• An increased incidence of B-cell lymphomas seen when cyclosporine was used in conjunction with cytotoxic agents or anti-lymphocyte globulin has very rarely been observed when concomitant immunosuppression has been limited to low-dose corticosteroids. (nih.gov)
  • Standard therapy to control graft rejection generally involves a combination of corticosteroids, a calcineurin inhibitor (cyclosporine or tacrolimus), and an antiproliferative agent. (medscape.com)
  • Cyclosporine should be administered with adrenal corticosteroids but not with other immunosuppressive agents. (drugs.com)
  • Treatment is with angiotensin inhibition and, for idiopathic disease, corticosteroids and sometimes other immunosuppressive agents. (msdmanuals.com)
  • EoG/EoGE treatment largely relies on systemically active immunosuppressive agents (e.g., corticosteroids), although clinical trials are investigating biologic agents," the study authors wrote. (medpagetoday.com)
  • However, the success of second-generation direct-acting antiviral (DAA) agents has significantly reduced the number of HCV-related registrations. (medscape.com)
  • Antiviral treatment(s) for mpox have minimal interaction with antiretroviral therapy and with common immunosuppressive medications. (cdc.gov)
  • 1 It was later shown to have antibacterial, antiviral, antifungal, antitumoral and immunosuppressive properties. (skintherapyletter.com)
  • Others classes of hazardous drugs include some hormonal, immunosuppressive and antiviral agents, monoclonal antibodies and several miscellaneous drugs. (cdc.gov)
  • The Academy strongly recommends that patients should not stop their ongoing systemic immunosuppressive therapy without consulting their physicians. (aad.org)
  • There is insufficient evidence to recommend discontinuation of systemic immunosuppressive agents at this time. (aad.org)
  • We recommend physicians discontinue or postpone the systemic immunosuppressive agents until the patient recovers from COVID-19, consistent with guidelines on the management of patients with active infections on systemic non-biologic and biologics therapy. (aad.org)
  • We recommend physicians can re-initiate the systemic immunosuppressive therapy after ensuring the patients have completely recovered from COVID-19. (aad.org)
  • The systemic organ-specific therapeutic approach may follow, as a general rule, the sequential (or combined) use of glucocorticoids, immunosuppressive agents, and biologics. (medscape.com)
  • This is because the long-term effects of generalized, systemic immunosuppression, even with a mixture of relatively mild agents, won't be known for several years. (diabetesjournals.org)
  • Chemotherapeutic or immunosuppressive agents can have the same effect. (cap.org)
  • Azathioprine (Prometheus' Imuran), is the main immunosuppressive cytotoxic substance. (wikipedia.org)
  • Immunosuppressive agents (eg, leflunomide, methotrexate, azathioprine, mycophenolate, cyclophosphamide) should be mainly used as glucocorticoid-sparing agents, with no evidence supporting the choice of one agent over another. (medscape.com)
  • Vaccination with JYNNEOS is considered safe for people who are immunocompromised, including those with HIV or primary immunodeficiency or from immunosuppressive therapies. (cdc.gov)
  • Despite activity as single agent cancer therapies, Rapamycin (rapa) and its rapalogs may have their greatest effects when combined with other therapeutic modalities. (nih.gov)
  • Immunosuppressive therapies after heart transplantation - The balance between under- and over-immunosuppression. (lu.se)
  • It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and the expression of the IL-2 receptor were suppressed by this agent. (nih.gov)
  • The long-term efficacy of immunosuppressive therapy is still in doubt. (medscape.com)
  • Immunosuppressive therapy. (nih.gov)
  • Antibodies are sometimes used as a quick and potent immunosuppressive therapy to prevent the acute rejection reactions as well as a targeted treatment of lymphoproliferative or autoimmune disorders (e.g., anti-CD20 monoclonals). (wikipedia.org)
  • Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe cyclosporine. (drugs.com)
  • In phases of clinical activity the combination of immunosuppressive agents with cortisonoids is the therapy of choice. (unboundmedicine.com)
  • Steroids still constitute the back bone of treatment although occassionally other immunosuppressive agents such as Methotrexate are used. (ndtv.com)
  • Immunosuppressive drugs can be classified into five groups:[citation needed] glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs In pharmacologic (supraphysiologic) doses, glucocorticoids, such as prednisone, dexamethasone, and hydrocortisone are used to suppress various allergic, inflammatory, and autoimmune disorders. (wikipedia.org)
  • 0.5 mg/kg/d in moderate/less-severe presentations, with a final target of withdrawing glucocorticoids in patients with inactive disease as soon as possible or at least trying to target a maintenance dose of 5 mg/daily or less with the aid of glucocorticoid-sparing immunosuppressive agents). (medscape.com)
  • Case reports have described the use of other immunosuppressive medications in the long-term management of idiopathic pulmonary hemosiderosis. (medscape.com)
  • Immunosuppressive drugs, also known as immunosuppressive agents, immunosuppressants and antirejection medications, are drugs that inhibit or prevent the activity of the immune system. (wikipedia.org)
  • Following transplantation, a patient will require immunosuppressive medications for the rest of her life to prevent rejection of the transplanted kidney. (marlerblog.com)
  • Many other immunosuppressive medications and other medications (anti-hypertensive agents, anti-acids, etc.) are prescribed in the post-operative period. (marlerblog.com)
  • Immunomodulatory drugs modify the response of the immune system by increasing (immunostimulators) or decreasing (immunosuppressives) the production of serum antibodies. (slideshare.net)
  • Patients also received a cocktail of mild, nonsteroidal immunosuppressive agents. (diabetesjournals.org)
  • Diethylstilbestrol (DES), dexamethasone (DEX), cyclophosphamide (CPS), and 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) are immunosuppressive chemicals that induce similar immunotoxic effects in the thymus, however, the mechanism of toxicity is purported to be different for each compound. (nih.gov)
  • These include increasing numbers of patients with cancer and other chronic illnesses, the use of higher doses of drugs (made possible by strategies to reduce the toxic side-effects of the drugs), noncancer use of antineoplastic drugs and the development of other potent drugs, such as antiviral agents. (cdc.gov)
  • The alkylating agents used in immunotherapy are nitrogen mustards (cyclophosphamide), nitrosoureas, platinum compounds, and others. (wikipedia.org)
  • Cyclophosphamide (Baxter's Cytoxan) is probably the most potent immunosuppressive compound. (wikipedia.org)
  • Use of bone-targeting agents for bone loss prevention in the setting of osteoporosis was not permitted in clinical studies. (drugs.com)
  • The use of cyclosporin A (CsA) as an immunosuppressive agent has markedly improved the clinical outcome in solid organ transplantation. (jci.org)
  • These agents inhibit immune reactions that result from diverse stimuli. (medscape.com)
  • These agents are used for patients with conditions caused by immune dysregulation and autoimmunity. (medscape.com)
  • To better serve patients and their physicians, the Academy has created interim recommendations on the use of immunosuppressive agents and spironolactone during COVID-19, available below. (aad.org)
  • We recommend physicians assess the risk vs. benefits in lower-risk patients before initiating immunosuppressive agents on a case-by-case basis, recognizing that anyone may develop serious complications from COVID-19 infection. (aad.org)
  • For patients currently on spironolactone, we recommend continuation of spironolactone for those patients who are currently prescribed such agents for indications for which these agents are known to be beneficial. (aad.org)
  • In view of the harms induced by the use of antipsychotic agents (APs) for the symptomatic treatment of aggression and psychotic symptoms in elderly patients in residential facilities, [7] , [8] in 2008 the European national regulatory agencies recommended limiting their use to patients not responding to other interventions, and to reconsider their prescription at every follow up visit, with close patient follow up. (rxisk.org)
  • commonly used immunosuppressive and anti- inflammatory drug. (slideshare.net)
  • As an alkylating agent, the mechanism of action of the active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)
  • Female B6C3F1 mice were exposed to these immunosuppressive agents and changes in gene expression and immune cell subpopulations were evaluated. (nih.gov)
  • Captopril oral solution can be used alone or in combination with other antihypertensive agents (see sections 4.3, 4.4, 4.5 and 5.1). (medicines.org.uk)
  • Captopril oral solution may be used alone or with other antihypertensive agents, especially thiazide diuretics. (medicines.org.uk)
  • It belongs to a group of medicines known as immunosuppressive agents. (drugs.com)
  • People who are immunocompromised from other conditions or using immunosuppressive agents may be at increased risk of severe mpox. (cdc.gov)
  • Various immunosuppressive agents are used in the treatment of microscopic polyangiitis (MPA). (medscape.com)
  • The choice of agents depends on the treatment phase (induction versus maintenance of remission) and disease severity. (medscape.com)
  • Peliosis hepatis as the cause of liver affection in a patient treated with immunosuppressive agents]. (nih.gov)
  • These agents prevent thromboembolic disorders. (medscape.com)
  • Consider analgesics or other pain-modifying agents for musculoskeletal pain, considering the balance between potential benefits and side-effects. (medscape.com)
  • These agents have vasodilatory effects. (medscape.com)
  • These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)
  • As the risk associated with second-generation APs is not lower than that of first-generation agents, sedation and resulting hypoventilation, anticholinergic effects, and their effects on immunity have been proposed as the main mechanisms, rather than their extrapyramidal effects. (rxisk.org)
  • The latter group has often been classified as nosocomial meningitis because a different spectrum of microorganisms (ie, resistant gram-negative bacilli and staphylococci) is the more likely the etiologic agents, and different pathogenic mechanisms are associated with the development of this disease. (idsociety.org)
  • Healthcare professionals caring for people who are immunocompromised from HIV or other conditions or who are taking immunosuppressive agents. (cdc.gov)