PestisStrainsPseudotuberculosisPathogensInfection and ImmuSalmonella and YersiniaEscherichiaPathogenesisInduceEntericAntibodiesPathogenicityInnate and adaptiveCell-mediatedIsolatesEnteropathogenicGram-negativeAbstractInfectionsListeriaMonocytogenesBacteriaYersiniosisBrucellaDendriticPlagueIntestinalDiagnosisProtectiveSignificantlyHostDiseaseCellularPatientsBloodPositiveImportant
Pestis14
- In the Falkow Lab, he worked on the conserved virulence plasmids in Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis, and discovered what turned out to be the first effectors of type III secretion. (wikipedia.org)
- My research is centered on bacterial pathogenesis of Yersinia enterocolitica and Y. pestis , etiologic agents of yersiniosis and bubonic plague respectively. (uidaho.edu)
- Yersinia pestis and Yersinia pseudotuberculosis have ecological and genetic similarities, but epidemiological differences. (wikilectures.eu)
- Yersinia pestis is G- bacteria and a major pathogen causing plague pandemics . (wikilectures.eu)
- In the wild, Yersinia pestis was found in several rodent species. (wikilectures.eu)
- However, Yersinia pestis circulates through flea bites, in humans it is a rat flea bite. (wikilectures.eu)
- Yersinia pestis is a pleomorphic rod-shaped bacterium with a capsule . (wikilectures.eu)
- The pathogenicity of Yersinia pestis is determined by a complex of chromosome and plasmid-linked factors. (wikilectures.eu)
- During infection, Yersinia pestis , an facultative intracellular bacterium, exhibits the ability to first invade cells and then thwart phagocytosis of the host cell. (wikilectures.eu)
- A secondary disease, Pneumonia, may develop, causing Yersinia pestis to spread to the surrounding area by coughing up, and the infected person will develop primary pneumonia - a pulmonary form of the plague . (wikilectures.eu)
- When testing Yersinia pestis for antibiotic susceptibility, the bacteria were found to be susceptible to chloramphenicol , streptomycin, kanamycin, tetracycline, quinolones. (wikilectures.eu)
- However, plague vaccines produced by Yersinia pestis are in clinical development. (wikilectures.eu)
- Yersinia pestis biofilms. (microbiologyresearch.org)
- The team headed to Madagascar to boost diagnostic capabilities in the field, and they worked with colleagues from the Institut Pasteur de Madagascar to characterize the Yersinia pestis strains responsible for the outbreak. (pasteur.fr)
Strains3
- Strains of Y. enterocolitica biotype 1A (1 of the 6 biotypes) lack the pYV plasmid and the major chromosomal determinants of virulence and, thus, have been regarded as avirulent ( 2 ). (cdc.gov)
- Attachment of YadA-positive and YadA-negative recombinant Yersinia enterocolitica strains to cartilage-derived human cellular fibronectin and human plasma fibronectin in the solid phase revealed that YadA mediates binding of yersiniae to cellular fibronectin in a saturable, concentration- dependent manner. (nyu.edu)
- Furthermore, these conventional vaccines mainly provide homotypic protection with little cross protective immunity as vaccine strains should closely match to the circulating field strains. (biomedcentral.com)
Pseudotuberculosis6
- 3 isolates were identified as Y. enterocolitica and 1 was Y. pseudotuberculosis. (who.int)
- Y. enterocolitica a été identifiée dans 3 cas et Y. pseudotuberculosis dans 1. (who.int)
- Y. pseudotuberculosis et Salmonella typhi ou S. paratyphi B, et entre Y. enterocolitica et Brucella a été détectée sérologiquement. (who.int)
- A common feature of Y. pseudotuberculosis and Y. enterocolitica is that it stains polar . (wikilectures.eu)
- We report that larvae of the wax moth ( Galleria mellonella ) are susceptible to infection with the human enteropathogen Yersinia pseudotuberculosis at 37 °C. Confocal microscopy demonstrated that in the initial stages of infection the bacteria were taken up into haemocytes. (microbiologyresearch.org)
- The phages exhibited relatively wide host ranges among Yersinia pseudotuberculosis and related species. (mdpi.com)
Pathogens4
- Enteric pathogens such as Yersinia enterocolitica readily colonize and induce disease within the lymphatic tissues of the small intestine. (wustl.edu)
- To gain a comprehensive view of the host response to pathogens within these tissues, we determined the transcriptional profiles of intestinal lymphatic tissue infected with Y. enterocolitica. (wustl.edu)
- Many studies have demonstrated the advantage of mucins for reducing the translocation of pathogens, such as Yersinia enterocolitica or Escherichia coli in calves. (dairyglobal.net)
- P. aeruginosa , S. aureus , A. Vulgaris , etc.) while kefir is also shown to support the immunity of the skin and treat skin pathogens through the production of antimicrobial substances and prebiotics. (mdpi.com)
Infection and Immu2
Salmonella and Yersinia2
- pGLO could be used in food safety experiments done by the food safety department that helped to identify Salmonella and Yersinia enterocolitica in pig slurry, so they were able to calculate how long these bacteria lived in certain conditions before disinfectants were used. (bartleby.com)
- Both Salmonella and Yersinia can cause watery and or bloody diarrhea. (wikidoc.org)
Escherichia1
- Common bacterial causes of gastroenteritis include, Escherichia coli sp , Salmonella sp , Yersinia enterocolitica and Vibrio sp that can cause watery diarrhea and Shigella sp and Campylobacter sp that can cause dysenteric diarrhea . (wikidoc.org)
Pathogenesis3
- He has made seminal contributions to multiple aspects of bacterial pathogenesis, cell biology, innate immunity, and cell mediated immunity using L. monocytogenes as a model system and has helped to push forward the use of attenuated L. monocytogenes as an immunotherapeutic tool in the treatment of cancer. (wikipedia.org)
- Further experiments might answer the question whether binding of YadA to cellular fibronectin contributes to the pathogenesis of yersiniae, both to the initial adhesion of the bacteria to the matrices of the host and to the arthritogenic potential of enteropathogenic yersiniae. (nyu.edu)
- The triggered immunity involves considerable increases in the endogenous levels of SA and its conjugates prior to the induction of pathogenesis-related (PR) proteins and the onset of local and systemic acquired resistance [ 8 ]. (researchsquare.com)
Induce1
- We can induce short-term immunity when a dead vaccine with a protective antigen is given. (wikilectures.eu)
Enteric2
- Besides contributing to host nutrition, physiology and mucosal immunity, the intestinal microbiota protects the host from enteric infections, a function designated as colonization resistance. (intestinal-microbiota.de)
- Gnotobiotic mouse models and metagenomic analyses will provide new insights into the intricate interaction between Yersinia , the intestinal microbiota and the mucosal immune system, and might result in novel strategies for treatment of enteric infections. (intestinal-microbiota.de)
Antibodies1
Pathogenicity2
- Pathogenicity of the isolated Yersinia was determined. (who.int)
- Yersinia enterocolitica affect this interrelationship, and whether and how specific components of the microbiota might be used to interfere with Yersinia pathogenicity. (intestinal-microbiota.de)
Innate and adaptive2
- Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. (intestinal-microbiota.de)
- Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. (joplink.net)
Cell-mediated2
- Dr. Portnoy collaborated with Dr. Yvonne Paterson, who also arrived at Penn in 1988, on the use of L. monocytogenes as a recombinant vector-based vaccine for the induction of cell-mediated immunity. (wikipedia.org)
- 0.05) higher M2e-specific humoral and cell-mediated immunity compared to JOL2074 alone vaccinated group. (biomedcentral.com)
Isolates2
- In contrast with Y. enterocolitica isolates from adults, which were primarily biotype 1A, isolates from children were primarily bioserotype 3/O:3. (cdc.gov)
- All Y. enterocolitica isolates belonged to the nonpathogenic 1A biotype. (docksci.com)
Enteropathogenic2
- Yersinia enterocolitica is an enteropathogenic bacterium that causes gastrointestinal disorders, as well as extraintestinal manifestations. (uchile.cl)
- We investigated interactions of the plasmid-encoded outer membrane protein YadA, which confers pathogenic functions on enteropathogenic yersiniae, with fibronectin. (nyu.edu)
Gram-negative1
- Yersinia enterocolitica is a gram-negative straight rod that is only mobile at lower temperatures. (wikilectures.eu)
Abstract1
Infections3
- Moreover, these infections the survival of Yersinia and other bacteria show a modest predilection for males, with in cold enrichment. (who.int)
- Today at the Institut Pasteur in Paris, his research on plague and other Yersinia infections follows on from the work of his predecessors and also explores the history of deadly epidemics of the past. (pasteur.fr)
- Children do build up immunity to diseases as they get older but they still contract all manner of illnesses and infections whilst still very young. (medic8.com)
Listeria3
- In 1997, Dr Portnoy moved to UC Berkeley where his lab continues to examine fundamental aspects of L. monocytogenes biology, and has expanded to focus on both innate and acquired immunity in the context of Listeria infection. (wikipedia.org)
- Listeria monocytogenes, and Yersinia enterocolitica in freshwater fish in Latvia. (docksci.com)
- Listeria monocytogenes, and Yersinia enterocolitica (12, 33). (docksci.com)
Monocytogenes6
- In contrast, the overall prevalence of L. monocytogenes and Y. enterocolitica in freshwater fish was 13% (30 of 235) and 14% (34 of 235), respectively, and no significant difference between the prevalence of L. monocytogenes and Y. enterocolitica was observed (P . 0.05). (docksci.com)
- The prevalence of L. monocytogenes and Y. enterocolitica in freshwater lake fish was 2% (2 of 129) and 3% (4 of 129), respectively. (docksci.com)
- In contrast, the prevalence of L. monocytogenes and Y. enterocolitica in fish at retail markets was 26% (28 of 106) and 28% (30 of 106), respectively. (docksci.com)
- In retail samples, 9 of 58 positive fish contained both L. monocytogenes and Y. enterocolitica. (docksci.com)
- In general, differences in the prevalences of L. monocytogenes and Y. enterocolitica in retail samples were significantly higher than those in freshly caught fish (P , 0.05). (docksci.com)
- The results of this study indicate that freshwater fish could be an important source of Y. enterocolitica and L. monocytogenes for consumers in Latvia. (docksci.com)
Bacteria2
- During these two distinct phases, the invasion phase and the anti-phagocytic factor phase , the bacteria in manipulating the host cell help to complete each of these functions, but the mechanism by which Yersinia regulates these functions during each step remains unclear. (wikilectures.eu)
- Furthermore, our group also expected to see inhibited bacterial growth in the LB/amp +pGLO dish as there was ampicillin in the dish, but some of the bacteria were immune as they possessed immunity to the ampicillin. (bartleby.com)
Yersiniosis2
- Yersiniosis is a rare disease in Muslim of Yersinia from the stool samples only to countries due to the scarcity of pork con- determine the highest possible number of sumption. (who.int)
- Because yersiniosis is not notifiable through the national surveillance systems in China, most hospitals do not routinely tested for Y. enterocolitica . (cdc.gov)
Dendritic1
Plague1
- In 2017, Javier became Head of the Yersinia Unit and the World Health Organization (WHO) Collaborating Center for Plague, where his teams work on bubonic and pneumonic plague. (pasteur.fr)
Intestinal1
- Hoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway .Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassbly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (joplink.net)
Diagnosis1
- In this population, the presence of fecal leukocytes was a characteristic of Y. enterocolitica infection and should be used as an indication for microbiological diagnostic testing, rather than for the diagnosis of bacillary dysentery. (cdc.gov)
Protective1
- This may be protective in the short term, providing a form of 'nutritional immunity' against invading microbes by diminishing access to free iron in response to infection. (biomedcentral.com)
Significantly2
Host2
- Expression analysis using Affymetrix GeneChips revealed a complex host response in the Peyer's patches and mesenteric lymph nodes after oral infection with Y. enterocolitica. (wustl.edu)
- Although histamine is well known for its role in allergy and for its effects on immunity and inflammation, little is known about its role or specific histamine receptors during the host response to bacterial infection. (wustl.edu)
Disease1
- When a patient manages to overcome the disease, he develops good immunity. (wikilectures.eu)
Cellular1
- An anti-β1-integrin antibody and the synthetic peptide G-R-G-D- S-P, representing the binding site for α5β1-integrin on fibronectin, did not block attachment of YadA-positive yersiniae to cellular fibronectin, indicating a binding site for YadA on cellular fibronectin independent of the R-G-D-S-containing site. (nyu.edu)
Patients1
Blood1
- The blood culture was also positive for Y. enterocolitica in 1 case. (who.int)
Positive1
- L'hémoculture était également positive à Y. enterocolitica dans 1 cas. (who.int)
Important1
- In this study, we provide evidence that histamine signaling through the histamine Hz but not the H 1 receptor is important for controlling Y. enterocolitica infection within the Peyer's patches and mesenteric lymph nodes of mice. (wustl.edu)