Intraductal papillary mucinous neoplasmCarcinomasCarcinomaTumorsPapillaryPancreasEpithelialNeoplasmMetastasisMetastatic adenocarcinomaPancreaticSubtypesMucinHistologicMetaplasiaHistopathologicalSmall-intestinalImmunohistochemistryLesionsGastric cancerTumorSecretionsClassificationEntericPhenotypeCarcinoembryonic antigenSubtypeHepatoidPrecursorColumnarProteinHER2ObstructionEpithelium0.04GlandularPoorlyCancersVariantBenignBiopsyBladderLung
Intraductal papillary mucinous neoplasm3
- INTRODUCTION Since the 1st description more than three decades ago1, intraductal papillary mucinous neoplasm (IPMN) of the pancreas has become widely recognized as one of the most common cyst-forming pancreatic neoplasms, and several variants of intraductal neoplasms have been described including the gastric, intestinal, or pancreatobiliary subtypes2C9. (opioid-receptors.com)
- To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
- Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
Carcinomas6
- Ampullary carcinomas (ACs) are most frequently intestinal or pancreatobiliary adenocarcinomas but other subtypes, such as medullary, mucinous, or signet ring/poorly cohesive cell carcinoma, may be encountered. (bvsalud.org)
- For example, the protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. (wikipedia.org)
- Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma. (biomedcentral.com)
- The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
- Mucinous skin carcinomas are mostly seen in the head and neck region and isolated specimens from this area should raise suspicion for a PMCS. (asploro.com)
- Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
Carcinoma18
- In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
- Using WHO classification, 43.8% were tubular adenocarcinoma, 7.8% were mucinous adenocarcinoma, 17.2% were signet-ring cell carcinoma, and 31.3% were undifferentiated carcinoma. (edu.vn)
- Despite the troubles of 41575-94-4 determining the degree of invasive carcinoma in many cases, the overall end result appears relatively beneficial and considerably better than that of standard ductal adenocarcinoma, even when only the instances with invasive carcinoma are considered. (opioid-receptors.com)
- Immunohistochemical analysis of metastasis allowed to identify immunophenotypes of different types of metastatic carcinoma and melanoma and estimate the origin of unknown primary metastasis. (ungthuvn.org)
- However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
- IPMN is thought to represent a precursor lesion to pancreatic adenocarcinoma due to its association with invasive carcinoma [ 5 ]. (gastrores.org)
- In addition to CEA being used to stratify mucinous vs. non-mucinous lesions, several studies have attempted to correlate pancreatic cyst fluid CEA level and the presence of invasive carcinoma, with discordant results [ 17 , 18 ]. (gastrores.org)
- The differential diagnosis includes glandular differentiation of transitional cell carcinoma and direct extension or metastatic spread of adenocarcinoma arising primarily from the colon, prostate, appendix or endometrium. (biomedcentral.com)
- In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
- Herein, we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma (collision tumor) in the ampulla of Vater, which has seldom been reported in the literature. (koreamed.org)
- Pathologically, sections on the ampulla of Vater showed conventional ductal adenocarcinoma extended and collided with poorly differentiated neuroendocrine carcinoma. (koreamed.org)
- In conclusion, we hereby presented a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma in the ampulla of Vater. (koreamed.org)
- We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. (asploro.com)
- However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. (asploro.com)
- Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. (asploro.com)
- This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. (asploro.com)
- A 67-year-old female presented with a suspicious swelling on the right supraclavicular region two years after resection of a mucinous carcinoma on the surface of the skin overlying the right mastoid. (asploro.com)
- The mastoid skin lesion was originally diagnosed by two separate institutes to be most likely a metastatic mucinous carcinoma. (asploro.com)
Tumors3
- A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
- mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
- Because of positivity for GATA 3 ( an immunomarker found for example in breast and salivary glands but also in skin tumors [5,6] and expression of mammaglobin, an immunohistochemical marker found in breast cancer [7], mammography was done also and ultrasonography was performed to rule out a salivary gland origin because of its anatomic proximity. (asploro.com)
Papillary1
- The most commonly used clinical classifications of gastric cancer are Lauren classification (intestinal, diffuse, mixed) and World Health Organization(WHO) classification (papillary adenocarcinoma, tubular adenocarcinoma, mucinous glands cancer and low-adhesion cancer). (centerwatch.com)
Pancreas4
- PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
- Gross section of an adenocarcinoma of the pancreas measuring 5 × 6 cm resected from the pancreatic body and tail. (medscape.com)
- It is indicated for metastatic adenocarcinoma of the pancreas as first-line treatment in combination with gemcitabine. (medscape.com)
- Irinotecan liposomal is used in combination with fluorouracil and leucovorin for metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. (medscape.com)
Epithelial1
- Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
Neoplasm1
- The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
Metastasis1
- A 72 years old female that 8 years ago was diagnosed with adenocarcinoma of the sigma with liver metastasis. (doctorsmedicalopinion.com)
Metastatic adenocarcinoma2
- Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. (asploro.com)
- Well-differentiated metastatic adenocarcinoma was found within the mesenteric nodule, without lymphatic components (Figure 2 ). (biomedcentral.com)
Pancreatic9
- Herein, we present the largest clinicopathologic studies of ITPN in an effort to more fully define the histologic and immunohistochemical features, medical behavior, and similarities and variations from IPMNs as well as other pancreatic neoplasms. (opioid-receptors.com)
- In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
- During the diagnostic workup for pancreatic cysts, CEA is often utilized to distinguish those pancreatic cystic lesions that are likely to be mucinous [ 13 - 16 ]. (gastrores.org)
- Value of intraoperative neck margin analysis during whipple for pancreatic adenocarcinoma: a multicenter analysis of 1399 patients. (vumc.org)
- See also Pancreatic Adenocarcinoma Imaging: What You Need to Know , a Critical Images slideshow, to help identify which imaging studies to use to identify and evaluate this disease. (medscape.com)
- Histological evaluation determined this was locally invasive pancreatic adenocarcinoma, and therefore the true etiology of the original cecal perforation. (biomedcentral.com)
- Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is used for maintenance therapy in pancreatic adenocarcinoma. (medscape.com)
- Olaparib has US Food and Drug Administration (FDA) approval for adults with germline BRCA -mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
- It is indicated for maintenance treatment of adults with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
Subtypes4
- Four main histologic subtypes of IPMN have been described: gastric, intestinal, pancreaticobiliary and oncocytic. (gastrores.org)
- Although these biomarkers are useful in helping distinguish individual IPMN subtypes, this immunohistochemical assessment is often only possible after resection. (gastrores.org)
- Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes. (cdc.gov)
- Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
Mucin4
- Immunohistochemical examination of this tumor revealed positive staining for Cytokeratin 20, Mucin 2, and CDX2, although Cytokeratin 7 and Mucin 6 were negative. (hindawi.com)
- All IPMNs have variable papilla formation and create mucin, but each subtype offers certain unique histologic, immunohistochemical and genetic features. (opioid-receptors.com)
- Prostate biopsies showed mucinous adenocarcinoma in six of eight cores with large collections of mucin dissecting the prostatic parenchyma. (biomedcentral.com)
- Bladder washings and biopsies revealed copious amounts of mucin with associated malignant nests and single cells also consistent with mucinous adenocarcinoma. (biomedcentral.com)
Histologic2
- The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. (biomedcentral.com)
- For instance, in one institutional review five cases diagnosed asinvasive adenocarcinoma over a 14-year period were reclassified as benign mimics (1).Although a variety of immunoperoxidase stains have been tried, ultimately therecognition of benign pseudoneoplastic glandular lesions of the cervix rests upon theirdistinctive histologic features. (fliphtml5.com)
Metaplasia2
- The region of columnar esophageal metaplasia is considered the "cancerization field" in which esophageal adenocarcinoma (EAC) develops [ 3 - 5 ]. (jcancer.org)
- It is widely accepted that chronic GERD leads to inflammation and ulceration of the esophageal squamous mucosa and that persistent and recurrent inflammation and ulceration may lead to columnar metaplasia and, ultimately, intestinal metaplasia. (jcancer.org)
Histopathological2
- This study is aimed at the assessing endoscopic and histopathological characteristics of gastric adenocarcinoma and their relationship with HER2 overexpression. (edu.vn)
- Histopathological diagnosis of locally advanced, recurrent or metastatic HAS (pathological histomorphology and immunohistochemical diagnosis of AFP, sal-like 4(SALL4), Hep, glypican-3(GPC3), etc. (centerwatch.com)
Small-intestinal4
- Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. (oncotarget.com)
- To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
- Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)
- A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
Immunohistochemistry1
- In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein. (wikipedia.org)
Lesions3
- PATHOLOGY Ductal adenocarcinomas are firm to hard mass lesions that are often poorly defined grossly. (coek.info)
- many of these benign yet floridly proliferative lesions have been mistaken for invasive adenocarcinoma. (fliphtml5.com)
- 2Introduction The distinction between benign proliferative glandular lesions of the endocervixand well-differentiated invasive cervical adenocarcinoma continues to be problematic, ashighlighted by the number of reports in the literature considering this diagnostic issue.Interestingly, the relatively recent recognition of a number of potential mimics ofinvasive adenocarcinoma of the endocervix underscores the likelihood that in the pastmany of these benign yet floridly proliferative lesions have been mistaken for invasiveadenocarcinoma. (fliphtml5.com)
Gastric cancer2
- Objectives and methods: Biopsy samples from 64 gastric cancer patients were examined for HER2 status by immunohistochemical staining. (edu.vn)
- Hepatoid adenocarcinoma of the stomach (HAS) is a special and rare type of gastric cancer. (centerwatch.com)
Tumor2
- Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. (hindawi.com)
- The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
Secretions1
- The common admixture of type A and B tunnelclusters, in combination with the predominantly lobulated architecture, absence ofdesmoplasia and lack of deep, widely infiltrative glands helps distinguish it fromadenoma malignum.Type B tunnel clusters Type B tunnel clusters also have a lobular architecture, but are composed ofdilated glands lined by cuboidal or flattened epithelium and filled with inspissated,mucinous secretions. (fliphtml5.com)
Classification2
- Ampullary cancer can also be subclassified based on immunohistochemical features, however these classification systems fail to show robust prognostic reliability. (bvsalud.org)
- Using the Lauren classification, 42.2% were intestinal type and 57.8% were diffuse type. (edu.vn)
Enteric1
- There is the hypothesis that such misplaced remnants transformed into a tubulovillous adenocarcinoma of enteric type. (hindawi.com)
Phenotype1
- Conclusions: Low grade MALToma is concerned significantly with infection of HP and immunohistochemical stain is important to identify exactly B cell and T cell phenotype. (ungthuvn.org)
Carcinoembryonic antigen1
- Immunohistochemical evaluation revealed that neoplastic cells were positive for carcinoembryonic antigen, cytokeratin-7, cytokeratin-20 and were negative for prostate specific antigen and prostatic acid phosphatase. (biomedcentral.com)
Subtype2
- The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
- REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)
Hepatoid1
- The aim of this study was to evaluate the efficacy and safety of apatinib with oxaliplatin and S-1 treatment advanced hepatoid adenocarcinoma of the stomach. (centerwatch.com)
Precursor2
- Concomitant cystitis glandularis occurs in the majority of cases, but is not considered a definitive precursor lesion since adenocarcinoma can develop in the absence of cystitis glandularis and only a small number of bladders with cystitis glandularis actually develop malignancies [ 2 ]. (biomedcentral.com)
- BE is known as a precursor of esophageal adenocarcinoma. (jcancer.org)
Columnar1
- 3Type A tunnel clusters Type A tunnel clusters are characterized by a lobulated proliferation of small,closely packed glands that are lined by columnar mucinous epithelium. (fliphtml5.com)
Protein2
- Immunohistochemical assays generally detect nuclear accumulational alterations and a prolonged hafl-life of the encoded protein. (ungthuvn.org)
- It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. (wikipedia.org)
HER23
- HER2 overexpression in intestinal type was higher than that in diffuse type (37% vs. 13.5%, p = 0.04). (edu.vn)
- In this study, we aimed to determine the pattern of immunohistochemical profiles of IDC using oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 receptor (HER2) and proliferative index (Ki-67) biomarkers in our tertiary healthcare facility in Uyo, Akwa Ibom State, Nigeria given the dearth of its data in our environment. (bvsalud.org)
- We carried out immunohistochemical evaluation using ER, PR, HER2 and Ki-67 biomarkers. (bvsalud.org)
Obstruction1
- Intestinal intussusception in adult patients is a rare entity, which corresponds to about 5% of all causes of intestinal obstruction, its diagnosis is not easy given the lack of specific symptoms of patients who present it. (bvsalud.org)
Epithelium1
- Villoglandular mucinous adenocarcinoma arises in the surface epithelium of the vulva. (hindawi.com)
0.041
- P =0.04) and more likely to have mucinous adenocarcinomas ( P= 0.003), and tended to survive longer ( P =0.11) than those with sporadic cases. (oncotarget.com)
Glandular1
- Benign Mimics of Invasive Adenocarcinoma of the Cervix Tunnel Clusters Microglandular Hyperplasia Mesonephric Hyperplasia Endocervical Glandular Hyperplasias Arias-Stella ReactionTunnel Clusters Fluhmann first introduced the term "tunnel cluster" in his description of thehistology of the endocervix (2;3). (fliphtml5.com)
Poorly1
- Biopsy was also performed under ERCP, and poorly differentiated adenocarcinoma was noted. (koreamed.org)
Cancers1
- Primary adenocarcinoma of the urinary bladder accounts for approximately 0.5-2% of all bladder cancers [ 1 ]. (biomedcentral.com)
Variant1
- Primary adenocarcinomas of the vulva are rare and especially the villoglandular mucinous adenocarcinoma of intestinal type is rare variant of vulvar adenocarcinoma. (hindawi.com)
Benign1
- A number of benign processes may mimic adenocarcinoma in situ, invasiveadenocarcinoma or both. (fliphtml5.com)
Biopsy1
- The specimen of the vulvar biopsy was diagnosed vulvar adenocarcinoma. (hindawi.com)
Bladder3
- We report a 57-year-old Caucasian man presenting with penile discharge for 30 years following ileal conduit surgery for neurogenic bladder, and who was found to have primary mucinous adenocarcinoma of his defunctionalized bladder. (biomedcentral.com)
- The potential for adenocarcinoma to develop in the defunctionalized bladder that is left in-situ at the time of urinary diversion is rare [ 3 - 5 ]. (biomedcentral.com)
- We describe the fifth case of primary mucinous adenocarcinoma arising in a longstanding defunctionalized bladder. (biomedcentral.com)
Lung1
- REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. (cancerindex.org)