CytokinesDiseaseSystemicInflammationChronic inflammatoryVirologicDiseasesCardiovascularFactorsPathogenesisViralGeneticDisordersInfiltratePathwaysReactionAcuteMechanisms are involvedResponsesProcessesClinicalRheumatoidImmuneLesionsTrypanosomaInvolvesPatientsMarkersPrevalenceResponseTherapyStimulationResearchEffectsTherapeuticSymptomsCells
Cytokines4
- Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which are recognized by different cellular pathogen recognition receptors (PRRs) and trigger production of type I interferons (IFN-I) and pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors. (etsu.edu)
- At lower levels, they can trigger release of mediators (cytokines, chemokines, immunoglobulins, and oxidants) of allergic and inflammatory responses [Pandya et al. (cdc.gov)
- After a tubal injury, pro-inflammatory cytokines are upregulated, which encourages embryo implantation, invasion, and angiogenesis inside the fallopian tube. (tutorialspoint.com)
- Les numérations plaquettaire et leucocytaire ainsi que la concentration en cytokines (IL-2R, IL-8 et TNF-) ont été me- surées. (who.int)
Disease22
- The inflammatory response that follows the infection by T. cruzi is essential to the host resistance, but it is also responsible for the damage observed in Chagas disease [ 4 ]. (hindawi.com)
- Pediatric Crohn's disease is a rare, inflammatory bowel disease characterized by severe, chronic inflammation of the intestinal wall or any portion of the gastrointestinal tract. (rarediseases.org)
- The exact cause of pediatric Crohn's disease is not fully understood, but this is thought to develop because of multiple different factors occurring together including genetic, immunologic and environmental triggers. (rarediseases.org)
- Immunologic and inflammatory diseases contribute to the progression of the disease. (emedicinehealth.com)
- The present invention relates to the novel use of Ramalin for treatment of inflammatory disease or immune disease. (justia.com)
- More specifically, the present invention relates to a pharmaceutical composition for preventing and treating inflammatory disease or immune disease, which contains Ramalin having anti-inflammatory activity or a salt thereof, and a method of preventing or treating inflammatory disease or immune disease using the composition. (justia.com)
- 2002]. Diesel particles may promote expression of the immunologic response phenotype (Th2) associated with asthma and allergic disease and may have greater immunologic effects in the presence of environmental allergens. (cdc.gov)
- Aspirin exacerbated respiratory disease (AERD) or NSAID exacerbated respiratory disease (NERD) is not an allergy in that there is no causal immunologic response. (aaaai.org)
- Crohn disease is an idiopathic, chronic inflammatory bowel disease characterized by cycles of relapse and remission. (medscape.com)
- Infection, ischaemia, physical damage, or specific immunologic sensitivity should be excluded as far as possible before a diagnosis of non-specific inflammatory bowel disease is made. (nih.gov)
- Ulcerative colitis (UC) is an inflammatory bowel disease. (psychiatrist.com)
- A few studies 2,4 have shown a positive association between inflammatory bowel disease and major depressive disorder, BD, and anxiety. (psychiatrist.com)
- Factors like brain-gut axis interactions, immunologic disturbances, oxidative stress, and vagus nerve dysfunction can cause inflammatory bowel disease and mental disorders. (psychiatrist.com)
- 3. Lee SH, Kwon JE, Cho ML. Immunological pathogenesis of inflammatory bowel disease. (psychiatrist.com)
- Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, frequently co-occurs with the immune-mediated inflammatory condition, psoriasis. (hcplive.com)
- New research suggests a causal effect between inflammatory bowel disease (IBD), particularly in Crohn's disease, and both psoriasis (PsO) and psoriatic arthritis (PsA), although not vice versa. (hcplive.com)
- Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis A Bidirectional 2-Sample Mendelian Randomization Study. (hcplive.com)
- Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment. (bvsalud.org)
- To understand the pathophysiology of immunologic and nonimmuno- allergic disease to those who research, treat, or manage allergic disease. (cdc.gov)
- The MASP-2 deficiency is associated with susceptibility to infections and with the development of immunologic disease. (lu.se)
- A number of factors trigger the disease process by causing a juxtaepithelial inflammatory reaction in the oral mucosa. (medscape.com)
- Psoriasis is a complex, chronic, multifactorial, inflammatory disease that involves hyperproliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate (see the image below). (medscape.com)
Systemic3
- Immunologic or inflammatory disorders of the ear may be localized, as in contact dermatitis , or may be a manifestation of a systemic process, such as atopic dermatitis , psoriasis, gout, sarcoidosis, or relapsing polychondritis. (medscape.com)
- Systemic immunologic and inflammatory aspects of allergic rhinitis. (medscape.com)
- About 30% of patients with psoriasis experience psoriatic arthritis, a systemic inflammatory arthritis sharing common pathogenetic and immunologic features with psoriasis," investigators stated. (hcplive.com)
Inflammation5
- The various etiologies that result in inflammation of the ear are numerous and may be categorized broadly as infectious, traumatic, and immunologic. (medscape.com)
- Eighteen rheumatoid arthritis (RA) patients, who had been treated with nonsteroidal antiinflammatory drugs (NSAIDs) only, were enrolled in a 12‐week, open‐label, randomized protocol to determine whether clinical responses might be associated with improvement in laboratory measures of inflammation and immunologic activity in RA patients treated with NSAIDs. (elsevierpure.com)
- In most cases, such inflammatory responses lead to the removal of pathogenic factors and the induction of adaptive immunity by the components of innate immunity (Hawiger J., Innate Immunity and Inflammation: A Transcriptional Paradigm. (justia.com)
- Encephalitis is inflammation of the parenchyma of the brain, resulting from direct viral invasion or occurring as a postinfectious immunologic complication caused by a hypersensitivity reaction to a virus or another foreign protein. (merckmanuals.com)
- One of our overarching strengths is our extensive therapeutic area expertise in relation to inflammatory bowel diseases, which often overlap with other diseases that can cause inflammation of the large intestine. (parexel.com)
Chronic inflammatory3
- Previously, we reported how the human Vitamin-D receptor (VDR) and its ligand, 1,25-dihydroxyvitamin-D (1,25-D), are associated with many chronic inflammatory and autoimmune diseases. (springer.com)
- Histology indicated a chronic inflammatory reaction to the photooxidized implant. (biomedcentral.com)
- Actinic Cheilitis (AC) was first described in 1923 as a chronic inflammatory disorder of the lips apparently due to actinic or solar rays 1 . (bvsalud.org)
Virologic5
- For more information, see the Virologic and Immunologic Characteristics of Severe Mpox among Persons with Advanced HIV Presentation [600 KB, 28 pages] . (cdc.gov)
- Describe the association between clinical outcomes and virologic and immunologic parameters among patients with severe mpox and advanced HIV. (cdc.gov)
- Characterize the effects of antivirals to treat mpox and/or HIV infection on virologic and immunologic parameters among patients with severe mpox and advanced HIV. (cdc.gov)
- Initiation of therapy in the asymptomatic person is more complex and involves consideration of multiple virologic, immunologic, and psychosocial factors. (cdc.gov)
- Although the pathogenesis of HIV infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, unique therapeutic and management considerations apply to HIV-infected children. (cdc.gov)
Diseases3
- Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases. (justia.com)
- 1998]. The immunologic evidence is consistent with results of epidemiologic studies that associate traffic-related air pollution, especially diesel exhaust particles, with an increase in respiratory diseases. (cdc.gov)
- Breast milk also contains immunologic agents or the mother's antibodies to diseases. (kkh.com.sg)
Cardiovascular2
- 8 Investigators seeking to understand the biological mechanisms linking depression and medical conditions have drawn attention to cardiovascular, immunologic, inflammatory, metabolic, and neuroendocrine pathways. (bmj.com)
- 2012]. Noncancer health effects also are associated with diesel exhaust exposure, including immunologic, respiratory, and cardiovascular effects. (cdc.gov)
Factors3
- Inflammatory responses are defensive responses which are caused by various factors such as infection with pathogens or injury of tissue in the body and perform initial protective action to limit damage to infected or injured areas. (justia.com)
- The etiology of this immune-related disorder comprises genetic, immunologic, and environmental factors. (medscape.com)
- Environmental, genetic, and immunologic factors appear to play a role. (medscape.com)
Pathogenesis2
- Inflammatory infiltrate shows an important role in the pathogenesis of chronic chagasic myocarditis [ 6 ] and inflammatory lesions in the enteric nervous system, associated with a drastic reduction in the number of neurons, reinforcing clinical findings in chagasic megacolon/megaesophagus [ 7 - 10 ]. (hindawi.com)
- The findings from our study are contrary to what we expected based on prior studies 2,4 and inflammatory pathogenesis. (psychiatrist.com)
Viral3
- The extent to which the pathology of mpox in patients with advanced HIV is driven by mpox viral effects versus a dysregulated immune response - and potentially immune reconstitution inflammatory syndrome (IRIS) - is unclear. (cdc.gov)
- CDC is collaborating with the National Institutes of Health (NIH) to study the extent of mpox viral spread and immunologic markers in people with advanced HIV. (cdc.gov)
- Encephalitis can occur as a secondary immunologic complication of certain viral infections or vaccinations. (merckmanuals.com)
Genetic1
- single-cell sequencing combined with new macrophage-specific genetic tools has provided unexpected insights into the tissue-specific and inflammatory diversity of macrophages. (nature.com)
Disorders1
- We propose a cellular trial operation at UCSF that will focus on childhood hereditary hematological and immunologic disorders and in anti-inflammatory lung cellular therapies. (ca.gov)
Infiltrate2
- To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). (hindawi.com)
- In the connective tissue, solar elastosis was found in 100% of the patients with varied degrees of inflammatory infiltrate and vessel dilatation. (bvsalud.org)
Pathways2
- In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. (justia.com)
- Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways. (cdc.gov)
Reaction1
- Bruxism: Bruxism, or teeth grinding, is a habit that can result in muscle spasm and an inflammatory reaction that can cause the initial pain. (emedicinehealth.com)
Acute3
- The acute inflammatory response to LPS stimulation was not negatively affected. (nih.gov)
- Cytokine assessment indicated that Sceletium possesses mild anti-inflammatory properties, but does not hinder the mounting of an adequate immune response to acute immune challenge. (nih.gov)
- Acute inflammatory dermatosis conditions include erythema multiforme (EM), pruritus (urticaria), and eczema ( TABLE 1 ). (uspharmacist.com)
Mechanisms are involved2
- 3 Inflammatory mechanisms are involved in UC and BD, and psychiatric comorbidity in UC increases morbidity and deteriorates the quality of life by increasing relapses and treatment nonresponsiveness. (psychiatrist.com)
- Since inflammatory mechanisms are involved in UC and BD, the findings from our analysis are counterintuitive. (psychiatrist.com)
Responses3
- Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization. (medscape.com)
- Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. (justia.com)
- The University of Washington team, led by Joshua Thaler, MD, PhD, associate professor of medicine with the UW Medicine Diabetes Institute, genetically engineered mice to prevent microglia from activating inflammatory responses, and found that these mice ate 15 percent less and gained 40 percent less weight on a high fat diet, suggesting that the inflammatory capacity of microglia itself is responsible for the animals' overeating and weight gain. (sciencedaily.com)
Processes4
- MS is driven by inflammatory processes in the CNS that involve autoreactive lymphocytes (T- and B-cells), depletion of oligodendrocytes (that normally produce the myelin sheath that allow for saltatory conduction throughout axons), and, ultimately, the degradation of axons in the CNS. (psychiatrist.com)
- These inflammatory, immunologic, and degenerative processes are tightly interconnected. (psychiatrist.com)
- The third hypothesis states that these inflammatory and neurodegenerative processes contribute equally, or simultaneously, to the pathophysiologic picture of MS, but occur independently of one another. (psychiatrist.com)
- put out new autoimmune hypothesis for atherogenesis in the context of many data that speak for an important role of inflammatory-immunologic processes. (scielo.br)
Clinical2
- clinical, laboratory, and immunologic assessments were done biweekly for 10 weeks. (elsevierpure.com)
- CONCLUSIONS AND CLINICAL RELEVANCE These data indicated that calcitriol induced an anti-inflammatory shift in canine leukocytes exposed to LPS, LTA, and MDP in vitro, without altering phagocytosis or TLR4 expression. (avma.org)
Rheumatoid1
- Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. (wikipedia.org)
Immune4
- Therefore, the effect of Sceletium supplementation on immune cell functionality is of interest, since the efficacy of potential depression treatments could, at least in part, rely on downregulation of pro-inflammatory signalling. (nih.gov)
- The Immunologic adjuvant properties known to enhance the immune system. (planetayurveda.com)
- The presence of anti-inflammatory agents in breast milk also helps to regulate the body's immune system response against infection. (kkh.com.sg)
- T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions. (bvsalud.org)
Lesions2
- 4 The loss of axons and neurons is central to MS, which often begins with focal inflammatory lesions. (psychiatrist.com)
- Describe the relationship between the immunologic response and the persistence and replication competence of mpox virus at rash lesions, in blood, in tissue, and at mucosal sites over the course of severe mpox illness among patients with advanced HIV. (cdc.gov)
Trypanosoma1
- Reviewing the literature, we came across few studies of direct microscopic examination of Trypanosoma cruzi in chronically infected human tissues and we did not find studies evaluating both research on T. cruzi and inflammatory infiltration simultaneously in histological sections of esophagus and colon from chagasic patients with and without mega. (hindawi.com)
Involves1
- Chorioretinitis (CR) is an inflammatory process that involves the uveal tract of the eye. (medscape.com)
Patients4
- The aim of this study was to evaluate comparatively the inflammatory process in muscular and myenteric plexus of esophagus and colon from chronic chagasic patients with and without mega, with the purpose of ascertaining whether there are similarities between the process in esophagus and colon and between cases with and without evident parasitism in the organ. (hindawi.com)
- We analyzed changes in immunologic values over time for 28 hospitalized patients with pandemic (H1N1) 2009. (cdc.gov)
- We retrospectively analyzed immunologic changes for hospitalized patients through the entire course of pandemic (H1N1) 2009. (cdc.gov)
- Another explanation for the reciprocal relationship between UC and BD could be the use of anti-inflammatory agents in UC patients. (psychiatrist.com)
Markers2
- Unfortunately, our dataset could not ascertain information about the inflammatory markers in UC and BD. (psychiatrist.com)
- Also, it is possible that treatment of BD could influence inflammatory markers and hence UC symptoms. (psychiatrist.com)
Prevalence1
- It is hypothesized that an inflammatory gut causes a higher prevalence of psychiatric illness. (psychiatrist.com)
Response2
- To confirm this finding, the UCSF researchers developed a strain of genetically engineered mice in which they could use a drug to activate the inflammatory response of microglia at will. (sciencedaily.com)
- Once there, the new recruits shape-shift to take on features similar to those of the brain's own microglia, augmenting the inflammatory response and its impact on energy balance. (sciencedaily.com)
Therapy1
- Three-quarters, two-thirds probably need some type of a biologic, immunologic therapy from the start. (hcplive.com)
Stimulation1
- Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g. (bvsalud.org)
Research1
- Immunologic Research. (justia.com)
Effects1
- It has anti-inflammatory, immunologic and antiallergenic effects. (wikipedia.org)
Therapeutic1
- These phytochemicals are known to provide therapeutic properties such as - antioxidant, analgesic, anti-inflammatory, stimulatory etc. (planetayurveda.com)
Symptoms1
- Rather the inhibition of cyclo-oxygenase 1 (COX-1) is the primary stimulus of symptoms and signs, with the reduction of the anti-inflammatory PgE2 (1). (aaaai.org)
Cells1
- Recent studies indicate that atopic dermatitis may be the result of an altered immunologic balance in which T H 2 cells (a subtype of helper T lymphocytes) predominate. (medscape.com)