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  • human
  • A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. (google.com.au)
  • duplications
  • The protein hinge region is encoded at the 5' end of the second exon, and the rapid evolutionary changes in length of the hinge correspond to duplications or deletions within the hinge-coding region, probably facilitated by repeats in the DNA sequence. (ox.ac.uk)
  • Polypeptide
  • In an effort to identify the active region of AGRP polypeptide, various peptides of the full length molecule have been prepared and tested for activity. (google.com)
  • known
  • Gene amplification is one of the primary genetic alterations in solid tumors, and most of the chromosomal regions that undergo amplification are not well characterized and do not harbor known oncogenes (Knuutila et al. (google.com)
  • expression
  • Rahnama R, Seyfi Abad Shapouri M, Peyghan R, Rezaie A, Shahbazian N. Cloning and expression of the constant region of rainbow trout (Onchorhynchus mykiss) µ immunoglobulin chain in Escherichia coli. (jifro.ir)
  • One type of mutation is gene amplification or overexpression, i.e., where a specific chromosomal region (including the cancer gene) has undergone a relative increase in DNA copy number, such that more copies of the cancer gene are present, or where the level of expression of a gene is increased, such that a correspondingly higher amount of mRNA and protein is produced, causing deleterious effects. (google.com)
  • binds
  • 10. The TCR of claim 1 wherein the TCR binds specifically to a ligand with an equilibrium binding constant KD of between about 10 "6 M and 10 "12 M. (google.com.au)
  • high
  • The variable regions have approximately 110 amino acids with high sequence variability. (abcam.com)