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  • soluble
  • The alcohol soluble proteins (prolamins) from wheat, rye, barley and oats produce the harmful effect of coeliac disease or gluten sensitive enteropathy in humans by causing characteristic changes in the intestinal mucosa. (abcam.com)
  • Blue Carrier Protein is more soluble than mcKLH, especially when maleimide-activated forms are compared. (thermofisher.com)
  • viral
  • A current trend in the design of universal flu vaccines is the construction of recombinant proteins based on combinations of various conserved epitopes of viral proteins (M1, M2, HA2, NP). (springer.com)
  • Recent studies show that conserved influenza viral proteins (such as HA2, M2, NP and M1) can provide protective immune response against a range of influenza virus subtypes. (springer.com)
  • This viral protein not only confers structural stability and homogeneity to virosome-based formulations, but it significantly contributes to the immunological properties of virosomes, which are clearly distinct from other liposomal and proteoliposomal carrier systems. (wikipedia.org)
  • However, the classical vaccination approaches that have been successful in the control of various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the case of HIV-1. (wikipedia.org)
  • conjugates
  • Antibody Responses to Haemophilus influenzae Type b and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the Nontoxic Protein CRM",Infect. (patentgenius.com)
  • vesicle
  • Type 2 RIPs consist of an A chain that is functionally equivalent to a type 1 RIP, covalently connected by a single disulfide bond to a B chain that is catalytically inactive, but serves to mediate transport of the A-B protein complex from the cell surface, via vesicle carriers, to the lumen of the endoplasmic reticulum (ER). (wikipedia.org)
  • Imject
  • Imject Maleimide-Activated Carrier Proteins are prepared using a rigorous, carefully optimized manufacturing procedure, and each lot is tested to confirm that a high level of activation was achieved. (thermofisher.com)
  • molecular weight
  • Both encode large glycosylated proteins consisting of around 3400 amino acids and a molecular weight of around 390,000 Daltons, excluding the glycosylation. (wikipedia.org)
  • Because of its evolutionary distance from mammals, high molecular weight and complex structure it is usually immunogenic in vertebrate animals. (wikipedia.org)
  • residues
  • The sequence of the protein is characterized by a signal sequence (amino acids 1-30), a prodomain (amino acids 31-152), and a catalytic domain, followed by a C-terminal region of 243 amino acids which is rich in cysteine and histidine residues Fig. 1 . (proteopedia.org)
  • The ricin precursor protein is 576 amino acid residues in length and contains a signal peptide (residues 1-35), the ricin A chain (36-302), a linker peptide (303-314), and the ricin B chain (315-576). (wikipedia.org)
  • Typically
  • S. pneumoniae resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity. (wikipedia.org)
  • Form
  • The CCH protein is composed of two very large polypeptide subunits (404/351 kDa) that form an extremely stable heterodidecameric structure even in the absence of divalent cations. (thermofisher.com)
  • The simultaneous expression of different M2e and HA2-2(76-130) in recombinant protein form induces a strong M2e-specific IgG response and CD4+/ CD8+ T-cell response. (springer.com)
  • The protein oligomerises to form a barrel shaped didecameric complex which is composed of 20 monomers. (wikipedia.org)
  • Whereas type 1 RIPs are composed of a single protein chain that possesses catalytic activity, type 2 RIPs, also known as holotoxins, are composed of two different protein chains that form a heterodimeric complex. (wikipedia.org)
  • propensity
  • Some disadvantages of MC include its limited propensity for protein adsorption and neuronal cellular adhesion making it a non-bioactive hydrogel. (wikipedia.org)
  • properties
  • The use of reconstituted virally derived proteins in the formation of the virosome allows for the utilization of what would otherwise be the immunogenic properties of a live-attenuated virus, but is instead a safely killed virus. (wikipedia.org)
  • PCSK9
  • Pro-protein convertase subtilisin/kexin type 9 (PCSK9) the ninth known member of the mammalian serine proprotein convertase (PC) family, and plays an important role in low density lipoproteins (LDL) metabolism. (proteopedia.org)
  • PCSK9 is the ninth known member of the mammalian subtilisin (S8) serine proprotein convertase (PC) family that carries out the proteolytic maturation of secretory proteins such as neuropeptides, prohormones and cytokines. (proteopedia.org)
  • After being processed in the ER, PCSK9 co-localizes with the protein sortilin on its way through the Golgi and trans-Golgi complex. (wikipedia.org)
  • PCSK9 gene expression can be regulated by sterol-response element binding proteins (SREBP-1/2), which also controls LDLR expression. (wikipedia.org)
  • widely
  • KLH is the most widely employed carrier protein for this purpose. (wikipedia.org)
  • In 1944 Oswald Avery, Colin MacLeod, and Maclyn McCarty demonstrated the transforming factor in Griffith's experiment was not protein, as was widely believed at the time, but DNA. (wikipedia.org)
  • tissue
  • S100 is a multigenic family of calcium modulated proteins involved in intracellular and extracellular regulatory activities with a connection to cancer as well as tissue, particularly neuronal, injury. (wikipedia.org)
  • Superior
  • The rapidly growing interest in therapeutic vaccines (i.e. active immunotherapies) for cancer and the documented efficacy of KLH as a superior carrier protein for cancer vaccines are creating a significant biopharmaceutical market for KLH formulations. (wikipedia.org)
  • barley
  • For example, plants that contain only protein chain A, such as barley, are not toxic because without the link to protein chain B, protein chain A cannot enter the cell and do damage to ribosomes. (wikipedia.org)
  • cysteines
  • Within the lumen of the ER the propolypeptide is glycosylated and a protein disulfide isomerase catalyzes disulfide bond formation between cysteines 294 and 318. (wikipedia.org)
  • Golgi
  • The propolypeptide is further glycosylated within the Golgi apparatus and transported to protein storage bodies. (wikipedia.org)
  • Different
  • Different proteins were added at 200mg/mL to ultrapure water and then incrementally diluted until they dissolved. (thermofisher.com)
  • Among these, those classified as protein-bound compounds require special attention because they are associated with toxic activities in different biological systems and are difficult to remove by dialysis. (pubmedcentralcanada.ca)
  • complex
  • It aims to study the complex protein-protein interactions and networks and allows a better understanding of immune responses and their role during normal, diseased and reconstitution states. (wikipedia.org)
  • ions
  • If the protein becomes denatured or if the copper ions are lost in the purification process, the opalescent blue color disappears and the solution becomes a dull grayish color. (wikipedia.org)
  • Lastly, nickel allergy is caused by nickel metal ions penetrating the skin and binding to skin proteins. (wikipedia.org)
  • structure
  • Computational immunology is a branch of bioinformatics and it is based on similar concepts and tools, such as sequence alignment and protein structure prediction tools. (wikipedia.org)
  • infants
  • Immunization of 2-month-old infants with protein-coupled oligosaccharides derived from the capsule of Haemophilus influenzae type b",J. Pediatrics,107:346-351,(1985). (patentgenius.com)
  • antibody
  • Binding of a particular protein by an antibody reagent involving denaturation of the protein and use of an antibody reagent specific for binding a linear peptide epitope therein. (google.com)
  • This invention relates to methods for binding a protein with an antibody reagent such as is accomplished in the performance of immunoassays. (google.com)
  • There is a continuing need to improve the specificity of antibody binding to proteins, particularly proteins of analytical significance. (google.com)
  • The specific detection of particular proteins in biological samples such as blood is limited by the ability to obtain antibody reagents directed to unique binding sites or epitopes on the accessible portions of the proteins. (google.com)
  • There are situations where the most desirable epitope for specific detection of a particular protein is inaccessible or has only limited accessibility for binding to an antibody reagent. (google.com)
  • form
  • The present invention is useful in the determination of proteins of analytical significance, such as the glucosylated form of hemoglobin known as Hb Alc. (google.com)
  • When absorbed through the skin from a poison ivy plant, urushiol undergoes oxidation in the skin cells to generate the actual hapten, a reactive quinone-type molecule, which then reacts with skin proteins to form hapten adducts. (wikipedia.org)
  • The protein oligomerises to form a barrel shaped didecameric complex which is composed of 20 monomers. (wikipedia.org)
  • Whereas type 1 RIPs are composed of a single protein chain that possesses catalytic activity, type 2 RIPs, also known as holotoxins, are composed of two different protein chains that form a heterodimeric complex. (wikipedia.org)
  • gene
  • Join us in February 2019, as SMi's RNA Therapeutics Conference brings together industry experts from leading RNA therapeutics companies to discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies , and present an overview of the applications of RNA-based drugs for modulation of gene and protein expression, and genome editing. (smi-online.co.uk)
  • Our data suggest that early in Drosophila development, HP1a collaborates with the Polycomb/trithorax groups of proteins to regulate gene expression and that the two chromatin systems do not act separately as convention describes. (fsu.edu)
  • We find that HP1a, which is normally critical for the formation of constitutive heterochromatin, also affects the generation of the epigenetic marks of the Polycomb/trithorax groups of proteins, chromatin modifiers which are key to maintaining gene expression in euchromatin. (fsu.edu)
  • PCSK9 gene expression can be regulated by sterol-response element binding proteins (SREBP-1/2), which also controls LDLR expression. (wikipedia.org)
  • therapies
  • They were used as a drug carrier mechanism for experimental cancer therapies. (wikipedia.org)
  • Alternatively, these stem cells can act as carriers for other therapies, though the positive effects of using stem cells as a delivery mechanism has not been confirmed. (wikipedia.org)
  • cells
  • The DNA is injected into cells, whose "inner machinery" uses the DNA to synthesize the proteins. (wikipedia.org)
  • One way of enhancing protein expression is by optimising the codon usage of pathogenic mRNAs for eukaryotic cells. (wikipedia.org)
  • The chromatin-associated protein high-mobility group box 1 (HMGB1) is a prototypical leaderless secreted protein [LSP] secreted by hematopoietic cells through a lysosome-mediated pathway. (wikipedia.org)
  • sequences
  • The Food Allergy Research and Resource Program (FARRP) Protein Allergen-Online Database contains sequences of known and putative allergens derived from scientific literature and public databases. (wikipedia.org)
  • resides
  • S. pneumoniae resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity . (wikipedia.org)
  • This process is catalysed by the protein PDI (protein disulphide isomerase) that resides in the lumen of the ER. (wikipedia.org)
  • regulatory
  • This protein plays a major regulatory role in cholesterol homeostasis, mainly by reducing LDLR levels on the plasma membrane. (wikipedia.org)
  • S100 is a multigenic family of calcium modulated proteins involved in intracellular and extracellular regulatory activities with a connection to cancer as well as tissue, particularly neuronal, injury. (wikipedia.org)
  • drug
  • Our research program involves the application of drug carriers for the treatment of infectious diseases and cancer. (buffalo.edu)
  • Research interests center on the use of drug carriers such as liposomes to improve the therapy of diseases that include ovarian cancer and opportunistic infections associated with AIDS. (buffalo.edu)
  • Research
  • In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms. (wikipedia.org)
  • cell
  • For example, plants that contain only protein chain A, such as barley, are not toxic because without the link to protein chain B, protein chain A cannot enter the cell and do damage to ribosomes. (wikipedia.org)
  • potential
  • A potential advantage of CRM197 over toxoided proteins is that, because it is genetically detoxified, it retains its full complement of lysine amines for conjugation. (wikipedia.org)
  • Such data is valuable for investigation of cross-reactivity between known allergens and analysis of potential allergenicity in proteins. (wikipedia.org)
  • Similar
  • Computational immunology is a branch of bioinformatics and it is based on similar concepts and tools, such as sequence alignment and protein structure prediction tools. (wikipedia.org)
  • formation
  • Within the lumen of the ER the propolypeptide is glycosylated and a protein disulfide isomerase catalyzes disulfide bond formation between cysteines 294 and 318. (wikipedia.org)
  • improve
  • Utilizes liposomes and other carrier techniques to improve the solubility and delivery of taxol and other poorly-soluble anticancer agents. (buffalo.edu)
  • group
  • A balancing act: heterochromatin protein 1a and the Polycomb group coordinate their levels to silence chromatin in Drosophila. (fsu.edu)