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  • efficacy of adoptive
  • We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred. (nih.gov)
  • In this proposal, we aim to evaluate the safety and estimate the efficacy of adoptive cellular therapy targeting CMV pp65 during hematopoietic recovery from TMZ-induced lymphopenia in patients with newly-diagnosed GBM. (grantome.com)
  • Dendritic
  • The cost of ACT is, however, much lower than a full course of other immunotherapies, such as the dendritic cell vaccine Provenge (which is not indicated for melanoma) or the immunotheraputic MAb drug ipilimumab, both of which cost approximately $120,000. (biopharmconsortium.com)
  • targets
  • The recent finding and confirmation by four independent laboratories, including ours, that human cytomegalovirus (CMV) propagates within a high proportion of GBMs, without infecting surrounding normal brain, provides an unparalleled opportunity to direct brain tumor immunotherapy against well-characterized and highly immunogenic viral targets. (grantome.com)
  • systemic
  • The effect of whole-body sublethal irradiation appeared to eliminate a systemic host suppression mechanism, since partialbody irradiation involving the tumor-bearing area did not permit successful immunotherapy. (aacrjournals.org)
  • immunity
  • To determine if adoptive immunotherapy with donor-derived CD4+ and CD8+ CMV- specific cytotoxic lymphocyte cell lines can augment T-cell immunity and treat CMV infection post transplant in a patient with severe combined immunodeficiency syndrome. (clinicaltrials.gov)
  • Strategies to reconstitute immunity by adoptive transfer of EBV-specific cytotoxic T lymphocyte (CTL) therapy while highly effective in the HSCT setting where immunosuppression can be withdrawn have been less successful in the SOT setting where continued immunosuppression therapy is necessary. (jpt.com)
  • transfer
  • Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. (nih.gov)
  • Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy," Journal of Immunology Research , vol. 2015, Article ID 902137, 8 pages, 2015. (hindawi.com)
  • Additionally, the complexity and time taken to generate EBV-CTLs for adoptive transfer limit the clinical applicability. (jpt.com)
  • potential
  • Immunotherapies have the potential to fulfill this need, since they are highly tumor-specific and cause minimal bystander cell damage. (dana.org)
  • And although it has highlighted the tangible potential for an immunotherapy to reach approval, the attention garnered by these approaches also has underscored the need for significant improvements in bioprocessing technologies and capacities to meet potential and expected market requirements. (bioprocessintl.com)
  • Research on the mechanistic basis of adoptive immunotherapy, as well as on means to improve ACT technologies, is ongoing, so there is the potential to improve the durable complete response rate further. (biopharmconsortium.com)
  • viral
  • The principle behind the company's business is based on the emerging field of adoptive immunotherapy , or biological therapy, which has been successfully used around the world to treat a wide variety of cancers and chronic viral infections. (thefreedictionary.com)