• hybridization (Seafood) and/or immunohistochemistry (IHC) isn't consistently performed in sufferers with Sq-LC, resulting in inadequate identification from the molecular tumor subtype, that may affect decisions relating to the best treatment plans. (exposed-skin-care.net)
  • The term carcinoma of unknown primary site (CUPS) is used when dealing with a metastasis that occurs before primary tumor diagnosis. (medscape.com)
  • [ 2 ] On the other hand, some metastases may be epidermotropic and simulate a primary epidermal tumor. (medscape.com)
  • We collected paired PL and LM tumor samples to analyze the organ-specific difference using whole-exome sequencing, RNA sequencing, and multiplex immunohistochemistry. (bmj.com)
  • Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
  • Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. (gastrores.org)
  • With the destruction of the alveolar framework by tumor growth, BAC develops into mixed BAC and invasive adenocarcinoma, which is a natural model of transformation from carcinoma in situ to invasive carcinoma. (elis.sk)
  • Previous studies had confirmed that Lasp1 was significantly overexpressed in multiple malignant tumors including non-small-cell lung cancer (NSCLC) and enhanced tumor proliferation, invasion and metastasis [ 7 - 13 ]. (oncotarget.com)
  • The tumor was completely resected, the pathological diagnosis being adenocarcinoma, and small clump of cancer cells having been found in the muscularis propria (pathological stage T2N0M0 (AJCC classification), pathological effect grade 2) (Fig. 2 ). (springeropen.com)
  • SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis. (nih.gov)
  • SPARC expression was mainly in the stromal cells surrounding the colon cancer, and was significant difference in those tissues with the lymph node metastasis and differentiation degree of tumor. (nih.gov)
  • Invasive adenocarcinoma was discovered during a biopsy of the tumor. (ircmj.com)
  • In contrast, metastases located in the axillary region are more likely to be related to a primary tumor in the breast while metastases on the lower trunk are mostly seen in colorectal carcinomas. (asploro.com)
  • An example of this challenge is distinguishing gastric metastases originating from breast cancer from a gastric primary tumor. (biomedcentral.com)
  • Immunohistochemistry suggested adenocarcinoma and possible breast or primary gynecologic tumor. (surgicalneurologyint.com)
  • Open up in another home window Fig. 1 a Macroscopic appearance of the pancreatic ductal adenocarcinoma displaying a badly demarcated company white tumor in the pancreatic parenchyma (Tumor, pancreatic parenchyma, duodenum). (mslideas.com)
  • Immunohistochemistry demonstrated that these tumor cells were positive for both cytokeratin 7 (CK7) and thyroid transcription factor-1 (TTF-1) and were negative for both CK20 and thyroglobulin, which concords with metastatic disease from lung origin (Figs. 1 and 2 ). (biomedcentral.com)
  • Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
  • Digital papillary adenocarcinoma (DPA) is a rare malignant eccrine tumor. (turkjpath.org)
  • Small bowel metastasis from malignant tumors is generally rare and underreported. (karger.com)
  • Some common tumors, however, may not result in metastasis in a manner that parallels their incidence in the overall population. (medscape.com)
  • Certain attributes distinguish metastases from primary tumors. (medscape.com)
  • Ex vivo analysis of tumors and lymph nodes was performed via autoradiography, histopathology, and immunohistochemistry. (snmjournals.org)
  • CNS metastases from any gynecological neoplasia are a rare occurrence and amount to about 1% of all tumors of uterine, cervical, or ovarian origin. (clinsurgeryjournal.com)
  • We performed immunohistochemistry analysis of HNF4A, ER, PR and GCDFP-15 in 126 patients divided into three cohorts: primary breast cancer, primary gastric cancer and both types of tumors. (biomedcentral.com)
  • however, the prognosis and treatment substantially differ among patients who present with (1) both primary tumors (BC and gastric) and (2) primary BC and metastases to stomach. (biomedcentral.com)
  • The majority of tumors related in feline uterus are adenocarcinomas and leiomyoma. (vin.com)
  • Although pyometra must be the first differential diagnosis, the tumors must also be considerate in differentials, mainly in old cats, with histologically and immunohistochemistry evaluation used as the most important tools for diagnosis and differentiation. (vin.com)
  • The primary microscopic differential medical diagnosis includes PDAC precursor lesions, various other malignant pancreatic tumors (Desk?1), adenocarcinoma and pancreatitis metastasis. (mslideas.com)
  • Using paclitaxel (Taxol), another antimicrotubule drug, alone has had moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma. (medscape.com)
  • Biopsy of these nodules showed several malignant glandular structures infiltrating the corpus cavernosa of the penis suggestive of a poorly differentiated adenocarcinoma, confirmed immunohistologically (Figure 2 ) as of prostatic origin. (biomedcentral.com)
  • Herein, we report a rare case of a small colon cancer with a depressed component and aggressive malignant potential with systemic metastasis, where the chief complaint was cervical lymph node swelling. (biomedcentral.com)
  • Malignant lymphoma (ML) was first suspected, but aspiration cytology and biopsy of the lymph node suggested metastatic adenocarcinoma resulting from breast cancer. (biomedcentral.com)
  • Cutaneous metastasis may herald the diagnosis of internal malignancy, and early recognition can lead to accurate and prompt diagnosis and timely treatment. (medscape.com)
  • The pathology diagnosis was liver with metastatic hepatoid adenocarcinoma consistent with colonic primary. (gastrores.org)
  • Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. (spandidos-publications.com)
  • Lung cancer is the leading cause of cancer-related death worldwide, with most patients presenting with metastases during diagnosis ( 1 ). (spandidos-publications.com)
  • Furthermore, the literature relevant to the occurrence, diagnosis and treatment of GI metastasis of lung cancer was reviewed. (spandidos-publications.com)
  • A clinical diagnosis of penile metastases was made. (biomedcentral.com)
  • Immunohistochemistry for PSA confirmed histological diagnosis. (biomedcentral.com)
  • Pathological examination of an open muscle biopsy showed a poorly differentiated adenocarcinoma, supporting a diagnosis of gastric cancer metastases in multiple skeletal muscles. (springeropen.com)
  • The patient died of respiratory failure with rapid collection of pleural effusion 54 days after admission, 18 days after establishment of the diagnosis of gastric cancer metastases. (springeropen.com)
  • 1 ) About 20% of patients may have distant metastases at the time of diagnosis, and the remaining 30% may develop metastases during the course of the disease. (ircmj.com)
  • The accurate diagnosis of primary gastric cancer compared to gastric metastasis from BC can be difficult. (biomedcentral.com)
  • Using an approach that includes consideration of the morphologic features, appropriate immunohistochemistry, and correct clinical context aids in making the proper diagnosis. (medscape.com)
  • Because local invasion and metastasis occurs early in the pathogenesis of esophageal adenocarcinoma, we hypothesized that EMT may be important in this disease. (aacrjournals.org)
  • Many molecular and phenotypic events underlie the development of invasion and metastases ( 3 ). (aacrjournals.org)
  • In addition, myofibroblast positive expression was associated with lymph node metastasis, high stage, high grade, vascular invasion and shortened survival time in patients with lung adenocarcinoma. (elis.sk)
  • These data suggest that myofibroblasts are likely to facilitate the invasion and metastasis of the lung adenocarcinoma, and can be used as a prognostic marker. (elis.sk)
  • Histopathological examination revealed adenocarcinoma with lymphovascular invasion. (ircmj.com)
  • A biopsy was performed, and a histopathological examination showed adenocarcinoma with lymphovascular invasion. (ircmj.com)
  • An essential process for promotion of metastasis is cancer cell invasion, which is controlled by several biological factors, most notably tumour proliferation and invasion. (biomedcentral.com)
  • b Perineural invasion of the pancreatic ductal adenocarcinoma. (mslideas.com)
  • This protein enhances cell motility, invasion and metastasis of cancer cells. (cancer-genetics.org)
  • HNF4A alone could be a gold standard marker for distinguishing primary gastric cancer from breast metastasis, thus validating its potential clinical use, especially in populations with high genetic diversity. (biomedcentral.com)
  • Application of Machine Learning Algorithms to Predict Lymph Node Metastasis in Early Gastric Cancer. (cdc.gov)
  • The expression level of CDK10 was analyzed using qRT-PCR, western blotting, and immunohistochemistry on tissue samples from 189 post-resection gastric cancer patients. (jcancer.org)
  • Immunohistochemistry data indicated that CDK10 expression was significantly decreased in 92 of 189 (48.7%) gastric cancer cases. (jcancer.org)
  • Cutaneous metastases from carcinoma (see the image below) are relatively uncommon in clinical practice, but they are very important to recognize. (medscape.com)
  • Because breast cancer is so common, cutaneous metastasis of breast cancer is the most frequently encountered type of cutaneous metastasis in most clinical practices. (medscape.com)
  • The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)
  • This suggests that the process of GI metastasis of lung cancer is subtle and lacks specific clinical symptoms. (spandidos-publications.com)
  • 4 ) For this reason, the authors would like to present a clinical experience with rectal cancer that has metastases to the scrotal skin. (ircmj.com)
  • Following a detailed review of the clinical context, we concluded the lesion to be consistent with a late metastasis of a PMCS. (asploro.com)
  • The clinical importance of mitotic factors was analyzed by heatmap analysis, a KM plot, and immunohistochemistry in lung adenocarcinoma (LUAD) patients. (biomedcentral.com)
  • The first clinical impression is that of a cyst, basal cell carcinoma, keratoacantoma, nevus, apocrine hidrocystoma, another location primary tumour metastasis and in certain circumstances the clinical differentiation includes vascular lesions as those found in the Kaposi sarcoma 5. (constiintaortodoxa.ro)
  • In our clinical case, the thyroid was the site of an unusual metastasis revealing an underlying lung adenocarcinoma not initially suspected. (biomedcentral.com)
  • Cytokeratins can be used to detect small nodal metastases or subtle invasive carcinomas such as invasive lobular carcinomas. (bmj.com)
  • Immunohistochemistry plays a useful role in diagnosing spindle cell lesions such as a panel of cytokeratins to identify spindle cell carcinomas. (bmj.com)
  • Primary cutaneous adnexal carcinomas may be difficult to distinguish from metastases in certain situations. (medscape.com)
  • Primary cutaneous apocrine carcinomas can be particularly difficult to differentiate from adenocarcinomas of mammary origin because of the identical morphological and immunohistochemical features they may exhibit. (medscape.com)
  • In basaloid-appearing eyelid carcinomas, p16 immunopositivity should be followed by reflex HR-HPV mRNA ISH, as p16 immunohistochemistry alone has low specificity. (bvsalud.org)
  • The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
  • In this report, we highlight an unusual site of metastasis of an endometrial adenocarcinoma to the small intestine. (karger.com)
  • The most common site of metastasis of these cancers is the liver, followed by the lung. (biomedcentral.com)
  • He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)
  • In this present case, we report the observation of a patient who presented with an acute intestinal intussusception caused by a jejunal metastasis of pulmonary combined small cell carcinoma and adenocarcinoma and we present a review of the literature. (hindawi.com)
  • The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. (lu.se)
  • Tissue microarrays from 629 resected primary lung cancers and 422 resected pulmonary epithelial metastases from various sites (whereof 275 colorectal cancer) were investigated for the immunohistochemical expression of CDH17, GPA33, MUC2, MUC6, SATB2, and SMAD4, for comparison with CDX2, CK20, CK7, and TTF-1. (lu.se)
  • The most sensitive markers for GI origin were GPA33 (positive in 98%, 60%, and 100% of pulmonary metastases from. (lu.se)
  • MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. (lu.se)
  • Combining six GI markers did not perfectly separate primary lung cancers from pulmonary metastases including subgroups such as mucinous adenocarcinomas or CK7-positive GI tract metastases. (lu.se)
  • In comparison, SATB2 and CK20 showed higher specificity, with expression in 5% and 10% of mucinous primary lung adenocarcinomas and both in 0% of TTF-1-negative non-mucinous primary lung adenocarcinomas (25-50% and 5-16%, respectively, for GPA33/CDX2/CDH17). (lu.se)
  • PCMC cells remain positive for CK 7 and negative for CK 20, the same occurs for the mucinous adenocarcinoma of the breast, but in the case of the mucinous colorectal adenocarcinoma CK 7 is negative and CK 20 is positive. (constiintaortodoxa.ro)
  • This way, the absence of Carcinom papilar tiroidian metastaze 20 excludes skin metastases originated from the mucinous colorectal adenocarcinoma. (constiintaortodoxa.ro)
  • Appendiceal goblet cell carcinoid (GCC) and adenocarcinoma ex-goblet cell carcinoid (AdexGCC) have previously been described as two entities in a spectrum of neoplasms showing both glandular/mucinous and neuroendocrine differentiation [ 1 ]. (gastrores.org)
  • Further investigations are necessary in order high risk breast papilloma eliminate the skin metastasis 7,8. (constiintaortodoxa.ro)
  • Poorly differentiated ductal adenocarcinomas have significantly more smaller sized and irregular glands and significant pleomorphism. (mslideas.com)
  • The tumour cells with oval to round nuclei with prominent nucleoli were found to be showing partial ductal structures, leading us to suspect poorly differentiated adenocarcinoma. (biomedcentral.com)
  • In this study, the expression of myofibroblasts in BAC, mix-BAC and invasive adenocarcinoma was examined by immunohistochemical staining of surgical specimens from 102 patients. (elis.sk)
  • Histology confirms the presence of invasive adenocarcinoma invading the corpora cavernosa (CC) (15×, H/E). (biomedcentral.com)
  • The CT scan of the chest, abdomen, and pelvis exhibited a locally invasive RC with no distant metastases. (ircmj.com)
  • Background The liver is a frequent site of metastases and liver metastases (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). (bmj.com)
  • To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases. (biomedcentral.com)
  • Seventy primary colorectal cancer specimens from patients without liver metastases were used as controls. (biomedcentral.com)
  • PTEN was strongly expressed in 44 (62.9%) colorectal cancer specimens from patients without liver metastases. (biomedcentral.com)
  • In contrast, PTEN was weakly expressed in 52 (75.4%) primary colorectal cancer specimens from patients with liver metastases, and was absent in liver metastases. (biomedcentral.com)
  • PTEN expression was significantly stronger in primary colorectal cancer specimens from patients without liver metastases. (biomedcentral.com)
  • Furthermore, among colorectal cancer patients with liver metastases, the 5-year survival rate was significantly higher in patients with positive PTEN expression compared to those with negative PTEN expression ( p = 0.012). (biomedcentral.com)
  • It is therefore reasonable to expect that evaluation of PTEN expression levels in primary colorectal cancer and in liver metastases may provide information that will allow better prediction of therapy benefit. (biomedcentral.com)
  • The recognition of cutaneous metastases often dramatically alters therapeutic plans, especially when metastases signify persistence of cancer originally thought to be cured. (medscape.com)
  • Cutaneous metastases are frequent and small 1-2 cm nodules that often simulate epidermal cysts, kerato-acanthomas, or pyogenic granulomas. (ircmj.com)
  • After melanoma and lung cancer, colorectal cancer was the third most prevalent cause of cutaneous metastases in men and the seventh most common cause in women. (ircmj.com)
  • This report documents the case of a 57‑year‑old male patient initially diagnosed with non‑metastatic lung adenocarcinoma, who presented with abdominal pain 6 months later. (spandidos-publications.com)
  • To the best of our knowledge, only a few cases of metastatic lung adenocarcinoma to the thyroid gland have been reported, describing all together four cases of thyroid lesions revealing a lung carcinoma. (biomedcentral.com)
  • Of note, distant metastases occur most commonly in the brain, liver, adrenal glands and bones. (spandidos-publications.com)
  • Ready-to-use antibodies, which were not diluted, were purchased from Beijing Zhongshan Golden Bridge Biological Technology Co., Ltd. Whole-body CT examination revealed no distant metastases anywhere, including the brain. (spandidos-publications.com)
  • Nonetheless, even after curative resection, 50-60 % of patients relapse locally or with distant metastases. (springeropen.com)
  • Although small intestinal metastasis from lung cancer is rare and difficult to diagnose accurately, it should be considered when encountering a patient with lung cancer exhibiting abdominal symptoms and associated imaging findings. (spandidos-publications.com)
  • Sixty-nine pairs of primary colorectal cancer and corresponding liver metastasis specimens were analyzed immunohistochemically, and the correlation between immunohistochemical findings and clinicopathological factors was investigated. (biomedcentral.com)
  • Radiologic findings were negative for both lymph node and adrenal metastases. (biomedcentral.com)
  • A recent retrospective study showed a possible increased risk of brain metastases for patients with type II endometrial cancers [4]. (clinsurgeryjournal.com)
  • The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
  • We report a case of aggressive colon cancer resulting in systemic metastasis despite small tumour size. (biomedcentral.com)
  • We concluded that this lesion was the site of origin of the metastasis despite the small tumour size, and performed diagnostic endoscopic mucosal resection. (biomedcentral.com)
  • Histology confirmed the presence of metastatic moderately well differentiated prostatic adenocarcinoma (Figure 1 ) extending through the length of the penis and into the glans and spreading to the surface of the skin at the corona with vascular and lymphatic permeation. (biomedcentral.com)
  • We report a sporadic case of an 84-year-old man with a pacemaker diagnosed with heart osteosarcoma, hepatocellular and prostatic adenocarcinoma and presenting with symptoms mimicking infective endocarditis. (journalmc.org)
  • For example, prostate cancer is very common, but cutaneous metastasis from prostate carcinoma is relatively uncommon. (medscape.com)
  • He had had a primary well-differentiated adenocarcinoma of the prostate diagnosed 11 years previously. (biomedcentral.com)
  • Purpose: The aim of this study was to determine whether modified citrus pectin, a complex polysaccharide rich in galactosyl residues, could inhibit spontaneous metastasis of prostate adenocarcinoma cells in the rat. (johnshopkins.edu)
  • Conclusions: We present a novel therapy in which oral intake of modified citrus pectin acts as a potent inhibitor of spontaneous prostate carcinoma metastasis in the Copenhagen rat. (johnshopkins.edu)
  • Implications: Further investigations are warranted to determine the following: 1) the role of galectin-3 in normal and cancerous prostate tissues and 2) the ability of modified citrus pectin to inhibit human prostate metastasis in nude mice. (johnshopkins.edu)
  • PET imaging of CA125 expression by ovarian cancer cells may enhance the evaluation of the extent of disease and provide a roadmap to surgery as well as detect recurrence and metastases. (snmjournals.org)
  • Controlling liver metastasis is considered essential in the treatment of colorectal cancer. (biomedcentral.com)
  • Sixty-nine pairs of primary colorectal cancer and corresponding liver metastasis specimens were analyzed in this study. (biomedcentral.com)
  • Seventy primary colorectal cancer specimens from patients without liver metastasis were used as controls. (biomedcentral.com)
  • Metastasis from endometrial cancer to small bowel is very rare [ 3 ]. (karger.com)
  • in none of these cases, however, was the patient affected by MS: this might be the first case described in the literature of endometrial cancer manifesting itself with a single brain metastasis in a patient diagnosed with MS. (clinsurgeryjournal.com)
  • However, intussusception due to a jejunal metastasis of combined lung cancer is extremely rare [ 3 ]. (hindawi.com)
  • Indeed, lung cancer metastasis to the bowel is uncommon, reported in less than 1% of patients [ 4 ]. (hindawi.com)
  • The occurrence of small intestinal metastases from primary lung cancer is rare. (spandidos-publications.com)
  • Patients with early-stage lung cancer are asymptomatic, whereas those with advanced metastasis are frequently symptomatic due to metastatic sites. (spandidos-publications.com)
  • Furthermore, the gastrointestinal (GI) tract is not a common site of primary lung cancer metastasis ( 4 ). (spandidos-publications.com)
  • The present report describes an uncommon case of small intestinal metastasis from lung cancer. (spandidos-publications.com)
  • Reported cases of skeletal muscle metastases from gastric carcinoma are extremely rare. (springeropen.com)
  • We report here a case of a patient with swelling in the thigh that was diagnosed as skeletal muscle metastases from gastric carcinoma. (springeropen.com)
  • A few cases involving the skin have been described in the literature, and solitary metastasis to the deep soft-tissue (eg, subcutis and skeletal muscle) was reported less than 10 times. (amjcaserep.com)
  • Low-power view of breast cancer metastasis with surrounding fibrosis. (medscape.com)
  • Breast cancer metastasis with hyperchromatic cells extending between thickened collagen bundles. (medscape.com)
  • We report the case of a 26-year-old female with cavernous sinus syndrome due to breast cancer metastasis, who was subjected to chemotherapy with complete neurological recovery. (surgicalneurologyint.com)
  • This is done using human material and mouse models of breast cancer metastasis. (lu.se)
  • Understanding the immune suppression in breast cancer patients may lead to insights into treatment responses, resistance mechanisms and novel treatment modalities aimed to hinder this phenomenon which would eventually encumber the devastating progression of breast cancer metastasis. (lu.se)
  • Johnsson A, Kiani NA, Gernaat SAM, Wilking U, Shabo I, Hedayati E. Planning for return to work during the first year after breast cancer metastasis: A Swedish cohort study. (cancercentrum.se)
  • Metastases to the region are uncommon and often associated with a headache, facial pain, or progressive neurological deficit in III, IV, and VI cranial nerves. (surgicalneurologyint.com)
  • Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. (asploro.com)
  • After careful assessment, a high-grade endometrial carcinoma was diagnosed and a decision was made to remove both the primary lesion and the brain metastasis in one sitting, through a conjoined surgery session involving neurosurgeons and gynecologists. (clinsurgeryjournal.com)
  • Multiplex immunohistochemistry detected significantly lower fractions of CD8 + cells (p=0.036) and CD56 dim+ cells (p=0.016) in LM compared with PL. Single-cell RNA sequencing also characterized lower effector CD8 + T cells activation and NK cells cytotoxicity in LM. (bmj.com)
  • The patient was diagnosed with lung adenocarcinoma (pT4N2M0 stage IIIB) ( 7 ). (spandidos-publications.com)
  • The patient recovered fully, and didn't have any sign of metastasis at the moment. (vin.com)
  • The histologic subtype, metastasis site, and certain patient characteristics can offer clues to the cancer primary. (medscape.com)