Immunosuppressive therapy regimens organ recipients organ transplanted. Medical search. Frequent questions

The two belatacept-based regimens evaluated in the study did not employ long-term use of prednisone (a corticosteroid) or tacrolimus (a calcineurin inhibitor). (sciencedaily.com)
Her maintenance immunosuppressive regimen included tacrolimus, mycophenolate mofetil, and prednisone. (cdc.gov)
1 . Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. (drugbank.com)
Recipients in the low-dose tacrolimus + daclizumab group had a 3.8% better 1-year graft survival, a 1.8% lower incidence of acute rejection, and a creatinine clearance at 1 year which was 2.3 ml/min higher (relative increase 4%) compared to patients in the standard-dose ciclosporin group without daclizumab. (5dok.net)
In one study of 121 kidney transplant recipients treated with a tacrolimus- and mycophenolate-based regimen, the incidence of hyperuricemia at one year posttransplant was 38 percent [ 9 ]. (medilib.ir)
In the retrospective study of Medicare recipients cited above, the incidence of new-onset gout at three years posttransplant was lower with tacrolimus compared with cyclosporine (6.1 versus 7.9 percent) [ 11 ]. (medilib.ir)
Another immunosuppressive medication, tacrolimus, is currently used in the vast majority of lung transplant recipients and was common to all patients in the study. (sciencedaily.com)
The typical regimen consists of three drugs: tacrolimus, a cell cycle inhibitor, and steroids (prednisone)," said Dr. Wijesinha. (sciencedaily.com)
The majority of patients in the database, nearly 5,800, were given MMF plus tacrolimus, a combination that has become the de facto standard immunosuppression after lung transplant. (sciencedaily.com)
Sirolimus plus tacrolimus maintenance therapy was provided to slightly more than 200 patients. (sciencedaily.com)
Solid organ transplant patients are usually maintained on a corticosteroid combined with a calcineurin inhibitor (ciclosporin or tacrolimus), or with an antiproliferative drug (azathioprine or mycophenolate mofetil), or with both. (obaid.info)
The introduction of calcineurin inhibitor (CNI) therapy - first cyclosporine (CsA) in the 1980s and later tacrolimus - was initially hampered by early dosing regimens that led to a wide variety of side effects. (biomedcentral.com)

In both arms, urine CXCL10 levels were monitored at three specific time points (1, 3, and 6 months post-transplant). (bvsalud.org)
We present the clinical course of 3 kidney transplant recipients who developed HZ after transplantation at different times post-transplant with varying clinical manifestations. (scienceopen.com)
Careful pretransplant screening, immunization, and post-transplant prophylactic antimicrobials may all reduce the risk for post-transplant infection. (scienceopen.com)
This article reviews common post-transplant infections, including prophylactic, diagnostic, and treatment strategies, providing guidance regarding care of kidney transplant patients with infection. (scienceopen.com)
Medical diagnosis of severe rejection Within this research the occurrence and intensity (dependant on histological quality) of severe rejection Atorvastatin calcium through the post-transplant period had been noticed. (biospraysehatalami.com)
As of December 1993, RATG was routinely used with a dose of 1.5 mg/kg given intravenously on post-transplant days 1, 2, 3, 5, and 7 after pre-medication with diphen- hydramine and acetaminophen. (pdfdrugs.com)
OKT3 (5 mg/kg) was given intravenously on post-transplant days 1 to 5 with Methylprednisolone 500 mg IV was given to all patients immediately before reperfusion. (pdfdrugs.com)
Chronic GVHD usually occurs at about three months post-transplant, although in some cases it may not develop for a year or more after the transplant. (drcremers.com)
However, increasing evidence has shown the same features of chronic histological damage as early as three months post-transplant. (biomedcentral.com)
Nephrotoxicity in the first year post-transplant correlates with the 60% rate of such pathology in CNI-treated recipients [ 6 ]. (biomedcentral.com)
To provide outstanding multidisciplinary clinical care for pre- and post-transplant patients with cancer. (cancerandtransplant.org)
Post-transplant lymphoproliferative disorder (PTLD) is a leading cause of cancer death in solid organ transplant recipients (SOTRs). (cancerandtransplant.org)

Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
Principles, such as reliance on living organ donors and payments for organs, have increased in some places over the past dozen years. (who.int)
To improve cell health, he increased the dose of cells - using tissue from two to four donors per recipient - and reduced the time between harvesting and implantation. (ashdin.com)
Kidneys (and other organs) from HIV-infected deceased donors are discarded. (scielo.org.za)
Arguments are presented that led to our initiation of renal transplantation from HIV-positive deceased donors to HIV-positive recipients at Groote Schuur Hospital, Cape Town. (scielo.org.za)
Both were from cytomegalovirus (CMV) positive donors and the recipient was CMV positive as well. (hindawi.com)
Many of those issues are overcome by organ registries, in which individuals choose to become organ donors. (britannica.com)
Through such registries, donors can indicate which organs they are willing to donate upon death. (britannica.com)
Furthermore, there is a danger of commercial interests becoming involved with people willing to sell their organs for personal gain, and there is definite risk of illegal organ trafficking, in which organs are procured from unwilling donors and then sold to facilities that offer transplant services. (britannica.com)
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. (lookformedical.com)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)

However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. (ersjournals.com)
After single LTx, survival after BOS onset is longer in recipients with emphysema compared with recipients with idiopathic pulmonary fibrosis 8 . (ersjournals.com)
When the cohort of deceased donor single kidney recipients between 1994 and 2007 (n=99,860) is studied, all important end points after transplantation, including acute rejection and graft survival, are strongly influenced by a few hours rise in cold ischemic time above 8 hours (Figure 1a-e). (5dok.net)
Heart transplant remains the gold standard therapy for patients with end stage heart disease and offers improved survival and quality of life. (lidsen.com)
Long term survival of heart transplant recipients is limited by chronic rejection, cardiac allograft vasculopathy (CAV), and malignancy. (lidsen.com)
Short-term survival following heart transplantation has improved with the evolution of transplant immunology & immunosuppressive therapy, advances in organ preservation & surgical techniques, as well as diagnosis & management of acute rejection. (lidsen.com)
Future studies should aim to characterize the relationship between different immunosuppressive regimens (combinations, doses), melanoma risk, incidence of metastatic disease, and survival. (medscape.com)
There were no significant differences in survival, acute rejection rate, freedom from BOS, norinfection between single and double lung transplant recipients. (pdfdrugs.com)
Induction therapy with RATG(group V) was associated with significantly improved survival and freedom from acute rejection,BOS, and infection when compared to OKT3 induction therapy (group IV). (pdfdrugs.com)
An earlier impression that RATG is superior to OKT3 induction therapy has borne true in terms ofoverall survival and incidence of BOS, acute rejection and infection rates. (pdfdrugs.com)
Since OB is difficult to diagnose, a committee sponsored by now accepted as appropriate treatment for end-stage the International Society for Heart and Lung Transplan- tation (ISHLT) proposed a clinical description of OB, One-year survival for lung transplant recipients has termed bronchiolitis obliterans syndrome This risen from 47% in 1988 to 75% in 2001. (pdfdrugs.com)
Existing immunosuppressive drugs for organ transplantation may achieve sufficient immunosuppression to prevent organ rejection or limit autoreactivity, but they are typically not successful in achieving long-term survival of the graft or preventing progression of fibrosis and chronic rejection [ 3 ]. (biomedcentral.com)
Median survival after lung transplant is less than six years. (sciencedaily.com)
To see what might help lung transplant recipients live longer, researchers analyzed US lung transplant data, focused on immunosuppression regimes, and found a drug combination that appears to significantly extend patient survival. (sciencedaily.com)
Lung transplantation can prolong the lives of patients with end-stage lung disease, but the median survival rate after lung transplant is less than six years, which has improved only slightly in recent decades. (sciencedaily.com)
What we found could improve survival of lung transplant patients on a larger scale. (sciencedaily.com)
Using a database of over 9,000 lung transplant patients maintained by the United Network for Organ Sharing (UNOS), the researchers categorized patients by their immunosuppression regimen and compared survival rates. (sciencedaily.com)
They singled out an immunosuppressive drug called sirolimus, in a class of drugs called cell cycle inhibitors, based on a few small, long-term studies that found dramatically improved survival, reduced incidence of chronic rejection, and improved lung function in lung transplant patients who took sirolimus. (sciencedaily.com)
Sullivan and colleagues developed a transplantation conditioning regimen that included high-dose chemotherapy plus whole-body radiation to fully destroy the patient's defective immune-forming system to improve survival and diminish the effects of the disease. (dukehealth.org)
The primary endpoint at 54 months was a global rank composite score based on a hierarchy of scleroderma features including survival, organ function, quality of life, and skin hardening. (dukehealth.org)
Overall survival at 72 months was 86% after transplant vs 51% after cyclophosphamide-a highly significant benefit. (dukehealth.org)
In parallel to better patient care and new immunosuppressive regimens the median survival of renal allograft improved continuously. (imedworks.com)
Mycophenolate mofetil has been demonstrated to inhibit immunologically mediated inflammatory responses in animal models and to inhibit tumor development and prolong survival in murine tumor transplant models. (nih.gov)
IF/TA is associated with decreased graft survival, especially when it is accompanied by transplant vasculopathy, subclinical rejection, or transplant glomerulopathy. (biomedcentral.com)
In a 3-month protocol biopsy study in which biopsies were classified according to the presence or absence of arterial intimal thickening, graft survival was significantly reduced in patients with transplant vasculopathy [ 3 ]. (biomedcentral.com)
The simultaneous presence of IF/TA and incipient transplant glomerulopathy implies a shorter graft survival than the presence of IF/TA without transplant glomerulopathy. (biomedcentral.com)

He underwent a first RT in 2000, with cyclosporine (CyA), mycophenolate mofetil (MMF), and prednisolone as immunosuppressive therapy. (hindawi.com)
Only physicians experienced in immunosuppressive therapy and management of renal, cardiac or hepatic transplant patients should prescribe mycophenolate mofetil. (nih.gov)
Mycophenolate mofetil was used alone or in combination with other immunosuppressive agents in these studies. (nih.gov)

In addition, melanomas appear to be more lethal in elderly and male transplant recipients, and those who continue immunosuppressive therapy with cyclosporine or sirolimus. (medscape.com)
EPIDEMIOLOGY AND RISK FACTORS - Hyperuricemia and gout are common in kidney transplant recipients, particularly in those receiving the calcineurin inhibitor cyclosporine to prevent graft rejection [ 1,2,5-15 ]. (medilib.ir)
In one study of kidney transplant recipients, the incidence of hyperuricemia was 84 percent in those treated with cyclosporine and prednisone versus 30 percent in those treated with azathioprine and prednisone [ 1 ]. (medilib.ir)
Since the first successful kidney transplantation as early as the early 1950s, immunosuppressive therapies improved considerably, the most revolutionary development being the introduction of cyclosporine in the early 1980s. (imedworks.com)
Cyclosporine (CsA) is a calcineurin inhibitor that prevents allograft rejection after solid organ transplantation. (ectrx.org)

The aim of this study was to analyse patient and graft outcomes of kidney allograft recipients stratified by donor age. (bvsalud.org)
Objective: To investigate long-term outcomes of adult renal allograft recipients receiving a kidney from small pediatric donor (SPD) in terms of kidney function and early features of hyperfiltration injury such as histological changes and proteinuria. (bvsalud.org)
Drug development of immunosuppressive therapies (ISTs) for use in transplantation has historically focused on morbidity and mortality as the primary clinical outcomes of interest, with patient experiences often being an afterthought. (lww.com)
In transplanted patients the incidence of this opportunistic agent is even more frequent, with 512 cases/100.000 inhabitants/year and it is often linked to adverse outcomes [ 1 - 3 ]. (hindawi.com)
This knowledge with single-dose basiliximab for induction therapy in DCD kidney transplantation demonstrated that favorable scientific outcomes had been achieved with regards to graft success and function within 12 months. (biospraysehatalami.com)
The purpose of this study was to review a single institution'slong-term experience with single and double lung transplantation and to assess the effect ofdifferent immunosuppressive therapies on outcomes. (pdfdrugs.com)
Because most Coccidioides infections resolve without specific therapy, few clinical trials have assessed outcomes in less-severe disease. (medscape.com)
Close coordination of care between the medical oncologist and transplant specialist is encouraged to help optimize treatment outcomes. (cancerandtransplant.org)

Kidney transplant recipients require lifelong immunosuppression to prevent organ rejection. (scienceopen.com)

Rarely, living adult (usually parent-to-child) lobar transplantation is done when deceased-donor organs are unavailable. (msdmanuals.com)
Another area of ethical concern is the dilemma posed by the shortage of donor organs. (britannica.com)
Advances in immunosuppressive therapy have put increasing pressure on the supply of donor organs, and medical personnel sometimes find themselves having to determine who among the potential recipients should receive a lifesaving graft. (britannica.com)

[ 3 ] Corticosteroids are used as adjunctive initial therapy only in patients with HIV infection who have severe PJP. (medscape.com)
The BEST study is the first large, multicenter trial to remove both corticosteroids and CNIs from a patient's drug regimen after kidney transplantation. (sciencedaily.com)
prophylaxes of acute renal, cardiac, or hepatic transplant rejection (in combination with ciclosporin and corticosteroids). (obaid.info)
dose lower if given concomitantly with other immunosuppressant therapy (e.g. corticosteroids). (obaid.info)

Further, the U.S. Food and Drug Administration has not approved any immunosuppressive drugs or drug regimens specifically for use in patients with a lung transplant. (sciencedaily.com)

As a result, conventional immunosuppressive drug treatment remained the standard of care in the United States. (dukehealth.org)
prophylaxis of organ rejection in liver, kidney, and heart allograft recipients and allograft rejection resistant to conventional immunosuppressive regimens. (obaid.info)

CNIs have also shown toxicity to transplanted kidneys. (sciencedaily.com)
However, with the advent of highly active antiretroviral therapy (HAART), renal transplantation using HIV-negative donor kidneys has successfully been employed for HIV-infected patients with end-stage renal failure. (scielo.org.za)
The transplantation of HIV-positive donor kidneys to HIV-infected recipients is now a viable alternative to chronic dialysis or transplantation of HIV-negative donor kidneys. (scielo.org.za)
Deceased donor kidneys should always be transplanted as soon as possible, for a few hours reduction in cold ischemic time will result in a significant and clinically relevant improvement in outcome. (5dok.net)
For many years, chronic allograft nephropathy (CAN) was used to describe the progressive loss of renal function in transplanted kidneys over time not related to acute rejection. (biomedcentral.com)

Mycophenolic acid is an antimetabolite immunosuppressant indicated for prophylaxis of organ rejection in adult patients receiving kidney transplants and in pediatric patients at least 5 years of age and older who are at least 6 months post kidney transplant. (drugbank.com)
Fourteen days after the medical procedures all recipients received anti-prophylaxis with sulfamethoxazole/trimethoprim Atorvastatin calcium for three months. (biospraysehatalami.com)
Appropriate patient surveillance and prophylaxis are essential to ensure the best long-term kidney transplant results. (lidsen.com)
It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)

In one study, pediatric recipients of liver transplants, when compared with other groups of chronically ill children, scored lower in many motor and psychological tests and obtained fewer academic achievements. (medscape.com)
it varies between 1 and 2% in pediatric renal transplant recipients and up to 20% in recipients of lung or intestinal transplants [2-4]. (colinsbraincancer.com)
Current applications and safety profile of laser interstitial thermal therapy in the pediatric population: a systematic review of the literature. (omeka.net)
OBJECTIVE: Laser interstitial thermal therapy (LITT) provides a minimally invasive alternative to open brain surgery, making it a powerful neurosurgical tool especially in pediatric patients. (omeka.net)

Despite advances in the field, transplant recipients may face several avoidable risks. (who.int)
The Technological advances in transplantation have enabled thousands of procedures that benefit organ and tissue recipients worldwide. (imedworks.com)
Despite advances in therapy, the infection continues to be associated with significant morbidity and mortality. (unboundmedicine.com)
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2021 0 0. (cdc.gov)

52 years at transplantation and receiving a liver transplant. (cdc.gov)
a Early treatment refers to starting within the first 2 weeks after liver transplant but preferably within the first week when the patient is clinically stable. (hcvguidelines.org)
Organ Transplant Rejection, Prevention of Cardiac Transplant Rejection, Prevention of Kidney Transplant Rejection, Prevention of Liver Transplant Rejection, Graft Versus Host Disease, Prevention of Graft Versus Host Disease, Prevention of Lung Transplant Rejection, Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia. (obaid.info)

For the 16,000 people who receive a kidney transplant in the U.S. each year, the standard of care involves a post-surgery regimen that includes corticosteroid and calcineurin inhibitor (CNI) immunosuppressants -- drugs that for decades have helped organ transplant patients live, but can also come with long-term effects such as kidney toxicity or cardiovascular damage. (sciencedaily.com)

Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)

Unfortunately, this therapeutic strategy is vulnerable by the occurrence of chronic rejection, which occurs when the recipient's immune response impairs the transplanted organ through microvascular disruption. (biomedcentral.com)
To prevent chronic rejection, the most common cause of death after a lung transplant, patients must take immunosuppressive drugs for the rest of their lives. (sciencedaily.com)

Abstract Background The incidence of herpes zoster is up to 9 times higher in immunosuppressed solid organ transplant recipients than in the general population. (scienceopen.com)
In a retrospective cohort study of 29,597 United States Medicare kidney transplant patients, the cumulative incidence of new-onset gout was 7.6 percent at three years posttransplant [ 11 ]. (medilib.ir)

The transplantation of solid organs, such as kidney, liver, heart or lung, is increasingly a regular component of health care in all countries, and is no longer a feature of health care in high-income countries alone. (who.int)
Of the 70 000 or so solid organs transplanted annually, 50 000 are kidney replacements, more than one-third of the latter operations are done in low- or medium-income countries. (who.int)
A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
Transplantation benefits patients who need solid organs, tissues and cells by means of the development and improvement of surgical techniques, inputs, equipment and immunosuppressive drugs needed to this therapy. (imedworks.com)

Bronchiolitis obliterans (BO) after LTx was first described in 1984 at Stanford University, Stanford, CA, USA, in heart-lung transplant recipients who showed a progressive decline inforced expiratory volume in one second (FEV 1 ) 3 . (ersjournals.com)

Trimethoprim-sulfamethoxazole (TMP-SMX) has been shown to be as effective as intravenous pentamidine and more effective than other alternative treatment regimens. (medscape.com)
Furthermore, treatment regimens may be complicated by drug interactions and the need to maintain immunosuppression to avoid allograft rejection. (scienceopen.com)

Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. (wikipedia.org)
In 2018 the Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation. (wikipedia.org)
Crucially, he realised that the drugs previously used to prevent the immune system from attacking the transplanted tissue were likely damaging the cells as well. (ashdin.com)
In this study, we compared immune responses to the BNT162b2 mRNA Coronavirus Disease 2019 vaccine in patients with solid tumors ( n = 53) who were on active cytotoxic anti-cancer therapy to a control cohort of participants without cancer ( n = 50). (nature.com)
Hence, it remains important to continuously seek for improvement of posttransplant protocols, with a main focus on new drugs, novel combinations of pharmacologic regimens, and other interventions that will modulate the host immune response in order to prevent acute rejection and chronic allograft nephropathy. (5dok.net)
Can immune checkpoint inhibitors, such as ipilimumab , be used safely in this high-risk population, [ 7 ] and is there a way to encourage the host's immune response to melanoma cells without risking organ failure? (medscape.com)
Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)
Immunosuppressive induction and maintenance regimens were instituted to prevent organ graft rejection from the recipient's immune system. (colinsbraincancer.com)
To see what might help lung transplant recipients live longer, researchers at the University of Maryland School of Medicine (UMSOM) developed a novel epidemiological analysis of lung transplant data in the United States focused on regimens that prevent the body's immune system from attacking the transplanted lung. (sciencedaily.com)
The regimen destroyed the patients' defective autoreactive immune system and replaced it with the patient's blood stem cells that had been removed and treated to eliminate self-reacting lymphocytes. (dukehealth.org)
These mechanisms, which collectively make up the immune system , cannot, unfortunately, differentiate between disease-causing microorganisms and the cells of a lifesaving transplant. (britannica.com)
This immune reaction leads to rejection, the greatest problem in successful tissue and organ grafting. (britannica.com)
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
Humoral Immune Response to SARS-CoV-2 Vaccination after a Booster Vaccine Dose in Two Kidney Transplant Recipients with Fabry Disease and Variable Secondary Immunosuppressive Regimens. (cdc.gov)

Remdesivir, a viral RNA polymerase inhibitor, has constituted a key component of therapeutic regimens against the pandemic caused by severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2). (spandidos-publications.com)
Therapeutic options may be a problem in the context of an immunosuppressed patient, requiring adjustment of maintenance therapy. (hindawi.com)
The authors report two cases of isolated gastro-intestinal tuberculosis in renal transplant recipients that illustrates the difficulty of making this diagnosis and a brief review of the literature on its clinical presentation, diagnosis, and therapeutic approach. (hindawi.com)
These study findings also raise a therapeutic challenge, because renal transplant recipients with melanoma need to be treated. (medscape.com)
The introduction of new immunosuppressive agents has further increased the therapeutic options for immunosuppressive combination therapies in transplanted patients. (imedworks.com)

Prophylactic a /preemptive b treatment with a pangenotypic DAA regimen is recommended. (hcvguidelines.org)
For this reason, prophylactic sirolimus maintenance therapy is typically not started until three to 12 months after surgery. (sciencedaily.com)

The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
In Europe, hundreds of thousands of tissue transplants are performed each year, and in 1999 an estimated 750 000 people in the United States of America received human tissue, twice as many as in 1990. (who.int)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

Epidemiology of lower respiratory tract infections and community-acquired respiratory viruses in patients with bronchiolitis obliterans syndrome after hematopoietic cell transplant: a retrospective cohort study. (stanford.edu)

She had begun infliximab therapy in September 2001 and received 7 doses before onset of fever and weight loss in April 2002. (cdc.gov)
Methods In this phase 3, randomized (1:1), observer-blind, multicenter trial, RT recipients were enrolled and received 2 doses of RZV or placebo 1-2 months (M) apart 4-18M posttransplant. (scienceopen.com)
The travel health care provider may need to contact the traveler's primary or specialty care providers (with the patient's permission) to discuss the traveler's fitness to travel, give specific medical advice for the proposed itinerary, verify the drugs and doses composing their usual maintenance regimen, and discuss whether any of the disease-prevention measures recommended for the proposed trip could destabilize the underlying medical condition, directly or through drug interactions. (unboundmedicine.com)
Maintenance steroids at physiologic doses (replacement therapy). (unboundmedicine.com)

HEV can lead to chronic infection in solid-organ transplant (SOT) patients ( 14 - 16 ), in patients who have had chemotherapy ( 11 , 17 , 18 ), and in patients infected with HIV ( 19 , 20 ). (cdc.gov)
Among transplant recipients, it is especially critical to detect infection, often viral, to prevent unnecessary interruption of treatment. (cdc.gov)
Sternal wound infection with Mycoplasma salivarium following bilateral lung transplant. (stanford.edu)
Infection is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD), including those receiving maintenance dialysis or with a kidney transplant. (scienceopen.com)
However, because transplant recipients may not manifest typical signs and symptoms of infection, diagnoses may be confounded. (scienceopen.com)
In transplant recipients, MT infection can be due to primary infection, reactivation of latent TB foci favored by immunosuppression (IS), or, in a lesser extent (4%), it can be transmitted by the allograft [ 3 , 5 , 6 ]. (hindawi.com)
The objectives of treatment are resolution of infection, decrease of antibody titers, return of function of involved organs, and prevention of relapse. (medscape.com)
Itraconazole (400 mg/day) appears to have efficacy equal to that of fluconazole in the treatment of nonmeningeal infection and have the same relapse rate after therapy is discontinued. (medscape.com)

Immunosuppressants are used to suppress rejection in organ transplant recipients and to treat a variety of chronic inflammatory and autoimmune diseases. (obaid.info)

Cell-mediated immunotherapy is emerging as an alternative in single and combination therapies to rescue rejecting transplants. (biomedcentral.com)

The use of monoclonal antibodies in cancer therapy was first introduced in 1997 with rituximab, an anti-CD20 antibody for treatment of B cell lymphoma. (wikipedia.org)
Notably, organ transplant recipients mount very poor antibody responses to the first mRNA immunization relative to healthy individuals 10 , which increase somewhat after the second immunization 8 . (nature.com)
In 2007 the large (n=1,645) prospective multicenter Symphony study compared various posttransplant immunosuppressive protocols, among which a regimen consisting of low-dose ciclosporin combined with daclizumab (an anti-CD25 antibody) induction therapy, and a regimen with standard-dose ciclosporin without daclizumab. (5dok.net)
What monoclonal antibody therapies are available for prevention or treatment of COVID-19 disease? (hematology.org)
Initial clinical trials of monoclonal antibody therapies in hospitalized patients with severe COVID-19 disease were stopped due to futility, with no evidence of benefit in preventing ICU admission or death, or other critical disease endpoints. (hematology.org)
A database of information provided by manufacturers, regulators, and academics on the activity of both vaccines and antibody therapies against variants is updated daily by the National Institutes of Health (NIH) . (hematology.org)
In what settings should treatment with monoclonal antibody therapies be considered for immunocompromised or other hematology patients? (hematology.org)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
In the past several decades, numerous studies have been conducted to understand the pathogenesis of IF/TA and multiple factors and mechanisms have been demonstrated to be involved in the progress of the IF/TA, including immunosuppressive drug toxicity, antibody-mediated injury, and epithelial-mesenchymal transition (EMT) (Figure 1 ). (biomedcentral.com)

BO and its clinical correlate bronchiolitis obliterans syndrome (BOS) affect up to 50-60% of patients who survive 5 yrs after surgery, irrespective of the type of transplant procedure 1 , 4 - 6 . (ersjournals.com)

In this study, we report the isolation and full description of Microbacterium yannicii isolated from the sputum sample from a lung transplanted CF adult patient for which we have recently published the genome sequence [ 13 ]. (biomedcentral.com)
Beginning in September 2012, the BEST Trial enrolled more than 300 adult kidney transplant patients at eight transplant centers across the U.S. In the randomized trial, the patients received one of two belatacept-based immunosuppressive regimens, or the typical corticosteroid-based immunosuppressive regimen as a control. (sciencedaily.com)
Registry of the international society for heart and lung transplantation: twenty-second official adult lung and heart-lung transplant report-2005. (medigraphic.com)

Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
Scleroderma hardens the skin and connective tissues and, in its severe form, leads to fatal organ failure, most often the lungs," says lead author Keith Sullivan, MD, the James B. Wyngaarden Professor of Medicine and Cellular Therapy at Duke. (dukehealth.org)
Kidney transplantation requires compatibility between tissues obtained for the Human Leukocytes Antigen typing (HLA).While waiting for a donor, the chronic renal disease patients have other forms of Renal Replacement Therapy (RRT) which allow the maintenance of their life and also justify the increasing number of patients registered on the waiting list for kidney transplantation. (imedworks.com)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)

Its pathogenesis has not been fully elucidated and existing therapy is not effective in improving renal transplant function. (biomedcentral.com)

One downside for sirolimus, though, is that it interferes with wound healing, a potentially life-threatening complication if the drug is administered in the initial days and weeks following transplant surgery. (sciencedaily.com)

Mycophenolic acid is an immunosuppressant used to prevent organ transplant rejections. (drugbank.com)

Before the 1980s, fewer than 100 cases of PJP were reported annually in the United States, occurring in patients who were immunosuppressed (eg, cancer patients receiving chemotherapy and solid-organ transplant recipients receiving immunosuppressants). (medscape.com)
These clinical trials, however, largely excluded immunocompromised individuals, including patients on immunosuppressive therapies to control chronic inflammatory conditions, patients with primary immunodeficiencies, recipients of organ transplants and patients with cancer on cytotoxic chemotherapy. (nature.com)
Criteria relevant to hematology patient populations specifically include immunosuppressive disease or immunosuppressive treatment (thus post-allogeneic transplantation, active or recent chemotherapy or immunotherapy, active malignancy) or sickle cell anemia, in patients unlikely to respond optimally to vaccination, or in those not fully vaccinated. (hematology.org)

A quick PubMed search on February 8, 2011 yielded approximately 87,000 articles on the topic "kidney transplantation", of which almost 40,000 include the word "immunosuppression", or "immunosuppressive" in the abstract. (5dok.net)

Tuberculosis is a disease relatively frequent in renal transplant patients, presenting a wide variety of clinical manifestations, often involving various organs and potentially fatal. (hindawi.com)
Gastrointestinal tuberculosis, although rare in the general population, is about 50 times more frequent in renal transplant patients. (hindawi.com)
In 88 Iranian renal transplant patients receiving CsA, CYP3A5 and MDR1 genotypes were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. (ectrx.org)

METHODS: We retrospectively investigated n = 491 patients from a prospective, observational renal transplant cohort. (bvsalud.org)
This large retrospective cohort analysis confirms that renal transplant recipients have a fivefold increased risk of developing malignant melanoma. (medscape.com)

On the other hand, patients who receive a kidney transplant typically live longer than those who stay on dialysis. (imedworks.com)

There Atorvastatin calcium have been 10 situations of postponed graft function among the recipients. (biospraysehatalami.com)
In organ transplantation, the key tenet remains the maintenance of graft function through the induction of allograft tolerance. (northwestern.edu)
Immunosuppression has been the mainstay of therapy to maintain graft function and induce tolerance. (northwestern.edu)

Solid organ transplant recipients are highly susceptible to infections that sometimes have uncommon clinical manifestations ( 1 - 3 ). (cdc.gov)

A standard induction regimen with daclizumab will cost approximately E 5,000 extra per patient. (5dok.net)
Immunosuppressive regimen Ahead of this research basiliximab (Novartis Pharmaceuticals Corp. East Hanover NJ USA) was found in induction therapy in regular two dosages (times 0 and 4 post-transplantation). (biospraysehatalami.com)
and group V, RATG induction therapy recipients ( n ϭ 100). (pdfdrugs.com)
Lung transplantation,using RATG induction therapy, remains an important modality for end-stage pulmonary disease. (pdfdrugs.com)
The study also considered induction therapy, an optional addition to maintenance therapy used in over half of transplant centers in the U.S. In induction therapy, patients are given a high dose of immunosuppression at the time of transplantation for a short duration -- three to 14 days, with drugs such as basiliximab, daclizumab, alemtuzumab, or antithymocyte globulin. (sciencedaily.com)

2 weeks) therapy with daily or alternate-day dosing of ≥20 mg of prednisone or equivalent, some experts will still wait 2 weeks or more before administering live vaccines. (unboundmedicine.com)
Types and Contents of Vaccines Available for Use in Canada at https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-1-key-immunization-information/page-15-contents-immunizing-agents-available-use-canada.html#p1c14t1 . (therapeuticresearch.com)

This review examines the characteristics of both traditional and new pharmacological agents, describes a patient-centered approach to their use following lung transplantation, and discusses the controversies surrounding immunosuppression in the lung transplant recipient. (northwestern.edu)
However, if we can extend the life of a lung transplant recipient by two years, you're talking a major accomplishment. (sciencedaily.com)

Transplant recipients who developed malignant melanoma did so within a median of 1.45 years. (medscape.com)

Anatomy17

Organisms10

Diseases76

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment70

Psychiatry and Psychology1

Phenomena and Processes21

Disciplines and Occupations1

Information Science4

Named Groups2

Health Care21

Tacrolimus12

Post-transplant12

Donors11

Survival26

Mycophenolate mofetil3

Cyclosporine5

Outcomes8

Immunosuppression to prevent organ rejection1

Donor organs3

Corticosteroids4

Drug regimens1

Conventional immunosuppressive2

Kidneys5

Prophylaxis4

Pediatric4

Advances4

Liver transplant3

Calcineurin1

Transplantation of organs and living1

Chronic rejection2

Incidence2

Solid organs4

Heart-lung transplant recip1

Treatment regimens2

Immune14

Therapeutic5

Prophylactic2

Tissue4

Hematopoietic cell transplant1

Doses4

Infection8

Suppress1

Combination therapies1

Antibody9

Bronchiolitis obliterans syndrome1

Adult3

Tissues6

Pathogenesis1

Sirolimus1

Prevent organ1

Chemotherapy3

Abstract1

Renal transplant patients3

Cohort2

Receive a kidney transplant1

Graft function3

Clinical manifestations1

Induction5

Vaccines2

Lung transplant recipient2

Median1