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  • Immunology
  • Full Text PA-97-079 INNATE IMMUNITY NIH GUIDE, Volume 26, Number 24, July 25, 1997 PA NUMBER: PA-97-079 P.T. 34 Keywords: Immunology National Institute of Allergy and Infectious Diseases National Institute of Dental Research PURPOSE The National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Dental Research (NIDR), National Institutes of Health (NIH), invite applications for research studies of the innate immune system. (nih.gov)
  • pattern recogniti
  • Genetic variations leading to the altered production or function of circulating innate immune proteins, cellular pattern recognition receptors and inflammatory cytokines are linked to obesity, insulin resistance and type 2 diabetes. (springer.com)
  • infection
  • and o studies of the genetic control of innate resistance to infection. (nih.gov)
  • Dysregulation of innate immune processes can lead to widespread infection, sepsis, and immunodeficiencies. (qiagen.com)
  • This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel prevention strategies (vaccines and microbicides). (mendeley.com)
  • Importantly, there is increasing evidence to suggest that many arms of the innate response play both protective and pathogenic roles in HIV infection. (mendeley.com)
  • Priority areas are identified where there are opportunities to accelerate the translation of recent gains in understanding of innate immunity into the design of improved or novel vaccine and microbicide strategies against HIV infection. (mendeley.com)
  • DALLAS - July 6, 2018 - A DNA-sensing enzyme forms droplets that act as tiny bioreactors creating molecules to stimulate innate immunity - the body's first response to infection, UT Southwestern researchers report. (eurekalert.org)
  • To our knowledge, our study is the first to use comprehensive deep-sequencing technology to clearly demonstrate that lncRNAs are involved in the host response to viral infection and innate immunity," says Michael Katze of the University of Washington, and STRIDE (Center for Systems and Translational Research on Infectious Disease) in Seattle, a lead researcher on the study. (scienceblog.com)
  • These findings represent the first discovery of the widespread differential expression of long ncRNAs in response to virus infection and suggest that ncRNAs are involved in regulating the host response, including innate immunity," says Katze. (scienceblog.com)
  • antimicrobial
  • Innate immunity is phylogenetically older and has often been viewed as a vestige of ancient antimicrobial systems made redundant by the evolution of acquired immunity. (nih.gov)
  • Progress in these general areas would provide a better understanding of the functional links between innate and acquired immunity, and would lead to new approaches for immunomodulation, vaccine development, and design of broad-spectrum antimicrobial agents. (nih.gov)
  • resistance
  • In the paper, the notion was introduced that activated innate immunity and the acute-phase response was a mechanism that could explain a number of well-known characteristics of type 2 diabetes, such as dyslipidaemia, insulin resistance, impaired insulin secretion, accelerated atherosclerosis, central obesity and hyperfibrinogenaemia. (springer.com)
  • The concept that activation of innate immunity underlies the pathophysiology of type 2 diabetes, insulin resistance and atherosclerosis [ 2 , 3 ] has been upheld by more recent research. (springer.com)
  • In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. (pnas.org)
  • 1997
  • In this edition of 'Then and now' the initial studies by J.C. Pickup and colleagues supporting the hypothesis that type 2 diabetes is caused by activated innate immunity, published in Diabetologia in 1997 (40:1286-1292), are discussed. (springer.com)
  • regulation
  • QIAGEN provides a broad range of assay technologies for innate immunity research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • triggers
  • Dr. Chen also identified the small molecule cGAMP, which is produced by the enzyme cGAS and functions as a secondary messenger that triggers innate immune responses. (eurekalert.org)
  • cells
  • The fact that SR/CR mice survived the initial challenge with cancer cells without any prior exposure suggests that the anticancer response is innate immunity. (pnas.org)
  • regulate
  • R. Lin reviewed the recent knowledge on how immune signals regulate vitamin D metabolism and how innate immune responses are modulated by ligand-bound vitamin D receptor. (hindawi.com)
  • infectious
  • This PA, "INNATE IMMUNITY", is related to the priority areas of Immunization and Infectious Diseases and Diabetes and Chronic Disabling Diseases. (nih.gov)
  • It's just not supposed to be there, and its presence gets interpreted as a sign of infectious attack, triggering the innate immune system . (sciencemag.org)
  • More than 95% of living organisms on the world protect themselves from infectious challenges using their innate immune system. (frontiersin.org)
  • response
  • Consequently, understanding the contributions made by components of the host innate response to HIV acquisition/spread versus control is a critical pre-requisite for the employment of innate immunity in vaccine or microbicide design, so that appropriate responses can be targeted for up- or down-modulation. (mendeley.com)
  • role
  • We began our research into the role of innate immunity in type 2 diabetes at this time, with the aim of exploring whether type 2 diabetes, dyslipidaemia and atherosclerosis were maladaptations of normal physiological responses to injury rather than the result of abnormalities in biochemical pathways. (springer.com)
  • research
  • The Clinical Sciences Research Institute is hosting a seminar entitled 'Glycomics and innate immunity in human disease' from 12:30pm to 1:30pm on Thursday 21 January 2010 in the Large Seminar Room, CSRI, CSB Building UHCW. (warwick.ac.uk)