Loading...
  • lymphocytes
  • In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. (rcsb.org)
  • These findings are unexpected, given that immunoglobulin gene expression normally associates with lineage fidelity in B lymphocytes. (aacrjournals.org)
  • tumor
  • Among B-cell malignancies, follicular lymphomas (FL) more frequently show acquired, potential N-glycosylation sites (AGS) within tumor-specific immunoglobulin. (cun.es)
  • In our series, all cases of FL had AGS within their tumor-specific immunoglobulin heavy chain variable regions. (cun.es)
  • Of interest in this regard, two studies of epithelial breast cancer reported that IgG can be identified in tumor cells directly based on assays specific for the heavy chain constant region ( 1 , 2 ). (aacrjournals.org)
  • aggregation
  • These data provide evidence for common genetic susceptibility to AL amyloidosis and MM. Cyclin D1 is a more prominent driver in AL amyloidosis than in MM, but the links to aggregation of light chains need to be demonstrated. (lu.se)
  • Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. (semanticscholar.org)
  • molecular
  • As low molecular weight proteins, restriction from glomerular filtration is minimized, permitting significant amounts of Ig light chains to be endocytosed into the proximal tubule epithelium, particularly in plasma cell dyscrasias. (asnjournals.org)
  • Major functions of the proximal tubule include reclamation of filtered low molecular weight proteins, such as Ig light chains, and other essential molecules that are carried by proteins, such as folate ( 1 - 3 ). (asnjournals.org)
  • An internal molecular deletion occurring in a human lambda type immunoglobulin light (L)-chain (Sm lambda) has been defined by sequence analysis. (eurekamag.com)
  • monoclonal
  • In the setting of a plasma cell dyscrasia, however, light chain production increases significantly, producing circulating concentrations of monoclonal light chain that can approach 100,000 mg/L ( 7 , 14 ). (asnjournals.org)
  • Although saturation of the multiligand endocytotic receptor complex of the proximal tubule permits light chains to appear in the tubule fluid of the distal nephron and finally in the urine, overproduction of monoclonal light chains can result in significant concentration of these proteins in the proximal tubule. (asnjournals.org)
  • disease
  • Conclusions These data demonstrate that CSF immunoglobulin κ:λ ratios, determined at the time of diagnostic lumbar puncture, predict MS disease progression and may therefore be useful prognostic markers for early therapeutic stratification. (bmj.com)
  • normally
  • The approximate 500 mg of free light chains that is produced by the normal lymphoid system daily is filtered and catabolized by the kidney in the proximal tubule, such that only approximately 1 to 10 mg of polyclonal light chains normally appears in the urine ( 4 - 8 ). (asnjournals.org)
  • Human
  • Nuclear factor κB binding sites were shown to be primarily responsible for the positive activity contributed by the HS1,2 and HS4 regions, and we observed the in vivo interaction of these factors with the human immunoglobulin heavy chain gene enhancer regions in t(14;18) cells. (aacrjournals.org)
  • AL-Base, a curated database of human immunoglobulin (Ig) light chain (LC) sequences derived from patients with AL amyloidosis and controls, is described, along with a collection of analytical and graphic tools designed to facilitate their analysis. (semanticscholar.org)
  • expression
  • The purpose of this study was the cloning and expression of the constant region of rainbow trout IgM heavy chainchain) gene in Escherichia coli . (jifro.ir)
  • Rahnama R, Seyfi Abad Shapouri M, Peyghan R, Rezaie A, Shahbazian N. Cloning and expression of the constant region of rainbow trout (Onchorhynchus mykiss) µ immunoglobulin chain in Escherichia coli. (jifro.ir)
  • recognition
  • Carbohydrate is attached to an Asx residue at position 25, in the first hypervariable region, associated with the sequence triplet Asx-Ser-Ser, which is postulated to be a common recognition site for glycosylation of immunoglobulins. (eurekamag.com)
  • patients
  • Patients with immunoglobulin light chain amyloidosis are at risk for both thrombotic and bleeding complications. (haematologica.org)
  • This retrospective study examined the frequency of venous thromboembolism in 929 patients with immunoglobulin light chain amyloidosis presenting to a single referral center, correlated risk of venous thromboembolism with clinical and laboratory factors, and examined complications of anticoagulation in this population. (haematologica.org)
  • Objectives To define whether the high sensitivity cardiac troponin T (hs-cTnT) assay in patients with immunoglobulin light chain amyloidosis (AL) improves risk prediction. (bmj.com)
  • We found a statistically significant increase in free κ chains in both AChR- and MuSK-MG patients, while free λ chain levels were increased only in AChR-MG. We also observed a significant reduction of both free κ and λ chains in 1/4 MuSK-MG patients along with specific abs titer, two months after RTX treatment. (hindawi.com)
  • Several new classes of drugs, such as proteasome inhibitors and immunomodulatory drugs, along with high-dose chemotherapy and autologous haematopoietic stem cell transplantation, have led to rapid and deep suppression of amyloid light chain production in the majority of patients. (ucl.ac.uk)
  • specific
  • The phylogeny also showed that sigma-2 IgL chains initially regarded as specific for cartilaginous fish are present in holosteans, polypterids, and even in turtles. (frontiersin.org)
  • Structure
  • The carbohydrate moiety is a complex oligosaccharide with a branched chain structure containing sialic acid, fucose, mannose, N-acetylglucosamine, and galactose. (eurekamag.com)