Immunol murine t cell. Medical search. Frequent questions

Front Immunol. (ucdavis.edu)

Morphine has been shown to negatively impact macrophage function by impairing the proliferation of macrophage progenitor cells, inhibiting cytokine secretion leading to decreased chemotaxis, hindering the ability of macrophages to directly phagocytize pathogens, and inhibiting nitric oxide production. (uspharmacist.com)
Dr. Welm's group discovered that the Ron kinase pathway is an important facilitator of breast cancer metastasis through its unique dual function in tumor cells and in resident macrophages. (utah.edu)
2000. Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery. (dbkgroup.org)
FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
Further analyses on wild-type and CLECSF8 -/- primary macrophages in vitro , or cells harvested after intra-peritoneal and intra-tracheal instillation of BCG demonstrated a lack of Mincle-upregulation in the absence of CLECSF8. (biomedcentral.com)
All pathogenic Salmonella species, when present in the gut are engulfed by phagocytic cells, which then pass them through the mucosa and present them to the macrophages in the lamina propria. (medscape.com)
Macrophages and intestinal epithelial cells then attract T cells and neutrophils with interleukin 8 (IL-8), causing inflammation and suppressing the infection. (medscape.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Faustman hypothesized that this regeneration may be attributed in part to the re-differentiation of the spleen cells - that although the splenic stem cells were not obligatory for regeneration to occur, these cells could hasten regeneration. (wikipedia.org)
Broadly, inception of PF is considered as a cumulative effect of repetitive Alveolar Epithelial Cell (AEC) injury, abnormal wound healing, fibroblasts proliferation and subsequently their differentiation into myofibroblasts, which leads to accumulate voluminous Extracellular Matrix (ECM) within interstitial spaces and finally materialized as fibrosis[ 2 ]. (ijpsonline.com)
Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. (southernbiotech.com)
The expression of CSF-1R, a receptor important for myeloid cell migration, differentiation and survival, and the effect of its therapeutic blockade in the context of GVAX in PDAC has not been investigated. (bmj.com)
By integrating advanced molecular, imaging, single cell transcriptomics, and statistical approaches, we study how molecules work together to control the timing and the spatial pattern of cell differentiation in developing tissues and stem cell systems. (usc.edu)
8. Lui O, Mak N, Leung K. Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells. (southernbiotech.com)
To this end, we have focused on investigating the cellular and molecular mechanisms governing T cell differentiation, activation and effector function after allo-HCT. (umaryland.edu)
Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction. (bvsalud.org)
We tested the contribution of mucosal Langerhans cells (LCs) to alveolar bone homeostasis in mice following oral colonization with a well-characterized human periodontal pathogen, Porphyromonas gingivalis We found that oral mucosal LCs did not protect from or exacerbate crestal alveolar bone destruction but were responsible for promoting differentiation of Th17 cells specific to P. gingivalis. (bvsalud.org)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8 + T cells and evaluate its potential efficacy in murine breast cancer models. (frontiersin.org)

For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
J Immunol;197(4): 1435-46, 2016 08 15. (bvsalud.org)

2019 Cell Mol Immunol. (invivogen.com)

J Allergy Clin Immunol 125:S41-52.3. (scriptiebank.be)
Curr Opin Allergy Clin immunol 5:119-124. (cdc.gov)

13 Morphine has been shown to decrease IL-23 production in murine models, decreasing dendritic cell antimicrobial protein production. (uspharmacist.com)

Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
Several lines of evidence support the hypothesis that gonadal steroids exert effects on the development of B cells in bone marrow. (jci.org)
Androgens also exert effects on B cell development in bone marrow. (jci.org)
reported the discovery of a novel infects a large range of cell types and causes a variety of virus in human skin specimens and named it human pathologies (including bone marrow aplasia leading to gyrovirus (HGyV) ( 1 ). (cdc.gov)
CD25 is expressed on precursor B cells in bone marrow. (southernbiotech.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Splenic endothelial cell lines support development of dendritic cells from bone marrow. (southernbiotech.com)
Characterization of immune cell contexture in adult ALL bone marrow microenvironment. (helsinki.fi)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

Stange, J. & Veldhoen, M. The aryl hydrocarbon receptor in innate T cell immunity. (nature.com)
The anti-IFV mechanism of MM-2 involves innate immunity through significant increases in NK cell activities in the lungs and spleen and a significant increase in pulmonary gene expression of NK cell activators such as IFN-γ, IL-2, IL-12 and IL-18. (nih.gov)
Oral administration of MM-2 for 17 days activates systemic immunoreactivity in PPs, which contributes to innate immunity, including NK cell activation, resulting in an anti-IFV effect. (nih.gov)
CD4 + T cells play an important role in conferring protective immunity towards the liver stages of the malaria parasite [ 3 ]. (omicsonline.org)
It has also been reported that protective immunity can be transferred to naive hosts by transfer of immune CD4+ T cells [ 4 ]. (omicsonline.org)
Describes robust CD8+ T cell-mediated vaccine-induced immunity in a murine immunosenescence model. (mpg.de)
The scientific interests of my lab have been directed towards understanding the complexities of T cell biology and how T cells contribute to tumor immunity and transplantation immunity. (umaryland.edu)

2B4 antibody activates lytic and secretory functions of IL-2-cultured NK cells and CD244.2+ T cells. (bdbiosciences.com)
CD4 + T cells stimulate B cells to induce significant level of antimalarial antibody response and also help in the induction of CD8 + T-cell responses which help in arresting the growth of liver-stage parasites in the host. (omicsonline.org)
In the pre-clinical murine model, administering anti-CSF-1R antibody prior to and after GVAX/αPD-1 ("pre/post-αCSF-1R + αPD-1 + GVAX") enhanced the survival rate compared to GVAX/αPD-1 dual therapy ( p = 0.005), but administering anti-CSF-1R only before GVAX/αPD-1 did not ( p = 0.41). (bmj.com)
Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes. (ucdavis.edu)
B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection. (lsuhsc.edu)
Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation (1-3). (rndsystems.com)
Continuous cultures of fused cells secreting antibody of predefined specificity. (scriptiebank.be)

Aryl hydrocarbon receptor is critical for homeostasis of invariant γδ T cells in the murine epidermis. (nature.com)
The murine IL 2 receptor. (southernbiotech.com)
Monoclonal anti-IL 2 receptor antibodies as specific inhibitors of T cell function in vitro. (southernbiotech.com)
Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs. (utah.edu)
CD244 is a type I transmembrane glycoprotein that is also known as Natural killer cell receptor 2B4 (NKR2B4), or Signaling lymphocytic activation molecule 4 (SLAMF4). (bdbiosciences.com)
G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)
A 438079 hydrochloride is a competitive P2X 7 receptor antagonist (pIC 50 = 6.9 for the inhibition of Ca 2+ influx in the human recombinant P2X 7 cell line). (tocris.com)
How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells? (biomedcentral.com)
T-cell receptor (TCR)-induced IL-2 expression is suppressed at the level of mRNA and protein following chronic culture of T cells with tumour necrosis factor (TNF) at picomolar concentrations, an effect that is reversible upon removal of TNF. (biomedcentral.com)
Clark JM, Annenkov AE, Panesar M, Isomäki P, Chernajovsky Y, Cope AP: T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha. (biomedcentral.com)
CD4(+) Th cells activated by a microbial biofilm are thought to contribute to the destruction of alveolar bone surrounding teeth by influencing osteoclastogenesis through IL-17A and receptor activator for NF-κB ligand effects. (bvsalud.org)

It also delivers its function without activating regulatory T cells (Tregs) ( 9 ) and mediating activation-induced cell death of effector cytotoxic T cells ( 10 ). (frontiersin.org)
Leigh ND, O'Neill RE, Du W, Chen C, Qiu J, Ashwell J, McCarthy PL, Chen G, Cao X . Host-derived CD70 suppresses murine GVHD by limiting donor T cell expansion and effector function. (umaryland.edu)

Later, an in vivo study was planned to evaluate and compare the efficacy of two selected compounds namely forskolin (20 mg/kg) and rutin (100 mg/kg), individually and in combination against standard drug pirfenidone (50 mg/kg) using bleomycin-triggered pulmonary fibrosis murine model. (ijpsonline.com)
To elucidate the biological mechanisms underlying pulmonary metastasis and identify superior therapeutic strategies, we developed a novel and clinically relevant murine RCC model exhibiting enhanced pulmonary metastasis. (biologists.com)

Somatic mutations in in expanded T cell clones were discovered in patients with immune-mediated aplastic anemia. (helsinki.fi)
T cells with somatic mutations on JAK-STAT and MAPK pathway genes were characterized by single-cell transcriptomics. (helsinki.fi)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells. (southernbiotech.com)

Injecting the mice with a common inflammatory agent that increases the production of TNF-α, called complete Freund's adjuvant (CFA), and a preparation of spleen cells reversed type 1 diabetes in mice with end-stage disease and allowed the beta islet cells to regenerate. (wikipedia.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
In mice that were intranasally inoculated with IFV, oral administration of MM-2 for 17 consecutive days improved clinical symptoms, reduced mortality, suppressed inflammation in the lower respiratory tract, and decreased virus titers, cell death, and pro-inflammatory cytokines such as IL-6 and TNF-α in bronchoalveolar lavage fluid. (nih.gov)
Even in non-infected mice, MM-2 administration also induced significant enhancement of both IFN-γ production by Peyer's patch cells (PPs) and splenetic NK cell activity. (nih.gov)
Kumar V, Rakha A, Saroa R, Bagai U (2015) CD4+T Cells Expansion in P. berghei (NK-65) Infected and Immunized BALB/C Mice. (omicsonline.org)
Experiments with B cell deficient mice have demonstrated that B cells and antibodies are essential for complete clearance of parasites from blood of the host [2]. (omicsonline.org)
Mice underwent intrarenal implantation using luciferase-expressing Renca, a murine renal adenocarcinoma cell line. (biologists.com)
Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia. (lsuhsc.edu)
In mice, MDSC can be identified by species-specific cell surface markers (CD11b + Gr-1 + ) and may be further classified as monocytic (M-MDSC, Ly-6C hi ) or granulocytic (G-MDSC, Ly-6G + ) based on additional cell surface markers [ 6 ]. (iospress.com)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Because alcohol blocks airway epithelial cell release of IL-6 in vitro , we hypothesized that alcohol exposure would alter mouse lung inflammatory responses to HDE. (cdc.gov)

however, they did not find that the splenic cells played a role and suggested that the source of islet cell regeneration was proliferation of existing pancreatic islet cells. (wikipedia.org)
IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)

I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. (southernbiotech.com)
T cells provide protection to infection by cytokine-mediated mechanisms or through production of antibodies. (omicsonline.org)
Breaking chemoresistance and radioresistance with [ 213 Bi]anti-CD45 antibodies in leukemia cells. (southernbiotech.com)
New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells. (southernbiotech.com)
In the absence of mature B cells, patients lack lymphoid tissue and fail to develop plasma cells, the cells that manufacture antibodies. (medscape.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

CD25 + regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine. (southernbiotech.com)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Flow cytometry analysis of tumor infiltrating T-cells in a murine model of PDAC was performed to investigate the therapeutic effects and mechanism of anti-CSF-1R/anti-PD-1/GVAX combination immunotherapy. (bmj.com)

2 Previous studies have evaluated the opioid receptors on a wide array of immune cells. (uspharmacist.com)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)

J. Cell Biol. (nature.com)
Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration Front Cell Dev Biol. (usc.edu)
In vivo time-lapse imaging reveals extensive neural crest and endothelial cell interactions during neural crest migration and formation of the dorsal root and sympathetic ganglia Dev Biol. (usc.edu)
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death Integr Biol 7, 1339-1377. (dbkgroup.org)

Targeted delivery of tumor necrosis factor-α to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin. (southernbiotech.com)

J Immunol Methods. (southernbiotech.com)

We are studying the mechanisms by which chronic TNF suppresses T-cell responses in the CD4 + mouse T-cell hybridoma clone, 11A2. (biomedcentral.com)

Hayday, A.C. γδ T cells and the lymphoid stress-surveillance response. (nature.com)
Germinal centers where B cells proliferate and differentiate are poorly developed in all lymphoid tissue, including the spleen. (medscape.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)

2002. Formation and resuscitation of 'non-culturable' cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase. (dbkgroup.org)

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). (southernbiotech.com)

E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells. (invivogen.com)
This subset of T cells play critical role in maintaining immune homeostasis and controlling excessive immune responses [ 5 ]. (omicsonline.org)
Natural Treg cells during primary exposure to malaria enhanced Th1 memory responses and increased disease severity during re-infection. (omicsonline.org)
CD4(+) T-Cell-Independent Secondary Immune Responses to Pneumocystis Pneumonia. (lsuhsc.edu)
Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)
From a physiological standpoint, MDSC can be thought of as effectors of a homeostatic mechanism that regulate T cell-mediated inflammatory responses to pathogens [ 5 ]. (iospress.com)
These altered responses may affect the ability of TNF-treated cells to remodel pIL-2 productively through NFκB consensus binding upon cell stimulation [ 4 ]. (biomedcentral.com)
O'Neill RE, Du W, Mohammadpour H, Alqassim E, Qiu J, Chen G, McCarthy PL, Lee KP, Cao X. T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses. (umaryland.edu)
The relative roles of mucosal Ag presentation cells in directing Th cell immune responses against oral pathogens and their contribution to destruction of alveolar bone remain unknown. (bvsalud.org)
A few of these inflammatory responses, such as inflammatory cell recruitment, can be modulated by alcohol exposure [ 1 , 2 , 3 , 4 ]. (cdc.gov)
Since mast cells are active during inflammatory responses it becomes crucial to find out if these cells are actually present and play a role in dental pulp under normal and inflammatory conditions either in humans or in rats. (bvsalud.org)

Faustman's hypothesis is that certain autoimmune diseases can be treated by stimulating TNF-α to trigger apoptosis in autoimmune T cells. (wikipedia.org)
Dual B-cell targeting therapy ameliorates autoimmune cholangitis. (ucdavis.edu)
Treatment with a JAK1/2 inhibitor ameliorates murine autoimmune cholangitis induced by IFN overexpression. (ucdavis.edu)

Intraperitoneal administration of IL-15cx results in a moderate inhibition of breast cancer growth that is associated with an increase in the frequency of cytotoxic CD8 T cells and the improvement of their function. (frontiersin.org)
The depletion of myeloid-derived suppressor cells (MDSCs) has no impact on mouse breast cancer growth. (frontiersin.org)
Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). (umassmed.edu)
Ali MA, Choy H, Habib AA, Saha D. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. (famri.org)
Viable cells produce a pheromonal factor which is necessary for such resuscitation, and this system represents the first example of an autocrine bacterial growth factor or cytokine. (dbkgroup.org)

Further, forskolin and rutin co-administration showed effectively decline in Szapiel's and Ashcroft scores and maximally diminish mast cell accumulation than that manifested by pirfenidone in lungs. (ijpsonline.com)
Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis. (southernbiotech.com)

The antitumor efficacy was studied in mouse mammary carcinoma models (Her2/neu transgenic and 4T1-luc mammary cancers) treated with systemic recombinant protein with/without the depletion of myeloid-derived suppressor cells or intra-tumoral gene electrotransfer (GET). (frontiersin.org)

The incidence of renal cell carcinoma (RCC) is high, and its outcomes remain poor. (biologists.com)

It is expressed on all natural killer (NK) cells, IL-2-activated NK (LAK) cells, committed progenitors of NK cells, and a subset of T lymphocytes which mediate non-MHC-restricted cytoxicity, including dendritic epidermal T cells. (bdbiosciences.com)
Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)

Bifidobacterium longum MM-2 (MM-2), a very safe bacterium in humans, was isolated from healthy humans and its protective effect against IFV infection in a murine model shown. (nih.gov)
Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis. (lsuhsc.edu)
Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD. (lsuhsc.edu)
The immunomodulatory potential of microRNA 210 and regulatory T cells in a murine model of chemical sensitization. (cdc.gov)
Our data indicate that both LCs and Th17 cells are redundant in contributing to alveolar bone destruction in a murine model of periodontitis . (bvsalud.org)

Micro-aspiration of gut bacteria or movement of sensitized immune cells through lymph or bloodstream can also influence immune response of other organs. (frontiersin.org)
PD-L1 is expressed mainly on tumor-infiltrating immune cells in roughly 41% of patients with triple negative breast cancer ( 5 ). (frontiersin.org)
There were also significant differences in microbial composition in dust samples and in innate immune cells between the two groups of children. (medscape.com)

On the other hand, donor-derived T cells can protect the host from infection, and can also identify and attack host tumor cells, producing the beneficial graft-versus-tumor (GVT) effect. (umaryland.edu)

The biochemical features of murine CD25 have been characterized in detail. (southernbiotech.com)
To pursue a research career with a goal to improve cancer treatment, I enrolled in PhD training at the University of Florida in Dr. Stratford May's laboratory where I studied the biochemical pathways regulating cell death in the setting of blood cancers. (umaryland.edu)

Discovery of beneficial immunomodulatory effects of dasatinib in murine solid tumor models. (helsinki.fi)

Resistance to GVAX was associated with an immune-suppressive myeloid cell infiltration, which may limit further therapeutic gains of GVAX/αPD-1 therapy. (bmj.com)

We have found that, although chronic TNF attenuates TCRζ expression and TCR-proximal signalling, IL-2 expression is suppressed regardless of whether cells are stimulated via the TCR, or with phorbol ester and calcium ionophore to activate the MAPK and NFAT pathways directly. (biomedcentral.com)
Chronic culture of murine T cells in TNF does not alter the stability of IL-2 mRNA induced via TCR, or by PMA and ionomycin, in those cells. (biomedcentral.com)

Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells. (nature.com)
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
Alcohol-associated intestinal dysbiosis alters mucosal-associated invariant T-cell phenotype and function. (lsuhsc.edu)

Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b + CD11c + dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. (southernbiotech.com)

An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)

3. Radu DL, Weksler ME, Bona CA. Maintenance of size and function of influenza virus hemagglutinin specific transgenic T-cell clone during life. (southernbiotech.com)

Faustman hypothesizes that BCG could induce a permanent gene expression that restores regulatory T cells (Tregs), helping to prevent the immune system attack which characterizes type 1 diabetes. (wikipedia.org)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)

Turchinovich, G. & Hayday, A.C. Skint-1 identifies a common molecular mechanism for the development of interferon-γ -secreting versus interleukin-17-secreting γδ T cells. (nature.com)

Faustman's current research is based on the observation that autoreactive T cells (T cells that mistakenly attack the body's own cells and tissues) are more sensitive than normal T cells to the effects of TNF-alpha (TNF-α), a cytokine that influences the immune system. (wikipedia.org)
The immune system consists of many cell types and is highly integrated within other tissues. (nature.com)
GVHD is mediated by donor-derived T cells which recognize and damage genetically distinct normal host tissues. (umaryland.edu)
In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) are also involved in the mechanism of immune regulation against Plasmodium infection. (omicsonline.org)

11,12 Dendritic cells are essential to the innate immune system through their presentation of foreign antigens to T-cells. (uspharmacist.com)

Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)

Participants who received BCG vaccination also experienced a transient increase in the number of circulating dead autoreactive T cells against insulin. (wikipedia.org)

Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. (lu.se)

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. (nature.com)
The genome of HGyV, which resembles CAV more aimed at defi ning the prevalence of HGyV infection in closely than other members of the family ( 1 , 3 ), contains different human populations, portal of entry, type of cells an untranslated region of 380 nt and 3 major partially targeted during primary amplifi cation, and site of latency/ overlapping open reading frames (named viral protein [VP] persistence. (cdc.gov)
At least two isoforms of CD244.2 protein, products of alternative splicing of hnRNA, are expressed on IL-2-activated C57BL/6 NK cells. (bdbiosciences.com)
Ingmundson, A., Alano, P., Matuschewski, K., and Silvestrini, F. (2014) Feeling at home from arrival to departure: Protein export and host cell remodeling during Plasmodium liver stage and gametocyte maturation. (mpg.de)
Overview on protein export and host cell remodeling beyond asexual replication, in Plasmodium gametocytes and liver stages. (mpg.de)
Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)

2. de Goër de Herve MG, Jaafoura S, Vallée M, Taoufik Y. FoxP3 + regulatory CD4 T cells control the generation of functional CD8 memory. (southernbiotech.com)
Interestingly, we find that in vivo clonal expansion of P. gingivalis-specific Th cells and induced regulatory T cells does not depend on mucosal LCs. (bvsalud.org)

The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)

Stem Cells. (southernbiotech.com)

Anatomy31

Organisms24

Diseases16

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes57

Disciplines and Occupations1

Information Science3

Health Care1

Front Immunol1

Macrophages8

Differentiation12

Efficacy in murine1

20162

20191

Clin Immunol2

Dendritic cell1

Bone marrow14

Immunity7

Antibody7

Receptor11

Effector2

Pulmonary2

Mutations3

Hematopoietic cells1

Mice11

Vitro1

Proliferation3

Antibodies6

Immunotherapy3

Receptors2

Biol4

Protects1

Methods1

Suppresses1

Lymphoid4

20021

Glycoprotein1

Responses11

Autoimmune3

Growth5

Mast cell2

Suppressor cells1

Renal1

Lymphocytes2

Model5

Immune cells3

Tumor cells1

Biochemical2

Immunomodulatory1

Therapeutic1

Chronic2

Intestinal3

Chemotaxis1

Myeloid-derived suppressor1

Transgenic1

Induce2

ELISA1

Interleukin1

Tissues5

Tregs1

Innate immune1

Plasmacytoid Dendr1

Autoreactive T cells1

Secretion1

Protein6

Regulatory2

Spleen1

Stem cells1