AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Adenocarcinoma, MucinousAdenocarcinomaAppendiceal NeoplasmsCarcinoma, Signet Ring CellPseudomyxoma PeritoneiRectal FistulaCecal NeoplasmsCystadenoma, MucinousUrachal CystImmunohistochemistryCalymmatobacteriumPerineumCystadenocarcinoma, MucinousMucin-2MucinsColorectal NeoplasmsStomach NeoplasmsTumor Markers, BiologicalNeoplasm StagingOvarian NeoplasmsPrognosisColonic NeoplasmsRectal NeoplasmsMicrosatellite InstabilityHistologyLung NeoplasmsKaplan-Meier EstimatePancreatic NeoplasmsEsophageal NeoplasmsAdenocarcinoma, PapillaryImmunoenzyme TechniquesBarrett EsophagusCarcinoma, Pancreatic DuctalAdenocarcinoma, Bronchiolo-AlveolarCardiaKeratin-7Mohs SurgerySkin NeoplasmsFrozen SectionsDermatologic Surgical ProceduresDermatofibrosarcomaCarcinoma, Basal CellSkin DiseasesOsteitis DeformansPaget's Disease, MammaryPaget Disease, ExtramammaryMyositis, Inclusion BodyCarcinoma, Intraductal, NoninfiltratingNipples
Papillary mucinous neoplasmCarcinomasSquamous cell carcHistopathologicalTumorLined by columnarTumorsSubtypeDifferentiationOvarianDuctal adenocarcinomaHistologicClinicopathological featuresDiagnosisMalignantMetastaticSerousProstaticStainsCytologyLesionsPrecursorInvasive adenocarcinomaMetaplasiaPoorly differentiatedLungTissueSituResectionGlandsVariantsFindingsAbundantMolecularClinicallyPredictiveMarkersCuboidalBenignCancersAntibodyPrimaryConventionalPattern
Papillary mucinous neoplasm2
  • INTRODUCTION Since the 1st description more than three decades ago1, intraductal papillary mucinous neoplasm (IPMN) of the pancreas has become widely recognized as one of the most common cyst-forming pancreatic neoplasms, and several variants of intraductal neoplasms have been described including the gastric, intestinal, or pancreatobiliary subtypes2C9. (opioid-receptors.com)
  • Tumors of the pancreas that contain substantial cystic components include mainly mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, solid pseudopapillary tumor, and cystadenomas (which encompass microcystic, macrocystic/oligocystic, and rare solid serous adenomas). (hindawi.com)
Carcinomas6
  • In addition, other diagnostic systems also for urachal carcinomas that are not adenocarcinomas have been proposed. (wikipedia.org)
  • New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
  • The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
  • Mucinous skin carcinomas are mostly seen in the head and neck region and isolated specimens from this area should raise suspicion for a PMCS. (asploro.com)
  • Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
  • Expression of p40 in Primary Cutaneous Mucinous Carcinoma Versus Primary Mucinous Carcinomas of the Breast and Colon. (jefferson.edu)
Squamous cell carc1
  • We identified a unique case of triple SLC, including adenocarcinoma, squamous cell carcinoma, and mixed small and large cell neuroendocrine carcinoma, which has poor prognostic implications. (biomedcentral.com)
Histopathological4
  • Immunohistochemical stains are usually less helpful in the histopathological differential diagnosis of urachal adenocarcinomas. (wikipedia.org)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. (asploro.com)
  • Generalized Multinucleate Cell Angiohistiocytoma: Histopathological and Immunohistochemical Analyses of 10 Lesions. (jefferson.edu)
Tumor3
  • However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. (asploro.com)
  • Herein, we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma (collision tumor) in the ampulla of Vater, which has seldom been reported in the literature. (koreamed.org)
  • Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
Lined by columnar2
  • The mucinous acini are lined by columnar cells filled with abundant pale, foamy cytoplasm to the extent of nearly occluding the acinar lumen and contain small basal nuclei without conspicuous nucleoli. (medscape.com)
  • 3Type A tunnel clusters Type A tunnel clusters are characterized by a lobulated proliferation of small,closely packed glands that are lined by columnar mucinous epithelium. (fliphtml5.com)
Tumors3
  • With recent advancements in pathology, gene expression profiling, identification of subtypes and various modalities available for exploring the GI tract, it has become possible to find the precise origin of mucinous tumors. (thieme-connect.de)
  • Pancreatic cystic tumors fall into the serous or mucinous category. (hindawi.com)
  • Because of positivity for GATA 3 ( an immunomarker found for example in breast and salivary glands but also in skin tumors [5,6] and expression of mammaglobin, an immunohistochemical marker found in breast cancer [7], mammography was done also and ultrasonography was performed to rule out a salivary gland origin because of its anatomic proximity. (asploro.com)
Subtype5
  • 1 ] Mucinous ovarian cancer (MOC) is a rare subtype of malignant ovarian cancer. (thieme-connect.de)
  • The terms BAC and mixed subtype adenocarcinoma are no longer used. (qxmd.com)
  • All IPMNs have variable papilla formation and create mucin, but each subtype offers certain unique histologic, immunohistochemical and genetic features. (opioid-receptors.com)
  • The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
  • REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)
Differentiation1
  • Appendiceal goblet cell carcinoid (GCC) and adenocarcinoma ex-goblet cell carcinoid (AdexGCC) have previously been described as two entities in a spectrum of neoplasms showing both glandular/mucinous and neuroendocrine differentiation [ 1 ]. (gastrores.org)
Ovarian3
  • Objective To evaluate the clinicopathological features and survival outcomes of mucinous ovarian cancer (MOC) patients in an Asian population. (thieme-connect.de)
  • However, how Sp17 expression varies with histology, grade, and stage of EOC and its expression in other ovarian neoplasms has not been defined. (biomedcentral.com)
  • CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. (novodiax.com)
Ductal adenocarcinoma2
  • Despite the troubles of 41575-94-4 determining the degree of invasive carcinoma in many cases, the overall end result appears relatively beneficial and considerably better than that of standard ductal adenocarcinoma, even when only the instances with invasive carcinoma are considered. (opioid-receptors.com)
  • Pathologically, sections on the ampulla of Vater showed conventional ductal adenocarcinoma extended and collided with poorly differentiated neuroendocrine carcinoma. (koreamed.org)
Histologic4
  • Adenocarcinoma is the most common histologic type of lung cancer. (qxmd.com)
  • Herein, we present the largest clinicopathologic studies of ITPN in an effort to more fully define the histologic and immunohistochemical features, medical behavior, and similarities and variations from IPMNs as well as other pancreatic neoplasms. (opioid-receptors.com)
  • Available gross photographs and descriptions as well as all histologic sections were re-evaluated to confirm the diagnosis and further characterize the spectrum of histology findings. (opioid-receptors.com)
  • For instance, in one institutional review five cases diagnosed asinvasive adenocarcinoma over a 14-year period were reclassified as benign mimics (1).Although a variety of immunoperoxidase stains have been tried, ultimately therecognition of benign pseudoneoplastic glandular lesions of the cervix rests upon theirdistinctive histologic features. (fliphtml5.com)
Clinicopathological features1
  • Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)
Diagnosis3
  • This new classification strategy is based on a multidisciplinary approach to diagnosis of lung adenocarcinoma that incorporates clinical, molecular, radiologic, and surgical issues, but it is primarily based on histology. (qxmd.com)
  • What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? (novodiax.com)
  • A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and p63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens. (novodiax.com)
Malignant1
  • The mucinous cystadenomas on the other hand, even though slow growing, have high chances of malignant transformation and hence need to be managed earlier, surgically [ 3 ]. (hindawi.com)
Metastatic2
  • Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. (asploro.com)
  • The mastoid skin lesion was originally diagnosed by two separate institutes to be most likely a metastatic mucinous carcinoma. (asploro.com)
Serous1
  • Serum concentrations were higher in patients with Sp17 tissue expression, and the highest concentrations were noted among patients with serous and clear cell adenocarcinomas. (biomedcentral.com)
Prostatic2
  • The Cowper's glands comprise mucinous glands with small to absent central lumina, seen just deep to prostatic urethral mucosa. (medscape.com)
  • Mucinous metaplasia of prostatic acini: This condition features cells that contain abundant mucin-filled cytoplasm that mimic Cowper's glands (bulbourethral glands). (medscape.com)
Stains1
  • Evaluation of the primary DCIS and lymph node inclusions, by routine and immunohistochemical stains, was performed for assessment. (hindawi.com)
Cytology1
  • The aim of the study was to evaluate the performance of the Xpert®-BC-Detection and the Bladder-Epicheck®-test in the detection of UTUC and compare it with cytology and the Urovysion®-FISH test using histology and URS as gold standard. (bvsalud.org)
Lesions3
  • These findings can be precursor lesions of a primary bladder adenocarcinoma. (wikipedia.org)
  • many of these benign yet floridly proliferative lesions have been mistaken for invasive adenocarcinoma. (fliphtml5.com)
  • 2Introduction The distinction between benign proliferative glandular lesions of the endocervixand well-differentiated invasive cervical adenocarcinoma continues to be problematic, ashighlighted by the number of reports in the literature considering this diagnostic issue.Interestingly, the relatively recent recognition of a number of potential mimics ofinvasive adenocarcinoma of the endocervix underscores the likelihood that in the pastmany of these benign yet floridly proliferative lesions have been mistaken for invasiveadenocarcinoma. (fliphtml5.com)
Precursor2
Invasive adenocarcinoma3
  • For resection specimens, new concepts are introduced such as adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) for small solitary adenocarcinomas with either pure lepidic growth (AIS) or predominant lepidic growth with ≤ 5 mm invasion (MIA) to define patients who, if they undergo complete resection, will have 100% or near 100% disease-specific survival, respectively. (qxmd.com)
  • Benign Mimics of Invasive Adenocarcinoma of the Cervix Tunnel Clusters Microglandular Hyperplasia Mesonephric Hyperplasia Endocervical Glandular Hyperplasias Arias-Stella ReactionTunnel Clusters Fluhmann first introduced the term "tunnel cluster" in his description of thehistology of the endocervix (2;3). (fliphtml5.com)
  • Tunnel clusters have been separated by Fluhmann into two subcategories: Type Aand Type B. Although type A and B tunnel clusters are often intermixed, their distinctionis important as they each pose their own relatively unique problems in the discriminationfrom invasive adenocarcinoma. (fliphtml5.com)
Metaplasia1
  • The region of columnar esophageal metaplasia is considered the "cancerization field" in which esophageal adenocarcinoma (EAC) develops [ 3 - 5 ]. (jcancer.org)
Poorly differentiated2
  • He had recently been diagnosed with adenocarcinoma in the right upper lobe, with a poorly differentiated carcinoma favoring squamous cell cancer based on bronchoalveolar lavage of the right lower lobe for which treatment was started. (biomedcentral.com)
  • Biopsy was also performed under ERCP, and poorly differentiated adenocarcinoma was noted. (koreamed.org)
Lung5
  • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. (qxmd.com)
  • To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society. (qxmd.com)
  • The patient's past medical history included a cerebrovascular accident with residual left-sided weakness, bronchial asthma, lung adenocarcinoma (stage IIIB) diagnosed by computed tomography (CT)-guided right upper lobe biopsy 5 months previously. (biomedcentral.com)
  • REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. (cancerindex.org)
  • Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
Tissue6
  • The Cowper's glands (bulbourethral glands) can be recognized microscopically as a dimorphic population of mucinous acini and excretory ducts, arranged in a lobular pattern with interspersed fibrous tissue and variable amount of striated muscle bundles (see the image below). (medscape.com)
  • This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies. (qxmd.com)
  • Immunohistochemical (IHC) staining with anti-Sp17 antibody was performed on tissue specimens and the intensity scored as weak, moderate, or strong. (biomedcentral.com)
  • In order to further evaluate the overall validity of Sp17 as a biomarker for EOC, more complete data are needed with regards to Sp17 tissue expression across the different histologies, grades, and stages. (biomedcentral.com)
  • Materials and methods: We carried out a retrospective hospital-based immunohistochemical study of archival IDC tissue blocks over a four- and half-year period. (bvsalud.org)
  • Using basic histology staining, immunohistochemistry methods, and blood chemistry analysis, we observed profound kidney tissue injury such as glomerular and tubular damage in the experimental group, which were substantially ameliorated by metformin. (bvsalud.org)
Situ2
  • A number of benign processes may mimic adenocarcinoma in situ, invasiveadenocarcinoma or both. (fliphtml5.com)
  • Comparative Immunohistochemical Study of P63, SMA, CD10 and Calponin in Distinguishing In Situ from Invasive Breast Carcinoma. (novodiax.com)
Resection3
  • Surgical management is en bloc resection of bladder, urachal remnant, and umbilicus. (wikipedia.org)
  • We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. (asploro.com)
  • A 67-year-old female presented with a suspicious swelling on the right supraclavicular region two years after resection of a mucinous carcinoma on the surface of the skin overlying the right mastoid. (asploro.com)
Glands1
  • The common admixture of type A and B tunnelclusters, in combination with the predominantly lobulated architecture, absence ofdesmoplasia and lack of deep, widely infiltrative glands helps distinguish it fromadenoma malignum.Type B tunnel clusters Type B tunnel clusters also have a lobular architecture, but are composed ofdilated glands lined by cuboidal or flattened epithelium and filled with inspissated,mucinous secretions. (fliphtml5.com)
Variants1
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
Findings1
  • Together with the strong link between GERD and esophageal adenocarcinoma, these findings suggest that bile salts play a role in the pathophysiology of BE and EAC. (jcancer.org)
Abundant1
  • This is in keeping with ultrastructural studies in GCCs that showed the presence of abundant mucinous vacuoles, in comparison with the extremely difficult to locate, occasional membrane-bound, electron-dense granules [ 3 ]. (gastrores.org)
Molecular1
  • Recent research has also revealed clinical, radiologic, and pathologic correlates, leading to greater knowledge in molecular profiling and targeted therapeutics, as well as an emphasis on the rising incidence of adenocarcinoma histology. (scienceopen.com)
Clinically1
  • We describe two cases of rectal herpes simplex virus (HSV) infection in men that clinically mimicked rectal adenocarcinoma. (hindawi.com)
Predictive1
  • Sensitivity, specificity, and predictive values were calculated using histology results/URS as reference. (bvsalud.org)
Markers1
  • Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. (asploro.com)
Cuboidal1
  • Amidst the mucinous acini are excretory ducts lined by low cuboidal cells. (medscape.com)
Benign1
  • Benign pathology of the prostate gland, and prostate histology and anatomy are dealt with in the ''[[prostate gland]]'' article. (librepathology.org)
Cancers1
  • Mohs surgery is a surgical technique used to treat various skin cancers that allows precise microscopic control of the margins by utilizing tangentially cut frozen-section histology. (medscape.com)
Antibody1
  • An immunohistochemical study using monoclonal antibody. (novodiax.com)
Primary1
Conventional1
  • In conclusion, we hereby presented a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma in the ampulla of Vater. (koreamed.org)
Pattern1
  • In this study, we aimed to determine the pattern of immunohistochemical profiles of IDC using oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 receptor (HER2) and proliferative index (Ki-67) biomarkers in our tertiary healthcare facility in Uyo, Akwa Ibom State, Nigeria given the dearth of its data in our environment. (bvsalud.org)