Loading...
  • cellular
  • As the main target for a potential vaccine is the (overexpressed / mutated) p53 protein we will focus on studies aimed at the induction of humoral and cellular responses against this antigen. (biomedcentral.com)
  • However, before reviewing these studies we will briefly introduce some general aspects of the cellular immune system including antigen encounter, antigen processing and presentation and factors influencing the outcome of the immune response in ovarian cancer. (biomedcentral.com)
  • To determine if basiliximab enhances the magnitude or character of pp65-specific vaccine-induced cellular or humoral immune responses, inhibits or enhances activation-induced cell death, or induces immunologic or clinical evidence of autoimmunity. (clinicaltrials.gov)
  • All patients will undergo leukapheresis again for DC generation and immunologic monitoring with specific assessment of baseline antigen-specific cellular and humoral immune responses 3 + 1 weeks after vaccine #3. (clinicaltrials.gov)
  • CTLs
  • There is an urgent need to find a new approach to generate tumor-reactive CTLs for successful ACT-based therapies. (aacrjournals.org)
  • intratumoral
  • Reovirus efficiently destroys local as well as distant metastatic tumors in immunocompromised animals even after a single injection administered through intravenous, intraperitoneal, or intratumoral routes ( 25 - 28 ). (aacrjournals.org)
  • Vivo
  • In vivo evaluation shows that host immune response was generated against the HER2 tumor antigen, despite the high homology between HER2 and its murine counterpart ( neu gene). (hindawi.com)
  • patients
  • Patients will have blood drawn for immunologic monitoring before basiliximab infusions and prior to vaccines 1, 2, 3, and prior to monthly vaccines and then bimonthly through TMZ cycles without receiving any other prescribed antitumor therapy until progression. (clinicaltrials.gov)
  • Patients with high-risk localized tumors are usually treated with combinations of surgery, radiation, and/or chemotherapy. (hindawi.com)
  • Based on observations of tumor regressions in patients with concomitant streptococcal infections, William B. Coley injected streptococcal organisms into tumors, especially sarcomas, in the last decade of the 19th century [ 2 ]. (hindawi.com)
  • Cause of Cushing's syndrome in patients with tumors arising from "nonendocrine" tissue. (pubmedcentralcanada.ca)
  • chemotherapy
  • Neuropilin-1 expressing monocytes (NEM) are able to stabilize the tumor vasculature, thereby improving tumor oxygenation and reducing tumor malignancy, invasiveness, and resistance to chemotherapy. (aacrjournals.org)
  • human
  • Gamma-, or Type C, retroviruses are the most common retroviral elements in the human genome [ 20 ] and several examples have also been identified in mouse tumors [ 21 ]. (pubmedcentralcanada.ca)