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  • CD23
  • We show that the human and mouse proteins cause extensive morphological changes to human monocytes with an associated up-regulation of major histocompatibility complex class II antigens and the low-affinity receptor for immunoglobulin E (Fc epsilon RII or CD23). (pnas.org)
  • Falaleeva N. A., Osmanov E. A., Tupitsyn N. N. Federal State Budgetary Institute N. N. Blokhin Russian Cancer Research Center, Health Ministry of Russian Federation, Moscow, Russia SUMMARY Follicular dendritic cells, expressing Fc ε RII or CD23 (Fc ε RIIFDCs) as a component of non-tumor environment have been studied in 232 follicular lymphoma (FL) patients. (scirp.org)
  • CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. (wikipedia.org)
  • Unlike many of the antibody receptors, CD23 is a C-type lectin. (wikipedia.org)
  • The IgE immune complexes that are formed bind to CD23 molecules on B cells, and are transported to the B cell follicles of the spleen. (wikipedia.org)
  • The allergen responsible in dust mite allergy Der p 1 is known to cleave CD23 from a cells surface. (wikipedia.org)
  • As CD23 is soluble, it can move freely and interact with cells in plasma. (wikipedia.org)
  • Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. (wikipedia.org)
  • In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell lymphoma (CD23-negative). (wikipedia.org)
  • CD23 can also be demonstrated in germinal centre B-cells using immunohistochemistry, but it is not present in the resting cells of the surrounding mantle zone. (wikipedia.org)
  • Lymphomas arising from the mantle zone are generally negative for CD23, but most B-cell chronic lymphomocytic leukaemias and low-grade B-cell lymphomas are positive, allowing immunohistochemistry to distinguish these conditions, which otherwise have a similar appearance. (wikipedia.org)
  • Reed-Sternberg cells are usually positive for CD23. (wikipedia.org)
  • lymphocytes
  • FL originates from immunity cells, peripheral B-lymphocytes of lymph node follicular centers. (scirp.org)
  • Peripheral blood lymphocytes from old male individuals and young controls were fused with a Chinese hamster cell line (CHO-YH21), yielding 10 HAT-resistant rodent-human clones from the old propositi and 22 from the young controls. (worldwidescience.org)
  • Our laboratory continues to work on fundamental processes by which T lymphocytes recognize foreign pathogens including viruses such as smallpox, vaccinia, HIV, and influenza A. We have analyzed the basic function and structure of the T cell receptor (TCR) components: TCRalphabeta heterodimer, CD3epsilongamma and CD3epsilondelta heterodimers, and CD3zetazeta homodimer. (dana-farber.org)
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • binds
  • When FcαRI monovalently binds monomeric, non-antigen bound IgA, the form most common in serum, the resulting signals result in inactivation of other activating receptors such as FcγR and FcεRI. (wikipedia.org)
  • Each Fc region of a particular antibody isotype is able to bind to its specific Fc Receptor (except for IgD, which is essentially the BCR), thus allowing the antigen-antibody complex to mediate different roles depending on which FcR it binds. (wikipedia.org)
  • IgE's Fab paratope binds to allergic antigen, for example house dust mite particles, while its Fc region binds to Fc receptor ε. (wikipedia.org)
  • IL-13 also binds to another receptor known as IL-13Rα2. (wikipedia.org)
  • Immunology
  • We are currently pursuing new mass spectrometry approaches to identify peptides arrayed on individual types of antigen-presenting cells, and defining at a molecular level the extent of T cell recognition of individual immunodominant epitopes as well as non-immunodominant epitopes.In the next year, we expect to apply these tools and approaches for characterizing human immune recognition to the area of tumor immunology. (dana-farber.org)
  • A model of the Fc of immunoglobulin E". Molecular Immunology. (wikipedia.org)
  • reactivity
  • About 20% of all pollen allergic patients tested (n = 65) displayed immunoglobulin E (IgE) reactivity to recombinant birch profilin that was expressed in pKK223-3. (rupress.org)
  • encodes
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • protein
  • Furthermore, the human protein induced considerable levels of IgM and IgG, but no IgA production, in cultures in which highly purified human surface IgD+ or total B cells were cocultured with an activated CD4+ T-cell clone. (pnas.org)
  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. (wikipedia.org)
  • Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. (abnova.com)
  • Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene. (wikipedia.org)
  • An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. (wikipedia.org)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), SHP-2, or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. (wikipedia.org)
  • histamine release
  • Moreover, all pollen profilins purified from these far distantly related plant species, and likewise the purified recombinant birch profilin, are able to elicit dose-dependent histamine release via high affinity Fc epsilon receptor of blood basophils from profilin allergic patients. (rupress.org)
  • For example, IgE is responsible for an allergic response consisting of mast cell degranulation and histamine release. (wikipedia.org)
  • molecules
  • The T-cell receptor complex with TCR-α and TCR-β chains, CD3 and ζ-chain accessory molecules. (wikipedia.org)
  • When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction, that is, a series of biochemical events mediated by associated enzymes, co-receptors, specialized adaptor molecules, and activated or released transcription factors. (wikipedia.org)
  • PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (wikipedia.org)
  • mast cell
  • IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, Natural killer T cell, Mast cell, Basophil cells, Eosinophil cells and Nuocyte cells. (wikipedia.org)
  • A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response. (wikipedia.org)
  • molecular
  • Thus, rather than a lymphoid cytokine, IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cell to the non-immune cells in contact with them, thereby altering physiological function. (wikipedia.org)
  • bind
  • Inside-out signaling primes FcαRI in order for it to bind its ligand, while outside-in signaling caused by ligand binding depends on FcαRI association with the Fc receptor gamma chain (FcR γ-chain). (wikipedia.org)
  • Priming occurs when cytokines signaling the presence of an infection bind their receptors on FcαRI-expressing cells, activating the kinase PI3K. (wikipedia.org)
  • chains
  • In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by TRA and TRB , respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by TRG and TRD , respectively). (wikipedia.org)
  • T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate receptor, formed by variable gamma (γ) and delta (δ) chains, referred as γδ T cells. (wikipedia.org)
  • human
  • Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. (pnas.org)
  • We have isolated the human cDNA homologue of a mouse helper T-cell-specific cDNA sequence, called P600, from an activated human T-cell cDNA library. (pnas.org)
  • The vector of anti-MUC1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human MUC1. (creative-biolabs.com)
  • Furthermore, IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells. (wikipedia.org)
  • Research has shown that cell-surface expression of IL-13Rα2 on human asthmatic airway fibroblasts was reduced compared with expression on normal control airway fibroblasts. (wikipedia.org)
  • differentiation
  • CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. (creative-biolabs.com)
  • The BCR is found only on the surface of B cells and facilitates the activation of these cells and their subsequent differentiation into either antibody factories called plasma cells or memory B cells that will survive in the body and remember that same antigen so the B cells can respond faster upon future exposure. (wikipedia.org)
  • Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium. (wikipedia.org)
  • transduction
  • The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-MUC1 antibody linked to FcεRIγ signaling domains. (creative-biolabs.com)
  • deletion
  • Interestingly, deletion of IL-13 from mice does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. (wikipedia.org)
  • myeloid
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • stem
  • We cover the development of feather buds in chicken embryos, regenerative cycling of feather follicle stem cells, formation of barb branching patterns, emergence of intrafeather pigmentation patterns, interplay of hormones and feather growth, and the genetic identification of several feather variants. (jove.com)
  • Human
  • Furthermore, IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells. (wikipedia.org)
  • Research has shown that cell-surface expression of IL-13Rα2 on human asthmatic airway fibroblasts was reduced compared with expression on normal control airway fibroblasts. (wikipedia.org)
  • soluble
  • As CD23 is soluble, it can move freely and interact with cells in plasma. (wikipedia.org)
  • Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. (wikipedia.org)
  • known
  • IL-13 is known to induce changes in hematopoietic cells, but these effects are probably less important than that of IL-4. (wikipedia.org)
  • The allergen responsible in dust mite allergy Der p 1 is known to cleave CD23 from a cells surface. (wikipedia.org)
  • regulatory
  • IL-13Rα2 (which is labelled as a decoy receptor) is derived from Th2 cells and is a pleotropic immune regulatory cytokine. (wikipedia.org)
  • This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. (wikipedia.org)
  • responses
  • The ensuing signaling cascades lead to pro-inflammatory responses such as release of cytokines, phagocytosis, respiratory bursts, antibody-dependent cell-mediated cytotoxicity, production of reactive oxygen species, and antigen presentation. (wikipedia.org)
  • expression
  • 7. The method according to claim 1, wherein at least a portion of the cells of the cancer are characterized by surface expression of CCR6 and CXCR4. (patents.com)
  • antibody
  • Choose between properties like host, clone and antigen to get the antibody you need. (antibodies-online.com)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival). (wikipedia.org)
  • In most cases, interaction of the B cell with a T helper cell is necessary to produce full activation of the B cell and, therefore, antibody generation following antigen binding. (wikipedia.org)
  • Unlike many of the antibody receptors, CD23 is a C-type lectin. (wikipedia.org)
  • The CD11c+ cells in turn present the antigen to CD4+ T cells, which can lead to an enhanced antibody response. (wikipedia.org)
  • regulator
  • Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. (wikipedia.org)
  • airway
  • These enzymes are required to induce aggression of parenchymal inflammatory cells into the airway lumen, where they are then cleared. (wikipedia.org)