity, and fat and energy metabolism, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)

suggested that metabolites of the dysfunctional propionic acid and methylmalonic acid pathways may be selectively toxic to the endothelial cells in the basal ganglia. (medscape.com)

Taken together, the inhibition of hsa_circ_0046060 expression in exosomes from GDM-derived UMSCs can alleviate GDM by reversing abnormal glucose metabolism and insulin resistance in vivo and in vitro . (hindawi.com)
Our study suggests that UGT8 contributes to the aggressiveness of basal-like breast cancer and that pharmacological inhibition of UGT8 by zoledronic acid offers a promising opportunity for the clinical treatment of this challenging disease,' Dong says. (news-medical.net)
Apart from these remarkable actions of vinpocetine it also acts though PDE1 inhibition Phosphodiesterases (PDEs) are the enzymes which reduce the level of cyclic nucleotides by their metabolism (Oliva Jr et al. (researchsquare.com)

This study proposes to describe the basal hepatic metabolism at the level of mRNA in mule duck embryos in order to reveal potential interesting programming windows in the context of foie gras production. (biomedcentral.com)
Hepatic lipid accumulation was also significantly reduced in caffeine treatment larvae. (biomedcentral.com)

Abstract The present study was performed to investigate the possible effects of wheat germ supplementation on lipid metabolism in humans. (cryonet.org)
But the study, which will be published May 4 in the Journal of Experimental Medicine , reveals that the widely used osteoporosis drug zoledronic acid inhibits UGT8 and prevents the spread of basal-like breast cancer in mice, suggesting that this drug could also be used to treat the disease in humans. (news-medical.net)
These organic compounds are often used in cell metabolism in humans, where they are partially converted into boric acid. (borates.today)

Thus the lipoprotein pattern was comparable to that obtained with the low fat diet, but the VLDL lipid composition remained altered. (cryonet.org)

The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)

How Does the Gut Microbiome Affect Absorption and Metabolism? (layerorigin.com)

Impaired glucose metabolism and insulin sensitivity have been linked to the pathogenesis of gestational diabetes mellitus (GDM). (hindawi.com)
Various genetic polymorphisms including IL-1 are implicated in pathogenesis of psoriasis. (e-ijd.org)
Our recent work had shown that patients suffering from chronic airway inflammation exhibit transcriptional reprogramming of MDM 14 , a cell type implicated in COVID-19 pathogenesis 7 . (nature.com)

There is acute 'atherosis' in PE placenta, and lipid accumulation within glomerular cells and liver. (gla.ac.uk)
Because of the advantage of transparent body in juvenile period suitable for identifying lipid accumulation in liver by whole-mount oil red O staining, in present study we attempted to determine whether juvenile zebrafish can be used as a model for diet-induced NAFLD. (biomedcentral.com)

However, prior studies have primarily focused on biological tissues outside of the basal ganglia, despite the known relevancy of this brain region in motor and cognitive dysfunction associated with PD and LBD. (mdpi.com)
Clinical and imaging evidence suggests that propionic acidemia predisposes patients to bilateral infarcts of the basal ganglia involving the caudate, putamen, and globus pallidus. (medscape.com)
Numerous theories regarding basal ganglia infarction resulting from the effects of these metabolites have been suggested. (medscape.com)
The authors confirmed that basal ganglia lesions were not due to hypoxemia, because the hippocampus, which is relatively more sensitive to hypoxemia, was spared. (medscape.com)
An alternative hypothesis implicates direct basal ganglia damage due to dysfunction of cytochrome-c oxidase. (medscape.com)
This excess glutamate may be excitotoxic to neuronal cells in the basal ganglia. (medscape.com)

ATRA perturbs the homeostasis of numerous lipids and the most relevant effects are observed on cardiolipins, which are located in the mitochondrial inner membranes and play a role in oxidative-phosphorylation. (slub-dresden.de)
Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)

UGT8 catalyzes the first step in the synthesis of sulfatide, a type of lipid that is found on the surface of cells and has been implicated in cancer progression. (news-medical.net)
Sebaceous glands' output is on a holocrine platform, built upon disintegration of sebocytes where their lipids synthesis into the droplets occurs. (hippocratesusa.com)

I determined ex vivo lipolytic activity (basal, isoprotenerol stimulated and insulin suppression of lipolysis) and adipokine production in response to lipopolysaccharide (LPS) stimulation from these biopsies. (gla.ac.uk)
TNF alpha is an important correlate of basal lipolysis in SAT. (gla.ac.uk)
We measured body energy balance, tissue capacity to store exogenous lipids, lipogenesis and lipolysis rates in non-transgenic and apoCIII overexpressing mice fed a HFD during two months. (biomedcentral.com)

There is growing evidence that reprogramming of cellular lipid metabolism contributes to malignant transformation and progression. (slub-dresden.de)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)

We first review the basics of microglial metabolism and the effects of common metabolites, such as glucose, lipids, ketone bodies, glutamine, pyruvate and lactate, on microglial inflammatory and phagocytic properties. (biomedcentral.com)

Lipogenesis rates were similar, while exogenous lipid retention was increased in perigonadal (2-fold) and brown adipose tissues (40 %) of apoCIII mice. (biomedcentral.com)
Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1). (biomedcentral.com)
We induced hepatoteatosis in zebrafish by overfeeding regimen and demonstrated caffeine have a role in suppression of hepatosteatosis by downregulation of genes associated with lipogenesis, ER stress, inflammatory response and enhancement of lipid oxidation, indicating zebrafish model may be used to identify putative pharmacological targets and to test novel drugs for human NAFLD treatment. (biomedcentral.com)

Vitamin D is a lipid-soluble hormone and micronutrient whose primary function is to regulate calcium and phosphorus homeostasis. (karger.com)

Therefore, the aim of the present study was to analyze a wide range of genes involved in liver development, cell stress, lipid and carbohydrate metabolisms throughout embryogenesis in mule ducks to better understand the ontogeny of pathways related to liver fattening. (biomedcentral.com)
Dong and colleagues found that breast cancer cells expressing high levels of UGT8 produce large amounts of sulfatide, which in turn activates signaling pathways crucial for the survival and metastasis of basal-like breast cancer. (news-medical.net)
Functionally, QXHC candidate targets were significantly associated with several biological pathways, such as VEGF and Chemokine signaling pathways, Alanine/aspartate/glutamate metabolism, Long-term depression and T/B cell receptor signaling pathway. (biomedcentral.com)

Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable. (news-medical.net)

Sebaceous products ought to be differentiated from skin surface lipids, and the two nomenclatures may not interchangeably be used since skin surface lipids are derived from two major sources, sebaceous glands which produces sebum, an oily substance, and makes up to 90% of skin surface lipids, and epidermal keratinocytes which give rise to epidermal, stratum corneum, lipids with equal amounts of ceramides, cholesterol and fatty acids. (hippocratesusa.com)

Interestingly, most mRNAs involved in lipid metabolism are overexpressed after hatching (FASN, SCD1, ACOX1), whereas genes implicated in carbohydrate metabolism (HK1, GAPDH, GLUT1) and development (HGF, IGF, FGFR2) are predominantly overexpressed from E12 to E20. (biomedcentral.com)

the implicated mechanisms are yet to be elucidated. (cryonet.org)
Lipid metabolism is implicated in cell differentiation and metastatic colonization and it is involved in the mechanisms of sensitivity/resistance to different anti-tumor agents. (slub-dresden.de)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)

Occult primary ovarian insufficiency presents as unexplained infertility in a patient with a normal basal serum follicle-stimulating hormone (FSH) level. (medscape.com)
Next on the continuum, biochemical primary ovarian insufficiency presents as unexplained infertility in patients with an elevated basal serum FSH level. (medscape.com)
This clinical state is characterized by elevated basal serum FSH levels in association with disordered menstrual cycles as demonstrated by oligomenorrhea, polymenorrhea, or metrorrhagia. (medscape.com)
The objectives of this population-based study were to investigate the potential association between bone mineral density (BMD) and serum lipid profiles and to compare the effects of serum lipids on BMD at various skeletal sites in pre- and post-menopausal women. (who.int)
Our data indicate a relationship between BMD values and serum lipid levels and suggest differences between pre- and post-menopausal women in terms of the effects of serum lipids on BMD at various skeletal sites. (who.int)

Emerging research implicates the microbiota's ability to modulate these interactions at two primary levels: energy balance and metabolite balance. (layerorigin.com)
Emerging data implicate both 5-LOX and FLAP in the disease process of cerebral ischemia [ 6 ]. (biomedcentral.com)

These proteins belong to different functional classes, such as inflammatory response, immune system and metabolism. (biomedcentral.com)

Authors Lairon D. Lacombe C. Borel P. Corraze G. Nibbelink M. Chautan M. Chanussot F. Lafont H. Title Beneficial effect of wheat germ on circulating lipoproteins and tissue lipids in rats fed a high fat, cholesterol-containing diet. (cryonet.org)

Thus, SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/ macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19. (nature.com)

Apart from MMD, RNF213 has been implicated in other vascular pathologies like intracranial atherosclerosis ( 3 ) and in angiogenesis, as shown by studies in mice ( 4 ), zebrafish ( 5 ), and tissue culture ( 4 , 6 ). (biorxiv.org)

Other molecules aside from SCFAs are also implicated in modulation of gastric hormone secretion. (layerorigin.com)

Cerebral ischemia-reperfusion (IR) triggers lipid peroxidation and inflammation, which exacerbate injury. (biomedcentral.com)

In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. (karger.com)

Sphingolipids constitute a complex class of bioactive lipids with diverse structural and functional roles in neural tissue. (mdpi.com)

Title Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects. (cryonet.org)

Sive first identified and named "basal constriction" as a cell-shape-change occurring during brain morphogenesis. (wikipedia.org)
We implemented a non-oriented mass-spectrometry based approach to define the lipidomic profiles of each cell-line grown under basal conditions and following treatment with ATRA. (slub-dresden.de)
In the cell, RNF213 is involved in lipid droplet formation, lipotoxicity, hypoxia, and NF-κB signaling, but its exact function in these processes is unclear. (biorxiv.org)

However some negative effects have also been observed (decrease in hatchability, slight decrease in quality of the final product) showing that a better understanding of the metabolism at the embryonic stage in ducks is needed. (biomedcentral.com)

Dong and colleagues confirmed that zoledronic acid is a direct inhibitor of UGT8 that reduces the levels of sulfatide in basal-like breast cancer cells. (news-medical.net)

One microbe implicated in mediating these differences is Akkermansia muciniphila , which resides in the mucus layer and helps to control gut permeability. (layerorigin.com)

Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)

This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)

The role played by lipids in the anti-tumor activity of ATRA has never been studied. (slub-dresden.de)
The novel classes of antifungal agents, the lipid formulation of amphotericins, and the echinocandins have demonstrated unique antifungal activity against the resistant Candida biofilms, providing a breakthrough in the treatment of life-threatening invasive systemic mycoses. (cdc.gov)

By studying transcriptome- and lipid mediator profiles in MDM of convalescent SARS-CoV-2-infected individuals with previous mild disease, we show that inflammatory gene expression and eicosanoid profiles as well as altered responsiveness to inflammatory cues are maintained at 3-5 months post infection as well as throughout macrophage differentiation. (nature.com)

Anatomy3

Organisms1

Diseases3

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes18

Technology, Industry, Agriculture2

Reactive oxygen1

Adipose tissue2

Glucose and lipid2

Involved in fatty acid metab1

Drug metabolism1

Adipocyte8

Regulation6

Metabolic6

Endothelial cells1

Inhibition3

Hepatic2

Humans3

Lipoprotein1

Tumor metabolism1

Absorption and Metabolism1

Pathogenesis3

Accumulation2

Ganglia6

Oxidative2

Synthesis2

Lipolysis3

Cellular2

Metabolites1

Lipogenesis3

Homeostasis1

Pathways3

Progression1

Fatty1

MRNAs1

Mechanisms3

Serum5

Emerging2

Proteins1

Cholesterol1

Immune1

Mice1

Modulation1

Inflammation1

Diabetes1

Tissue1

Plasma1

Cell3

Effects1

Reduces1

Differences1

Levels1

Survival1

Activity2

Profiles1