Immunodeficiency virusAntigenInfectionHHV8PathogenesisDiagnosing Kaposi's sarcomaKaposi'sPapillomavirusCytomegalovirusCastleman'sKSHVKaposiAntiviralEpithelial cellsHumanoPatientsLymphoproliferative1999LymphomaNuclearCasosImmunohistochemistryDiseaseMethodsDetectionImmunocompetentTypeVirusesPrevalenceReactionProteinAnalysisVirusVirologyMicrobiomeVascularPatientStrainsStudyCellsLeukocyteFeverCellFeaturesYearsRisk
Immunodeficiency virus11
- Simian immunodeficiency virus (SIV) belongs to the family Retroviridae (subfamily Lentivirinae) and is closely related to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2), the etiologic agents of acquired immunodeficiency syndrome (AIDS). (cdc.gov)
- In the context of human immunodeficiency virus (HIV) infection, CD is associated with human herpesvirus-8 (HHV8) infection. (bvsalud.org)
- It is mostly benign and is characterized by non-neoplastic lymph node hypertrophy, associated with infection by human herpesvirus-8 in people with the human immunodeficiency virus/acquired immunodeficiency syndrome. (biomedcentral.com)
- Considering the importance of differential diagnosis of lymphoid disorders, Castleman's disease is a challenging diagnosis in people living with human immunodeficiency virus/acquired immunodeficiency syndrome and can be easily misdiagnosed when lymphoid disorders are present in the human immunodeficiency virus/acquired immunodeficiency syndrome population due to nonspecific symptoms and signs. (biomedcentral.com)
- A 41-year-old feoderm man diagnosed with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) since 2000 and on antiretroviral therapy (ART) with tenofovir, lamivudine, and lopinavir/ritonavir presented to the Department of Infectious Diseases of the Hospital das Clínicas in May 2015, with irregular fever history (38 to 39 °C), dyspnea, weight loss (8 kg/1 year), asthenia, and enlarged and painless cervical lymph nodes of 1-year duration. (biomedcentral.com)
- The situation has been further complicated by the human immunodeficiency virus (HIV) pandemic and its associated vascular lesions in bone, such as bacillary angiomatosis and Kaposi's sarcoma. (basicmedicalkey.com)
- AIDS (Acquired Immunodeficiency Syndrome) is a condition caused by the Human Immunodeficiency Virus (HIV). (clinmedjournals.org)
- Approximately 37.6 million people (about twice the population of New York) worldwide are infected with the human immunodeficiency virus (HIV) according to data from the Joint United Nations Program on HIV-AIDS [ 1 ]. (clinmedjournals.org)
- Molecular characterization of human immunodeficiency virus (HIV)-1 and -2 in individuals from Guinea-Bissau with single or dual infections: predominance of a distinct HIV-1 subtype A/G recombinant in West Africa. (microbiologyresearch.org)
- Human immunodeficiency virus (HIV) type 2-mediated inhibition of HIV type 1: a new approach to gene therapy of HIV-infection. (microbiologyresearch.org)
- Cytotoxic T cells from human immunodeficiency virus type 2-infected patients frequently cross-react with different human immunodeficiency virus type 1 clades. (microbiologyresearch.org)
Antigen7
- Kaposi's sarcoma is the most common neoplasia diagnosed in AIDS patients and the expression of the human herpesvirus-8 (HHV-8) latent nuclear antigen-1 has been useful for its histological diagnosis. (fiocruz.br)
- C) Immunohistochemical testing showed a positive signal for HHV-8 infection (latent nuclear antigen [LANA-1]) and CD34 (data not shown). (cdc.gov)
- SIV antigen has been demonstrated by immunohistochemical methods in lymph node sinus histiocytes, macrophages, and giant cells (14) as well as in macrophage-derived cells in brain tissue from diseased monkeys (8). (cdc.gov)
- The standard vascular markers used in pathologic differential diagnosis of vascular conditions include von Willebrand factor (vWF), factor VIII-associated protein, platelet endothelial cell adhesion molecule-1 (CD31), human hematopoietic progenitor cell antigen (CD34), v- ets avian erythroblastosis virus E26 oncogene homolog (ERG), human herpes virus 8 (HHV-8), latency-associated nuclear antigen (LANA1), podoplanin (D2-40), and PROX1. (basicmedicalkey.com)
- Individuals possessing human leukocyte antigen (HLA)-B12 are 3 times more likely to develop this disorder. (medscape.com)
- Immunohistochemistry or immunohistochemical staining is a specific use case of immunostaining when the antigen - antibody reaction is used to study the status of molecules in tissue (from the Greek histos , which means tissue). (technologynetworks.com)
- 2015) 9 , detected human herpesvirus-1 antigen in OSCC and apparently healthy control in Iraq. (bvsalud.org)
Infection12
- Histologic patterns of cutaneous Kaposi sarcoma (KS) associated with a human herpesvirus 8 (HHV-8) type E infection. (cdc.gov)
- D) Immunohistochemistry showed a lower positive signal for HHV-8 infection (LANA-1) and CD34 (data not shown). (cdc.gov)
- Although no reports of infection in humans have been documented, the expanding use of SIV as a model of HIV infection has raised concern about the potential risk of SIV transmission to humans. (cdc.gov)
- The clinical course of this infection in monkeys, like that of AIDS in humans, is complicated by various opportunistic infections (7). (cdc.gov)
- 3 In the United States, men who have sex with men (MSM) and persons with HIV infection are at increased risk for HHV-8 infection. (hiv.gov)
- Among MSM without HIV infection, the seroprevalence ranges from 13% to 20% and HHV-8 seroprevalence increases to 30% to 35% among MSM with HIV infection. (hiv.gov)
- Although the precise pathogenesis for these tumors remains unclear, infection with HHV-8 precedes their development. (hiv.gov)
- Recent reports of KS occurring at higher CD4 cell counts in the United States 26,27 suggest that clinicians caring for patients with HIV should be vigilant for the clinical manifestations of KS in patients at risk of HHV-8 infection, regardless of CD4 cell count. (hiv.gov)
- 28 Immunocompetent children and organ transplant recipients infected with HHV-8 may develop a primary infection syndrome consisting of fever, rash, lymphadenopathy, bone marrow failure, and occasional rapid progression to KS. (hiv.gov)
- Review - Defense and infection of the human placenta [2] "The placenta functions as a shield against infection of the fetus. (edu.au)
- Epidemiological and molecular studies have determined that the persistence of infection with high-risk human papillomaviruses (HR-HPVs) types is the most common risk factor for the development of head and neck malignancies 10-12 . (bvsalud.org)
- EBV is one of the eight known human herpesviruses, and like other herpesviruses, results in lifelong infection after primary infection. (juniperpublishers.com)
HHV81
- Se describen dos casos de enfermedad de Castleman multicéntrica HHV8- positiva en pacientes con enfermedad HIV/SIDA. (bvsalud.org)
Pathogenesis3
- The dysfunctions and malformations of these systems contribute to the pathogenesis of many human diseases and frequently give rise to tumors and tumorlike malformations in the skin, soft tissue, and viscera. (basicmedicalkey.com)
- The features including targeting cancer-related factors Rb and p53, the ability of cellular transformation "in vitro", encoding proteins with oncogenic functions such as IE and pp65, employing mechanisms of oncomodulation and evading the immune system responses, have turned HCMV into an influential factor involved in pathogenesis of human malignancies, such as glioma, neuroblastoma, and breast cancer [10-11]. (waocp.com)
- Dr. Ho did her PhD work in herpesvirus pathogenesis and postdoctoral research in CNS gene therapy with viral vectors at Stanford University. (stanford.edu)
Diagnosing Kaposi's sarcoma1
- HHV-8 immunohistochemical detection is an effective tool for diagnosing Kaposi's sarcoma, especially in early lesions in which neoplastic features are not evident. (fiocruz.br)
Kaposi's5
- Immunohistochemical and histological analyses were performed in 49 Kaposi's sarcoma skin biopsies and 60 of its histological simulators. (fiocruz.br)
- How does the Kaposi's sarcoma herpesvirus enter the cell? (pasteur.fr)
- The Kaposi's sarcoma herpesvirus causes skin cancers, especially in immunocompromised people. (pasteur.fr)
- In order to better treat this disease, it is essential to understand the functioning of Kaposi's sarcoma-associated herpesvirus (KSHV), which causes it. (pasteur.fr)
- Kaposi's sarcoma-associated herpesvirus (KSHV), which was originally detected in Kaposi's sarcoma, also has been found in primary effusion lymphomas (PELs) and some cases of multi-centric Castleman's disease. (tau.ac.il)
Papillomavirus1
- Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. (oncotarget.com)
Cytomegalovirus3
- The viruses including human papilloma viruses (HPVs), Epstein-Barr virus (EBV-also known as human herpes virus type 4), mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), and human cytomegalovirus (HCMV) have been mentioned to be related to breast cancer [7]. (waocp.com)
- Methods We treated cell cultures with BC/BL or defined single plant extracts, purified anthocyanins and astaxanthin in different concentrations and subsequently infected the cultures with the Measles virus (wild-type or vaccine strain Edmonston), Herpesvirus 1 or 8, or murine Cytomegalovirus. (uni-wuerzburg.de)
- Human Herpesvirus 1 and murine Cytomegalovirus replication was inhibited by BC/BL, single bilberry or black currant extracts, and the BC/BL component delphinidin-3-glucoside chloride. (uni-wuerzburg.de)
Castleman's4
- HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic, transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman's disease (MCD). (hiv.gov)
- 10 HHV-8 viremia typically accompanies symptomatic episodes of multicentric Castleman's disease. (hiv.gov)
- His immunohistochemical diagnosis presented Castleman's disease in plasmacytic/diffuse form. (biomedcentral.com)
- In the second case, a 35-year-old feoderm man presented at the same hospital with multiple cervical enlarged lymph nodes and histopathological evidence of Castleman's disease associated with human herpesvirus-8. (biomedcentral.com)
KSHV2
- The seroprevalence of human herpesvirus-8 (HHV-8)-also known as Kaposi sarcoma-associated herpesvirus (KSHV)-varies worldwide and is estimated to be 1% to 5% in the general U.S. population 1,2 compared with 10% to 20% in certain Mediterranean countries and 30% to 80% in parts of sub-Saharan Africa. (hiv.gov)
- In both cases, KSHV DNA was detected by polymerase chain reaction and Southern blotting, and KSHV vIL-6 protein expression was identified in affected tissues by immunohistochemical localization. (tau.ac.il)
Kaposi7
- O sarcoma de Kaposi é a neoplasia mais diagnosticada em pacientes com SIDA e a expressão do antígeno nuclear latente-1 do herpesvírus humano tipo-8 (HHV-8) tem se mostrado útil no seu diagnóstico histológico. (fiocruz.br)
- Positividade à imuno-histoquímica para o antígeno nuclear latente 1 do HHV-8 foi observada nos 49 casos de sarcoma de Kaposi e nenhuma reação foi detectada nos 60 simuladores analisados, resultando em 100% de sensibilidade e especificidade. (fiocruz.br)
- A detecção do HHV-8 por imuno-histoquímica é uma ferramenta útil para o diagnóstico de sarcoma de Kaposi, especialmente na lesão inicial cujo caráter neoplásico não é evidente, e contribui para seu diagnóstico diferencial histológico. (fiocruz.br)
- The breakthrough came in 1994, when the Kaposi sarcoma-associated herpes virus (human herpesvirus type 8 [HHV-8]) was identified using representational difference analysis. (medscape.com)
- HHV-8 has been linked closely with all 4 types of Kaposi sarcoma, ie, classic (traditional), endemic (African), epidemic (AIDS related), and iatrogenic (related to immunosuppression). (medscape.com)
- [ 3 ] Since then, much research has shown that HHV-8 appears to be necessary to, but not sufficient for, the development of Kaposi sarcoma. (medscape.com)
- Kaposi sarcoma and its causative agent, Karposi sarcoma-associated herpesvirus, have distinctive largely unexplained geographic distributions. (medscape.com)
Antiviral2
Epithelial cells3
- In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. (ijpmonline.org)
- Previous studies on the impact of CyaA on human epithelial cells have been carried out using cell lines derived from the airways or the intestinal tract. (uni-wuerzburg.de)
- Here, we investigated the interaction of CyaA and its enzymatically inactive but fully pore-forming toxoid CyaA-AC- with primary human airway epithelial cells (hAEC) derived from different anatomical sites (nose and tracheo-bronchial region) in two-dimensional culture conditions. (uni-wuerzburg.de)
Humano1
- En el contexto de la enfermedad debida al virus de la inmunodeficiencia humana (VIH), la EC se asocia en su patogenia a la infección por el herpes virus humano tipo-8 (HHV-8). (bvsalud.org)
Patients4
- 9 Patients who are HHV-8 seropositive and exhibit HHV-8 viremia are at increased risk (approximately nine-fold) for developing KS relative to those without HHV-8 viremia. (hiv.gov)
- To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
- 2014) 16 reported and compared the histologic, immunohistochemical and clinical features as well as the survival rates of carcinoma arising in patients with PVL (p-scca) and conventional squamous cell carcinoma (c-scca). (bvsalud.org)
- Existing data has shown the presence of CMV in different samples of patients with breast cancer [8]. (waocp.com)
Lymphoproliferative1
- IHC did not show malignant lymphoproliferative disease and marked the presence of human herpesvirus-8 (HHV-8) predominantly in mantle zone cells. (biomedcentral.com)
19994
Lymphoma1
Nuclear1
- Human sodium/iodide symporter (hNIS) is considered as one of the most prevalent nuclear imaging reporter transgenes that provides precise information regarding the kinetics of gene expression, viral biodistribution, toxicity, and therapeutic outcomes using the accumulation of radiotracers at the site of transgene expression. (biomedcentral.com)
Casos1
- La mayoría de los casos corresponden a la variante hialino-vascular (80/90%) en tanto un pequeño porcentaje (10/20%) son de la variante plasmocelular. (bvsalud.org)
Immunohistochemistry1
- Results: Out of 584 articles, 29 articles including 3158 samples were finally reviewed, of which 16 articles used PCR methods, 8 articles used serology method and 13 articles used other methods such as immunohistochemistry and in situ hybridization. (waocp.com)
Disease5
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- Two different classes of thymidine kinases have been identified and are included in this super family: one family groups together thymidine kinase from herpesvirus as well as cellular thymidylate kinases, the second family groups TK from various sources that include, vertebrates, bacteria, the bacteriophage T4, poxviruses, African swine fever virus (ASFV) and Fish lymphocystis disease virus (FLDV). (wikipedia.org)
- Health agencies initially made no link between avian and human disease, despite the temporal, clinical, and pathologic similarities. (vin.com)
- The oral cavity is the gateway between the external environment and the human body, maintaining oral homeostasis, protecting the mouth, and preventing disease. (encyclopedia.pub)
- Bourgade K, Garneau H, Giroux G, Le Page AY, Bocti C, Dupuis G, Frost EH, Fülöp T Jr . β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1 . (alzforum.org)
Methods2
- METHODS: The sample included 4,914 children aged 8 to 15 years from the 2005 to 2014 National Health and Nutrition Examination Survey (representing 20.7 million children). (cdc.gov)
- Methods Primary fibroblasts derived from human ligaments and tendons were isolated by enzymatic digestion and seeded in monolayer cultures in a humidified incubator in 5 % CO2 atmosphere at 37° C. After 80 % cell confluence regular culture medium was supplemented with 0.5 mg/ml of a specific collagen hydrolysate (FORTIGEL®, GELITA AG, Germany). (micrornaassay.com)
Detection1
- Alfieri AA, Leite JPG, Alfieri AF, Jiang B, Glass RI, Gentsch JR. Detection of field isolates of human and animal group C rotavirus by reverse transcription-polymerase chain reaction and digoxigenin-labeled oligonucleotide-probes. (unt.edu)
Immunocompetent1
- Infected immunocompetent animals exhibited widespread perivascular inflammation, which subsided by 8 weeks. (biomedcentral.com)
Type1
- Also, SIV is distinct from simian T-cell lymphotropic virus type I (STLY-I) which shares extensive genomic sequences with human T-lymphotropic virus type I and is associated with T-cell lymphomas in nonhuman primates (12). (cdc.gov)
Viruses3
- Bender C, Hall H, Huang J, Klimov A, Subbarao K. Characterization of the surface proteins of influenza A (H5N1) viruses isolated from humans in 1997-1998. (unt.edu)
- Although the exact role of these viruses in the breast cancer remains controversial, large body of studies reported an association between HCMV and breast cancer [8]. (waocp.com)
- Conclusions Our data indicate that Measles viruses and Herpesviruses are differentially susceptible to a specific BC/BL mixture, single plant extracts, purified anthocyanins and astaxanthin. (uni-wuerzburg.de)
Prevalence2
- The prevalence of oral cancer during 2003-2006 in Iraqi governorates in relation to sex, age and site has been estimated, and the study found that the highest prevalence (55.81%) was observed in tongue, while the lowest (3.87%) was found in the floor of the mouth (Al-Kawaz, 2010) 8 . (bvsalud.org)
- Moreover, Baghdad governorate was found to have the highest prevalence of OSCC (41.08%) 8 . (bvsalud.org)
Reaction1
- Among the IDC (NOS) lesions, six cases of grade III breast carcinoma exhibited a positive immunohistochemical reaction, the staining index of which varied from 2-6. (ijpmonline.org)
Protein2
- The article shows how the virus interacts with a receptor on human cells, the EphA2 receptor, via a surface protein complex made of glycoproteins H and L (gH/gL). (pasteur.fr)
- In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
Analysis4
- Results of immunohistochemical analysis have also shown lesion blister fluid to contain TNF, an important proinflammatory cytokine. (medscape.com)
- Immunohistochemical analysis revealed myofibroblasts as a major component of neointima. (biomedcentral.com)
- Zoetendal EG, Akkermans ADL, De Vos WM: Temperature PF-3084014 price gradient gel electrophoresis analysis of 16s rRNA from human fecal samples reveals stable and host-specific communities of active bacteria. (micrornaassay.com)
- Given the failure of traditional monitoring strategies (such as immunohistochemical analysis (in providing sufficient safety and efficacy necessary for virotherapy and continual pharmacologic monitoring to track pharmacokinetics in real-time, the development of alternative strategies for ongoing monitoring of oncolytic treatment in a live animal model seems inevitable. (biomedcentral.com)
Virus3
- A recent study offers new modellings of one of the virus' a surface proteins, and its receptor, on human cells. (pasteur.fr)
- WCS pathologists were instrumental in prompting action at the state and federal level that resulted in the diagnosis of West Nile virus (WNV) in birds, and subsequently as the cause of human illnesses and deaths. (vin.com)
- We hypothesised that a mixture of Ribes nigrum L. (Grossulariaceae) (common name black currant (BC)) and Vaccinium myrtillus L. (Ericaceae) (common name bilberry (BL)) extracts (BC/BL) with standardised anthocyanin content as well as single plant extracts interfered with the replication of Measles virus and Herpesviruses in vitro. (uni-wuerzburg.de)
Virology1
- A study in which the Structural Virology team at the Institut Pasteur participated investigates the way this herpesvirus manages to infect human cells. (pasteur.fr)
Microbiome2
- However, appreciation of the human microbiome and host cell-microbe interactions must be taken into consideration as we try to determine what interactions are pathologic. (edu.au)
- The human oral microbiome refers to an ecological community of symbiotic and pathogenic microorganisms found in the oral cavity. (encyclopedia.pub)
Vascular2
- La forma hialino-vascular suele ser asintomática y localizada en mediastino mientras que la plasmocelular se presenta frecuentemente con signo-sintomatología sistémica y suele ser difusa o multicéntrica. (bvsalud.org)
- Here we report that MCMV infections of gene-targeted mice lacking IFN-γR and subjected to whole body irradiation develop vascular lesions that over 4 months progress to severe vasculopathy characterized by significant neointima formation, a prominent feature of autoimmune vasculopathies in humans. (biomedcentral.com)
Patient1
- The compounds suppressed SARS-CoV-2 replication in cell culture cells and a patient-near replication system using human precision-cut lung slices by two orders of magnitude. (uni-wuerzburg.de)
Strains1
- Strains of SIV have been successfully cultured in human lymphocyte cell lines (e.g. (cdc.gov)
Study1
- cutánea maligna de células T. Luego se realizó el frotis de médula ósea, en el que se identificaron células «cerebriformes» study conception, manuscript que confirmaron el diagnóstico de síndrome de Sézary. (bvsalud.org)
Cells2
- The complex architecture of the human body requires an efficient life-support system that transports gases, liquids, and other nutrients as well as circulating cells that play important roles in body defense systems. (basicmedicalkey.com)
- 8 The sprouting of endothelial cells is regulated by Notch signaling receptors and their Delta-like 4 (DLL4) ligand. (basicmedicalkey.com)
Leukocyte1
- HuT 78, HT, CEMx174) and in primary human and nonhuman primate peripheral blood leukocyte cultures (13). (cdc.gov)
Fever1
- The first case is a 41-year-old feoderm man who presented to the Department of Infectious Diseases of the Hospital das Clínicas in May 2015, with irregular fever history (38-39 °C), dyspnea, weight loss (8 kg/1 year), and asthenia with increased cervical lymph nodes of 1-year duration. (biomedcentral.com)
Cell1
- Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
Features1
- SIV also causes a primary encephalopathy with many of the features of HIV-associated encephalopathy (8). (cdc.gov)
Years2
- A 49-year-old male resident of Cancun has the following significant history: full immunization, SARS-CoV-2, 2 AstraZeneca doses, previous hospitalizations on two occasions in the last three years for pneumonia, transfusions in March 2022 for anemia, alcoholism for 29 years at a rate of 14 gr/day suspended 8 months ago. (clinmedjournals.org)
- AN - check the tag INFANT HN - 2008 FX - Child Nutrition FX - Infant Nutrition Physiology FX - Milk FX - Milk, Human DH - Adolescent Nutrition DI - 052508 MN - SP6.021.067 MS - Nutrition of persons 10 through 19 years of age. (bvsalud.org)
Risk2
- Therefore, a working group was established by CDC and the National Institutes of Health (NIH) to formulate specific guidelines intended to minimize the risk of SIV transmission to humans. (cdc.gov)
- 4-6 Injection drug use may also be a risk factor for HHV-8 seropositivity, 7 although this association has not been consistently observed. (hiv.gov)