• However, this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties due to its ability to inhibit mTOR. (wikipedia.org)
  • Mycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. (drugbank.com)
  • Although anthracyclines have potent anti-proliferative effects that make them effective chemotherapeutic agents, a serious side effect of cardiotoxicity can develop 10-20 years later. (boisestate.edu)
  • Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. (researchwap.com)
  • Recent reports have identified a redox-silent analogue of VE, α -tocopheryl succinate ( α -TOS), as a potent anticancer agent with a unique structure and pharmacokinetics in vivo . (nature.com)
  • Polyphenols have both antioxidant and prooxidant properties. (hindawi.com)
  • are capable of detoxifying the body owing to their antioxidant properties thereby protecting the essential organs like the liver, kidney, heart, etc. (researchwap.com)
  • In this research work, we are more concerned about two bioactivities, i.e., antioxidant and anticancer properties. (ijpsr.com)
  • Reishi's antioxidant properties (3) protect the cells from mutations and reduce the risk of inflammation. (naturesrise.com)
  • Reishi extract has other bioactive proteins that contribute to (4) immunosuppressive and antioxidant medicinal properties. (naturesrise.com)
  • Sirolimus was initially developed as an antifungal agent. (wikipedia.org)
  • In 2009, the FDA notified healthcare professionals that a clinical trial conducted by Wyeth showed an increased mortality in stable liver transplant patients after switching from a calcineurin inhibitor-based immunosuppressive regimen to sirolimus. (wikipedia.org)
  • A 2019 cohort study of nearly 10,000 lung transplant recipients in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus instead of mycophenolate mofetil + tacrolimus for immunosuppressive therapy starting at one year after transplant. (wikipedia.org)
  • The antiproliferative effect of sirolimus has also been used in conjunction with coronary stents to prevent restenosis in coronary arteries following balloon angioplasty. (wikipedia.org)
  • An immunosuppressant with antiproliferative properties used as a disease-modifying antirheumatic drug (DMARD) in rheumatoid arthritis, psoriatic arthritis and in some neoplasms. (e-lactancia.org)
  • However, SRL may modulate TAC-associated kidney injury and may also have antiproliferative properties that are valuable in the management of patients following liver transplantation for HB. (childrensmercy.org)
  • FDA Approvals: Early testing revealed that rapamycin exhibits immunosuppressive activity.In September 1999, rapamycin received FDA approval as a drug to prevent organ rejection in patients receiving a kidney transplant. (dragonsmedicalbulletin.com)
  • Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines. (ac.ir)
  • Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. (nature.com)
  • 7 It was derived from Penicillium stoloniferum , and has also shown antibacterial, antifungal and antiviral properties. (drugbank.com)
  • They are antiviral and possess antioncogenic properties, macrophage and natural killer lymphocyte activation, and enhancement of major histocompatibility complex glycoprotein classes I and II, and thus presentation of foreign (microbial) peptides to T cells . (wikidoc.org)
  • These compounds play a crucial role in Reishi's cancer benefits-they inhibit cancer cells' growth and invasive properties. (naturesrise.com)
  • Mgf exhibits a high level of antioxidants properties in both in-vivo and in-vitro conditions by quenching free radicals and reactive oxygen species (ROS) due to the presence of a pharmacophore i.e., catechol moiety and free hydroxyl groups 14 . (ijpsr.com)
  • SRL-based immunosuppressive strategies in pediatric liver transplantation are not clearly defined, especially within the first year after liver transplant. (childrensmercy.org)
  • The mushroom has been used for centuries and is notable for its immune-enhancing, free-radical fighting, liver health benefits, stomach protection, and stress-relieving properties. (naturesrise.com)
  • The dosages of a chemotherapeutic agent cannot be increased because high dosages lead to various side effects like bone marrow suppression, cardiomyopathy, nephrotoxicity, neurotoxicity, and multidrug resistance 8 . (ijpsr.com)
  • Cyclophosphamide, [2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxzaphosphorine-2- oxide] is one of the most effective and widely used cytotoxic antitumor agents. (researchwap.com)
  • A series of in vitro and in vivo analyses, including physical and chemical characterizations, targeting property, biosafety, and antitumor efficacy of Wpep-DGL/Pt were systematically carried out. (thno.org)
  • Finally, α -TOS and similar agents are metabolised to VE, thereby yielding a compound with a secondary beneficial activity. (nature.com)
  • TGF-β unfolds its immunosuppressive impact by stimulating tumor-infiltrating T-lymphocytes (TIL) to differentiate into anergic, tumor-promoting, regulatory T cells (Treg). (haematologica.org)
  • 3 Interestingly and still poorly understood, the HRS cells themselves seem to remain unaffected by the tumor-suppressive properties of TGF-β. (haematologica.org)
  • Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses , parasites and tumor cells. (wikidoc.org)
  • Their growth arrest is reversible and under certain conditions, such as induction by growth factors, cytokines, nutrients, or chemical agents, the cells can re-enter the cell cycle to proliferate again. (biomedcentral.com)
  • Most uveitis seen in Western countries is noninfectious and appears to be autoimmune or autoinflammatory in nature, requiring treatment with immunosuppressive and/or anti-inflammatory drugs. (dovepress.com)
  • Importantly, uridine supplementation abrogated the antiproliferative effect of LAP, supporting that the pyrimidine metabolic pathway is the target of LAP. (biomedcentral.com)
  • By documenting the traditional uses and biological activities of Moringa species, we hope to support new research on these plants, especially on those species whose biological properties have not been studied to date. (frontiersin.org)
  • These findings also introduce new Artemis species cultivated in Iran as a useful anti-inflammatory agents. (ac.ir)
  • Boswellia species resins have also been considered throughout the ages to have a wealth of healing properties. (healthjade.net)
  • Sodium-2-mecarptoethane sulfonate (MESNA), a sulfhydryl-containing agent has long been used in detoxifying and ameliorating specifically the urotoxic effects of CP and other oxazaphosphorines. (researchwap.com)
  • Though cannabinoids are clinically used for anti-palliative effects, recent studies open a promising possibility as anti-cancer agents. (oncotarget.com)
  • In the past several decades, numerous studies have been conducted to understand the pathogenesis of IF/TA and multiple factors and mechanisms have been demonstrated to be involved in the progress of the IF/TA, including immunosuppressive drug toxicity, antibody-mediated injury, and epithelial-mesenchymal transition (EMT) (Figure 1 ). (biomedcentral.com)
  • The exact mechanism of immunosuppressive drug-mediated renal toxicity is not fully understood. (biomedcentral.com)
  • 1. Oral drug delivery devices for colonic release of active ingredients, comprising:a) an active agent capable of inactivating an antibiotic, andb) a drug delivery device comprising pectin beads, where the pectin is crosslinked with calcium ions, and reticulated with polyethyleneimine. (patentsencyclopedia.com)
  • 3. The drug delivery device of claim 1, wherein the active agent is an enzyme capable of inactivating beta-lactam antibiotics. (patentsencyclopedia.com)
  • Identification and validation of microtubule depolymerizing agent, CYT997, as a potential drug candidate for hepatocellular carcinoma. (stanford.edu)
  • Therefore, LAP could be considered as a potential immunosuppressive lead candidate with potential therapeutic implications for RA. (biomedcentral.com)
  • continued to use CP either alone or in combination with other agents in cancer chemotherapy due to its efficacy. (researchwap.com)
  • Here, we investigated lapachol (LAP), a natural naphthoquinone, as a potential DHODH inhibitor and addressed its immunosuppressive properties. (biomedcentral.com)
  • In the present study, we investigated the potential immunosuppressive properties of LAP. (biomedcentral.com)
  • Methotrexate (obstetric and immunosuppressive use) (Possibly safe. (e-lactancia.org)
  • This research article focuses on the use of Mangiferin as anti-cancer agent and its safe and effective delivery using nanotechnology. (ijpsr.com)
  • Many alkylating cytotoxic agents, which cyclophoshpamide (CP) is a member, have been well documented to be effective in management of many human malignancies in order to improve quality of life and extend patients life span (Philip et al. (researchwap.com)
  • Advantageously, the amount of polyethyleneimine is sufficient to allow a substantial portion of the pectin beads to pass through the gastrointestinal tract to the colon without releasing the active agent, and is also sufficient such that the pectin beads are sufficiently degraded in the colon to release an effective amount of the active agent. (patentsencyclopedia.com)
  • It has been shown that, due to its α -tocopheryl moiety, the agent activates protein phosphatase-2A that, in turn, inhibits protein kinase C (PKC). (nature.com)
  • Recently there has been an emerging trend in developing drugs from natural compounds to combat the problems associated with currently used chemo-preventive agents. (ijpsr.com)
  • OTT protects, monitors, markets and manages the wide range of NIH discoveries, inventions, and other intellectual property as mandated by the Federal Technology Transfer Act and related legislation. (nih.gov)
  • In one embodiment, the ocular insert comprising a polymer matrix and stable amorphous bimatoprost of the current disclosure includes at least one secondary therapeutic agent. (justia.com)
  • In another embodiment, the active agents are those that specifically treat colonic disorders, such as Chrohn's Disease, irritable bowel syndrome, ulcerative colitis, colorectal cancer or constipation. (patentsencyclopedia.com)