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  • Mice
  • Using this system and employing mutant mice in which the membrane exon of the mu chain, the lambda 5 gene, or the JH locus was inactivated by gene targeting, we found that expression of the pre-B cell receptor complex is necessary for the transition from the large CD43+ to the small CD43- pre-B cell stage. (nih.gov)
  • proteins
  • This study demonstrated that light chains belonged to a class of proteins that are capable of catalyzing the formation of hydrogen peroxide. (asnjournals.org)
  • Ig light chains, once termed Bence Jones proteins ( 4 ), appear in the circulation as monomers (M r approximately 22 kD) and dimers (M r approximately 44 kD). (asnjournals.org)
  • diagnosis
  • Objective To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts. (bmj.com)
  • Vk-Jk and Vlambda-Jlambda rearrangements showed a good stability between diagnosis and relapse and reached good sensitivities in real-time quantitative polymerase chain reaction analysis. (haematologica.org)
  • We provide an update regarding the diagnosis and classification of primary cerebral low-grade B-cell lymphomas and cerebral light chain deposit diseases. (biomedcentral.com)
  • synthesis
  • An RNA fraction isolated from a mouse myeloma functions as template for the synthesis of a mouse Ig light chain in a cell free system from rabbit reticulocytes. (umassmed.edu)
  • disease
  • Conclusions These data demonstrate that CSF immunoglobulin κ:λ ratios, determined at the time of diagnostic lumbar puncture, predict MS disease progression and may therefore be useful prognostic markers for early therapeutic stratification. (bmj.com)
  • Immunoglobulin light-chain amyloidosis (AL amyloidosis) is a rare and often fatal disease for which there is currently no treatment approved by the US Food and Drug Administration or the European Medicines Agency. (tlgqr.com)
  • recognition
  • Carbohydrate is attached to an Asx residue at position 25, in the first hypervariable region, associated with the sequence triplet Asx-Ser-Ser, which is postulated to be a common recognition site for glycosylation of immunoglobulins. (eurekamag.com)
  • Structural and functional data indicate that the IGH plays a more important role than immunoglobulin kappa (IGK) or lambda (IGL) light chain in the recognition mechanism of the IG. (springer.com)