A total of 126 Caucasian participants with glioblastoma were genotyped for several GM, KM, and FcgammaR alleles and characterized for IgG antibodies to EGFR and EGFRvIII antigens. (cdc.gov)
It was concluded that erythrocyte antibodies of patients with AHA are often restricted in respect to their Gm genetic characters with a preference for the Gm(a) allotype. (ashpublications.org)
The data suggest an association between certain erythrocyte antibodies and Ig allotypes. (ashpublications.org)
IgA-deficient patients with immunoglobulin E (IgE)-class anti-IgA antibodies are at risk for anaphylaxis if they receive blood or intravenous immunoglobulin, but this situation is extremely rare. (medscape.com)
It was able to replicate a new immunological test of rabbit serum that had been reported by Jacques Oudin in Paris one of the discoverers of rabbit allotypes (genetic types of rabbit antibodies). (nih.gov)
These immunoglobulins undergo mitosis , resulting in cell division, and manufacture antibodies continually as a result of the production of additional cells. (microbiologynote.com)
Antibodies are serum- and tissue-produced globulin proteins (immunoglobulins) that respond specifically with the antigen that prompted their synthesis. (microbiologynote.com)
Consequently, all antibodies are immunoglobulins, but not all immunoglobulins are antibodies. (microbiologynote.com)
Belonging to the immunoglobulin (Ig) superfamily, antibodies are large, Y-shaped glycoproteins produced by plasma cells. (ukdiss.com)
To date, the majority of recombinant glycoproteins in production from mammalian cell lines such as CHO, NS0 and Sp2/0 are monoclonal antibodies, among which are mainly either chimeric, humanized or human Immunoglobulin Gs (IgGs) [6]. (ukdiss.com)
Genes4
11. Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies. (nih.gov)
15. Restricted immunoglobulin constant heavy G chain genes in primary immunodeficiencies. (nih.gov)
Allelic variants of the gamma-immunoglobulin heavy chain ( IMMUNOGLOBULIN GAMMA-CHAINS ) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES . (nih.gov)
Years later, the "one gene one protein" dogma was overthrown at least not correct in the case of immunoglobulins which were shown to be assembled from several genes. (nih.gov)
Subclasses1
Collaborating international scientists evaluated the mAbs which showed reactivity and specificity for human IgG (11), the IgG subclasses (59), or Gm allotypes (4) by employing different assay techniques or protocols. (nih.gov)
Serum5
7. Serum Gm allotype levels in common variable immunodeficiency: preponderance of homozygous G2m(",") on IGHCG2. (nih.gov)
19. [Characteristics of the distribution of Gm(1), Gm(2) and Gm(10) factors in the blood serum of pregnant and nonpregnant women]. (nih.gov)
Immunoglobulin A deficiency (IgAD) is defined as an undetectable serum IgA level. (medscape.com)
Normal serum levels of IgG and IgM are necessary for a diagnosis of selective immunoglobulin A deficiency (SIgAD). (medscape.com)
All six persons were heterozygous for human IgG1 allotypes, and thus their serum immunoglobulins were Gm (a+f+). (ashpublications.org)
Selective1
Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary antibody deficiencies. (medscape.com)
Superfamily1
All except LIR-4 (which appears to encode a soluble molecule) encode type-1 transmembrane proteins, containing either two or four immunoglobulin superfamily (IgSF) domains in their extracellular regions. (biomedcentral.com)
Deficiency1
Anti-D immunoglobulin treatment for thrombocytopenia associated with primary antibody deficiency. (medscape.com)
Chains2
Immunoglobulin γ marker (GM) and κ marker (KM) allotypes, hereditary antigenic determinants of γ and κ chains, respectively, have been shown to be associated with immunity to a variety of self and nonself antigens, but their possible contribution to immunity to the tumor-associated antigens epidermal growth factor receptor (EGFR) and EGFR variant (v)III has not been evaluated. (nih.gov)
Identification and genetic control of L3 allotype of the light chains. (nih.gov)
Antibody levels1
The aim of the present investigation was to determine whether the interindividual variation in endogenous antibody responsiveness to EGFR and EGFRvIII is associated with particular GM, KM, and Fcγ receptor (FcγR) genotypes and whether antibody levels were associated with the overall survival of patients with glioblastoma. (nih.gov)
Glioblastoma1
GM allotypes contribute to humoral immunity to EGFR in glioblastoma. (cdc.gov)
Marker1
1. IgG heavy chain allotype (Gm), a genetic marker for human chromosome 14q32, and haematopoietic malignancies. (nih.gov)
Genetic2
3. Immunoglobulin G heavy-chain allotypes as possible genetic markers for human cancer. (nih.gov)
12. Genetic linkage studies in ataxia-telangiectasia: Gm markers. (nih.gov)
Gamma1
7. Expression of the C gamma-allotypes in domestic mink infected with the Aleutian disease virus. (nih.gov)
Receptor2
Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC molecules with low (μM) affinities. (biomedcentral.com)
Encoded from within the Leukocyte Receptor Cluster [ 3 ] (a region of human chromosome 19 which also encompasses the loci for the related Killer Inhibitory Receptor (KIR) and Leukocyte-Associated Immunoglobulin-like Receptor (LAIR) families), the LIRs are highly similar to one another (63-84% amino acid identity in the extracellular region). (biomedcentral.com)
Myeloma1
14. A biased Gm haplotype and Gm paraprotein allotype in multiple myeloma suggests a role for the Gm system in myeloma development. (nih.gov)
Preparations1
Individuals with such an unusual profile should receive only low IgA intravenous immunoglobulin preparations. (medscape.com)
Antigen1
The last antibody preparation varied from a disproportionately high Gm(a) concentration to equal allotype concentrations, depending on the antibody/antigen ratio used during the sensitization of the erythrocytes. (ashpublications.org)
Immunoglobulin (Ig) was coined in 1964 by the World Health Organization (WHO) to replace the term antibody. (microbiologynote.com)
Role1
Immunoglobulins play a key role in the immune system. (nih.gov)
Patients1
18. Immunoglobulin allotypes and IgG subclass antibody response to Aspergillus fumigatus in cystic fibrosis patients. (nih.gov)
Blood1
Establishment of an immunoglobulin A-deficient blood donor registry with a simple in-house screening enzyme-linked immunosorbent assay. (medscape.com)
Produced by plasma cells1
Immunoglobulins are produced by plasma cells and lymphocytes to a lesser extent. (microbiologynote.com)
Heavy3
2. Primary hepatocellular carcinoma and IgG heavy chain allotypes. (nih.gov)
4. Association between Crohn's disease and immunoglobulin heavy chain (Gm) allotypes. (nih.gov)
5. IgG heavy chain allotypes (Gm) in autoimmune diseases. (nih.gov)
Tests1
When I had my lab at NIH, I obtained some samples from the Jackson lab rabbits and we did typing tests to characterize their immunoglobulin allotypes using newer methods than the Oudin method. (nih.gov)
These findings are similar to a previous report from this laboratory that noted a preference for the Gm(a) allotype in many isoantibodies with Rh specificity. (ashpublications.org)