Immunology highlighting adoptive cellular immunotherapy adoptive. Medical search. Frequent questions

Biomarker development to support cellular therapies. (mayo.edu)
Finally, Dr. Gustafson and his lab foster critical collaborations with researchers and clinicians to bring novel cellular therapies to patients. (mayo.edu)
and next-generation adoptive cell therapies. (uchicagomedicine.org)
He went on to publish multiple papers highlighting the role of regulatory T cells in restricting immunity and immune-based therapies for patients with brain tumors. (wikipedia.org)
However, despite the success of checkpoint inhibitors and the advent of cellular therapies, novel strategies need to be explored to (1) improve treatment in patients where these approaches fail and (2) make such treatments widely and financially accessible. (mdpi.com)
highlights the rapid growth and diversity in the preclinical and clinical landscape of IO therapies with 91% growth as compared to the data published in 2017. (cancerresearch.org)
The largest increase is observed in the development of cellular therapies in the past two years. (cancerresearch.org)
On a global level, the overall number of trials for all adoptive cell therapeutics are fewer in comparison to trials for immune checkpoint inhibitors and other IO therapies, but rapid growth in clinical investigations for adoptive cell therapies in particular was seen after 2015. (cancerresearch.org)
Promising novel therapies for vitiligo are on the horizon, further highlighting the need for reliable outcome measurement instruments and greater emphasis on shared decision-making. (umassmed.edu)
Cancer immunotherapies can be divided into four major categories: - Cytokines/immunomodulation agents - Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest class of commercialized cancer immunotherapies, cell‑based therapies are rapidly making headway. (technologynetworks.com)
Researchers have engineered T cells to help develop new cancer immunotherapies, called adoptive T-cell therapies. (fredhutch.org)
Advances in adoptive cell therapies have led to a transformative change in immuno-oncology, providing personalized and effective treatment options for patients with relapsed or refractory cancers. (medpagetoday.com)
Hematologic malignancies have enjoyed the highest degrees of success thus far in the world of adoptive cell therapies with multiple FDA approvals for CAR T cell therapies for a variety of indications. (medpagetoday.com)
in their recent article in the ASCO Educational Book reflect on the recent advances in adoptive cell therapies and the lessons that can be learned for the development of future cellular products. (medpagetoday.com)
Background Adoptive cellular therapies with chimeric antigen receptor T cells have revolutionized the treatment of some malignancies but have shown limited efficacy in solid tumors such as glioblastoma and face a scarcity of safe therapeutic targets. (gpdunnlab.com)
We are also interested to test other types of immunotherapies and combination therapies in this model. (taconic.com)
Spurred by preclinical and correlative studies to understand mechanisms of non-response to the PD-(L)1 antagonists and by combination studies in animal tumor models, many drug development programs were designed to combine anti-PD-(L)1 with a variety of approved and investigational chemotherapies, tumor-targeted therapies, antiangiogenic therapies, and other immunotherapies. (emory.edu)

In this area, he wrote his first article in 2002 describing clinical immunotherapies for brain tumors. (wikipedia.org)

Antigen, Autoimmune disease, Demyelinating disease, Autoimmunity and Immune tolerance are the primary areas of interest in his Immunology study. (research.com)
His study in Antigen, Autoimmune disease, Autoimmunity, Multiple sclerosis and Inflammation falls within the category of Immunology. (research.com)
This mechanistically rational antigen selection sequence, effective even for unvaccinated donors, regardless of HLA-haplotype, enables rapid identification of tumor protein regions relevant for cancer immunology, including adoptive immunotherapy, vaccines, and even identification of tumor neo-antigens unique to each patient. (ndltd.org)
The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. (stanford.edu)
Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
The modification enables these cells to express the chimeric antigen receptor (CAR) on the cellular surface, directing the CAR T cells to recognize and kill cells expressing the target protein. (taconic.com)
Indeed, both DNA methylation and post-translational histone modifications have been described to regulate immune checkpoint inhibitor expression, tumor-associated antigen presentation or cancer cell editing by the immune system and therefore establishing epigenetic drugs as a potential complement to immunotherapies to improve their efficiency. (oaepublish.com)
Immunotherapy engages the immune system in the battle against cancer by taking advantage of the capacity of the T lymphocyte for antigen-directed cytotoxicity [ 14 ]. (biomedcentral.com)

Fecci's research centers around brain tumor immunology and immunotherapy, and T cell dysfunction in glioblastoma and other intracranial cancers. (wikipedia.org)
Fecci has curated a body of research focused on brain tumor immunology and immunotherapy. (wikipedia.org)

The Workshop associated with the 27th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), North Bethesda, MD, October 24-25, 2012 focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
To support these efforts, the Society for Immunotherapy of Cancer (SITC) held a workshop focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)

Dr. Gustafson's research also encompasses understanding systemic immunity in humans, how cancer alters the immune landscape in humans and how physical activity may be used to improve immune responses to immunotherapy. (mayo.edu)
In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)

The research interests of Keith L. Knutson, Ph.D., focus on the immunology and immunotherapy of breast and ovarian cancers, both the basic immunobiology and clinical translation, including clinical trials. (mayo.edu)
In recent years, immunotherapies have led to remarkable strides in treating certain cancers. (mdpi.com)
Dr O'Rourke reviews brain cancer vaccine trials at Penn Medicine, focusing on the EGFRvIII peptide vaccine, offers a synopsis of the application at Penn of adoptive T cell therapy to the brain cancers and considers GBM--surface antigens for CAR therapy in glioma. (pennmedicine.org)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Cancer immunotherapy, the immune system's artificial stimulation, is an efficient method for the treatment of different cancers [ 13 ]. (biomedcentral.com)

Recent advances in cancer immunology, highlighted by immune checkpoint inhibitors, have demonstrated that immunotherapy is a viable option in the oncologist's armamentarium. (ndltd.org)
In 2018, the Nobel Prize in medicine was awarded to James P. Allison and Tasuku Honjo for their work on the description of immune checkpoint inhibitors which contributed to the development of new anti-cancer immunotherapies. (oaepublish.com)

As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)

To aid in this effort, SITC provides a venue to facilitate the discussion of current clinical trial results and methodologies, as well as means to collaborate on new initiatives in tumor immunology and cancer immunotherapy with the ultimate goal of improving cancer patient outcomes. (biomedcentral.com)
Several immunotherapy combinations improved survival outcomes in a variety of indications including melanoma, lung, kidney, and liver cancer, among others. (emory.edu)

During a plenary session on precision medicine for immuno-oncology and the promise for the future, Thomas Gajewski, MD, PhD , AbbVie Foundation Professor of Cancer Immunotherapy, described how germline and microbiome variants impact immunotherapy efficacy through modulation of myeloid cells. (uchicagomedicine.org)

By focusing on the critical roles of different metabolic programs, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism, as well as their essential regulators in modulating Treg proliferation, migration, and function, we hope to provide new insights into Treg cell-targeted antitumor immunotherapies. (biomedcentral.com)
Treg deletion accelerates the development of atherosclerosis, and adoptive transfer Treg suppresses atherosclerosis [ 10 ]. (hindawi.com)

A second strategy under investigation is adoptive T cell therapy, which involves infusing high numbers of T cells into patients with active bulky malignancy. (mayo.edu)
In 2006, he published a paper entitled "Increased Regulatory T-cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma", in Cancer Research. (wikipedia.org)
Subsequently, Fecci conducted further research into the PD-1 / PD-L1 axis as an immunotherapy target in patients with cancer, co-authoring several subsequent papers on this topic in Nature Communications and Cancer Research. (wikipedia.org)
Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
Our research into personalised forms of immunotherapy has undergone rapid commercialisation to deliver life-saving results for patients worldwide. (manchester.ac.uk)
Our research revealed how to manipulate the immune system in order to achieve the best anti-cancer response - known as adoptive cell therapy (ACT) - and the team set up the infrastructure to deliver this as a therapy to patients. (manchester.ac.uk)
In the past decade, remarkable results have been obtained in clinical trials with immunotherapy for patients with advanced-stage cancer. (nature.com)
We previously published an immune-humanized mouse model in which we transplanted tumor cells and autologous tumor-infiltrating lymphocytes (TILs) from patients in a clinical trial of adoptive T cell transfer (ACT) in Herlev, Denmark - and demonstrated that responses in IL-2 transgenic NOG mice correlated to the responses of the patients in the trial 2 . (taconic.com)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
These data highlight the possibility that tumor-specific ATCT may lead to long-term disease-free survival without GvHD in patients with MM. (biomedcentral.com)
SITC is a non-profit group of medical professionals established in 1984 to facilitate the exchange and promotion of scientific information about the promise and breakthroughs of immunotherapy for cancer patients. (biomedcentral.com)
These data confirm the presence of tumor-specific TCR within the cancer tissue and suggest the existence of shared epitopes among different patients that might be used as targets for tumor immunotherapy. (oncotarget.com)

Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. (ijbs.com)
Thus, it is imperative to develop more competent and safer immunotherapy approaches by optimizing the design of CAR vectors, exploring new targets, incorporating conditional safe switches and combining with other strategies. (ijbs.com)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
The importance of these dynamic cellular interactions in the development of cancer has stimulated strong interest in evaluating components of the tumor microenvironment as targets for cancer therapy. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)

In a model of adoptive cellular therapy, the infusion of activated MISTIC T cells resulted in rapid intratumoral infiltration and profound antitumor effects with long-term cures in a majority of GL261-bearing mice. (gpdunnlab.com)
This immunotherapy renaissance, however, has led to many combinations being advanced to late-stage development without definitive predictive biomarkers, limited phase I and phase II data, or clinical trial designs that are not optimized for demonstrating the unique attributes of immune-related antitumor activity-for example, landmark progression-free survival and overall survival. (emory.edu)

He is an Associate Professor of Neurosurgery, Pathology and Immunology at Duke University School of Medicine. (wikipedia.org)

The intersection of Dr. Gustafson's interests in cellular therapy, human immunology and biomarker development all contribute to the goal of optimizing biomanufacturing processes to increase the efficacy of cell therapy products used in investigational new drug trials. (mayo.edu)
Researchers must ensure reproducibility, efficacy and potency of cancer immunotherapy treatments before these reach the clinic. (technologynetworks.com)
While different methods exist to evaluate the efficacy of immunotherapy products, more efficient and robust in vitro assays are still required to ensure their safety and consistency. (technologynetworks.com)
The need for a novel cancer immunotherapy assay The most significant challenge faced by cancer immunotherapy researchers is the inability to predict treatment efficacy and response. (technologynetworks.com)
CAR T cell therapy is a form of engineered adoptive cellular therapy that has shown remarkable efficacy in the treatment of cancer, especially hematologic malignancies. (apbmt.org)
The therapeutic efficacy of neoantigen-specific T cells was assessed through a model of cellular therapy consisting of the transfer of activated MISTIC T cells and interleukin 2 into lymphodepleted tumor-bearing mice. (gpdunnlab.com)
Combining tumor-specific adoptive T cell therapy to the aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 reg-imens enhances efficacy in a synergistic manner. (unav.edu)

Sean Pitroda, MD , Assistant Professor of Radiation and Cellular Oncology, spoke at a major symposium on "integrated molecular subtyping to personalize radiation therapy for oligometastatic disease. (uchicagomedicine.org)
Ralph Weichselbaum, MD , Daniel K. Ludwig Distinguished Service Professor and Chair of Radiation and Cellular Oncology, moderated a forum on oligometastatic disease. (uchicagomedicine.org)
During the forum, Steven Chmura, MD, PhD , Associate Professor of Radiation and Cellular Oncology, gave an update on the current landscape for oligometastases clinical trials. (uchicagomedicine.org)
I am currently postdoctoral research fellow pursuing immunotherapy research in the oncology department at Stanford University. (stanford.edu)
My clinical training as a pediatric hematology oncology fellow at Memorial Sloan Kettering Cancer Center highlighted the desperate need for novel therapeutic options for a subtype of aggressive pediatric leukemia, Acute Myeloid Leukemia (AML). (stanford.edu)
Experts from Penn Medicine review breast cancer highlights and updates from the 2020 International Oncology Meetings. (pennmedicine.org)

Adoptive T cell therapy. (mayo.edu)
We developed adoptive cell therapy (ACT) which uses a patient's own immune cells to fight cancer. (manchester.ac.uk)
One of the first UK clinical trials of adoptive cell therapy for lymphoma (a type of blood cancer) took place in Manchester. (manchester.ac.uk)
CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)
One of the advantages with adoptive T-cell therapy is that we have a lot of engineering strategies," she said. (fredhutch.org)
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
The subset of mice that did not respond to the adoptive cell therapy showed evidence of retained neoantigen expression but intratumoral MISTIC T cell dysfunction. (gpdunnlab.com)
Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)

He also chaired a minisymposium on immunotherapy combination strategies in clinical trials. (uchicagomedicine.org)
Highlights from clinical trials. (nature.com)

Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. (mdpi.com)
As shown by multiplex tissue immunofluorescence and intravital microscopy, combined immunotherapy treatments enhance T cell infiltration and the intratumoral performance of T lymphocytes. (unav.edu)

CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. (taconic.com)

While the pathogenesis of CRS involves the activation of complex immune axes, including both cellular networks and inflammatory cytokine milieu, the mechanism of ICANS has not been fully elucidated. (apbmt.org)

Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
As an alternative, T cell receptor (TCR)-engineered cellular therapy against tumor-specific neoantigens has generated significant excitement, but there exist no preclinical systems to rigorously model this approach in glioblastoma. (gpdunnlab.com)
Q: How do you see this model/approach impacting preclinical CAR-T and immunotherapy development? (taconic.com)
This fact has huge implications for research focusing on preclinical CAR-T (or other immunotherapy) development. (taconic.com)

His PhD thesis highlighted the role of regulatory T cells in restricting anti-tumor responses against glioblastoma. (wikipedia.org)

Each year, the American Association for Cancer Research (AACR) Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world. (uchicagomedicine.org)
In this Perspective, June, Bluestone and Warshauer discuss potential cellular and molecular explanations for the autoimmunity often associated with immunotherapy, and propose additional research and changes to reporting practices to aid efforts to understand and minimize these toxic side effects. (nature.com)
Background The success and limitations of current immunotherapies have pushed research toward the development of alternative approaches and the possibility to manipulate other cytotoxic immune cells such as natural killer (NK) cells. (bmj.com)

Cancer immunotherapy consists of multiple approaches that harness and enhance the innate powers of the immune system to fight the disease. (technologynetworks.com)

Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)

Using immunology and genomics tools, we study how the immune response to brain tumors happens. (gpdunnlab.com)

Importantly, they highlight the need to have an eye on manufacturing, scalability, process development, and cost of goods early in the development process. (medpagetoday.com)
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. (unav.edu)
A major requirement for cancer immunotherapy is the development of biomarkers for prognosis and for monitoring therapy response. (oncotarget.com)

A number of different mechanisms and several areas of immune escape are being investigated, including cellular reprogramming (for example, epithelial to mesenchymal transition) and recruitment of regulatory T cells and myeloid derived suppressor cells into the tumor microenvironment. (mayo.edu)
Rosenberg and colleagues review evidence suggesting that T cells that target tumor neoantigens arising from cancer mutations are the main mediators of many effective cancer immunotherapies in humans. (nature.com)
In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)
These areas highlight some of the many challenges of the currently available CAR T cell products, which rely on high-quality autologous cells to be re-engineered and eventually reinfused, in an often costly, labor-intensive process which suffers from unanticipated delays and slow turnaround times. (medpagetoday.com)
Immunotherapy protocols are designed to annihilate immune escape in cancer cells and restore elimination of cancer cells. (oaepublish.com)
suggesting that this substance could influence the response of cancer cells to immunotherapy. (biomedcentral.com)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)

at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. (stanford.edu)

State-of-the art tumour-genome sequencing and analysis is enabling researchers to provide uniquely personalized immunotherapy. (nature.com)
For researchers interested in making foundational discoveries and improving human health, immunology is the best of both worlds, she said. (fredhutch.org)

What were the highlights of his more recent work (between 2012-2021)? (research.com)
It is currently viewed as one of the most promising forms of cancer treatment with 12 cancer immunotherapies approved in recent years. (technologynetworks.com)

It is a dose-limited factor of cancer immunotherapy and affects the prognosis and quality of life [ 15 ]. (hindawi.com)

She is a member of the Cancer Biology, Biophysics, and Immunology graduate programs. (stanford.edu)

As a result, the team, led by Professor Robert Hawkins, set up their own spin-out company, Cellular Therapeutics Ltd, in 2008. (manchester.ac.uk)
The University's spin-out company, Immetacyte (formerly Cellular Therapeutics Ltd), merged with Instil Bio in 2020. (manchester.ac.uk)

Michael P. Gustafson, Ph.D., is the scientific director of the Nyberg Human Cellular Therapy Laboratory at Mayo Clinic's Arizona campus. (mayo.edu)

Multiple myeloma is a chronic and incurable cancer," said Frederick L. Locke, MD, chair of the Blood and Marrow Transplant and Cellular Immunotherapy Department at Moffitt Cancer Center and senior author of the study. (medicalxpress.com)

In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)

Anatomy4

Organisms1

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes1

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Named Groups1

Health Care1

Geographicals1

Therapies17

Describing clinic1

Antigen8

Brain tumor immunology2

Society for Immunotherapy of Cancer2

Immunity4

Cancers5

Checkpoint inhibitors2

Advances1

Outcomes2

Myeloid cells1

Treg2

Patients12

Targets5

Therapeutic strategies1

Antitumor2

Neurosurgery1

Efficacy7

Oncology6

Cell therapy9

Clinical trials2

Lymphocytes2

20171

Cytokine1

Preclinical4

Glioblastoma1

Research3

Approaches1

Novel therapeutic1

Genomics1

Development3

Cells7

Molecular1

Researchers2

Recent2

Prognosis1

Cancer Biology1

Therapeutics2

Therapy1

Department1

Invasion1