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  • tumor antigens
  • This review aims to describe the vast spectrum of tumor antigens and strategies to develop cancer vaccines. (asm.org)
  • Active immunotherapy is aimed either at eliciting a specific de novo host immune response against selected tumor antigens (Ags) by employing cancer vaccines or at amplifying the existing antitumor immune response by administering nonspecific proinflammatory molecules or adjuvants. (asm.org)
  • In this context, considering the disappointing results up to now, the quest for specific and selective tumor antigens for developing tumor-specific cancer vaccines, optimal delivery systems (i.e., dendritic cell [DC]-based vaccines), adjuvants, and strategies to overcome immune tolerance and regulatory T (Treg) cell responses is the main goal for several research groups and leading health care companies. (asm.org)
  • Vaccinia was engineered to express tumor antigens and serve as a cancer vaccine. (guwsmedical.info)
  • Vaccines
  • However, while vaccines have proven to be effective in combating pathogenic microorganisms, based on the immune recognition of these foreign antigens, vaccines aimed at inducing effective antitumor activity are still unsatisfactory. (asm.org)
  • reaction
  • Because there are significant differences in molecular weights of tested carrier proteins, this presentation is more relevant to practical uses than the mole-to-mole comparison (i.e., conjugation protocols are alike in specifying a given milligram amount of carrier protein for reaction regardless of its molecular weight). (thermofisher.com)
  • ELISA
  • Serologic responses by ELISA were largely IgM against each antigen with the exception of Tn-MUC1 where both IgM and IgG responses were induced. (aacrjournals.org)
  • molecular
  • Crosslinking reagents are used in a variety of techniques to assist in determining partners and domains of protein interactions, three-dimensional structures of proteins, and molecular associations in cell membranes. (thermofisher.com)
  • Experiments with different lengths of otherwise identical crosslinkers can reveal the molecular distance between particular functional groups in the secondary, tertiary or quaternary protein structure. (thermofisher.com)
  • Because of its evolutionary distance from mammals, high molecular weight and complex structure it is usually immunogenic in vertebrate animals. (wikipedia.org)
  • amine
  • For example, if a short amine-to-amine crosslinker does not successfully crosslink subunits of a dimeric protein, but a slightly longer crosslinker does, one can conclude that the relevant amino acids in the native dimeric structure exist at a distance approximately equal to the length of the longer crosslinker. (thermofisher.com)
  • immunologic
  • By way of example, the purified protein derivative (PPD) of tuberculin from Mycobacteriumtuberculosis, which is the preferred carrier of the invention, is a unique immunologic reagent, because virtually everyone in the world with a functional immune response who has been exposed to BCG or M. tuberculosis infections will have a T-cellmediated, delayed-type hypersensitivity response to minute amounts of PPD. (patentgenius.com)
  • facilitate
  • Moreover, all the oligomers were endowed with a suitable linker at the anomeric position of the reducing end in order to facilitate subsequent conjugation to multivalent scaffolds. (unimi.it)
  • Investigation
  • The structure of the Vi antigen makes it an ideal candidate for our investigation, since its fragments can be easily converted into zwitterionic derivatives by formal N-deacetylation, without introducing huge structural modifications. (unimi.it)
  • Because Hib carrier status is usually determined by culture techniques, the efficiency of every step in the microbiologic investigation must be maximized. (cdc.gov)
  • polypeptide
  • The CCH protein is composed of two very large polypeptide subunits (404/351 kDa) that form an extremely stable heterodidecameric structure even in the absence of divalent cations. (thermofisher.com)
  • cells
  • However, it must be clarified if the introduction of the zwitterionic motif into a naturally non-zwitterionic polysaccharide confers to the resulting ZPS the ability to activate T cells without protein conjugation. (unimi.it)
  • CD4 + Th1 and CD8 + T cells) immune systems, whose final goal is to kill the antigen-bearing tumor cells. (asm.org)
  • cell
  • Ovarian cancers express a rich array of cell surface antigens. (aacrjournals.org)
  • Through four independent experimental approaches -dilution of an inducible histone 2B-green fluorescent protein (H2BGFP) through cell division, incorporation of BrdU, labeling with the cell cycle marker Ki67, and genetic lineage analysis, we aimed to investigate the adult adipose tissue maintenance and its behavior in the cell cycle. (oatd.org)
  • An immunogen is any antigen that is capable of inducing humoral and/or cell-mediated immune response rather than immunological tolerance. (wikipedia.org)