AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Troponin ITroponinTroponin TTroponin CImmunoassayTropomyosinMyocardiumImmunoenzyme TechniquesBiological MarkersMyofibrilsCreatine KinaseActin CytoskeletonSensitivity and SpecificityCalciumFluorescence Polarization ImmunoassayRabbitsEnzyme Multiplied Immunoassay TechniqueMusclesChest PainMyocardial ContractionMuscle ProteinsSarcomeresMyocardial InfarctionFluoroimmunoassayActomyosinReagent Kits, DiagnosticMyoglobinMyosinsCardiomyopathy, RestrictiveHeartPeptide FragmentsPredictive Value of TestsEnzyme-Linked Immunosorbent AssayAmino Acid SequenceActinsCreatine Kinase, MB FormCa(2+) Mg(2+)-ATPaseChickensCardiomyopathy, HypertrophicElectrocardiographyAngina, UnstableMuscle, SkeletalMolecular Sequence DataPsoas MusclesThiadiazinesMuscle, StriatedMyocytes, CardiacCardiac MyosinsCardiomyopathy, Hypertrophic, FamilialPhosphorylationNatriuretic Peptide, BrainAcute Coronary SyndromeProspective StudiesElectrophoresis, Polyacrylamide GelROC CurveMuscle ContractionNaphthalenesulfonatesTime FactorsMyocardial IschemiaFalse Positive ReactionsProtein IsoformsAdenosine TriphosphatasesCross ReactionsCyclic AMP-Dependent Protein KinasesCardiomyopathiesAcute DiseaseCattlePrognosisIsoenzymesProtein BindingRadioimmunoassayAntibodies, MonoclonalClinical Chemistry TestsCalcium-Binding ProteinsBinding SitesCardiotonic AgentsLuminescent MeasurementsReference ValuesSpectrometry, FluorescenceSalmineHeart DiseasesBepridilKineticsRecombinant ProteinsMuscle Fibers, Slow-TwitchEvaluation Studies as TopicProtein ConformationHeart InjuriesReproducibility of ResultsMutationMyosin SubfragmentsMyocardial StunningHeart VentriclesAutoanalysisIsotachophoresisCardiomyopathy, DilatedMyocardial Reperfusion InjuryCalmodulinSubstance Abuse DetectionIsometric Contraction
AssaysCTnIAnalyzerAssayHigh sensitivityAcuteClinicalSerumDigital immunoassayBinds to tropomyosinCTnTTumor markersBiomarkersLactate dehydrogenaseProteinsConcentrationNecrosisDetectionMeasurementSkeletal muscleMyoglobinBiotinELISAElevationDiagnosticsMyocardial infarctionInterferenceSubunitsAnalyzersDiagnosticLevelInhibitActinMyocarditisSpecificityChest painProteinMusclesDifferentiateAnalysesPatientsHospitals
Assays11
  • We report analytical data from a fully automated digital immunoassay for cardiac troponin I (cTnI) based on Single Molecule Array (Simoa) technology with a limit of detection 2 logs lower than contemporary high sensitivity troponin assays. (quanterix.com)
  • Trial design for assessing analytical and clinical performance of high-sensitivity cardiac troponin I assays in the United States: The HIGH-US study. (duke.edu)
  • Background:High-sensitivity cardiac troponin I (hs-cTnI) assays have been developed that quantify lower cTnI concentrations with better precision versus earlier generation assays. (duke.edu)
  • Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome. (lifelabs.com)
  • These changes were instituted following the introduction of increasingly sensitive and precise troponin assays. (medscape.com)
  • Two different reference ranges are used in troponin assays. (medscape.com)
  • Biotin interference can happen because most immunoassay manufacturers rely on biotin-streptavidin capture in their assays. (aacc.org)
  • The very recent commercialization of methods with further improved analytical sensitivity (i.e., "ultra-sensitive" assays), which allow to measure cardiac troponin values in the vast majority of healthy subjects, is now challenging the diagnostic paradigm based on early rule-out of subjects with cardiac troponin values comprised between the 99th percentile and LoD. (srce.hr)
  • Calbiotech specializes in immunoassay development and manufacturing, with a comprehensive range of ELISA and CLIA assays for human and animal research, including specific assays for hormone, autoimmune disorders, cancer, infectious diseases and much more. (calbiotech.com)
  • We have established elsewhere that HPLC and LC/MS are routinely used in clinical diagnostics , for example, in the detection and monitoring of biomarkers for both non-communicable and infectious diseases, and in therapeutic drug monitoring.1 Many thousands of papers have been written on the development and use of HPLC- related assays and immunoassays such as ELISA in this area. (elgalabwater.com)
  • The sensitivity, specificity, and precision of the different commercially available troponin assays vary considerably. (medscape.com)
CTnI5
  • Objective -To compare cardiac troponin I (cTnI) concentrations determined by use of a point-of-care analyzer with values determined by use of a bench-top immunoassay in plasma samples obtained from clinically normal horses with and without experimentally induced cardiac disease, and to establish a reference range for plasma equine cTnI concentration determined by use of the point-of-care analyzer. (avma.org)
  • In a prospective study with children and adults cardiac troponin I (cTnI) serum concentrations were determined by immunoassay (AxSYM, Abbott Laboratories) before, during, and up to 20 months after surgical or transcatheter ASD closure. (bmj.com)
  • This device offers a complete cardiovascular menu which includes Cardiac Troponin I (cTnI), N-terminal pro brain natriuretic peptide (NT-proBNP), D-Dimer, Myoglobin, Creatinine Kinase (CK-MB), and high-sensitivity C-reactive protein (hsCRP). (physiciansofficeresource.com)
  • The product is used to determine the content of cardiac troponin I (cTnI) in whole blood, plasma and serum of human body and is mainly used clinically for auxiliary diagnosis of myocardial infarction. (fiapoct.com)
  • Cardiac troponin I (cTnI) is a 22.5KD myocardial protein. (diagreat.com)
Analyzer4
  • The PATHFAST system is a unique, self-contained, bench-top chemiluminescence immunoassay analyzer that rapidly measures concentrations of emergency biomarkers from a single whole blood sample. (physiciansofficeresource.com)
  • Shine i1910 is a fully automatic and simple-to-use benchtop chemiluminescence immunoassay analyzer with a throughput of 120 tests per hour. (daangene.com)
  • As a fully automated immunoassay analyzer with high quality, Shine i1910 with the characteristics of simplicity, reliability and flexibility, which can help optimize your laboratory analysis performance. (daangene.com)
  • Based on various antigen-antibody immunoreaction modes, the full automatic hemiluminescence immunoassay analyzer takes paramagnetic particles as the carrier, and makes use of the direct chemiluminescence method of acridinium ester. (daangene.com)
Assay9
  • With growing interest in exploring as an early indicator of adverse heart health trends, the ability to quantitate troponin in healthy control populations is emerging as a highly desirable assay capability. (quanterix.com)
  • It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay. (wikipedia.org)
  • He also developed the troponin T assay. (wikipedia.org)
  • Analytical performance evaluation of the Elecsys® Troponin T Gen 5 STAT assay. (duke.edu)
  • A recent publication has shown that cardiac troponin T (TnT) concentrations measured with a highly sensitive assay were significantly associated with the incidence of cardiovascular death and heart failure in stable coronary artery disease after adjustment for other independent prognostic indicators [ 13 ]. (hindawi.com)
  • During the quarter the US Food and Drug Administration cleared Beckman Coulter's Access AccuTnl+3 troponin l assay for use on the company's UniCel Dxl series of immunoassay instruments. (genomeweb.com)
  • In June, FDA gave 510(k) clearance to the assay for use on the company's Access 2 immunoassay system. (genomeweb.com)
  • For the first time since 2010 Beckman can offer the troponin assay to existing and new customers in the US for use on all of our immunoassay and integrated chemistry … systems. (genomeweb.com)
  • Immunoassay interference blocker kit consists of reagents that are specifically designed to that neutralize or inhibit the interference and prevent faulty results that enhances the overall assay performance as well. (alliedmarketresearch.com)
High sensitivity2
  • The reference range for the high sensitivity troponin T is a normal 52 ng/L. The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. (wikipedia.org)
  • A laboratory's strategy to reduce the time from "order to result" of high-sensitivity troponin, defined as an imprecision level (%CV) of ?10% at the 99th percentile of normal by the joint ESC/ACC committee, is discussed. (clpmag.com)
Acute10
  • In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack). (wikipedia.org)
  • Up to 80% of patients with acute MI will have an elevated troponin level within 2-3 hours of emergency department (ED) arrival, versus 6-9 hours or more with CK-MB and other cardiac markers. (medscape.com)
  • Recognizing that cardiac troponin measurements may be elevated in disease states not primarily related to myocardial ischemia, a fourth universal definition of acute MI was developed by the American College of Cardiology (ACC), European Society of Cardiology (ESC), American Hospital Association (AHA), and World Health Federation (WHF) in 2018. (medscape.com)
  • The measurement of cardiac troponins, either cardiac troponin I or T, has become the culprit of clinical decision making in patients with suspected acute coronary syndrome (ACS), especially in those with non-ST elevation myocardial infarction (NSTEMI). (srce.hr)
  • Troponin T - contemporary approach towards diagnosing acute myocardial ischemia. (medline.ru)
  • We have researched a possibility to apply the Enzyme Multiplied Immunoassay Technique (EMIT-test) for Troponin T to diagnose death resulting from the acute myocardial ischemia in the biological laboratory of the Leningrad Regional Bureau of Forensic Medical Examination. (medline.ru)
  • It means that Troponin T lends itself most widely for a diagnosis uniting the advantages of the quick and slow markers with the acute myocardial ischemia. (medline.ru)
  • See also Acute coronary syndromes Two subtypes of troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle ( myocardium ). (wikidoc.org)
  • Objective: To assess if the combination of cardiac troponin (cTn) and Ischemia Modified Albumin (IMA) can be used for early exclusion of acute myocardial infarction (AMI). (westminster.ac.uk)
  • Indeed, cardiac troponin is central to the definition of acute myocardial infarction (MI) in the consensus guidelines from the European Society of Cardiology (ESC) and the American College of Cardiology (ACC). (medscape.com)
Clinical9
  • The cardiac troponins, in particular, have become the cardiac markers of choice for patients with ACS, eclipsing CK-MB and myoglobin in terms of clinical value. (medscape.com)
  • He added that growth in Beckman Coulter occurred across all product lines, "particularly clinical automation and immunoassay. (genomeweb.com)
  • Heavy investments in research and development activities related to immunoassay interference inhibitors with the motive of gaining accuracy in clinical diagnosis, to reduce the degree of errors for the results of biochemical analysis and advancement in blocker used for interference and kits manufacturing are the major drivers for growing immunoassay interference blocker market. (alliedmarketresearch.com)
  • Lindsay initiated and designed clinical research on women's health, troponin, thyroid function in pregnant women, prostate cancer, anemia of chronic disease, and etc. (beckmancoulter.com)
  • She has focused on supporting product development and initiating research studies to explore the clinical applications of immunoassay products. (beckmancoulter.com)
  • It integrates immunoassay and clinical chemistry analyzers with the new standard in sample-management technology so you can focus on driving better outcomes. (siemens-healthineers.com)
  • Electrocardiography and cardiac troponin (cTn) now form the diagnostic cornerstones of clinical assessment. (radcliffecardiology.com)
  • Cardiac Troponin in Endurance Exercise-Fragments of the Imagination or Clinical Significance? (westminster.ac.uk)
  • Myopericarditis is a primarily pericardial inflammatory syndrome occurring when clinical diagnostic criteria for pericarditis are satisfied and concurrent mild myocardial involvement is documented by elevated biomarkers of myocardial damage (i.e., increased troponins). (cdc.gov)
Serum3
  • Serum troponin (Tn) elevation is a specific and well-established necrosis biomarker in ACS, being the only biomarker currently used for risk stratification and guided invasive management decision in non-STEACS [ 8 , 9 ]. (hindawi.com)
  • The ST segment and serum troponin T levels were significantly increased in IMI rats. (hindawi.com)
  • For the quantitative detection of troponin I in human serum, plasma or whole blood. (diagreat.com)
Digital immunoassay1
Binds to tropomyosin1
  • Troponin T binds to tropomyosin and helps position it on actin, and together with the rest of the troponin complex, modulates contraction of striated muscle. (wikipedia.org)
CTnT1
Tumor markers1
Biomarkers1
  • Cardiac biomarkers are released into the bloodstream when heart muscle is damaged or stressed, and whilst not all tests for heart disease markers are HPLC-related, they are very often immunoassay-related (e.g. troponin I) and will therefore still rely implicitly on the provision of ultrapure water for their accuracy and reproducibility, whether done manually or as part of an automated workflow. (elgalabwater.com)
Lactate dehydrogenase1
  • Creatine kinase, aspartate amino-transferase, lactate dehydrogenase and Troponin T were determined by kit methods. (edu.pk)
Proteins5
  • Troponin T (shortened TnT or TropT) is a part of the troponin complex, which are proteins integral to the contraction of skeletal and heart muscles. (wikipedia.org)
  • The troponins are regulatory proteins found in skeletal and cardiac muscle. (medscape.com)
  • Substances present in the body such as polyreactive antibodies or heterophiles, or human anti-animal antibodies coupled with some other binding proteins can cause interference due to reactions between analyte and reagent antibodies in immunoassay. (alliedmarketresearch.com)
  • Determining the level of cardiac troponins (cTn), structural proteins unique to the heart, is a cornerstone of AMI diagnosis. (radcliffecardiology.com)
  • Troponin is a complex of three proteins that is integral to muscle contraction in skeletal and cardiac muscle , but not smooth muscle . (wikidoc.org)
Concentration2
  • It has been shown that even very small elevation in the troponin concentration is associated with increased risk of adverse outcomes in patients with ACS [ 12 ]. (hindawi.com)
  • These substances have the potential to change the concentration of the analytic or alter antibody binding resulting in immunoassay interference. (alliedmarketresearch.com)
Necrosis1
  • Cardiac troponins are components of the contractile apparatus of cardiomyocytes and are released during myocardial necrosis in patients with ACS [ 7 ]. (hindawi.com)
Detection1
  • Ultra-sensitive cardiac troponin measurement offers a promising new tool for early detection and monitoring of cardiovascular disease. (quanterix.com)
Measurement1
  • Conclusion: Admission measurement of cardiac troponin plus IMA can be used for early classification of patients presenting to the ED to assist in patient triage. (westminster.ac.uk)
Skeletal muscle4
Myoglobin2
  • During the past decade a number of new analysis have been studied and their respective performance have been documented which include myoglobin, CK isoform, myosin light chain, troponin T and troponin I. Sensitivity is not a major concern but specificity is a problem because the standard markers are not restricted to heart. (edu.pk)
  • As a company that offers immunoassays used in the research of heart diseases, such as CK-MB ELISA, Myoglobin ELISA and Troponin ELISA, we encourage people to live a healthy lifestyle by not smoking, managing stress and eating healthy, in conjunction with regular physical exercise and weight management. (calbiotech.com)
Biotin2
  • For example, biotin is used in hormone tests and tests for markers of cardiac health, such as troponin. (clpmag.com)
  • Immunoassay employing the biotin-streptavidin binding technique. (clpmag.com)
ELISA1
Elevation2
  • For example, patients with elevated troponin levels but negative CK-MB values who were formerly diagnosed with unstable angina or minor myocardial injury are now reclassified as non-ST-segment elevation MI (NSTEMI), even in the absence of diagnostic electrocardiographic (ECG) changes. (medscape.com)
  • The level of troponin is measured in the bloodstream and it is used to differentiate between unstable angina (no elevation of troponin, the myocardium is not irreversibly damaged) versus either non ST elevation MI or ST elevation MI (heart attack) in patients with chest pain . (wikidoc.org)
Diagnostics1
  • Since 1995, Boehringer Mannheim has suggested the express diagnostics to define the quality of Troponin T. The result is obtained in 20 minutes, and the method does not require any special equipment. (medline.ru)
Myocardial infarction2
Interference1
Subunits1
Analyzers2
Diagnostic3
  • The aim of this article is to provide an update on commercially available HS and "ultra"-sensitive techniques for measuring cardiac troponins, along with possible implications of increasingly enhanced analytical sensitivity on diagnostic algorithms for evaluating patients with suspected ACS. (srce.hr)
  • The EMIT-test for Troponin T - a protein of the myocardial troponin complex - is nowadays of the great diagnostic value. (medline.ru)
  • Discussions of troponin often pertain to its functional characteristics and/or to its usefulness as a diagnostic marker for various heart disorders. (wikidoc.org)
Level2
  • Troponin T appears in blood a little earlier that CK-MB, two and a half hours after the onset of the heart attack, reaches its maximum in 8-10 hours (the first peak) and in 3-4 days (the second peak), and its level becomes standard in 10-14 days. (medline.ru)
  • The standard level of Troponin T must be close to zero because it should not get into the blood flow with healthy people. (medline.ru)
Inhibit1
  • Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro . (wikidoc.org)
Actin4
Myocarditis1
  • COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? (cdc.gov)
Specificity1
  • The greatest advantage of Troponin T is its unique specificity that is close to 100 per cent. (medline.ru)
Chest pain2
  • One of the more common uses of troponin is to determine if a patient with chest pain has sustained death of the myocytes (heart muscle cells) as a result of thrombotic (blood clot related) occlusion of a coronary artery which would warrant urgent medical or interventional therapy. (wikidoc.org)
  • If a patient is troponin positive, and has signs and symptoms of ischemic heart disease (substernal chest pain or pressure, electrocardiographic EKG changes), then an early invasive strategy is warranted. (wikidoc.org)
Protein2
  • Troponin C Troponin I Calcium-binding protein Sliding filament model Jin, Jian-Ping (2016-01-01), Jeon, Kwang W. (ed. (wikipedia.org)
  • A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines. (duke.edu)
Muscles1
Differentiate1
  • However, the skeletal and cardiac subforms for TnI and troponin TnT are distinct, and immunoassays have been designed to differentiate between them. (medscape.com)
Analyses1
  • The histological data have confirmed the conclusions of the analyses for Troponin T. The presence of Troponin T has been revealed in cadaver blood in all these cases. (medline.ru)
Patients2
  • Patients receiving xenon had no major organ dysfunction: Troponin I and S100beta levels tended to be lower in patients receiving xenon. (asahq.org)
  • The cardiac troponins, in particular, have become the cardiac markers of choice for patients with ACS. (medscape.com)
Hospitals1
  • Studies of the test undertaken in American and European hospitals have testified that Troponin T is diagnostically the most efficient one at present. (medline.ru)