• What is a Thyroid Stimulating Immunoglobulin? (wisegeek.com)
  • A thyroid stimulating immunoglobulin , or TSI, is a type of molecule created by the immune system , known as an autoantibody. (wisegeek.com)
  • A thyroid stimulating immunoglobulin is one example of such an autoantibody, and it is able to act on the thyroid gland in the same way as a hormone called thyroid stimulating hormone, or TSH , which stimulates the thyroid to produce and release more thyroid hormone. (wisegeek.com)
  • The pituitary has no control over the amount of thyroid stimulating immunoglobulin in the blood, so TSI keeps stimulating the thyroid to make more and more thyroid hormone, leading to a condition known as Grave's disease. (wisegeek.com)
  • A prospective study by Östlund et al indicated that patients with PPS who respond to intravenous immunoglobulin therapy tend prior to treatment to have reduced physical function, muscle atrophy in the lower extremities, and greater fatigue and pain levels, as well as a visual analogue scale score above 20. (medscape.com)
  • Light microscopy of a glomerulus from a patient with immunoglobulin A nephropathy showing increased mesangial matrix and cellularity. (medscape.com)
  • We have designed a set of oligonucleotide primers to amplify the cDNA of mouse immunoglobulin heavy and light chain variable domains by the polymerase chain reaction. (pnas.org)
  • In 1995, Katherine Knight and her colleagues, at Loyola University of Chicago, succeeded in developing a double transgenic rabbit over-expressing the oncogenes v-abl and c-myc under the control of the immunoglobulin heavy and light chain enhancers. (wikipedia.org)
  • The CD79a/b heterodimer associates non-covalently with the immunoglobulin heavy chain through its transmembrane region, thus forming the BCR along with the immunoglobulin light chain and the pre-BCR when associated with the surrogate light chain in developing B cells. (wikipedia.org)
  • In humans, there are five heavy chain isotypes: heavy chain α - IgA δ - IgD γ - IgG ε - IgE μ - IgM IgM is the first immunoglobulin expressed during B cell development as a monomer on the surface of B naive cells. (wikipedia.org)