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  • cytotoxic
  • In an analysis of a panel of BALB/c 3-methylcholanthrene-induced tumors, we identified one tumor, CMS5, that elicited a strong cytotoxic T cell response with exquisite specificity for CMS5. (pnas.org)
  • peptide
  • We studied safety and mechanistic effects of injecting human leukocyte antigen-DR4( DRB1*0401 )-restricted immunodominant proinsulin peptide intradermally every 2 or 4 weeks for 6 months in newly diagnosed type 1 diabetes patients. (jhu.edu)
  • A CRT2-derived peptide was identified as an HLA-A24-restricted T-cell epitope that induced tumor-reactive CTLs. (aacrjournals.org)
  • 0.2 nmol/L), fully-human monoclonal antibody (mAb) specific for the WT1 RMF peptide/ HLA-A*02:01 complex, which selectively bound and killed WT1 + and HLA-A *02:01 + leukemia and solid tumor cell lines. (aacrjournals.org)
  • The data provide proof of concept that an Fc-enhanced mAb can improve efficacy against a low-density, tumor-specific, peptide/MHC target, and support further development of this mAb against an important intracellular oncogenic protein. (aacrjournals.org)
  • This study provides proof of concept that an ADCC-enhanced mAb construct can effectively treat cancers while targeting a low-density peptide/HLA epitope (500-6,000 per cell), and supports the clinical utility of ESKM. (aacrjournals.org)
  • The gene encoding the C18-defined antigen was identified as a mutated form of a mouse mitogen-activated protein kinase, ERK2, and a peptide incorporating the resulting amino acid substitution (lysine to glutamine) was efficiently recognized by C18. (pnas.org)
  • From our results, we can conclude that the Col-1 epitope of the glycoprotein CEA can be translated into an immunogenic peptide mimic. (aacrjournals.org)
  • The present invention relates to combination therapy for cancer with a WT1 peptide vaccine and temozolomide. (patents.com)
  • INTRODUCTION: Peptide vaccines offer anti-tumor efficacy with very low toxicity. (jcancer.org)
  • However, repeat stimulation with an immunogenic peptide leads to activation induced cell death (AICD), decreasing efficacy. (jcancer.org)
  • malignant
  • Hepatocellular carcinoma (HCC) is one of the most common primary malignant cancers and displays a predominant increase in incidence and mortality rates in patients with cirrhosis or chronic liver diseases. (springer.com)
  • In terms of colon cancer various approaches have been employed to define the transformation of colonocytes as they progress to the fully malignant phenotype. (jcancer.org)
  • PVSRIPO is currently in clinical trials against recurrent World Health Organization grade IV malignant glioma, a notoriously treatment-refractory cancer. (sciencemag.org)
  • Selective manipulation of B7-H1 pathway thus aids in the design of new regimens in the treatment of human autoimmune disease and the control of malignant cancers. (nih.gov)
  • Extensive efforts to isolate antigen-loss variants of CMS5 were unsuccessful, suggesting that the mutated mitogen-activated protein kinase is essential for maintenance of the malignant phenotype. (pnas.org)
  • therapeutic
  • In contrast, 9 of 9 colon cancer specimens showed overexpression of KNSL6 mRNA, ranging from 5 to 44 times the level detected in normal colon tissue, indicating that this antigen could also be a valuable therapeutic target. (aacrjournals.org)
  • There is an unmet need for improved therapeutic paradigms in colorectal cancer, the 3rd leading cause of cancer and 2nd leading cause of cancer mortality worldwide. (clinicaltrials.gov)
  • breast cancers
  • Mammographic screening of healthy women has resulted in the increased detection of ductal carcinoma in Situ (DCIS), such that one-fifth of all screen detected breast cancers are now so diagnosed [ 1 ]. (impactjournals.com)
  • Using publicly available gene expression datasets to interrogate the expression of CT genes in breast tumors, we have demonstrated that while a minority of unselected breast cancers expressed CT genes, a significantly higher expression frequency was detected in estrogen (ER) and progesterone receptor (PR) negative breast cancer cell lines and primary breast carcinomas [ 5 ]. (impactjournals.com)
  • Immunization
  • Resistance does not generally extend to other syngeneic tumors induced by the same carcinogen, but is restricted to challenge with the tumor used for immunization, indicating that the antigenic polymorphism of chemically induced sarcomas is apparently quite extensive ( 7 , 8 ). (pnas.org)
  • Recombinant
  • Sera and CSF of 320 patients suspected of suffering from an autoimmune neurological syndrome were comprehensively investigated for the presence of anti-neural IgG autoantibodies by IFA using mosaics of biochips with brain tissue cryosections and established cell-based recombinant antigen substrates as well as immunoblots. (frontiersin.org)
  • Serological analysis of recombinant cDNA expression libraries of human cancer has identified a number of immunogenic tumor antigens. (aacrjournals.org)
  • NY-ESO-1 was identified by serological analysis of a recombinant cDNA expression library (SEREX) from a squamous cell cancer of the esophagus ( 1 ). (aacrjournals.org)
  • metastatic tumors
  • Reovirus efficiently destroys local as well as distant metastatic tumors in immunocompromised animals even after a single injection administered through intravenous, intraperitoneal, or intratumoral routes ( 25 - 28 ). (aacrjournals.org)
  • recognition
  • The recognition of tumor escape from immune elimination as an emerging additional hallmark of cancer has constituted one of the major paradigm shift in the field ( 1-3 ). (aacrjournals.org)
  • Costimulatory molecules will subsequently determine the outcome of the primary antigen recognition by providing signals that will amplify, complement, and modulate those elicited from the TCR or CD16. (aacrjournals.org)
  • Recombination of many different V segments with several J segments provides a wide range of antigen recognition. (cancerindex.org)
  • regression
  • However, recent reports show that synchronized blockade or overriding of tumor immune evasion strategies with appropriate immunomodulatory intervention may overcome immunologic tolerance and promote tumor regression ( 1 , 17 , 18 ). (aacrjournals.org)
  • Molecular
  • The molecular basis of the polymorphic tumor rejection antigens of chemically induced sarcomas of inbred mice remains a mystery, despite the discovery of these antigens over 40 years ago and their critical importance to the foundation of tumor immunology. (pnas.org)
  • This study advances an emerging paradigm in colorectal cancer cell detection and eradication, employing GCC as a molecular marker and immunological target. (clinicaltrials.gov)
  • epitopes
  • Full-length tumor Ags intrinsically contain all possible CD4 + and CD8 + T cell epitopes for any type of HLA allele and thus they should potentially activate both T cell subsets. (jimmunol.org)
  • cell
  • T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study. (nih.gov)
  • The CCR has long been a leader in developing cell-based treatments for cancer. (cancer.gov)
  • They also play a role in tumor angiogenesis, cancer cell survival, proliferation, and metastatic potential. (aacrjournals.org)
  • Immunogenic cell death (ICD) activates both innate and adaptive arms of the immune system during apoptotic cancer cell death. (frontiersin.org)
  • This is largely because cancers employ numerous evasion strategies that are non-conducive toward T cell activation and function. (frontiersin.org)
  • ref. 31 ) cell lines were kindly provided by Dr. J. Xiang (Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada) and Dr. E. Podack (University of Miami School of Medicine, Miami, FL), respectively. (aacrjournals.org)
  • Superficial transitional cell carcinomas (TCC) account for about 70% of all bladder cancers in North America and Europe . (urofrance.org)
  • Postvaccine CD8+ T-cell clones recognized and lyzed HLA-matched tumor cell lines in an antigen-specific manner. (uzh.ch)
  • Within this set of overexpressed genes, we focused on those that may be functionally important to the cancer cell. (aacrjournals.org)
  • They provide evidence that tumor-infiltrated mMDSCs facilitate tumor cell dissemination from the primary site by inducing EMT/CSC phenotype. (immuneregulationnews.com)
  • CD95/Fas ligand (FasL) is a cell death-promoting member of the tumor necrosis factor family with important functions in the regulation of T-cell homeostasis and cytotoxicity. (immuneregulationnews.com)
  • But TACAs are also associated with cell signaling activities whereby anti-TACA antibodies are capable of direct induction of cell death of number of tumor cell lines, but this activity has not been investigated in great detail ( 9 , 10 ). (frontiersin.org)
  • patients
  • Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers. (nih.gov)
  • Serum samples from 34 of 74 (46%) colon cancer patients detected 1 or more of these 13 antigens. (aacrjournals.org)
  • Fifty-three of 74 colon cancer patients were of known clinicopathological stage. (aacrjournals.org)
  • SEREX analysis (7 , 8 , 12 , 13) has defined a subset of tumor antigens that react exclusively with serum antibodies derived from multiple cancer patients but do not react with sera from normal individuals. (aacrjournals.org)
  • Changes in the level of gene expression in cancer (3 , 6 , 9 , 12) and aberrant expression of tissue-restricted gene products in cancer (15 , 16 , 17) have also been related to the development of a humoral immune response in cancer patients. (aacrjournals.org)
  • RATIONALE: Gathering information about patients with breast cancer and their families may help the study of breast cancer in the future. (bioportfolio.com)
  • Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. (bioportfolio.com)
  • The focus of our research for the past decade has been the development of treatment strategies to modulate the immune system of patients with cancer. (dana-farber.org)
  • In addition, a higher proportion of patients with R/M HNSCC often have tumor-related symptoms, including pain, hemorrhage, respiratory, and nutritional disorders, which seriously affect the quality of life of patients and the choice of follow-up treatment ( 2 ). (frontiersin.org)
  • Five of these 9 patients did not express NY-ESO-1 in the autologous tumor. (uzh.ch)
  • Background: At present, it is difficult to predict which patients with ductal carcinoma-in-situ (DCIS) will subsequently develop frank invasive breast cancer (IDC). (impactjournals.com)
  • Results: 14 of 42 (33%) of patients developed invasive breast cancer during the follow up period. (impactjournals.com)
  • Conclusions: Expression of NY-ESO-1 may predict those patients who will not subsequently develop invasive breast cancer and could therefore potentially be helpful in defining prognosis in patients with DCIS. (impactjournals.com)
  • Employing an independent set of patients with a documented follow-up period, we have explored the relationship between NY-ESO-1 expression and subsequent development of invasive breast cancer. (impactjournals.com)
  • The data show that lack of NY-ESO-1 expression confers a higher risk of developing invasive breast cancer in this cohort of patients. (impactjournals.com)
  • We used tumors from 7 ovarian cancer patients to validate our protocol. (aacrjournals.org)
  • Ovarian cancer is the fifth leading cause of cancer-related death among women, and patients are often diagnosed in an advanced stage ( 1 ). (aacrjournals.org)
  • The characterization of the antigenome shows that a large number of cancer-germline antigens are expressed in all patients. (biomedcentral.com)
  • In contrast, neo-antigens are rarely shared between patients, indicating that cancer vaccination requires individualized strategy. (biomedcentral.com)
  • Discover the latest research on pediatric cancers and discuss strategies to help bridge the gap between basic research discoveries and treatments for pediatric and adolescent cancer patients. (nyas.org)
  • 10 patients were selected for treatment and enrolled for this therapy in a phase I dose escalation study, all of whom had progressive HER2+ metastatic breast and ovarian cancer, not considered curable by conventional therapies. (oncolink.org)
  • Of the 5 patients treated, 4 had breast cancer and 1 had ovarian cancer. (oncolink.org)
  • An objective tumor response was observed in 2 of the 5 patients treated and one other patient had stable disease following treatment. (oncolink.org)
  • receptor
  • From the immunoistochemical analysis of MAGE-A3 and PRAME, there did not seem to be a correlation between their expression and the receptor status of the tumor. (aacrjournals.org)
  • Immune System
  • It has become clear that the immune system is endowed with the paradoxical ability to exert both tumor-suppressing and tumor-promoting effects, well described in the seminal concept of cancer immunoediting ( 1 ). (aacrjournals.org)
  • Genetic and genomic technologies have facilitated a greater understanding of the Tasmanian devil immune system and the origins, evolution and spread of devil facial tumour disease (DFTD). (readbyqxmd.com)
  • A low level of inflammation is an integral part of the balance between the immune system and the microbiota in the high antigen environment of the gastrointestinal tract and maintains homeostasis. (readbyqxmd.com)
  • It also presents a conundrum: can the immune system mount an effective response to reject tumors? (biomedcentral.com)
  • This then causes tumors to mutate and survive the body's immune system. (dailytech.com)
  • The immune system now thinks it is being invaded by the viruses , which are expressing cancer-related antigens that should be eliminated. (dailytech.com)
  • suppressor gene
  • This seminal study defines a haploinsufficient tumor suppressor gene that provides a high-penetrance mechanism for inhibition of the antioncogenic phosphatase PP2A in human cancer. (aacrjournals.org)
  • MR traceable delivery of p53 tumor suppressor gene by PEI-functionalized superparamagnetic iron oxide nanoparticles," Journal of Biomedical Nanotechnology , vol. 8, no. 3, pp. 361-371, 2012. (hindawi.com)
  • necrosis factor
  • The tumor necrosis factor (TNF)-sensitive WEHI164S line was provided by E. Lattime (Thomas Jefferson University) ( 16 ). (pnas.org)