Immunity mechanisms. Medical search. Frequent questions

Innate or non-adaptive immunity refers to immune responses that are non-specific, but able to recognize invading organisms as foreign. (natap.org)
Interestingly, a recent study reported that topical appli- mation, ACD critically depends on adaptive immunity. (cdc.gov)
Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial activities, we assessed the therapeutic effects of catechins against SARS-CoV replication in Vero E6 cells, the preventive effect of catechins on CD25/CD69/CD94/CD8 + cytotoxic T lymphocytes-mediated adaptive immunity, and the protective effect on lipopolysaccharide-induced acute lung injury (ALI) in mice. (ntnu.edu.tw)
Four-week catechins ingestion increased CD8 + T cell percentage, upregulated CD69 + /CD25 + /CD94-NKG2A/CD8 + T lymphocytes-mediated adaptive immunity, and increased type I cytokines release responding to ovalbumin/alum. (ntnu.edu.tw)
In conclusion, our data indicated that catechins directly inhibited SARS-CoV replication, potentiated the CD25/CD69/CD94/CD8 + T lymphocytes-mediated adaptive immunity and attenuated lipopolysaccharide-induced ALI and cytokine storm by PI3K/AKT/mTOR-signaling-mediated autophagy, which may be applied to prevent and/or treat SARS-CoV infection. (ntnu.edu.tw)
It consists of physical barriers, mechanisms of innate immunity as well as adaptive immunity. (medscape.com)
The cells that have the inherent property of innate and adaptive immunity within the body are present at different sites including the blood, lymphatic system (lymph, lymphoid nodules and lymphoid organs), epithelium, and connective tissues. (medscape.com)

Together our results reveal the potential ability of gefitinib to initiate sterile inflammation via two distinct mechanisms, and identified IL-1β and HMGB1 as key determinants of gefitinib-induced inflammation that may provide insights into gefitinib-induced interstitial pneumonitis. (nature.com)

However, the host intracellular signaling pathways and the molecular mechanisms associated with Acanthamoeba -mediated HBMEC cytotoxicity have not been determined. (asm.org)
In Aim 1, we will employ series of in vitro and in vivo approaches to define the underlying cellular and molecular mechanisms of defect in glucose uptake and subsequent impairment in ROS production and antifungal activity of neutrophils during uremia. (grantome.com)
To this end, we apply recent advances in immunology and genomics-based technology to rigorously conducted longitudinal cohort studies in malaria-endemic areas to deepen our understanding of the interaction between P. falciparum and the human immune system and to define molecular and cellular signatures of malaria immunity. (grantome.com)
Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. (mdpi.com)
As such a more detailed understanding of the molecular mechanisms underlying selectivity of the tumor response and control of immune checkpoint components is urgently needed. (genengnews.com)
The exact molecular mechanisms still remain a topic for research, but the clinical spectrum of rubella uveitis resembles Fuchs heterochromic uveitis (FHU) in many aspects. (medscape.com)
Not only the molecular differences leading to the different clinical presentations need to be better understood, but also the pathogenic mechanisms of CLE in general: the precise role of involved cell types, the impact of different cytokines described in the disease, and their interaction and regulation in a complex network need further exploration. (frontiersin.org)
Elucidate the molecular mechanisms of PRRSV immunity. (usda.gov)
Here, the immunological and molecular mechanisms of metal allergy are described based on the findings of previous studies, including those that were recently published. (mdpi.com)

Genomic and transcriptomic signatures of both the host and parasite that correlate with malaria clinical outcomes are yielding new hypotheses regarding the biological mechanisms through which malaria immunity is induced by natural P. falciparum infection. (grantome.com)

Accumulating evidence indicates that the gut microbiome plays a key role in antitumor immunity and the effectiveness of immune checkpoint inhibitor treatments, but the underlying mechanisms aren't well understood. (genengnews.com)
Interestingly studies have indicated that changes to the gut microbiome can impact on antitumor immunity in both mice and humans, but the mechanisms underlying these observations aren't well understood. (genengnews.com)
these data establish that RNF5 plays an important role in control of intestinal DC recruitment and, consistent with previous reports," the recruitment of DCs underlies T-cell activation and antitumor immunity," Ronai and colleagues wrote. (genengnews.com)
mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis. (bvsalud.org)
Depletion of slow-cycling PDGFRα + ADAM12 + mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis. (bvsalud.org)
Altogether, our data show that depletion of tumor -induced slow-cycling PDGFRα+ MSCs through ADAM12 restores antitumor immunity . (bvsalud.org)

This article reviews the activity of humoral immunity against several biological agents, discusses the advantages and disadvantages of an antibody-based defense strategy ( Table ), and proposes stockpiling specific antibodies for use in the event of biological attacks. (cdc.gov)
In the section below the evidence that humoral immunity is active against important biological agents is reviewed. (cdc.gov)
[ 4 ] La Hey and associates analyzed the association between FHI and toxoplasmosis by studying humoral and cell-mediated immunity against T gondii in blood and aqueous humor in patients with FHI. (medscape.com)
Immunoglobulin (Ig) is the key component of humoral immunity. (medscape.com)

This is in part due to the multiple mechanisms that have been associated with targeting costimulatory molecules in mouse models such as expansion of antigen-specific effector T cells (Teff), decrease in number or functional activity of regulatory T cells (Treg), and activation of NK cells. (bmj.com)

Unlike vaccines, which require time to induce protective immunity and depend on the host's ability to mount an immune response, passive antibody can theoretically confer protection regardless of the immune status of the host. (cdc.gov)
The only currently available intervention that could provide a state of immediate immunity is passive immunization with protective antibody. (cdc.gov)
Importantly, protective immunity to malaria can be acquired after repeated P. falciparum infections but wanes rapidly in the absence of ongoing exposure. (grantome.com)
2.B. Investigate and develop vaccine platforms that induce broadly cross-protective immune responses against PEDV, override PEDV vaccine interference from passively acquired immunity, and rapidly adapt to new and emerging porcine coronaviruses. (usda.gov)
Development of vaccines that provide better cross-protective immunity than what is currently available with today's vaccines will be approached through vaccine vector platform development, attenuated strains for vaccines and other novel technologies. (usda.gov)

While the mechanisms of protection are not well understood, this knowledge is crucial for developing highly effective malaria vaccines. (edu.au)
Persons with impaired immunity are often unable to generate effective response to vaccination, and certain vaccines may be contraindicated for them ( 1 ). (cdc.gov)
The mechanisms of action of vaccines. (sfu.ca)
1.A. Characterize virus-host interactions and determine innate and adaptive immune pathways that contribute to PRRSV disease susceptibility or immunity to inform the development of highly effective vaccines against very virulent strains. (usda.gov)
1.B. Define mechanisms of immune evasion that contribute to PRRSV disease pathogenicity, and which can be targeted through recombinant vaccines to improve vaccine efficacy. (usda.gov)

3.A. Identify viral genes with mutations that are associated with SVA virulent and attenuated field strains and determine mechanisms of viral pathogenesis. (usda.gov)
These pathogens will be examined in the laboratory as well as in swine disease models to investigate mechanisms of pathogenesis, transmission, immunity, evolution and methods of intervention. (usda.gov)
Isocyanates have been a leading chemical cause of occupational asthma since their utility for generating polyurethane was first recognized over 60 years ago, yet the mechanisms of isocyanate asthma pathogenesis remain unclear. (cdc.gov)
The mechanisms by which isocyanates cause asthma remain unclear, hampering disease prevention, diagnosis, and treatment.7 It is assumed the reactive nature of N=C=O groups underlies isocyanate asthma, with a hapten-based mechanism as the most obvious pathway to pathogenesis.8 However, the critical "self" reaction targets for isocyanate in vivo remain uncertain. (cdc.gov)

Science shows that sleep is undeniably one of your best defense mechanisms for fighting off colds, viruses, and other illnesses. (truedark.com)
The results of the research demonstrated that at the neonatal animals the defense mechanisms are not sufficiently triggered in order to protect against the microorganisms, viruses and other pathogenic agents aggression. (uaiasi.ro)

This defence strategy is same for most type of infections or pathogens, hence called as non-specific defence mechanism. (biologyexams4u.com)

Neuropsychiatric symptoms and potential immunologic mechanisms. (bvsalud.org)

Preventing disease after exposure to a biological agent is partially a function of the immunity of the exposed individual. (cdc.gov)
Nevertheless, the underlying mechanisms of defect in antifungal immunity in kidney disease are poorly defined. (grantome.com)
The goal of this proposal is to define the mechanisms of defect in antifungal activity of neutrophils in kidney disease and eventually to exploit this information for therapeutic benefit. (grantome.com)
Therefore, to understand the mechanism of virus immune evasion and its implications in disease outcome is crucial to establish the rational basis for new vaccine designs and successful treatment strategies. (hindawi.com)
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand mechanisms of virus immune evasion and their implications in disease outcome mainly in HIV and HCV infections, but not limited to them. (hindawi.com)

Pertussis results in substantial morbidity among adults and adolescents whose immunity to past childhood vaccination or B. pertussis infection might have waned and who have not received booster immunization for pertussis with adult tetanus, reduced diphtheria, and acellular pertussis (Tdap) vaccine ( 1 , 2 ). (cdc.gov)
This course will examine the immunological mechanisms underlying human immunopathologies with emphasis on diagnostics and therapies, especially emerging immunotherapies (therapeutic antibodies, CAR-T cells, cellular engineering), as well as vaccination. (sfu.ca)

IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver. (cornell.edu)

Innate immunity is also known as inborn/familial/natural or genetic immunity. (biologyexams4u.com)
Another global collaboration, the COVID Human Genetic Effort , is focusing in part on the role of single-gene, inborn errors of immunity in severe COVID-19. (cdc.gov)

Our research involves using a range of biochemical approaches to address underlying mechanisms and processes in a range of biological and health related areas including innate immunity, rheumatoid arthritis, cancer, virology (including COVID19) and parasitology. (keele.ac.uk)
Spike-specific antibodies are central to effective COVID19 immunity. (lu.se)
article{014d014e-4a07-4d4f-9d94-15d649e06b3c, abstract = {{Spike-specific antibodies are central to effective COVID19 immunity. (lu.se)

Antibodies play a vital role in acquired immunity against malaria. (edu.au)
Antibody-dependent phagocytosis is an immune mechanism enhanced by opsonization, where typically, more bound antibodies trigger a stronger phagocyte response. (lu.se)

Details of the mechanisms through which the HIV Vif protein targets APOBEC for degradation, thereby allowing HIV replication, were presented by Mehle and coworkers (abstr. (natap.org)

The researchers report on their findings in a paper titled, " Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 -/- mice . (genengnews.com)
In C57BL/6 mice, Leishmania donovani infection in the liver provoked IFN-γ-induced expression of the immunity-related GTPases (IRG), Irgm1 and Irgm3. (cornell.edu)

Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. (mdpi.com)

In this context, HIV and HCV maintain a continuous race against host immune responses through multiple mechanisms of immune evasion favour by virus rapid evolution. (hindawi.com)

2.C. Determine genomic factors that drive coronavirus evolution and the mechanisms that lead to the emergence and spread of new porcine coronavirus strains. (usda.gov)

One critical mechanism in CLE is the chronic reactivation of innate and adaptive immune pathways. (frontiersin.org)

E-mail: [email protected] involved in anti-infectious immunity. (cdc.gov)
This and other ongoing projects are contributing to a more comprehensive understanding of the acquisition and maintenance of immunity to malaria, and also providing insights into the mechanisms at play in human immune responses to infectious diseases more generally. (grantome.com)

genetics and mechanisms of evolution. (bbk.ac.uk)

Although the association of job satisfaction with health has been well documented, little is known about the biological mechanisms underlying this relationship. (cdc.gov)

Although the exact mechanism by which TRIM5a proteins inhibit retroviral replication is yet unknown, they block an early step of post-entry infection, likely uncoating of the incoming virus. (natap.org)
Mechanisms involve competitive inhibition of carbohydrate binding within sets of defined proteins, in contrast to broadly indiscriminate, irreversible glycation of proteins. (nih.gov)

Innate antiviral immunity is ancient, and reflect eons of the struggle of multicellular organisms (like people) to survive. (natap.org)

Together, the data support a possible thiol mediated transcarbamoylating mechanism linking MDI exposure to pathogenic eosinophilic inflammatory responses. (cdc.gov)

The project may involve assays of functional immunity, cell culture, isolation and analysis of immune cells, flow cytometry, western blotting, ELISA (enzyme-linked immunosorbent assay), and epitope mapping. (edu.au)

Moreover, we showed that Acanthamoeba produces severe HBMEC cytotoxicity by secreting extracellular proteases, as well as using contact-dependent mechanisms such as phagocytosis ( 12 ), which may play an important role in blood-brain barrier perturbations. (asm.org)

30) presented evidence that APOBEC3G blocks viral replication by an additional mechanism. (natap.org)
Low virulence coupled with high diversity has led to the suggestion that bats have evolved mechanisms to control viral replication more effectively than have most mammals and that some attribute common to all bats might also explain the apparent low virulence of viral infections in these animals. (cdc.gov)
reviewed antiviral immune responses in bats and suggested the possibility that bats might be able to control viral replication through innate immunity. (cdc.gov)

This mechanism might account for the extent of tissue damage upon stress but also contributes to normal chondrogenesis by regulating chondroblast expansion. (univ-mrs.fr)
Although the results provide a support for the biological plausibility of the job satisfaction-health relationship, additional research is required to determine whether greater job satisfaction contributes to recovery/maintenance of NK cell immunity and host defense over time. (cdc.gov)

The results imply that multiple mechanisms are likely to also be relevant in the human setting. (bmj.com)

However, the mechanism of coordination of these cytoskeletal filaments is not understood. (ox.ac.uk)
Thus, the NLRP3 inflammasome is considered an attractive therapeutic target to improve the inflammatory diseases associated with IL-1β oversecretion, yet the regulatory mechanisms are not fully understood. (nature.com)

ABSTRACT To test the role of T helper cell Th1 immunity we recruited 24 patients with idiopathic thrombocytopenia associated with H. pylori seropositivity. (who.int)
The mechanisms responsible for the immunostimulatory role of the pineal hormone melatonin (MLT) are still obscure. (karger.com)

However, the mechanism through which RAD18 influences triple-negative breast cancer (TNBC), especially the interaction between tumor cells and the tumor microenvironment, remains elusive. (nature.com)

We set out to understand which mechanism of action of the CD27 antibody is related to its anti-tumor activity by developing mouse isotype variants of the antibody. (bmj.com)
The only available countermeasure that can provide immediate immunity against a biological agent is passive antibody. (cdc.gov)

RNF5 has also been implicated in the mechanisms that control T-cell priming and immune checkpoint efficiency, so the team investigated whether there was a link between RNF5 knockout on immune checkpoint control and tumor growth. (genengnews.com)
Its mechanism of benefit is through B-cell depletion. (medscape.com)
This is an irreversible effect, and reconstitution of B-cell immunity takes 6-12 months. (medscape.com)
Job satisfaction is associated with elevated natural killer cell immunity among healthy white-collar employees. (cdc.gov)
This study investigates the association of job satisfaction with cell-mediated immunity among Japanese white-collar daytime workers. (cdc.gov)

Anatomy33

Organisms30

Diseases28

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes51

Information Science3

Health Care1

Adaptive immunity7

Inflammation1

Molecular9

Malaria immunity1

Antitumor immunity6

Humoral4

Effector1

Protective5

Vaccines5

Pathogenesis4

Defense mechanisms2

Pathogens1

Immunologic1

Disease5

Vaccination2

Macrophage1

Inborn2

COVID193

Antibodies2

APOBEC1

Mice2

Elucidate1

Evasion1

Coronavirus1

Pathways1

Infectious2

Genetics1

Biological mechanisms1

Proteins2

Organisms1

Pathogenic1

Involve1

Brain1

Viral replication3

Contributes2

Multiple mechanisms1

Understood2

Role2

Triple-negati1

Antibody2

Cell5