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  • recognition
  • The correlation between T-cell stimulation and GAD65Ab levels was not absolute, suggesting that other variables such as autoantibody recognition of different regions of GAD65 and variable effects on processing of the 274-286 epitope may contribute. (lu.se)
  • Candidate epitopes were selected by ZnT8 plasmid DNA immunisation of HLA-A2/DQ8 transgenic mice and tested for T cell recognition in peripheral blood mononuclear cells of type 1 diabetic, type 2 diabetic and healthy participants by IFN-γ enzyme-linked immunospot. (nih.gov)
  • Mass
  • IgE-binding epitopes on rPen c 13 were mapped using an enzymatic digestion and chemical cleavage method, followed by dot-blotting and mass spectrometry. (duhnnae.com)
  • study
  • Furthermore, the ability of the epitope identified in this study to stimulate antibody production was also evaluated. (mdpi.com)
  • studies
  • Moreover, population-based studies revealed that at least in some CD8 epitopes selection of escape mutations is reproducible in subjects sharing the same restricting HLA alleles ( 16 , 34 , 35 , 42 ). (pubmedcentralcanada.ca)
  • potential
  • The GP 1,2 Ebola Zaire sequence from the 1976 outbreak was analyzed by both BIMAS and SYFPEITHI algorithms to identify potential immuno-dominant epitopes. (biomedcentral.com)
  • The G270A mutant of Pen c 13 has the potential to serve as an additional tool for the diagnosis-prognosis of mold allergy, and the K274A mutant, as a hypoallergenic form of the epitope, may provide a framework for the design and development of a safe and efficient therapeutic strategy for treating human allergic diseases. (duhnnae.com)
  • type
  • White HLA-A2(+) adults (83%) and children (60%) with type 1 diabetes displayed ZnT8-reactive CD8(+) T cells that recognised a single ZnT8(186-194) (VAANIVLTV) epitope. (nih.gov)
  • ZnT8-reactive CD8(+) T cells are predominantly directed against the ZnT8(186-194) epitope and are detected in a majority of type 1 diabetic patients. (nih.gov)
  • level
  • To verify the level of sensitivity of CII(954C968)2OH and of the immunodominant epitope to DM, we assessed the dissociation kinetics of fluorescein-labeled CII(954C968)2OH and CII(280C294) in complicated with DR1 in the existence or the lack of DM. (biosweepny.com)
  • Against our objectives, the CII dominating epitope also demonstrated level of sensitivity to DM-mediated dissociation (Fig. 2h). (biosweepny.com)
  • identify
  • We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets. (nih.gov)
  • blue
  • Various other CII-derived epitopes (proven in blue in Fig. 2aCe) had been also discovered in examples including DR with either DM, or cathepsins (Fig. 2aCc). (biosweepny.com)