Finally, TBI was no longer needed to regress tumors in mice who were depleted of host CD4 + T cells, given a tripartite ACT regimen and then treated with low dose LPS. (biomedcentral.com)
Collectively, their work revealed the importance of gasdermins in cancer immunity and paved the way for therapies now in the pipeline that target gasdermins to make tumors visible to the immune system and improve immunotherapy's effectiveness. (cancerresearch.org)
Dr. Martin Algarra areas main of interest have been the therapeutic development of immunotherapy and targeted therapies in Oncology, mainly in melanoma, sarcoma, and rare tumors. (unav.edu)
In this report, the biologic functions of MDSC are defined and evidence linking MDSC with the response to cancer immunotherapies in solid tumors are reviewed. (iospress.com)
However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. (mdpi.com)
Cells31
Adoptive cell transfer (ACT) is the transfer of cells into a patient. (wikipedia.org)
In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. (wikipedia.org)
In some patients, the administered antitumor cells represented up to 80% of the CD8+ T cells months after the infusion. (wikipedia.org)
Background Adoptive T cell transfer (ACT) therapy improves outcomes in patients with advanced malignancies, yet many individuals relapse due to the infusion of T cells with poor function or persistence. (bmj.com)
T cells expanded ex vivo from a CpG-treated culture demonstrated potent antitumor efficacy and prolonged persistence in vivo. (bmj.com)
CpG fostered the expansion of potent CD8 + T cells with the signature phenotype and antitumor ability via empowering a direct B-T cell interaction. (bmj.com)
Conclusions Our results demonstrate a novel way to use TLR agonists to improve immunotherapy and reveal a vital role for B cells in the generation of potent CD8 + T cell-based therapies. (bmj.com)
In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)
B16F10-bearing mice were preconditioned with 5Gy TBI and given a tripartite ACT therapy (consisting of transferred pmel-1 CD8 + T cells, vaccination with fowlpox encoding gp100, and IL-2) along with TLR4 agonist LPS. (biomedcentral.com)
In contrast, administering LPS after ACT potentiated the antitumor effectiveness of the regimen, thereby supporting the expansion of transferred tumor-specific CD8 + T cells over host CD4 + T cells. (biomedcentral.com)
We also found that non-toxic TLR agonists MPL and CpG potentiated the antitumor activity of infused CD8 + T cells. (biomedcentral.com)
A non-myeloablative lymphodepleting preparative regimen with 5Gy TBI prior to an ACT regimen can induce destruction of B16F10 melanoma in mice by removing cytokine sinks, depleting suppressive T reg cells, transiently ablating myeloid derived suppressor cells (MDSCs) and activating the innate immune system [ 11 ]. (biomedcentral.com)
TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
Here, the utility of OX40, a costimulatory molecule mainly expressed on activated effector T cells known to play an important role in eliminating cancer cells, was evaluated as a PET imaging biomarker to quantify and track response to immunotherapy. (aacrjournals.org)
Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8 + T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. (biomedcentral.com)
The antitumor immunity helps eliminate the uninfected cancer cells in primary and metastatic nodules, and enforce micrometastases in dormant state. (biomedcentral.com)
However, cancer cells exploit these checkpoints to evade immune surveillance and suppress antitumor immune responses. (biomedcentral.com)
Researchers have previously shown that mitophagy (the recycling and renewal of mitochondria) in mouse epithelial cells can increase CD8+ T cells in early intestinal tumorigenesis, but the efficacy of immunotherapy is limited by T cell exhaustion. (frontlinegenomics.com)
Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. (ijbs.com)
Immunotherapy with CAR-T cells has achieved tremendous successes in treatment of hematological malignancies. (ijbs.com)
Among PSCs, the donors available for induced pluripotent stem cells (iPSCs) are greatest, providing a potentially universal cell source for all types of cell therapies including cancer immunotherapies using natural killer (NK cells). (molcells.org)
There already exist several protocols to genetically modify and differentiate iPSCs into NK cells, and each has its own advantages with regards to immunotherapies. (molcells.org)
Tumor-specific neoantigens, which are expressed on tumor cells, can induce an effective antitumor cytotoxic T-cell response and mediate tumor regression. (wjgnet.com)
Cancer immunotherapies, which target neoantigens, could lead to a precise treatment for cancer patients, despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual patients. (cancerbiomed.org)
Therapies2
Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)
Immunotherapy is one of the novel treatment modalities that include the checkpoint blockade therapy, personalized cancer vaccines, and adoptive T-cell therapies. (cancerbiomed.org)
Immunity3
To determine the mechanisms of how innate immune activation via lymphodepletion potentiated antitumor T cell immunity, we utilized the pmel-1 melanoma mouse model. (biomedcentral.com)
The paper, published in the journal Immunity , demonstrates how urolithin A (UA) could be used to prevent T cell exhaustion and improve the effectiveness of cancer therapy. (frontlinegenomics.com)
Efficacy2
This antitumor efficacy was accomplished without in vivo administration of TLR agonists or other adjuvants of high-dose interleukin (IL)-2 or vaccination, which are classically required for effective ACT therapy. (bmj.com)
Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
Innate1
Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. (biomedcentral.com)
Immunogenicity2
This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)
Nevertheless, there is an established way through which to increase the immunogenicity of immunotherapy-by the use of adjuvants. (mdpi.com)
Melanoma3
How lymphodepletion augments ACT in these various clinical trials has been elucidated in clinically relevant mouse models of melanoma. (biomedcentral.com)
Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
Therapeutic3
AIM OF THE STUDY: To elucidate therapeutic effect of PH for CI as well as its underlying mechanisms with LPS-treated mice model. (bvsalud.org)
To demonstrate the therapeutic potential of UA, the team used UA food supplements in a mouse preclinical model and showed how this limited tumour growth. (frontlinegenomics.com)
Human clinical trials that investigate possible MDSC modulators are highlighted, and therapeutic strategies to leverage MDSC biology in bladder cancer immunotherapy are outlined. (iospress.com)
Patients7
Toll-like receptor (TLR) agonists can invigorate antitumor T cell responses when administered directly to patients, but these responses often coincide with toxicities. (bmj.com)
TIME influences the immune escape of cancer, the response to immunotherapy, and the survival rate of patients. (biomedcentral.com)
Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in patients with glioblastoma treated with immunotherapy. (aacrjournals.org)
Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
Precise prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients. (cancerbiomed.org)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
We first demonstrated that myeloma bearing-Balb/c mice initially respond clinically to irradiation and auto-BMT but eventually relapse, similar to MM patients undergoing induction therapy and ASCT. (biomedcentral.com)
Checkpoint blockade1
The team's results support the use of UA in combination with immune checkpoint blockade or in adoptive T cell therapy. (frontlinegenomics.com)
Agonists2
Herein, we used TLR4 agonist LPS as a tool to address how and when to use TLR agonists to effectively improve cancer immunotherapy. (biomedcentral.com)
Collectively, our results identify how and when to administer TLR agonists to augment T cell-based immunotherapy in the absence or presence of host preconditioning for treatment of advanced malignancies. (biomedcentral.com)
Inhibitors2
Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. (unav.edu)
Cancer immunotherapies, including immune checkpoint inhibitors, would be one of the potential approaches to apply the results of genomic sequencing most effectively. (cancerbiomed.org)
Precision1
In this review, we will discuss the current status and future direction of implementing cancer precision medicine in the clinical setting, specially focusing on the personalized immunotherapies. (cancerbiomed.org)
Effective2
Their work has deepened our understanding of the immune system's response to cancer and other diseases and advanced the development of effective immunotherapies. (cancerresearch.org)
Immunotherapy is among the most effective approaches for treating cancer. (mdpi.com)
Combination2
By possibly improving combination therapy with existing immunotherapies, the study opens up meaningful possibilities for further application in the clinic. (frontlinegenomics.com)
To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)
Survival1
Their isolation and infusion into MM-bearing mice resulted in a vigorous GvM response without induction GvHD and long-term survival. (biomedcentral.com)
Cancers2
The remarkable achievements witnessed in various cancers using monoclonal antibodies (mAb) targeting CTLA-4 and PD-1, exemplify the effectiveness and power of ICB therapy strategies [ 17 , 18 ]. (biomedcentral.com)
In recent years, immunotherapies have led to remarkable strides in treating certain cancers. (mdpi.com)
Response1
One of the key aspects for successful immunotherapy is to achieve a strong and stable antitumor immune response. (mdpi.com)
Transfer1
Adoptive cell transfer (ACT) is the latest arsenal in the battle against cancer. (molcells.org)
Donor1
2002, Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. (penpublishing.net)
Therapy1
Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)
Clinical trials1
Among tumor immunotherapies, neoantigen vaccines are in early human clinical trials and have demonstrated substantial efficiency. (wjgnet.com)
Agents1
Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. (biomedcentral.com)
Discuss1
In this short review, we detail the benefits of using iPSCs in NK cell immunotherapies and discuss the challenges that must be overcome before this approach becomes mainstream in the clinic. (molcells.org)
Study2
METHODS AND MATERIALS: In this study, male C57BL6/J mice received lipopolysaccharide (LPS) injection for 10 days to establish CI model and were administrated with PH for 14 days. (bvsalud.org)
Finally, knowledge gaps and areas for advancement in the study of MDSC to enhance bladder cancer immunotherapy are presented. (iospress.com)
Long-term1
Our results indicate that cancer immunotherapies can prevent intracranial progression, maintaining long-term effects intracranially as well as systemically. (bvsalud.org)
Effects2
High UA diets have already been shown to reduce the effects of aging and to increase recovery of muscle function in mice with Duchenne muscular dystrophy. (frontlinegenomics.com)
In addition, intracranial progression is common during systemic treatments due to the inability to penetrate central nervous system (CNS) barriers, whereas the intracranial effects of cancer immunotherapies remain unclear. (bvsalud.org)