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  • gamma 2b
  • The clones examined produce either mu, gamma 2b or no immunoglobulin chain. (uab.edu)
  • These findings formally exclude both unequal sister chromatid exchange and recombination between homologues as mechanisms for creating a gene encoding the gamma 2b chain. (uab.edu)
  • Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. (uab.edu)
  • The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells. (uab.edu)
  • clusters
  • Spectral precision distance microscopy was utilized to detect small but nonetheless consistently present conformational differences between the immunoglobulin heavy-chain gene clusters (IgH) that reside on the two chromosome 12 homologues in all diploid cells of the mouse. (semanticscholar.org)
  • lymphoid
  • The aim of our study was to assess the utility of flow cytometric analysis of surface Ig heavy chain (HC) expression in lymphoid tissues in distinguishing lymphoid hyperplasias from BCLs, and also differentiating various BCL subtypes. (semanticscholar.org)
  • Comparative analysis of light chain expression in germinal center cells and mantle cells of reactive lymphoid tissues. (semanticscholar.org)
  • region
  • To extend these findings, we focused on immunoglobulin variable ( V ) region gene analysis using well-defined breast cancer cell lines expressing the epithelial marker, epithelial cell adhesion molecule (EpCAM). (aacrjournals.org)