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  • inhibitors
  • Objective To compare the risk of serious infections associated with use of systemic steroids, non-biologic agents, or tumor necrosis factor α (TNF) inhibitors in pregnancy. (bmj.com)
  • No statistically significant differences in the risk of serious infections during pregnancy were observed among users of the three immunosuppressive drug classes: non-biologics v steroids, hazard ratio 0.81 (95% confidence interval 0.48 to 1.37), TNF inhibitors v steroids 0.91 (0.36 to 2.26), and TNF inhibitors v non-biologics 1.36 (0.47 to 3.93). (bmj.com)
  • properties
  • Therefore, the study proposed is a laboratory investigation (using blood samples collected from the subjects) comparing immune tolerance and alloreactivity profiles in LT recipients on monotherapy IS or converted to rapamycin monotherapy, to determine tolerogenic properties of the different IS agents. (clinicaltrials.gov)
  • conditions
  • Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. (pharmacycode.com)
  • work
  • Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. (pharmacycode.com)
  • several
  • Subsequent tapering of the dose or switching to an oral agent is continued over several weeks to months. (medscape.com)
  • Efficacy
  • LX211 is a novel calcineurin inhibitor (CNi) possessing four-fold greater potency, an altered metabolic and pharmakokinetic profile, and potentially improved safety compared to the prototypical CNi, cyclosporine A. Three pivotal dose-ranging clinical trials have been designed to evaluate the safety and efficacy of LX211 as a corticosteroid-sparing agent for the management of non-infectious uveitis. (arvojournals.org)
  • evidence
  • In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP), contribute to the development of bone marrow-derived tolerogenic DCs in vitro and in vivo. (jimmunol.org)
  • Mycobacterium and Propionibacteria species have both been suggested as the environmental agent, though the evidence for this is inconclusive. (wikipedia.org)
  • recent
  • In blood cultures, they are usually considered as contaminants, but in recent years they have been recognized as causal infectious agents of endocarditis, urinary tract infections, meningitis, intra-abdominal infections and bacteraemia. (biomedcentral.com)
  • patients
  • Study LX211-02-UV (LUMINATE Maintenance) will evaluate 220 patients whose disease is controlled and will be employed to spare the use of systemic corticosteroid and, if applicable, to replace the patient's current poorly-tolerated corticosteroid-sparing agent. (arvojournals.org)